Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/967 |
Resumo: | Introduction: Pancreatic malignant neoplasia represents one of the highest mortality neoplasms worldwide, almost always associated to a dismal prognosis, especially when associated with lymphatic spread and to distant organs. Objective: To assess the global survival in patients with pancreatic adenocarcinoma treated at a specialized oncology center. Method: From January 2011 to December 2014, 71 medical records were retrospectively evaluated. The data were analyzed using the STATA software version 14, using the Kaplan-Meier curve and the Cox regression. The confidence interval used was 95% (p<0.05). Ethical and confidentiality principles have been secured. Results: There was predominance of males, mixed race and over 61 years of age at diagnosis. As for the clinical characteristics, 87.8% of the tumors were located in the head of the pancreas. Abdominal pain (92.7%) was the most frequent symptom, followed by progressive weight loss (79.3%) and jaundice (57.3%). The three-month follow-up survival rate was 48.4%. Conclusion: The study shows that pancreatic cancer has an extremely negative repercussion, since most patients are diagnosed in advanced stages of the disease, hindering the possibility of curative treatment. |
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Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in OncologyPerfil Clínico-Epidemiológico y Supervivencia General en Pacientes com Adenocarcinoma de Páncreas em un Hospital de Referencia em OncologíaPerfil Clínico-Epidemiológico e Sobrevida Global em Pacientes com Adenocarcinoma de Pâncreas em um Hospital de Referência em OncologiaNeoplasias pancreáticas/epidemiologiaAnálise de SobrevidaDiagnóstico TardioPancreatic Neoplasms/epidemiologySurvival AnalysisDelayed DiagnosisNeoplasias Pancreáticas/epidemiologíaAnálisis de SupervivenciaDiagnóstico TardíoIntroduction: Pancreatic malignant neoplasia represents one of the highest mortality neoplasms worldwide, almost always associated to a dismal prognosis, especially when associated with lymphatic spread and to distant organs. Objective: To assess the global survival in patients with pancreatic adenocarcinoma treated at a specialized oncology center. Method: From January 2011 to December 2014, 71 medical records were retrospectively evaluated. The data were analyzed using the STATA software version 14, using the Kaplan-Meier curve and the Cox regression. The confidence interval used was 95% (p<0.05). Ethical and confidentiality principles have been secured. Results: There was predominance of males, mixed race and over 61 years of age at diagnosis. As for the clinical characteristics, 87.8% of the tumors were located in the head of the pancreas. Abdominal pain (92.7%) was the most frequent symptom, followed by progressive weight loss (79.3%) and jaundice (57.3%). The three-month follow-up survival rate was 48.4%. Conclusion: The study shows that pancreatic cancer has an extremely negative repercussion, since most patients are diagnosed in advanced stages of the disease, hindering the possibility of curative treatment.Introducción: La neoplasia maligna pancreática representa una de las neoplasias de mortalidad más altas del mundo, casi siempre vinculada a un pronóstico sombrío, especialmente cuando se asocia con diseminación linfática y órganos distantes. Objetivo: Evaluar la supervivencia global en pacientes con adenocarcinoma pancreático tratados en un centro de oncología especializado. Método: Desde enero de 2011 hasta diciembre de 2014, se evaluaron retrospectivamente 71 registros médicos. Los datos se analizaron utilizando el software STATA versión 14, utilizando la curva de Kaplan-Meier y la regresión de Cox. El intervalo de confianza utilizado fue del 95% (p<0,05). Se han preservado los principios éticos y de confidencialidad. Resultados: Predomino el sexo masculino, la raza mixta y los mayores de 61 años en el momento del diagnóstico. En cuanto a las características clínicas, el 87,8% de los tumores se ubicaron en la cabeza del páncreas. El dolor abdominal (92,7%) fue el síntoma más frecuente, seguido de pérdida progresiva de peso (79,3%) e ictericia (57,3%). La tasa de supervivencia de seguimiento a los tres meses fue del 48,4%. Conclusión: El estudio muestra que el cáncer de páncreas tiene un impacto extremadamente negativo, ya que la mayoría de los pacientes reciben el diagnostico en etapas avanzadas, obstaculizando la posibilidad de tratamiento curativo.Introdução: A neoplasia maligna de pâncreas configura uma das neoplasias de maior mortalidade em todo o mundo, quase sempre atrelada a um prognostico sombrio, principalmente quando associada a disseminação linfática e para órgãos distantes. Objetivo: Avaliar a sobrevida global em pacientes com adenocarcinoma de pâncreas atendidos em um centro especializado em oncologia. Método: No período de janeiro de 2011 a dezembro de 2014, foram avaliados retrospectivamente 71 prontuários. Os dados foram analisados pelo software STATA versão 14, utilizando análise de Kaplan-Meier e de regressão de Cox. O intervalo de confiança utilizado foi de 95% e considerado significante p<0,05. Foram preservados os princípios éticos e da confidencialidade. Resultados: Houve predomínio do sexo masculino, raça parda e com idade superior a 61 anos ao diagnóstico. Quanto as características clínicas, 87,8% dos tumores estavam localizados em cabeça de pâncreas. A dor