Clinical Evolution and Prognostic Factors of Cancer Patients with COVID-19 on Mechanical Ventilation
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng spa |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/4468 |
Resumo: | Introduction: Cancer patients were at risk of developing severe respiratory conditions when affected by COVID-19, requiring intensive support and invasive mechanical ventilation (IMV). Objective: Evaluate the factors associated with death of cancer patients by COVID-19 who developed respiratory failure and need of IMV. Method: Retrospective cohort study of cancer patients in an oncology intensive care unit (ICU), with COVID-19 and on IMV was carried out from April 2020 to December 2021. All patients with cancer admitted to the ICU on IMV or who developed IMV due to worsening of COVID-19 were sequentially included, excluding those who had been in follow-up of the oncological disease for more than five years. For statistical analysis, measures of central tendency and dispersion were used, as well as absolute and relative frequencies. Multiple logistic regression was applied to evaluate factors associated with mortality, considering statistically significant values of p < 0.05. Results: 85 patients were included in the study. Death was higher for patients with solid tumors (OR = 3.64; 95% CI, 1.06-12.52; p = 0.04), in addition to those who required renal support while in ICU (OR = 6.88; 95% CI, 1.82-25.98; p = 0.004), those who could not be extubated (OR = 8.00; 95% CI, 2.16-29.67; p = 0.002) and who presented an alveolar distension pressure value greater than 15cmH2O for at least one day (OR = 5.9; 95% CI, 1.76-19.80; p = 0.004). Conclusion: Clinical and IMV characteristics were associated with death in cancer patients with COVID-19 and IMV. |
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Clinical Evolution and Prognostic Factors of Cancer Patients with COVID-19 on Mechanical VentilationEvolución Clínica y Factores Pronósticos de Pacientes Oncológicos con COVID-19 en Ventilación MecánicaEvolução Clínica e Fatores Prognósticos de Pacientes Oncológicos com Covid-19 em Ventilação MecânicaNeoplasias/epidemiologiaCOVID-19Síndrome do Desconforto RespiratórioCuidados CríticosVentiladores MecânicosNeoplasms/epidemiologyCOVID-19Respiratory Distress SyndromeCritical CareVentilators, MechanicalNeoplasias/epidemiologíaCOVID-19Síndrome de Dificultad RespiratoriaCuidados CríticosVentiladores MecánicosIntroduction: Cancer patients were at risk of developing severe respiratory conditions when affected by COVID-19, requiring intensive support and invasive mechanical ventilation (IMV). Objective: Evaluate the factors associated with death of cancer patients by COVID-19 who developed respiratory failure and need of IMV. Method: Retrospective cohort study of cancer patients in an oncology intensive care unit (ICU), with COVID-19 and on IMV was carried out from April 2020 to December 2021. All patients with cancer admitted to the ICU on IMV or who developed IMV due to worsening of COVID-19 were sequentially included, excluding those who had been in follow-up of the oncological disease for more than five years. For statistical analysis, measures of central tendency and dispersion were used, as well as absolute and relative frequencies. Multiple logistic regression was applied to evaluate factors associated with mortality, considering statistically significant values of p < 0.05. Results: 85 patients were included in the study. Death was higher for patients with solid tumors (OR = 3.64; 95% CI, 1.06-12.52; p = 0.04), in addition to those who required renal support while in ICU (OR = 6.88; 95% CI, 1.82-25.98; p = 0.004), those who could not be extubated (OR = 8.00; 95% CI, 2.16-29.67; p = 0.002) and who presented an alveolar distension pressure value greater than 15cmH2O for at least one day (OR = 5.9; 95% CI, 1.76-19.80; p = 0.004). Conclusion: Clinical and IMV characteristics were associated with death in cancer patients with COVID-19 and IMV.Introducción: Los pacientes con cáncer corrían riesgo de desarrollar afecciones respiratorias graves al ser afectados por la COVID-19, requiriendo soporte intensivo y ventilación mecánica invasiva (VMI). Objetivo: Evaluar los factores asociados a la muerte en pacientes con cáncer que tuvieron COVID-19 y que desarrollaron insuficiencia respiratoria y necesidad de VMI. Método: Estudio de cohorte retrospectivo en pacientes oncológicos internados en una unidad de cuidados intensivos (UCI) de oncología, con COVID-19 y en VMI de abril de 2020 a diciembre de 2021. Se incluyeron secuencialmente todos los pacientes con cáncer ingresados en UCI con VMI o que necesitaron VMI por empeoramiento de la COVID-19, excluyendo