Antioxidant Vitamins and Cervix Cancer Prevention
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/1622 |
Resumo: | Cervix cancer is the third most frequent malignancy among women, although it presents one of the highest prevention and cure possibilities if early detected and appropriately treated. Its main etiological factor is the human papilomavirus (HPV) that induces cervix epithelium lesions, which can turn into precursor lesions or even invasive tumor. The dietetic factors play a major role as co-factors in the development of cervical intraepithelial neoplasm (CIN) and consequently of the cervix cancer. The main goal of this review study is to analyze the association of antioxidant vitamins and cervix cancer prevention, identify beneficial nutrients and its participation in the displasic lesions prevention. The antioxidant vitamins, such as vitamin A, C and E, present some beneficial properties in the prevention of the cervix cancer, especially in early stages of cervical carcinogenesis. Vitamin A, through carotenoids, has the capacity to inhibit the free radicals formation, and is also a powerful modulator of cellular differentiation, which protects against HPV development. Vitamins C and E can prevent carcinogens formation and can also improve immunity. Therefore, the nutritional therapy based on the use of antioxidant nutrients can be a preventive strategy for cervix cancer; this can give a new dimension to present oncological therapy, and allow better results in the management of this disease. |
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Antioxidant Vitamins and Cervix Cancer PreventionVitaminas Antioxidantes en la Prevención del Cáncer de Cuello UterinoVitaminas Antioxidantes na Prevenção do Câncer do Colo UterinoNeoplasias do Colo do Útero/EtiologiaNeoplasias do Colo do Útero/Prevenção & ControleInfecções por PapillomavirusTerapia NutricionalAntioxidantesRevisãoUterine Cervical Neoplasms/EtiologyUterine Cervical Neoplasms/Prevention & ControlPapillomavirus InfectionsNutrition TherapyAntioxidantsReviewNeoplasias del Cuello Uterino/EtiologíaNeoplasias del Cuello Uterino /Prevención & ControlInfecciones por PapillomavirusTerapia NutricionalAntioxidantesRevisiónCervix cancer is the third most frequent malignancy among women, although it presents one of the highest prevention and cure possibilities if early detected and appropriately treated. Its main etiological factor is the human papilomavirus (HPV) that induces cervix epithelium lesions, which can turn into precursor lesions or even invasive tumor. The dietetic factors play a major role as co-factors in the development of cervical intraepithelial neoplasm (CIN) and consequently of the cervix cancer. The main goal of this review study is to analyze the association of antioxidant vitamins and cervix cancer prevention, identify beneficial nutrients and its participation in the displasic lesions prevention. The antioxidant vitamins, such as vitamin A, C and E, present some beneficial properties in the prevention of the cervix cancer, especially in early stages of cervical carcinogenesis. Vitamin A, through carotenoids, has the capacity to inhibit the free radicals formation, and is also a powerful modulator of cellular differentiation, which protects against HPV development. Vitamins C and E can prevent carcinogens formation and can also improve immunity. Therefore, the nutritional therapy based on the use of antioxidant nutrients can be a preventive strategy for cervix cancer; this can give a new dimension to present oncological therapy, and allow better results in the management of this disease.El cáncer de cuello uterino es la tercera neoplasia maligna más frecuente en las mujeres, sin embargo tiene uno de los más altos potenciales para la prevención y la cura si se detecta a tiempo y se trata adecuadamente. El principal factor etiológico de este cáncer es el Virus del Papiloma Humano (VPH) que induce lesiones en el epitelio cervical, con riesgo de desarrollar lesiones precursoras y neoplasia invasiva. Los factores dietéticos tienen un papel importante como cofactores en el desarrollo de la neoplasia intraepitelial cervical (NIC) y consecuentemente del cáncer cervical. Este trabajo de revisión bibliográfica tiene por objeto analizar la asociación entre las vitaminas antioxidantes y la prevención del cáncer de cuello uterino, identificando sus acciones en la prevención de las lesiones displásicas. El suministro de vitaminas antioxidantes como las A, C y E muestra beneficios en la prevención del cáncer de cuello uterino, principalmente en las fases iniciales de la carcinogénesis cervical. La Vitamina A, a través de los carotenoides, es capaz de inhibir la formación de radicales libres, siendo también potentes moduladores de la diferenciación celular, lo que concede protección para inhibir el desarrollo del VPH. Las Vitaminas C y E pueden evitar la formación de carcinógenos, además de aumentar la inmunidad. Por lo tanto, la terapia nutricional, basada en la utilización de nutrientes antioxidantes, puede ser una estrategia preventiva para el cáncer del cuello uterino y, por tanto, ampliar los conceptos de la terapia oncológica actual, lo que permitirá mejores resultados en cuanto al control de esta enfermedad.O câncer do colo uterino é a terceira neoplasia maligna mais comum nas mulheres, entretanto apresenta um dos mais altos potenciais de prevenção e cura se descoberto no início e tratado adequadamente. O principal fator etiológico para esse câncer é o Papilomavírus Humano (HPV) que induz a lesões no epitélio cervical, podendo evoluir para lesões precursoras e neoplasia invasiva. Os fatores dietéticos apresentam papel importante como cofatores no desenvolvimento da neoplasia intraepitelial cervical (NIC) e consequentemente do câncer cervical. Este trabalho de revisão bibliográfica tem como objetivo analisar a associação das vitaminas antioxidantes com a prevenção do câncer do colo uterino, identificando suas ações na prevenção das lesões displásicas. A oferta de vitaminas antioxidantes como