Small Cell Carcinoma of the Esophagus: A case report and literature review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/3426 |
Resumo: | A case of primary small cell carcinoma in the lower third of the thorack esophagus in a 54- years old white man is presented. The initial symptoms was weight loss and epigastric pain in the last 3 months. The physical examination showed the evident signs ofthe constitutional disease. Accurate clinical staging was performed and revealed metastases in para-aortic, mesenteric and celiac lymph nodes. This case was characterized by a possible extensive local growth with invasion to the aorta. The treatment performed was systemic chemotherapy with cisplatin and etoposide (VP-16) combined with radiotherapy. Afier 3 courses of chemotherapy the complete clinical remission was achieved, and to consolidate the local result, the patient received externai beam irradiation and further chemotherapy with the same drugs. However, the local and systemic progression occurred 40 days after the radiotherapy. He died nine months after admission of respiratory infection with multiple metastases. We discuss the prognosis and the biological behavior of this aggressive disease and make the critical analysis of the therapeutic options. The main treatment for the advanced primary small cell carcinoma ofthe esophagus is based in systemic chemotherapy. |
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Small Cell Carcinoma of the Esophagus: A case report and literature reviewCarcinoma de Pequena Células em Esôfago: Relato de Caso e RevisãoCarcinoma de Pequenas CélulasCarcinoma de Pequenas Células do EsôfagoCarcinoma de EsôfagoSmall Cell CarcinomaSmall Cell Carcinoma of the EsophagusCarcinoma of the EsophagusA case of primary small cell carcinoma in the lower third of the thorack esophagus in a 54- years old white man is presented. The initial symptoms was weight loss and epigastric pain in the last 3 months. The physical examination showed the evident signs ofthe constitutional disease. Accurate clinical staging was performed and revealed metastases in para-aortic, mesenteric and celiac lymph nodes. This case was characterized by a possible extensive local growth with invasion to the aorta. The treatment performed was systemic chemotherapy with cisplatin and etoposide (VP-16) combined with radiotherapy. Afier 3 courses of chemotherapy the complete clinical remission was achieved, and to consolidate the local result, the patient received externai beam irradiation and further chemotherapy with the same drugs. However, the local and systemic progression occurred 40 days after the radiotherapy. He died nine months after admission of respiratory infection with multiple metastases. We discuss the prognosis and the biological behavior of this aggressive disease and make the critical analysis of the therapeutic options. The main treatment for the advanced primary small cell carcinoma ofthe esophagus is based in systemic chemotherapy.O caso de um paciente do sexo masculino com 54 anos, portador de carcinoma de pequenas Células primitivo em terço inferior de esôfago. As manifestações iniciais da doença se caracterizaram por emagrecimento acentuado e dores epigástricas com 3 meses de evolução. Ao exame físico observamos sinais evidentes de doença consuntiva. O estadiamento oncológico revelou acometimento secundário de linfonodos para-aórticos, mesentéricos e do tronco celíaco (doença extensa), além de possível invasão de aorta descendente. O tratamento baseou-se na quimioterapia com cisdiaminodicloroplatinum e etoposide, obtendo-se remissão clínica completa com três ciclos. Como consolidação do resultado, o paciente recebeu radioterapia externa dirigida ao local do tumor primário, porém a resposta obtida não se manteve, havendo progressão local e sistêmica após 40 dias do término da radioterapia. O óbito se deu em função de infecção respiratória e múltiplas metástases 9 meses do diagnóstico. Nós discutimos o mau prognóstico deste tipo de tumor, sobretudo em função do comportamento biológico agressivo e fazemos uma análise crítica da orientação terapêutica proposta, concluindo que o tratamento principal para os carcinomas de pequenas células de esôfago locorregionalmente avançado deve ser baseado na quimioterapia.INCA2022-12-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/342610.32635/2176-9745.RBC.2000v46n2.3426Revista Brasileira de Cancerologia; Vol. 46 No. 2 (2000): Apr./May/June; 191-196Revista Brasileira de Cancerologia; Vol. 46 Núm. 2 (2000): abr./mayo/jun.; 191-196Revista Brasileira de Cancerologia; v. 46 n. 2 (2000): abr./maio/jun.; 191-1962176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/3426/2292https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGuimarães , José Luiz MirandoNotari, AlessandraFranke, Fábio AndréColle, Marli BoniattiReiriz, André BorbaSutmöller , Sören Franz Marian ChicataMenezes, Marcelo Oliveira de2023-01-18T15:20:00Zoai:rbc.inca.gov.br:article/3426Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-01-18T15:20Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Small Cell Carcinoma of the Esophagus: A case report and literature review Carcinoma de Pequena Células em Esôfago: Relato de Caso e Revisão |
title |
Small Cell Carcinoma of the Esophagus: A case report and literature review |
spellingShingle |
Small Cell Carcinoma of the Esophagus: A case report and literature review Guimarães , José Luiz Mirando Carcinoma de Pequenas Células Carcinoma de Pequenas Células do Esôfago Carcinoma de Esôfago Small Cell Carcinoma Small Cell Carcinoma of the Esophagus Carcinoma of the Esophagus |
title_short |
Small Cell Carcinoma of the Esophagus: A case report and literature review |
title_full |
Small Cell Carcinoma of the Esophagus: A case report and literature review |
title_fullStr |
Small Cell Carcinoma of the Esophagus: A case report and literature review |
title_full_unstemmed |
Small Cell Carcinoma of the Esophagus: A case report and literature review |
title_sort |
Small Cell Carcinoma of the Esophagus: A case report and literature review |
author |
Guimarães , José Luiz Mirando |
author_facet |
Guimarães , José Luiz Mirando Notari, Alessandra Franke, Fábio André Colle, Marli Boniatti Reiriz, André Borba Sutmöller , Sören Franz Marian Chicata Menezes, Marcelo Oliveira de |
author_role |
author |
author2 |
Notari, Alessandra Franke, Fábio André Colle, Marli Boniatti Reiriz, André Borba Sutmöller , Sören Franz Marian Chicata Menezes, Marcelo Oliveira de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Guimarães , José Luiz Mirando Notari, Alessandra Franke, Fábio André Colle, Marli Boniatti Reiriz, André Borba Sutmöller , Sören Franz Marian Chicata Menezes, Marcelo Oliveira de |
dc.subject.por.fl_str_mv |
Carcinoma de Pequenas Células Carcinoma de Pequenas Células do Esôfago Carcinoma de Esôfago Small Cell Carcinoma Small Cell Carcinoma of the Esophagus Carcinoma of the Esophagus |
topic |
Carcinoma de Pequenas Células Carcinoma de Pequenas Células do Esôfago Carcinoma de Esôfago Small Cell Carcinoma Small Cell Carcinoma of the Esophagus Carcinoma of the Esophagus |
description |
A case of primary small cell carcinoma in the lower third of the thorack esophagus in a 54- years old white man is presented. The initial symptoms was weight loss and epigastric pain in the last 3 months. The physical examination showed the evident signs ofthe constitutional disease. Accurate clinical staging was performed and revealed metastases in para-aortic, mesenteric and celiac lymph nodes. This case was characterized by a possible extensive local growth with invasion to the aorta. The treatment performed was systemic chemotherapy with cisplatin and etoposide (VP-16) combined with radiotherapy. Afier 3 courses of chemotherapy the complete clinical remission was achieved, and to consolidate the local result, the patient received externai beam irradiation and further chemotherapy with the same drugs. However, the local and systemic progression occurred 40 days after the radiotherapy. He died nine months after admission of respiratory infection with multiple metastases. We discuss the prognosis and the biological behavior of this aggressive disease and make the critical analysis of the therapeutic options. The main treatment for the advanced primary small cell carcinoma ofthe esophagus is based in systemic chemotherapy. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Relato de Caso |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3426 10.32635/2176-9745.RBC.2000v46n2.3426 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/3426 |
identifier_str_mv |
10.32635/2176-9745.RBC.2000v46n2.3426 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3426/2292 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 46 No. 2 (2000): Apr./May/June; 191-196 Revista Brasileira de Cancerologia; Vol. 46 Núm. 2 (2000): abr./mayo/jun.; 191-196 Revista Brasileira de Cancerologia; v. 46 n. 2 (2000): abr./maio/jun.; 191-196 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042235652440064 |