a aquellos que llevaban más de cinco años bajo control de la enfermedad oncológica. Para el análisis estadístico se utilizaron medidas de tendencia central y dispersión, así como frecuencias absolutas y relativas. Se aplicó regresión logística múltiple para evaluar los factores asociados a la mortalidad, considerando valores de p < 0,05 estadísticamente significativos. Resultados: Se incluyeron en el estudio 85 pacientes. La muerte fue mayor entre los pacientes con tumores sólidos (OR = 3,64; IC 95%, 1,06-12,52; p = 0,04), entre los que requirieron soporte renal durante la estancia en UCI (OR = 6,88; IC 95%, 1,82-25,98; p = 0,004), entre los que no pudieron ser extubados (OR = 8,00; IC 95%, 2,16-29,67; p = 0,002) y entre los que presentaron un valor de presión de distensión alveolar mayor a 15cmH2O durante al menos un día (OR = 5,9; IC 95%, 1,76-19,80; p = 0,004). Conclusión: Las características clínicas y de VMI se asociaron con la muerte en pacientes oncológicos con COVID-19 y en VMI.Introdução: Pacientes com câncer apresentaram risco de desenvolver quadros respiratórios graves quando acometidos por covid-19, com necessidade de suporte intensivo e de ventilação mecânica invasiva (VMI). Objetivo: Avaliar os fatores associados ao óbito em pacientes oncológicos que tiveram covid-19 e evoluíram com insuficiência respiratória e necessidade de VMI. Método: Estudo de coorte retrospectivo de pacientes com câncer em uma unidade de terapia intensiva (UTI) oncológica, com covid-19 e em VMI de abril de 2020 a dezembro de 2021. Foram incluídos de forma sequencial todos os pacientes com câncer admitidos na UTI em VMI ou que evoluíram com VMI por agravamento da covid-19, sendo excluídos aqueles em controle da doença oncológica há mais de cinco anos. Para a análise estatística, foram utilizadas medidas de tendência central e dispersão, assim como frequências absolutas e relativas. A regressão logística múltipla foi aplicada para a avaliação dos fatores associados à mortalidade, considerando estatisticamente significantes valores de p < 0,05. Resultados: Foram incluídos no estudo 85 pacientes. O óbito foi maior entre os pacientes com tumores sólidos (OR = 3,64; IC 95%: 1,06-12,52; p = 0,04), entre os que necessitaram de suporte renal durante a internação na UTI (OR = 6,88; IC 95%: 1,82-25,98; p = 0,004), os que não puderam ser extubados (OR = 8,00; IC 95%: 2,16-29,67; p = 0,002) e os que apresentaram o valor de pressão de distensão alveolar maior do que 15cmH2O por pelo menos um dia (OR = 5,9; IC 95%: 1,76-19,80; p = 0,004). Conclusão: Características clínicas e de VMI estavam associadas à morte de pacientes oncológicos com covid-19 e em VMI.INCA2024-02-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdfapplication/pdftext/htmlhttps://rbc.inca.gov.br/index.php/revista/article/view/446810.32635/2176-9745.RBC.2024v70n1.4468Revista Brasileira de Cancerologia; Vol. 70 No. 1 (2024): Jan./Feb./Mar.; e-044468Revista Brasileira de Cancerologia; Vol. 70 Núm. 1 (2024): ene./feb./mar.; e-044468Revista Brasileira de Cancerologia; v. 70 n. 1 (2024): jan./fev./mar.; e-0444682176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporengspahttps://rbc.inca.gov.br/index.php/revista/article/view/4468/3357https://rbc.inca.gov.br/index.php/revista/article/view/4468/3358https://rbc.inca.gov.br/index.php/revista/article/view/4468/3401https://rbc.inca.gov.br/index.php/revista/article/view/4468/3387Copyright (c) 2024 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Michelle Queres dosCavalcante, Everton Araújo Almeida, Isabel Cid TaboadaGutierrez, Ana Cristina Machado LeãoFireman, KellyQuintão, Monica PenaBergmann, AnkeBarufaldi, Laura Augusta2024-04-08T14:22:50Zoai:rbc.inca.gov.br:article/4468Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2024-04-08T14:22:50Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Clinical Evolution and Prognostic Factors of Cancer Patients with COVID-19 on Mechanical Ventilation Evolución Clínica y Factores Pronósticos de Pacientes Oncológicos con COVID-19 en Ventilación Mecánica Evolução Clínica e Fatores Prognósticos de Pacientes Oncológicos com Covid-19 em Ventilação Mecânica |
title |
Clinical Evolution and Prognostic Factors of Cancer Patients with COVID-19 on Mechanical Ventilation |
spellingShingle |
Clinical Evolution and Prognostic Factors of Cancer Patients with COVID-19 on Mechanical Ventilation Santos, Michelle Queres dos Neoplasias/epidemiologia COVID-19 Síndrome do Desconforto Respiratório Cuidados Críticos Ventiladores Mecânicos Neoplasms/epidemiology COVID-19 Respiratory Distress Syndrome Critical Care Ventilators, Mechanical Neoplasias/epidemiología COVID-19 Síndrome de Dificultad Respiratoria Cuidados Críticos Ventiladores Mecánicos |