A, C e E apresenta benefícios para prevenção do câncer do colo uterino, principalmente nos estágios iniciais da carcinogênese cervical. A vitamina A, através dos carotenoides, tem capacidade de inibir a formação dos radicais livres, sendo também potentes moduladores da diferenciação celular, o que confere proteção para inibir o desenvolvimento do HPV. As vitaminas C e E podem evitar a formação de carcinógenos, além de aumentar a imunidade. Dessa forma, a terapêutica nutricional, baseada na utilização de nutrientes antioxidantes, pode ser uma estratégia preventiva para o câncer do colo uterino, podendo assim ampliar os conceitos da terapia oncológica atual, o que permitirá melhores resultados quanto ao controle dessa doença.INCA2009-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/162210.32635/2176-9745.RBC.2009v55n3.1622Revista Brasileira de Cancerologia; Vol. 55 No. 3 (2009): July/Aug./Sept.; 289-296Revista Brasileira de Cancerologia; Vol. 55 Núm. 3 (2009): jul./ago./sept.; 289-296Revista Brasileira de Cancerologia; v. 55 n. 3 (2009): jul./ago./set.; 289-2962176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1622/966Sampaio, Lúcia da CunhaAlmeida, Cristiane Fonseca deinfo:eu-repo/semantics/openAccess2021-11-29T20:20:18Zoai:rbc.inca.gov.br:article/1622Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:20:18Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Antioxidant Vitamins and Cervix Cancer Prevention Vitaminas Antioxidantes en la Prevención del Cáncer de Cuello Uterino Vitaminas Antioxidantes na Prevenção do Câncer do Colo Uterino |
title |
Antioxidant Vitamins and Cervix Cancer Prevention |
spellingShingle |
Antioxidant Vitamins and Cervix Cancer Prevention Sampaio, Lúcia da Cunha Neoplasias do Colo do Útero/Etiologia Neoplasias do Colo do Útero/Prevenção & Controle Infecções por Papillomavirus Terapia Nutricional Antioxidantes Revisão Uterine Cervical Neoplasms/Etiology Uterine Cervical Neoplasms/Prevention & Control Papillomavirus Infections Nutrition Therapy Antioxidants Review Neoplasias del Cuello Uterino/Etiología Neoplasias del Cuello Uterino /Prevención & Control Infecciones por Papillomavirus Terapia Nutricional Antioxidantes Revisión |
title_short |
Antioxidant Vitamins and Cervix Cancer Prevention |
title_full |
Antioxidant Vitamins and Cervix Cancer Prevention |
title_fullStr |
Antioxidant Vitamins and Cervix Cancer Prevention |
title_full_unstemmed |
Antioxidant Vitamins and Cervix Cancer Prevention |
title_sort |
Antioxidant Vitamins and Cervix Cancer Prevention |
author |
Sampaio, Lúcia da Cunha |
author_facet |
Sampaio, Lúcia da Cunha Almeida, Cristiane Fonseca de |
author_role |
author |
author2 |
Almeida, Cristiane Fonseca de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Sampaio, Lúcia da Cunha Almeida, Cristiane Fonseca de |
dc.subject.por.fl_str_mv |
Neoplasias do Colo do Útero/Etiologia Neoplasias do Colo do Útero/Prevenção & Controle Infecções por Papillomavirus Terapia Nutricional Antioxidantes Revisão Uterine Cervical Neoplasms/Etiology Uterine Cervical Neoplasms/Prevention & Control Papillomavirus Infections Nutrition Therapy Antioxidants Review Neoplasias del Cuello Uterino/Etiología Neoplasias del Cuello Uterino /Prevención & Control Infecciones por Papillomavirus Terapia Nutricional Antioxidantes Revisión |
topic |
Neoplasias do Colo do Útero/Etiologia Neoplasias do Colo do Útero/Prevenção & Controle Infecções por Papillomavirus Terapia Nutricional Antioxidantes Revisão Uterine Cervical Neoplasms/Etiology Uterine Cervical Neoplasms/Prevention & Control Papillomavirus Infections Nutrition Therapy Antioxidants Review Neoplasias del Cuello Uterino/Etiología Neoplasias del Cuello Uterino /Prevención & Control Infecciones por Papillomavirus Terapia Nutricional Antioxidantes Revisión |
description |
Cervix cancer is the third most frequent malignancy among women, although it presents one of the highest prevention and cure possibilities if early detected and appropriately treated. Its main etiological factor is the human papilomavirus (HPV) that induces cervix epithelium lesions, which can turn into precursor lesions or even invasive tumor. The dietetic factors play a major role as co-factors in the development of cervical intraepithelial neoplasm (CIN) and consequently of the cervix cancer. The main goal of this review study is to analyze the association of antioxidant vitamins and cervix cancer prevention, identify beneficial nutrients and its participation in the displasic lesions prevention. The antioxidant vitamins, such as vitamin A, C and E, present some beneficial properties in the prevention of the cervix cancer, especially in early stages of cervical carcinogenesis. Vitamin A, through carotenoids, has the capacity to inhibit the free radicals formation, and is also a powerful modulator of cellular differentiation, which protects against HPV development. Vitamins C and E can prevent carcinogens formation and can also improve immunity. Therefore, the nutritional therapy based on the use of antioxidant nutrients can be a preventive strategy for cervix cancer; this can give a new dimension to present oncological therapy, and allow better results in the management of this disease. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-09-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Revisão de literatura |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1622 10.32635/2176-9745.RBC.2009v55n3.1622 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/1622 |
identifier_str_mv |
10.32635/2176-9745.RBC.2009v55n3.1622 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1622/966 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 55 No. 3 (2009): July/Aug./Sept.; 289-296 Revista Brasileira de Cancerologia; Vol. 55 Núm. 3 (2009): jul./ago./sept.; 289-296 Revista Brasileira de Cancerologia; v. 55 n. 3 (2009): jul./ago./set.; 289-296 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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rbc@inca.gov.br |
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