Metastatic Merkel cell Carcinoma: Case Report: Carcinoma de Merkel

Detalhes bibliográficos
Autor(a) principal: Schoeler, Nathielen Caroline
Data de Publicação: 2021
Outros Autores: Kayser, Thayse Fachin Cormanique, Scandolara, Thalita Basso, Kern, Rodrigo, Alves, Fernanda Mara, Rech, Daniel, Panis, Carolina
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1107
Resumo: Introduction: The Merkel cell carcinoma is a rare cutaneous neuroendocrine tumor that originates from cells responsible for tactile sensitivity, it has an aggressive character, fast evolution and difficult treatment. Case report: 49 years Caucasian male patient, with a painless nodule, infiltrating deep tissue, not ulcerated and located in left arm identified during the dermatological consultation. The result of the incisional biopsy was positive for Merkel cell carcinoma. After resection of the lesion, complementary exams revealed metastatic disease in the axilla and chest wall. The chemotherapy treatment brought an initial improvement with tumor reduction, however, it was not durable, because new areas with tumor metastases in upper regions of the body were revealed, the patient was submitted to an another surgical procedure, after which a new chemotherapy regimen failed. Conclusion: At the time of the treatment of this patient, monoclonal antibodies, such as avelumab, were not available. Early diagnosis with immediate lesion excision surgery, before the involvement of other regions, remains the best option for a better prognosis. However, regardless of this, because of the limitations at the time of the treatment, the patient died.
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spelling Metastatic Merkel cell Carcinoma: Case Report: Carcinoma de MerkelCarcinoma de Células de Merkel Metastásico: Relato de Caso: Carcinoma de MerkelCarcinoma de Células de Merkel Metastático: Relato de Caso: Carcinoma de MerkelCarcinoma de Célula de MerkelCélulas de MerkelMetástase NeoplásicaNeoplasias CutâneasRelatos de CasosCarcinoma, Merkel CellMerkel CellsNeoplasm MetastasisSkin NeoplasmsCase ReportsCarcinoma de Células de MerkelCélulas de MerkelMetástasis de la NeoplasiaNeoplasias CutáneasInformes de CasosIntroduction: The Merkel cell carcinoma is a rare cutaneous neuroendocrine tumor that originates from cells responsible for tactile sensitivity, it has an aggressive character, fast evolution and difficult treatment. Case report: 49 years Caucasian male patient, with a painless nodule, infiltrating deep tissue, not ulcerated and located in left arm identified during the dermatological consultation. The result of the incisional biopsy was positive for Merkel cell carcinoma. After resection of the lesion, complementary exams revealed metastatic disease in the axilla and chest wall. The chemotherapy treatment brought an initial improvement with tumor reduction, however, it was not durable, because new areas with tumor metastases in upper regions of the body were revealed, the patient was submitted to an another surgical procedure, after which a new chemotherapy regimen failed. Conclusion: At the time of the treatment of this patient, monoclonal antibodies, such as avelumab, were not available. Early diagnosis with immediate lesion excision surgery, before the involvement of other regions, remains the best option for a better prognosis. However, regardless of this, because of the limitations at the time of the treatment, the patient died.Introducción: El carcinoma de células de Merkel es un tumor neuroendocrino cutáneo raro, que se origina en células responsables de la sensibilidad táctil, tiene un carácter agresivo, una evolución rápida y un tratamiento difícil. Relato del caso: Paciente masculino, de 49 años, caucásico, que en atención dermatológica encontró nódulo indoloro, infiltrando tejidos profundos, no ulcerados y ubicados en la región del brazo izquierdo. El resultado de la biopsia incisional fue positivo para el carcinoma de células de Merkel. Después de la resección de la lesión, los exámenes complementarios mostraron enfermedad metastásica en la axila y la pared torácica. Con el tratamiento de quimioterapia, hubo un beneficio inicial con la reducción del tumor, sin embargo, no es duradero, ya que se revelaron nuevas áreas con metástasis tumorales en las regiones superiores del cuerpo, que se sometieron a un nuevo procedimiento quirúrgico, que después de un nuevo régimen de quimioterapia no tuvo éxito. Conclusión: En el momento del tratamiento de este paciente, los anticuerpos monoclonales, como avelumab, no estaban disponibles. El diagnóstico temprano con cirugía para la escisión de la lesión inmediata, antes de la participación de otras regiones, sigue siendo la mejor opción para un pronóstico favorable para el paciente. Sin embargo, a pesar de esto, con las limitaciones al momento del tratamiento, el paciente falleció.Introdução: O carcinoma de células de Merkel é um raro tumor neuroendócrino cutâneo, que se origina das células responsáveis pela sensibilidade tátil, possui caráter agressivo, evolução rápida e difícil tratamento. Relato do caso: Paciente do sexo masculino, 49 anos, caucasiano, que, ao atendimento dermatológico, apresentou nódulo indolor, infiltrando tecidos profundos, não ulcerado e localizado na região do braço esquerdo. O resultado da biópsia incisional foi positivo para carcinoma de células de Merkel. Após ressecção da lesão, os exames complementares evidenciaram doença metastática na axila e parede torácica. Com o tratamento quimioterápico, houve um benefício inicial com redução tumoral, porém, não durável, uma vez que foram reveladas novas áreas com metástases tumorais em regiões superiores do corpo, sendo submetido a novo