abdominal (92,7%) foi o sintoma mais frequente, seguida de perda progressiva de peso (79,3%) e icterícia (57,3%). A taxa de sobrevida em três meses de acompanhamento foi de 48,4%. Conclusão: O estudo evidencia que o câncer de pâncreas tem uma repercussão extremamente negativa, visto que a maioria dos pacientes recebe o diagnostico em estágios avançados da doença, dificultando a possibilidade de tratamento curativo.INCA2021-01-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/96710.32635/2176-9745.RBC.2021v67n1.967Revista Brasileira de Cancerologia; Vol. 67 No. 1 (2021): Jan./Feb./Mar.; e-16967Revista Brasileira de Cancerologia; Vol. 67 Núm. 1 (2021): ene./feb./mar.; e-16967Revista Brasileira de Cancerologia; v. 67 n. 1 (2021): jan./fev./mar.; e-169672176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/967/911https://rbc.inca.gov.br/index.php/revista/article/view/967/1190Copyright (c) 2021 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessSilva, Wanessa Cristina Farias da Lima, Ana Gabriela Silva de Silva, Heverton Valentim Colaço da Santos, Rozangela Amorim 2021-11-29T18:27:42Zoai:rbc.inca.gov.br:article/967Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T18:27:42Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology Perfil Clínico-Epidemiológico y Supervivencia General en Pacientes com Adenocarcinoma de Páncreas em un Hospital de Referencia em Oncología Perfil Clínico-Epidemiológico e Sobrevida Global em Pacientes com Adenocarcinoma de Pâncreas em um Hospital de Referência em Oncologia |
title |
Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology |
spellingShingle |
Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology Silva, Wanessa Cristina Farias da Neoplasias pancreáticas/epidemiologia Análise de Sobrevida Diagnóstico Tardio Pancreatic Neoplasms/epidemiology Survival Analysis Delayed Diagnosis Neoplasias Pancreáticas/epidemiología Análisis de Supervivencia Diagnóstico Tardío |
title_short |
Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology |
title_full |
Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology |
title_fullStr |
Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology |
title_full_unstemmed |
Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology |
title_sort |
Clinical Epidemiological Profile and Global Survival in Patients with Pancreatic Adenocarcinoma at a Reference Hospital in Oncology |
author |
Silva, Wanessa Cristina Farias da |
author_facet |
Silva, Wanessa Cristina Farias da Lima, Ana Gabriela Silva de Silva, Heverton Valentim Colaço da Santos, Rozangela Amorim |
author_role |
author |
author2 |
Lima, Ana Gabriela Silva de Silva, Heverton Valentim Colaço da Santos, Rozangela Amorim |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva, Wanessa Cristina Farias da Lima, Ana Gabriela Silva de Silva, Heverton Valentim Colaço da Santos, Rozangela Amorim |
dc.subject.por.fl_str_mv |
Neoplasias pancreáticas/epidemiologia Análise de Sobrevida Diagnóstico Tardio Pancreatic Neoplasms/epidemiology Survival Analysis Delayed Diagnosis Neoplasias Pancreáticas/epidemiología Análisis de Supervivencia Diagnóstico Tardío |
topic |
Neoplasias pancreáticas/epidemiologia Análise de Sobrevida Diagnóstico Tardio Pancreatic Neoplasms/epidemiology Survival Analysis Delayed Diagnosis Neoplasias Pancreáticas/epidemiología Análisis de Supervivencia Diagnóstico Tardío |
description |
Introduction: Pancreatic malignant neoplasia represents one of the highest mortality neoplasms worldwide, almost always associated to a dismal prognosis, especially when associated with lymphatic spread and to distant organs. Objective: To assess the global survival in patients with pancreatic adenocarcinoma treated at a specialized oncology center. Method: From January 2011 to December 2014, 71 medical records were retrospectively evaluated. The data were analyzed using the STATA software version 14, using the Kaplan-Meier curve and the Cox regression. The confidence interval used was 95% (p<0.05). Ethical and confidentiality principles have been secured. Results: There was predominance of males, mixed race and over 61 years of age at diagnosis. As for the clinical characteristics, 87.8% of the tumors were located in the head of the pancreas. Abdominal pain (92.7%) was the most frequent symptom, followed by progressive weight loss (79.3%) and jaundice (57.3%). The three-month follow-up survival rate was 48.4%. Conclusion: The study shows that pancreatic cancer has an extremely negative repercussion, since most patients are diagnosed in advanced stages of the disease, hindering the possibility of curative treatment. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/967 10.32635/2176-9745.RBC.2021v67n1.967 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/967 |
identifier_str_mv |
10.32635/2176-9745.RBC.2021v67n1.967 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/967/911 https://rbc.inca.gov.br/index.php/revista/article/view/967/1190 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Revista Brasileira de Cancerologia info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Revista Brasileira de Cancerologia |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 67 No. 1 (2021): Jan./Feb./Mar.; e-16967 Revista Brasileira de Cancerologia; Vol. 67 Núm. 1 (2021): ene./feb./mar.; e-16967 Revista Brasileira de Cancerologia; v. 67 n. 1 (2021): jan./fev./mar.; e-16967 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042245989302272 |