Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/2811 |
Resumo: | Electrotherapy with direct electric current was performed on a subcutaneous murine tumor model (Ehrlich tumor). The current was supplied through Pt electrodes, where the cathode was inserted directly into the tumors and the anode subcutaneously in their vicinity. After the single shock electrotherapy the tumors volume diminish and the necrosis percentage were observed to be significant and dependent on direct electric current (1.8 and 4 mA). On the repetitive electrotherapy with 1.8 and 4 mA in different days and sites of tumor, tumor volume decrease was also observed. The control groups in both were subjected to the same conditions without electric current. These results show that electrotherapy in advanced stages also can be an effective antitumoral therapy and that its ejfects are better for the highest current intensity. It was concluded that electrotherapy for these stages must be applied by means of an electrodes array placed symmetrically all over the tumor, or in sections ofthe tumor separately, with the aim ofreducing the high voltage applied between the electrodes. |
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Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stagesEfectos de la corriente eléctrica directa en el tumor murinho subcutáneo de Ehrlich. I: Estúdios de necrosis y volumen dei tumor em estádios avanzadosCathodic ElectrotherapyEhrlich Ascitic TumorNecrosis PercentageTumorElectroterapia CatódicaTumor Ascítico de EhrlichPorcentaje de NecrosisVolumen del TumorElectrotherapy with direct electric current was performed on a subcutaneous murine tumor model (Ehrlich tumor). The current was supplied through Pt electrodes, where the cathode was inserted directly into the tumors and the anode subcutaneously in their vicinity. After the single shock electrotherapy the tumors volume diminish and the necrosis percentage were observed to be significant and dependent on direct electric current (1.8 and 4 mA). On the repetitive electrotherapy with 1.8 and 4 mA in different days and sites of tumor, tumor volume decrease was also observed. The control groups in both were subjected to the same conditions without electric current. These results show that electrotherapy in advanced stages also can be an effective antitumoral therapy and that its ejfects are better for the highest current intensity. It was concluded that electrotherapy for these stages must be applied by means of an electrodes array placed symmetrically all over the tumor, or in sections ofthe tumor separately, with the aim ofreducing the high voltage applied between the electrodes. La electroterapia con corriente eléctrica directa se aplico a un modelo de tumor murinho subcutáneo (tumor de Ehrlich). La corriente fue suministrada a través de electrodos de Pt, donde el cátodo fue introducido directamente en los tumores y el ánodo subcutáneamente en la vecindad de éstos. Después de la electroterapia de un solo estímulo se observo que la disminución dei volumen y el porcentaje de necrosis de los tumores fueron significativos y dependientes de la intensidad de corriente directa (1,8 y 4 mA). En la electroterapia repetitiva con 1,8 y 4 mA en diferentes dias y zonas dei tumor, también se observo disminución del volumen dei tumor. Los grupos controles en ambos casos fueron sometidos a Ias mismas condiciones, pero no se les suministró corriente eléctrica. Estos resultados indican que la electroterapia en estádios avanzados también puede ser una terapia antitumoral efectiva y que sus efectos son mejores a mayores intensidades de corriente. Se concluyó que la electroterapia para estos estádios debe aplicarse mediante el empleo de un arreglo de electrodos dispuesto simétricamente en todo el tumor o en secciones de éste por separado, con el objetivo de disminuir los altos voltajes que se aplican entre los electrodos.INCA2022-09-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/281110.32635/2176-9745.RBC.1998v44n3.2811Revista Brasileira de Cancerologia; Vol. 44 No. 3 (1998): July/Aug./Sept.; 203-210Revista Brasileira de Cancerologia; Vol. 44 Núm. 3 (1998): jul./ago./sept.; 203-210Revista Brasileira de Cancerologia; v. 44 n. 3 (1998): jul./ago./set.; 