Metastatic Castration-Resistant Prostate Cancer in Brazil: a Real-World Investigation Using INCA Database

Detalhes bibliográficos
Autor(a) principal: Pozzo, Lorena
Data de Publicação: 2023
Outros Autores: Oliveira, Mércia Liane de, Monteiro, Lucilena Rebelo, Menezes, Mario Olímpio de, Giammarile, Francesco, Sadi, Marcus Vinícius
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/3763
Resumo: Introduction: Prostate cancer is the second most common cancer in men worldwide. In Brazil, regional disparities in incidences of intermediate and high-risk in late-diagnosed PC cases are expected. Objective: To investigate the clinical and demographic profiles of patients treated with metastatic castration-resistant prostate cancer (mCRPC) in Brazil, using real-world data from public databases. Method: Prostate cancer data from the Brazilian cancer registries were filtered from Brazilian public databases from 2008 to 2018. The number of health institutions and registries at a cancer public database were used to separate the Brazilian Federative Units into two comparison groups. mCRPC patients were estimated by using a combination of filters of staging and treatment (Tx, Nx and M1 + chemotherapy). The patients’ median age and the number and type of treatments were evaluated. Results: A total of 325,987 patients with prostate cancer and 5,367 patients with mCRPC were identified. The median age of the mCRPC patients was 63 years. The percentage of patients who underwent one, two or three treatments was 21.0%, 43.2% and 28.1%, respectively. In addition, management differences were noticed depending on the group analyzed. Conclusion: The results revealed regional discrepancies in the distribution of registered mCRPC patients in the Brazilian territory and in their treatment. This information can be used to strengthen the recently updated treatment and improve the palliative care offered. This work presents suggestions to improve specific prostate cancer databases.
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spelling Metastatic Castration-Resistant Prostate Cancer in Brazil: a Real-World Investigation Using INCA DatabaseEl Cáncer de Próstata Metastático Resistente a Castración en el Brasil: Investigación en el Mundo Real Usando la Base de Datos del INCAO Câncer de Próstata Metastático Resistente à Castração no Brasil: um Estudo do Mundo Real Usando o Banco de Dados do INCAneoplasias de próstata resistentes à castraçãometástase neoplásicaregistros públicos de dados de cuidados de saúdeprostatic neoplasms, castration-resistantneoplasm metastasispublic reporting of healthcare dataneoplasias de la próstata resistentes a la castraciónmetástasis de la neoplasiareportes públicos de datos en atención de saludIntroduction: Prostate cancer is the second most common cancer in men worldwide. In Brazil, regional disparities in incidences of intermediate and high-risk in late-diagnosed PC cases are expected. Objective: To investigate the clinical and demographic profiles of patients treated with metastatic castration-resistant prostate cancer (mCRPC) in Brazil, using real-world data from public databases. Method: Prostate cancer data from the Brazilian cancer registries were filtered from Brazilian public databases from 2008 to 2018. The number of health institutions and registries at a cancer public database were used to separate the Brazilian Federative Units into two comparison groups. mCRPC patients were estimated by using a combination of filters of staging and treatment (Tx, Nx and M1 + chemotherapy). The patients’ median age and the number and type of treatments were evaluated. Results: A total of 325,987 patients with prostate cancer and 5,367 patients with mCRPC were identified. The median age of the mCRPC patients was 63 years. The percentage of patients who underwent one, two or three treatments was 21.0%, 43.2% and 28.1%, respectively. In addition, management differences were noticed depending on the group analyzed. Conclusion: The results revealed regional discrepancies in the distribution of registered mCRPC patients in the Brazilian territory and in their treatment. This information can be used to strengthen the recently updated treatment and improve the palliative care offered. This work presents suggestions to improve specific prostate cancer databases.Introducción: El cáncer de próstata es el segundo tipo más común en hombres en el mundo. En el Brasil, se espera encontrar diferencias regionales en la incidencia de diagnósticos tardíos de riesgo intermedio y alto. Objetivo: Investigar los perfiles clínico y demográfico de