The Genetic Risk of Cancer Therapy

Detalhes bibliográficos
Autor(a) principal: Minicucci, Eliana Maria
Data de Publicação: 2022
Outros Autores: Salvadari, Daísy Maria Favero, Ribeiro, Lúcia Regina, Maia, Maria Aparecida Conti, Camargo, João Lauro Viana de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/3410
Resumo: The presente paper indicates the effects of the most common practices for cancer treatment on the genetic sample of the patient. The main objective of this report is to stress the importance of the risk/benefit assessment of the different therapeutic protocols adopted for cancer and the need for the development of new therapeutic practices and chemotherapy agents. After stressing the fact that cancer is a genetic disease that develops through multiple steps, the effects of ionizing radiation and of some therapeutic Chemicals on the DNA are presented. Besides, the deleterious effects on the DNA of the technical personnel who provides treatment are also indicated. Therefore, this paper discusses tn a general way the genetic damage induced by anti-neoplastic agents, which increases the risk for the development of another primary tumor.
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spelling The Genetic Risk of Cancer TherapyO Risco Genético das Terapias do CâncerRisco GenéticoRadioterapiaBraquiterapiaQuimioterapiaGenetic RiskRadiotherapyBrachytherapyChemotherapyThe presente paper indicates the effects of the most common practices for cancer treatment on the genetic sample of the patient. The main objective of this report is to stress the importance of the risk/benefit assessment of the different therapeutic protocols adopted for cancer and the need for the development of new therapeutic practices and chemotherapy agents. After stressing the fact that cancer is a genetic disease that develops through multiple steps, the effects of ionizing radiation and of some therapeutic Chemicals on the DNA are presented. Besides, the deleterious effects on the DNA of the technical personnel who provides treatment are also indicated. Therefore, this paper discusses tn a general way the genetic damage induced by anti-neoplastic agents, which increases the risk for the development of another primary tumor.O presente artigo descreve as conseqüências de algumas terapias utilizadas para o câncer sobre o material genético de pacientes com neoplasias. O objetivo é ressaltar a importância da avaliação da relação risco/ benefício dos diferentes tratamentos utilizados para o câncer, e da continuidade de pesquisas para o desenvolvimento de novas formas de terapia e de novas drogas antineoplásicas. Faremos breve exposição sobre o processo de carcinogênese de múltiplas etapas, destacando o conceito geral de que o câncer é uma doença genética. São apresentados os efeitos mutagênicos das radiações ionizantes e de algumas classes de quimioterápicos sobre o material genético. Além dos efeitos deletérios desses agentes para o paciente, são também relatados efeitos nocivos para os indivíduos que manipulam ou que são responsáveis pela condução dos tratamentos. Abordaremos de modo geral, os danos genéticos induzidos por agentes antineoplásicos mutagênicos tanto para o paciente como para os indivíduos que os manipulam, predispondo-os ao desenvolvimento de um segundo tumor ou de um tumor primário, respectivamente.INCA2022-12-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/341010.32635/2176-9745.RBC.2000v46n2.3410Revista Brasileira de Cancerologia; Vol. 46 No. 2 (2000): Apr./May/June; 147-154Revista Brasileira de Cancerologia; Vol. 46 Núm. 2 (2000): abr./mayo/jun.; 147-154Revista Brasileira de Cancerologia; v. 46 n. 2 (2000): abr./maio/jun.; 147-1542176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/3410/2260https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMinicucci, Eliana MariaSalvadari, Daísy Maria FaveroRibeiro, Lúcia ReginaMaia, Maria Aparecida ContiCamargo, João Lauro Viana de2023-01-18T15:20:00Zoai:rbc.inca.gov.br:article/3410Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-01-18T15:20Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv The Genetic Risk of Cancer Therapy
O Risco Genético das Terapias do Câncer
title The Genetic Risk of Cancer Therapy
spellingShingle The Genetic Risk of Cancer Therapy
Minicucci, Eliana Maria
Risco Genético
Radioterapia
Braquiterapia
Quimioterapia
Genetic Risk
Radiotherapy
Brachytherapy
Chemotherapy
title_short The Genetic Risk of Cancer Therapy
title_full The Genetic Risk of Cancer Therapy
title_fullStr The Genetic Risk of Cancer Therapy
title_full_unstemmed The Genetic Risk of Cancer Therapy
title_sort The Genetic Risk of Cancer Therapy
author Minicucci, Eliana Maria
author_facet Minicucci, Eliana Maria
Salvadari, Daísy Maria Favero
Ribeiro, Lúcia Regina
Maia, Maria Aparecida Conti
Camargo, João Lauro Viana de
author_role author
author2 Salvadari, Daísy Maria Favero
Ribeiro, Lúcia Regina
Maia, Maria Aparecida Conti
Camargo, João Lauro Viana de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Minicucci, Eliana Maria
Salvadari, Daísy Maria Favero
Ribeiro, Lúcia Regina
Maia, Maria Aparecida Conti
Camargo, João Lauro Viana de
dc.subject.por.fl_str_mv Risco Genético
Radioterapia
Braquiterapia
Quimioterapia
Genetic Risk
Radiotherapy
Brachytherapy
Chemotherapy
topic Risco Genético
Radioterapia
Braquiterapia
Quimioterapia
Genetic Risk
Radiotherapy
Brachytherapy
Chemotherapy
description The presente paper indicates the effects of the most common practices for cancer treatment on the genetic sample of the patient. The main objective of this report is to stress the importance of the risk/benefit assessment of the different therapeutic protocols adopted for cancer and the need for the development of new therapeutic practices and chemotherapy agents. After stressing the fact that cancer is a genetic disease that develops through multiple steps, the effects of ionizing radiation and of some therapeutic Chemicals on the DNA are presented. Besides, the deleterious effects on the DNA of the technical personnel who provides treatment are also indicated. Therefore, this paper discusses tn a general way the genetic damage induced by anti-neoplastic agents, which increases the risk for the development of another primary tumor.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/3410
10.32635/2176-9745.RBC.2000v46n2.3410
url https://rbc.inca.gov.br/index.php/revista/article/view/3410
identifier_str_mv 10.32635/2176-9745.RBC.2000v46n2.3410
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/3410/2260
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 46 No. 2 (2000): Apr./May/June; 147-154
Revista Brasileira de Cancerologia; Vol. 46 Núm. 2 (2000): abr./mayo/jun.; 147-154
Revista Brasileira de Cancerologia; v. 46 n. 2 (2000): abr./maio/jun.; 147-154
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
_version_ 1797042235634614272

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