title_short |
Clinical Evolution and Prognostic Factors of Cancer Patients with COVID-19 on Mechanical Ventilation |
title_full |
Clinical Evolution and Prognostic Factors of Cancer Patients with COVID-19 on Mechanical Ventilation |
title_fullStr |
Clinical Evolution and Prognostic Factors of Cancer Patients with COVID-19 on Mechanical Ventilation |
title_full_unstemmed |
Clinical Evolution and Prognostic Factors of Cancer Patients with COVID-19 on Mechanical Ventilation |
title_sort |
Clinical Evolution and Prognostic Factors of Cancer Patients with COVID-19 on Mechanical Ventilation |
author |
Santos, Michelle Queres dos |
author_facet |
Santos, Michelle Queres dos Cavalcante, Everton Araújo Almeida, Isabel Cid Taboada Gutierrez, Ana Cristina Machado Leão Fireman, Kelly Quintão, Monica Pena Bergmann, Anke Barufaldi, Laura Augusta |
author_role |
author |
author2 |
Cavalcante, Everton Araújo Almeida, Isabel Cid Taboada Gutierrez, Ana Cristina Machado Leão Fireman, Kelly Quintão, Monica Pena Bergmann, Anke Barufaldi, Laura Augusta |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Michelle Queres dos Cavalcante, Everton Araújo Almeida, Isabel Cid Taboada Gutierrez, Ana Cristina Machado Leão Fireman, Kelly Quintão, Monica Pena Bergmann, Anke Barufaldi, Laura Augusta |
dc.subject.por.fl_str_mv |
Neoplasias/epidemiologia COVID-19 Síndrome do Desconforto Respiratório Cuidados Críticos Ventiladores Mecânicos Neoplasms/epidemiology COVID-19 Respiratory Distress Syndrome Critical Care Ventilators, Mechanical Neoplasias/epidemiología COVID-19 Síndrome de Dificultad Respiratoria Cuidados Críticos Ventiladores Mecánicos |
topic |
Neoplasias/epidemiologia COVID-19 Síndrome do Desconforto Respiratório Cuidados Críticos Ventiladores Mecânicos Neoplasms/epidemiology COVID-19 Respiratory Distress Syndrome Critical Care Ventilators, Mechanical Neoplasias/epidemiología COVID-19 Síndrome de Dificultad Respiratoria Cuidados Críticos Ventiladores Mecánicos |
description |
Introduction: Cancer patients were at risk of developing severe respiratory conditions when affected by COVID-19, requiring intensive support and invasive mechanical ventilation (IMV). Objective: Evaluate the factors associated with death of cancer patients by COVID-19 who developed respiratory failure and need of IMV. Method: Retrospective cohort study of cancer patients in an oncology intensive care unit (ICU), with COVID-19 and on IMV was carried out from April 2020 to December 2021. All patients with cancer admitted to the ICU on IMV or who developed IMV due to worsening of COVID-19 were sequentially included, excluding those who had been in follow-up of the oncological disease for more than five years. For statistical analysis, measures of central tendency and dispersion were used, as well as absolute and relative frequencies. Multiple logistic regression was applied to evaluate factors associated with mortality, considering statistically significant values of p < 0.05. Results: 85 patients were included in the study. Death was higher for patients with solid tumors (OR = 3.64; 95% CI, 1.06-12.52; p = 0.04), in addition to those who required renal support while in ICU (OR = 6.88; 95% CI, 1.82-25.98; p = 0.004), those who could not be extubated (OR = 8.00; 95% CI, 2.16-29.67; p = 0.002) and who presented an alveolar distension pressure value greater than 15cmH2O for at least one day (OR = 5.9; 95% CI, 1.76-19.80; p = 0.004). Conclusion: Clinical and IMV characteristics were associated with death in cancer patients with COVID-19 and IMV. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/4468 10.32635/2176-9745.RBC.2024v70n1.4468 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/4468 |
identifier_str_mv |
10.32635/2176-9745.RBC.2024v70n1.4468 |
dc.language.iso.fl_str_mv |
por eng spa |
language |
por eng spa |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/4468/3357 https://rbc.inca.gov.br/index.php/revista/article/view/4468/3358 https://rbc.inca.gov.br/index.php/revista/article/view/4468/3401 https://rbc.inca.gov.br/index.php/revista/article/view/4468/3387 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2024 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2024 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf text/html |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 70 No. 1 (2024): Jan./Feb./Mar.; e-044468 Revista Brasileira de Cancerologia; Vol. 70 Núm. 1 (2024): ene./feb./mar.; e-044468 Revista Brasileira de Cancerologia; v. 70 n. 1 (2024): jan./fev./mar.; e-044468 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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rbc@inca.gov.br |
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