pacientes con cáncer de próstata metastásico resistente a la castración (mCRPC) tratados en el Brasil utilizando datos del mundo real de bases de datos públicas brasileñas. Método: Los casos de cáncer de próstata fueron filtrados a partir de los registros brasileños de cáncer nel período de 2008 a 2018. El número de instituciones registradoras en la base de datos fue utilizado para separar los Estados Brasileños en dos grupos para comparación. El número de pacientes se estimó mediante una combinación de filtros de estadio y tratamiento (Tx, Nx y M1 + quimioterapia). Fueron evaluados la edad media y la cantidad y tipos de tratamiento realizados. Resultados: Se identificaron un total de 325.987 pacientes con cáncer de próstata y 5367 pacientes con mCRPC. La mediana de la edad de los pacientes con mCRPC fue de 63 años. El porcentaje de pacientes sometidos a uno, dos o tres tratamientos fue del 21,0%, 43,2% y 28,1%. Fueron observadas diferencias de manejo según el grupo analizado. Conclusión: Fueron reveladas diferencias regionales en la distribución de los pacientes con mCRPC en el Brasil y, especialmente, en el manejo de la enfermedad a partir de bases de datos públicas. Esta información puede apoyar las decisiones de incorporar nuevos tratamientos y mejorar los cuidados ofrecidos a los pacientes. Se presentan sugerencias para el desarrollo de bases de datos específicas y la mejora de las existentes.Introdução: O câncer de próstata é o segundo tipo mais comum em homens ao redor do mundo. No Brasil, diferenças regionais de incidência em casos de risco intermediário e alto tardiamente diagnosticados são esperadas. Objetivo: Investigar os perfis clínico e demográfico de pacientes com câncer de próstata metastático resistente à castração (mCRPC) tratados no Brasil usando dados do mundo real de bancos de dados públicos brasileiros. Método: Os casos de câncer de próstata foram filtrados a partir dos registros brasileiros de câncer no período de 2008 a 2018. O número de instituições de saúde que registram esses casos foi usado para separar as Unidades Federativas brasileiras em dois grupos. O número de pacientes com mCRPC foi estimado usando uma combinação de filtros de estadiamento e tratamento (Tx, Nx e M1 + quimioterapia). A idade média e o número e tipos de tratamento realizados foram avaliados. Resultados: O estudo identificou 325.987 pacientes com câncer de próstata e 5.367 com mCRPC. A mediana das idades de pacientes com mCRPC foi de 63 anos. O percentual de pacientes submetidos a um, dois ou três tratamentos foi de 21,0%, 43,2% e 28,1%, respectivamente. Foram observadas diferenças de manejo nos grupos analisados. Conclusão: Os resultados revelaram diferenças regionais nas distribuições de pacientes com mCRPC no território brasileiro e no manejo da doença. Essa informação pode subsidiar decisões de incorporação de novos tratamentos e de melhoria dos cuidados paliativos oferecidos aos pacientes com mCRPC. Este trabalho apresenta sugestoes para o desenvolvimento de bancos de dados específicos para câncer de próstata e aprimoramento dos já existentes.INCA2023-05-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdftext/htmlhttps://rbc.inca.gov.br/index.php/revista/article/view/376310.32635/2176-9745.RBC.2023v69n2.3763Revista Brasileira de Cancerologia; Vol. 69 No. 2 (2023): Apr./May/June; e-193763Revista Brasileira de Cancerologia; Vol. 69 Núm. 2 (2023): abr./mayo/jun.; e-193763Revista Brasileira de Cancerologia; v. 69 n. 2 (2023): abr./maio/jun.; e-1937632176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAenghttps://rbc.inca.gov.br/index.php/revista/article/view/3763/2852https://rbc.inca.gov.br/index.php/revista/article/view/3763/2860Copyright (c) 2023 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPozzo, LorenaOliveira, Mércia Liane deMonteiro, Lucilena RebeloMenezes, Mario Olímpio deGiammarile, FrancescoSadi, Marcus Vinícius2023-06-16T20:31:44Zoai:rbc.inca.gov.br:article/3763Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-06-16T20:31:44Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Metastatic Castration-Resistant Prostate Cancer in Brazil: a Real-World Investigation Using INCA Database
El Cáncer de Próstata Metastático Resistente a Castración en el Brasil: Investigación en el Mundo Real Usando la Base de Datos del INCA
O Câncer de Próstata Metastático Resistente à Castração no Brasil: um Estudo do Mundo Real Usando o Banco de Dados do INCA
title Metastatic Castration-Resistant Prostate Cancer in Brazil: a Real-World Investigation Using INCA Database
