Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology

Detalhes bibliográficos
Autor(a) principal: Silva, Wanessa Cristina Farias da
Data de Publicação: 2021
Outros Autores: Lima, Ana Gabriela Silva de, Silva, Heverton Valentim Colaço da, Santos, Rozangela Amorim
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/967
Resumo: Introduction: Pancreatic malignant neoplasia represents one of the highest mortality neoplasms worldwide, almost always associated to a dismal prognosis, especially when associated with lymphatic spread and to distant organs. Objective: To assess the global survival in patients with pancreatic adenocarcinoma treated at a specialized oncology center. Method: From January 2011 to December 2014, 71 medical records were retrospectively evaluated. The data were analyzed using the STATA software version 14, using the Kaplan-Meier curve and the Cox regression. The confidence interval used was 95% (p<0.05). Ethical and confidentiality principles have been secured. Results: There was predominance of males, mixed race and over 61 years of age at diagnosis. As for the clinical characteristics, 87.8% of the tumors were located in the head of the pancreas. Abdominal pain (92.7%) was the most frequent symptom, followed by progressive weight loss (79.3%) and jaundice (57.3%). The three-month follow-up survival rate was 48.4%. Conclusion: The study shows that pancreatic cancer has an extremely negative repercussion, since most patients are diagnosed in advanced stages of the disease, hindering the possibility of curative treatment.
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spelling Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in OncologyPerfil Clínico-Epidemiológico y Supervivencia General en Pacientes com Adenocarcinoma de Páncreas em un Hospital de Referencia em OncologíaPerfil Clínico-Epidemiológico e Sobrevida Global em Pacientes com Adenocarcinoma de Pâncreas em um Hospital de Referência em OncologiaNeoplasias pancreáticas/epidemiologiaAnálise de SobrevidaDiagnóstico TardioPancreatic Neoplasms/epidemiologySurvival AnalysisDelayed DiagnosisNeoplasias Pancreáticas/epidemiologíaAnálisis de SupervivenciaDiagnóstico TardíoIntroduction: Pancreatic malignant neoplasia represents one of the highest mortality neoplasms worldwide, almost always associated to a dismal prognosis, especially when associated with lymphatic spread and to distant organs. Objective: To assess the global survival in patients with pancreatic adenocarcinoma treated at a specialized oncology center. Method: From January 2011 to December 2014, 71 medical records were retrospectively evaluated. The data were analyzed using the STATA software version 14, using the Kaplan-Meier curve and the Cox regression. The confidence interval used was 95% (p<0.05). Ethical and confidentiality principles have been secured. Results: There was predominance of males, mixed race and over 61 years of age at diagnosis. As for the clinical characteristics, 87.8% of the tumors were located in the head of the pancreas. Abdominal pain (92.7%) was the most frequent symptom, followed by progressive weight loss (79.3%) and jaundice (57.3%). The three-month follow-up survival rate was 48.4%. Conclusion: The study shows that pancreatic cancer has an extremely negative repercussion, since most patients are diagnosed in advanced stages of the disease, hindering the possibility of curative treatment.Introducción: La neoplasia maligna pancreática representa una de las neoplasias de mortalidad más altas del mundo, casi siempre vinculada a un pronóstico sombrío, especialmente cuando se asocia con diseminación linfática y órganos distantes. Objetivo: Evaluar la supervivencia global en pacientes con adenocarcinoma pancreático tratados en un centro de oncología especializado. Método: Desde enero de 2011 hasta diciembre de 2014, se evaluaron retrospectivamente 71 registros médicos. Los datos se analizaron utilizando el software STATA versión 14, utilizando la curva de Kaplan-Meier y la regresión de Cox. El intervalo de confianza utilizado fue del 95% (p<0,05). Se han preservado los principios éticos y de confidencialidad. Resultados: Predomino el sexo masculino, la raza mixta y los mayores de 61 años en el momento del diagnóstico. En cuanto a las características clínicas, el 87,8% de los tumores se ubicaron en la cabeza del páncreas. El dolor abdominal (92,7%) fue el síntoma más frecuente, seguido de pérdida progresiva de peso (79,3%) e ictericia (57,3%). La tasa de supervivencia de seguimiento a los tres meses fue del 48,4%. Conclusión: El estudio muestra que el cáncer de páncreas tiene un impacto extremadamente negativo, ya que la mayoría de los pacientes reciben el diagnostico en etapas avanzadas, obstaculizando la posibilidad de tratamiento curativo.Introdução: A neoplasia maligna de pâncreas configura uma das neoplasias de maior mortalidade em todo o mundo, quase sempre atrelada a um prognostico sombrio, principalmente quando associada a disseminação linfática e para órgãos distantes. Objetivo: Avaliar a sobrevida global em pacientes com adenocarcinoma de pâncreas atendidos em um centro especializado em oncologia. Método: No período de janeiro de 2011 a dezembro de 2014, foram avaliados retrospectivamente 71 prontuários. Os dados foram analisados pelo software STATA versão 14, utilizando análise de Kaplan-Meier e de regressão de Cox. O intervalo de confiança utilizado foi de 95% e considerado significante p<0,05. Foram