procedimento cirúrgico, o qual, após novo regime quimioterápico, não obteve sucesso. Conclusão: Na ocasião do tratamento desse paciente, os anticorpos monoclonais, como o avelumab, não estavam disponíveis. O diagnóstico precoce com cirurgia de exérese da lesão imediata, antes do acometimento de outras regiões, permanece sendo a melhor opção para um prognóstico favorável ao paciente. Contudo, a despeito disso, com as limitações à época do tratamento, o paciente evoluiu a óbito.INCA2021-01-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/110710.32635/2176-9745.RBC.2021v67n1.1107Revista Brasileira de Cancerologia; Vol. 67 No. 1 (2021): Jan./Feb./Mar.; e-091107Revista Brasileira de Cancerologia; Vol. 67 Núm. 1 (2021): ene./feb./mar.; e-091107Revista Brasileira de Cancerologia; v. 67 n. 1 (2021): jan./fev./mar.; e-0911072176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/1107/822https://rbc.inca.gov.br/index.php/revista/article/view/1107/1062Copyright (c) 2021 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessSchoeler, Nathielen Caroline Kayser, Thayse Fachin Cormanique Scandolara, Thalita Basso Kern, RodrigoAlves, Fernanda MaraRech, DanielPanis, Carolina 2021-11-29T18:29:23Zoai:rbc.inca.gov.br:article/1107Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T18:29:23Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Metastatic Merkel cell Carcinoma: Case Report: Carcinoma de Merkel
Carcinoma de Células de Merkel Metastásico: Relato de Caso: Carcinoma de Merkel
Carcinoma de Células de Merkel Metastático: Relato de Caso: Carcinoma de Merkel
title Metastatic Merkel cell Carcinoma: Case Report: Carcinoma de Merkel
spellingShingle Metastatic Merkel cell Carcinoma: Case Report: Carcinoma de Merkel
Schoeler, Nathielen Caroline
Carcinoma de Célula de Merkel
Células de Merkel
Metástase Neoplásica
Neoplasias Cutâneas
Relatos de Casos
Carcinoma, Merkel Cell
Merkel Cells
Neoplasm Metastasis
Skin Neoplasms
Case Reports
Carcinoma de Células de Merkel
Células de Merkel
Metástasis de la Neoplasia
Neoplasias Cutáneas
Informes de Casos
title_short Metastatic Merkel cell Carcinoma: Case Report: Carcinoma de Merkel
title_full Metastatic Merkel cell Carcinoma: Case Report: Carcinoma de Merkel
title_fullStr Metastatic Merkel cell Carcinoma: Case Report: Carcinoma de Merkel
title_full_unstemmed Metastatic Merkel cell Carcinoma: Case Report: Carcinoma de Merkel
title_sort Metastatic Merkel cell Carcinoma: Case Report: Carcinoma de Merkel
author Schoeler, Nathielen Caroline
author_facet Schoeler, Nathielen Caroline
Kayser, Thayse Fachin Cormanique
Scandolara, Thalita Basso
Kern, Rodrigo
Alves, Fernanda Mara
Rech, Daniel
Panis, Carolina
author_role author
author2 Kayser, Thayse Fachin Cormanique
Scandolara, Thalita Basso
Kern, Rodrigo
Alves, Fernanda Mara
Rech, Daniel
Panis, Carolina
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schoeler, Nathielen Caroline
Kayser, Thayse Fachin Cormanique
Scandolara, Thalita Basso
Kern, Rodrigo
Alves, Fernanda Mara
Rech, Daniel
Panis, Carolina
dc.subject.por.fl_str_mv Carcinoma de Célula de Merkel
Células de Merkel
Metástase Neoplásica
Neoplasias Cutâneas
Relatos de Casos
Carcinoma, Merkel Cell
Merkel Cells
Neoplasm Metastasis
Skin Neoplasms
Case Reports
Carcinoma de Células de Merkel
Células de Merkel
Metástasis de la Neoplasia
Neoplasias Cutáneas
Informes de Casos
topic Carcinoma de Célula de Merkel
Células de Merkel
Metástase Neoplásica
Neoplasias Cutâneas
Relatos de Casos
Carcinoma, Merkel Cell
Merkel Cells
Neoplasm Metastasis
Skin Neoplasms
Case Reports
Carcinoma de Células de Merkel
Células de Merkel
Metástasis de la Neoplasia
Neoplasias Cutáneas
Informes de Casos
description Introduction: The Merkel cell carcinoma is a rare cutaneous neuroendocrine tumor that originates from cells responsible for tactile sensitivity, it has an aggressive character, fast evolution and difficult treatment. Case report: 49 years Caucasian male patient, with a painless nodule, infiltrating deep tissue, not ulcerated and located in left arm identified during the dermatological consultation. The result of the incisional biopsy was positive for Merkel cell carcinoma. After resection of the lesion, complementary exams revealed metastatic disease in the axilla and chest wall. The chemotherapy treatment brought an initial improvement with tumor reduction, however, it was not durable, because new areas with tumor metastases in upper regions of the body were revealed, the patient was submitted to an another surgical procedure, after which a new chemotherapy regimen failed. Conclusion: At the time of the treatment of this patient, monoclonal antibodies, such as avelumab, were not available. Early diagnosis with immediate lesion excision surgery, before the involvement of other regions, remains the best option for a better prognosis. However, regardless of this, because of the limitations at the time of the treatment, the patient died.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Relato de Caso
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1107
10.32635/2176-9745.RBC.2021v67n1.1107
url https://rbc.inca.gov.br/index.php/revista/article/view/1107
identifier_str_mv 10.32635/2176-9745.RBC.2021v67n1.1107
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1107/822
https://rbc.inca.gov.br/index.php/revista/article/view/1107/1062
dc.rights.driver.fl_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 67 No. 1 (2021): Jan./Feb./Mar.; e-091107
Revista Brasileira de Cancerologia; Vol. 67 Núm. 1 (2021): ene./feb./mar.; e-091107
Revista Brasileira de Cancerologia; v. 67 n. 1 (2021): jan./fev./mar.; e-091107
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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