spellingShingle Metastatic Castration-Resistant Prostate Cancer in Brazil: a Real-World Investigation Using INCA Database
Pozzo, Lorena
neoplasias de próstata resistentes à castração
metástase neoplásica
registros públicos de dados de cuidados de saúde
prostatic neoplasms, castration-resistant
neoplasm metastasis
public reporting of healthcare data
neoplasias de la próstata resistentes a la castración
metástasis de la neoplasia
reportes públicos de datos en atención de salud
title_short Metastatic Castration-Resistant Prostate Cancer in Brazil: a Real-World Investigation Using INCA Database
title_full Metastatic Castration-Resistant Prostate Cancer in Brazil: a Real-World Investigation Using INCA Database
title_fullStr Metastatic Castration-Resistant Prostate Cancer in Brazil: a Real-World Investigation Using INCA Database
title_full_unstemmed Metastatic Castration-Resistant Prostate Cancer in Brazil: a Real-World Investigation Using INCA Database
title_sort Metastatic Castration-Resistant Prostate Cancer in Brazil: a Real-World Investigation Using INCA Database
author Pozzo, Lorena
author_facet Pozzo, Lorena
Oliveira, Mércia Liane de
Monteiro, Lucilena Rebelo
Menezes, Mario Olímpio de
Giammarile, Francesco
Sadi, Marcus Vinícius
author_role author
author2 Oliveira, Mércia Liane de
Monteiro, Lucilena Rebelo
Menezes, Mario Olímpio de
Giammarile, Francesco
Sadi, Marcus Vinícius
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pozzo, Lorena
Oliveira, Mércia Liane de
Monteiro, Lucilena Rebelo
Menezes, Mario Olímpio de
Giammarile, Francesco
Sadi, Marcus Vinícius
dc.subject.por.fl_str_mv neoplasias de próstata resistentes à castração
metástase neoplásica
registros públicos de dados de cuidados de saúde
prostatic neoplasms, castration-resistant
neoplasm metastasis
public reporting of healthcare data
neoplasias de la próstata resistentes a la castración
metástasis de la neoplasia
reportes públicos de datos en atención de salud
topic neoplasias de próstata resistentes à castração
metástase neoplásica
registros públicos de dados de cuidados de saúde
prostatic neoplasms, castration-resistant
neoplasm metastasis
public reporting of healthcare data
neoplasias de la próstata resistentes a la castración
metástasis de la neoplasia
reportes públicos de datos en atención de salud
description Introduction: Prostate cancer is the second most common cancer in men worldwide. In Brazil, regional disparities in incidences of intermediate and high-risk in late-diagnosed PC cases are expected. Objective: To investigate the clinical and demographic profiles of patients treated with metastatic castration-resistant prostate cancer (mCRPC) in Brazil, using real-world data from public databases. Method: Prostate cancer data from the Brazilian cancer registries were filtered from Brazilian public databases from 2008 to 2018. The number of health institutions and registries at a cancer public database were used to separate the Brazilian Federative Units into two comparison groups. mCRPC patients were estimated by using a combination of filters of staging and treatment (Tx, Nx and M1 + chemotherapy). The patients’ median age and the number and type of treatments were evaluated. Results: A total of 325,987 patients with prostate cancer and 5,367 patients with mCRPC were identified. The median age of the mCRPC patients was 63 years. The percentage of patients who underwent one, two or three treatments was 21.0%, 43.2% and 28.1%, respectively. In addition, management differences were noticed depending on the group analyzed. Conclusion: The results revealed regional discrepancies in the distribution of registered mCRPC patients in the Brazilian territory and in their treatment. This information can be used to strengthen the recently updated treatment and improve the palliative care offered. This work presents suggestions to improve specific prostate cancer databases.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/3763
10.32635/2176-9745.RBC.2023v69n2.3763
url https://rbc.inca.gov.br/index.php/revista/article/view/3763
identifier_str_mv 10.32635/2176-9745.RBC.2023v69n2.3763
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/3763/2852
https://rbc.inca.gov.br/index.php/revista/article/view/3763/2860
dc.rights.driver.fl_str_mv Copyright (c) 2023 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 69 No. 2 (2023): Apr./May/June; e-193763
Revista Brasileira de Cancerologia; Vol. 69 Núm. 2 (2023): abr./mayo/jun.; e-193763
Revista Brasileira de Cancerologia; v. 69 n. 2 (2023): abr./maio/jun.; e-193763
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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