203-2102176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAspahttps://rbc.inca.gov.br/index.php/revista/article/view/2811/1690https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCabrales, Luis Bergues Aldana, Richard Hinojosa Bruzón, Rodolfo Pérez Ciria, Héctor Camué Gonzáiez, Liban Montes de Oca Quevedo, Catalina Suárez Lafargue, Alcibiades Lara Toirac, Ramón Ropero Reyes, Alfredo Fong 2023-01-18T15:10:58Zoai:rbc.inca.gov.br:article/2811Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-01-18T15:10:58Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages Efectos de la corriente eléctrica directa en el tumor murinho subcutáneo de Ehrlich. I: Estúdios de necrosis y volumen dei tumor em estádios avanzados |
title |
Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages |
spellingShingle |
Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages Cabrales, Luis Bergues Cathodic Electrotherapy Ehrlich Ascitic Tumor Necrosis Percentage Tumor Electroterapia Catódica Tumor Ascítico de Ehrlich Porcentaje de Necrosis Volumen del Tumor |
title_short |
Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages |
title_full |
Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages |
title_fullStr |
Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages |
title_full_unstemmed |
Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages |
title_sort |
Direct electric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages |
author |
Cabrales, Luis Bergues |
author_facet |
Cabrales, Luis Bergues Aldana, Richard Hinojosa Bruzón, Rodolfo Pérez Ciria, Héctor Camué Gonzáiez, Liban Montes de Oca Quevedo, Catalina Suárez Lafargue, Alcibiades Lara Toirac, Ramón Ropero Reyes, Alfredo Fong |
author_role |
author |
author2 |
Aldana, Richard Hinojosa Bruzón, Rodolfo Pérez Ciria, Héctor Camué Gonzáiez, Liban Montes de Oca Quevedo, Catalina Suárez Lafargue, Alcibiades Lara Toirac, Ramón Ropero Reyes, Alfredo Fong |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cabrales, Luis Bergues Aldana, Richard Hinojosa Bruzón, Rodolfo Pérez Ciria, Héctor Camué Gonzáiez, Liban Montes de Oca Quevedo, Catalina Suárez Lafargue, Alcibiades Lara Toirac, Ramón Ropero Reyes, Alfredo Fong |
dc.subject.por.fl_str_mv |
Cathodic Electrotherapy Ehrlich Ascitic Tumor Necrosis Percentage Tumor Electroterapia Catódica Tumor Ascítico de Ehrlich Porcentaje de Necrosis Volumen del Tumor |
topic |
Cathodic Electrotherapy Ehrlich Ascitic Tumor Necrosis Percentage Tumor Electroterapia Catódica Tumor Ascítico de Ehrlich Porcentaje de Necrosis Volumen del Tumor |
description |
Electrotherapy with direct electric current was performed on a subcutaneous murine tumor model (Ehrlich tumor). The current was supplied through Pt electrodes, where the cathode was inserted directly into the tumors and the anode subcutaneously in their vicinity. After the single shock electrotherapy the tumors volume diminish and the necrosis percentage were observed to be significant and dependent on direct electric current (1.8 and 4 mA). On the repetitive electrotherapy with 1.8 and 4 mA in different days and sites of tumor, tumor volume decrease was also observed. The control groups in both were subjected to the same conditions without electric current. These results show that electrotherapy in advanced stages also can be an effective antitumoral therapy and that its ejfects are better for the highest current intensity. It was concluded that electrotherapy for these stages must be applied by means of an electrodes array placed symmetrically all over the tumor, or in sections ofthe tumor separately, with the aim ofreducing the high voltage applied between the electrodes. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2811 10.32635/2176-9745.RBC.1998v44n3.2811 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/2811 |
identifier_str_mv |
10.32635/2176-9745.RBC.1998v44n3.2811 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2811/1690 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 44 No. 3 (1998): July/Aug./Sept.; 203-210 Revista Brasileira de Cancerologia; Vol. 44 Núm. 3 (1998): jul./ago./sept.; 203-210 Revista Brasileira de Cancerologia; v. 44 n. 3 (1998): jul./ago./set.; 203-210 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042232955502592 |