preservados os princípios éticos e da confidencialidade. Resultados: Houve predomínio do sexo masculino, raça parda e com idade superior a 61 anos ao diagnóstico. Quanto as características clínicas, 87,8% dos tumores estavam localizados em cabeça de pâncreas. A dor abdominal (92,7%) foi o sintoma mais frequente, seguida de perda progressiva de peso (79,3%) e icterícia (57,3%). A taxa de sobrevida em três meses de acompanhamento foi de 48,4%. Conclusão: O estudo evidencia que o câncer de pâncreas tem uma repercussão extremamente negativa, visto que a maioria dos pacientes recebe o diagnostico em estágios avançados da doença, dificultando a possibilidade de tratamento curativo.INCA2021-01-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/96710.32635/2176-9745.RBC.2021v67n1.967Revista Brasileira de Cancerologia; Vol. 67 No. 1 (2021): Jan./Feb./Mar.; e-16967Revista Brasileira de Cancerologia; Vol. 67 Núm. 1 (2021): ene./feb./mar.; e-16967Revista Brasileira de Cancerologia; v. 67 n. 1 (2021): jan./fev./mar.; e-169672176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/967/911https://rbc.inca.gov.br/index.php/revista/article/view/967/1190Copyright (c) 2021 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessSilva, Wanessa Cristina Farias da Lima, Ana Gabriela Silva de Silva, Heverton Valentim Colaço da Santos, Rozangela Amorim 2021-11-29T18:27:42Zoai:rbc.inca.gov.br:article/967Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T18:27:42Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology
Perfil Clínico-Epidemiológico y Supervivencia General en Pacientes com Adenocarcinoma de Páncreas em un Hospital de Referencia em Oncología
Perfil Clínico-Epidemiológico e Sobrevida Global em Pacientes com Adenocarcinoma de Pâncreas em um Hospital de Referência em Oncologia
title Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology
spellingShingle Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology
Silva, Wanessa Cristina Farias da
Neoplasias pancreáticas/epidemiologia
Análise de Sobrevida
Diagnóstico Tardio
Pancreatic Neoplasms/epidemiology
Survival Analysis
Delayed Diagnosis
Neoplasias Pancreáticas/epidemiología
Análisis de Supervivencia
Diagnóstico Tardío
title_short Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology
title_full Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology
title_fullStr Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology
title_full_unstemmed Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology
title_sort Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology
author Silva, Wanessa Cristina Farias da
author_facet Silva, Wanessa Cristina Farias da
Lima, Ana Gabriela Silva de
Silva, Heverton Valentim Colaço da
Santos, Rozangela Amorim
author_role author
author2 Lima, Ana Gabriela Silva de
Silva, Heverton Valentim Colaço da
Santos, Rozangela Amorim
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, Wanessa Cristina Farias da
Lima, Ana Gabriela Silva de
Silva, Heverton Valentim Colaço da
Santos, Rozangela Amorim
dc.subject.por.fl_str_mv Neoplasias pancreáticas/epidemiologia
Análise de Sobrevida
Diagnóstico Tardio
Pancreatic Neoplasms/epidemiology
Survival Analysis
Delayed Diagnosis
Neoplasias Pancreáticas/epidemiología
Análisis de Supervivencia
Diagnóstico Tardío
topic Neoplasias pancreáticas/epidemiologia
Análise de Sobrevida
Diagnóstico Tardio
Pancreatic Neoplasms/epidemiology
Survival Analysis
Delayed Diagnosis
Neoplasias Pancreáticas/epidemiología
Análisis de Supervivencia
Diagnóstico Tardío
description Introduction: Pancreatic malignant neoplasia represents one of the highest mortality neoplasms worldwide, almost always associated to a dismal prognosis, especially when associated with lymphatic spread and to distant organs. Objective: To assess the global survival in patients with pancreatic adenocarcinoma treated at a specialized oncology center. Method: From January 2011 to December 2014, 71 medical records were retrospectively evaluated. The data were analyzed using the STATA software version 14, using the Kaplan-Meier curve and the Cox regression. The confidence interval used was 95% (p<0.05). Ethical and confidentiality principles have been secured. Results: There was predominance of males, mixed race and over 61 years of age at diagnosis. As for the clinical characteristics, 87.8% of the tumors were located in the head of the pancreas. Abdominal pain (92.7%) was the most frequent symptom, followed by progressive weight loss (79.3%) and jaundice (57.3%). The three-month follow-up survival rate was 48.4%. Conclusion: The study shows that pancreatic cancer has an extremely negative repercussion, since most patients are diagnosed in advanced stages of the disease, hindering the possibility of curative treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/967
10.32635/2176-9745.RBC.2021v67n1.967
url https://rbc.inca.gov.br/index.php/revista/article/view/967
identifier_str_mv 10.32635/2176-9745.RBC.2021v67n1.967
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/967/911
https://rbc.inca.gov.br/index.php/revista/article/view/967/1190
dc.rights.driver.fl_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 67 No. 1 (2021): Jan./Feb./Mar.; e-16967
Revista Brasileira de Cancerologia; Vol. 67 Núm. 1 (2021): ene./feb./mar.; e-16967
Revista Brasileira de Cancerologia; v. 67 n. 1 (2021): jan./fev./mar.; e-16967
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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