Anaplastic Thyroid Carcinoma in a Young Woman: Case Report

Detalhes bibliográficos
Autor(a) principal: Boscoli, Sofia de Souza
Data de Publicação: 2022
Outros Autores: Pereira, Ighor Ramon Pallu Doro, Segalla, Mara Rejane Rodrigues Correa, Castro, Eduardo Morais de
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1860
Resumo: Introduction: The anaplastic thyroid carcinoma is a rare, aggressive tumor, and it affects mainly women over the age of 60 years, being less common in younger people. It is believed that this tumor appears due to the loss of differentiation in well differentiated thyroid carcinomas. Low iodine ingestion has also been suggested. Despite multimodal intervention attempts, prognosis is poor. Case report: A 41 year-old female patient underwent a total thyroidectomy because of to the rapid growth of a thyroid mass, associated with radiological suspicion of malignancy. The macroscopic evaluation showed that the tumor had a lobulated shape, necrotic and hemorrhagic areas, and poorly-defined margins. Microscopic findings confirmed an anaplastic thyroid carcinoma, characterized by the proliferation of spindle and osteoclast-like multinucleated cells, associated with a well differentiated papillary thyroid carcinoma. Conclusion: Despite its rarity, the anaplastic carcinoma should be thought as a possibility when evaluating a thyroid neoplasia, and differential diagnosis must be considered cautiously, since it can be misleading for other tumors, such as lymphomas and sarcomas. In addition, it is important to point out the necessity to admit it even when the patient does not belong to the typical epidemiological group.
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spelling Anaplastic Thyroid Carcinoma in a Young Woman: Case ReportCarcinoma Anaplásico de Tiroides en una Mujer Joven: Reporte de CasoCarcinoma Anaplásico de Tireoide em uma Paciente Jovem: Relato de Casoneoplasias da glândula tireoidecarcinoma anaplásico da tireoide/patologiacâncer papilífero da tireoideneoplasiasthyroid neoplasmsthyroid carcinoma, anaplastic/pathologythyroid cancer, papillaryneoplasmsneoplasias de la tiroidescarcinoma anaplásico de tiroides/ patologíacáncer papilar tiroideoneoplasiasIntroduction: The anaplastic thyroid carcinoma is a rare, aggressive tumor, and it affects mainly women over the age of 60 years, being less common in younger people. It is believed that this tumor appears due to the loss of differentiation in well differentiated thyroid carcinomas. Low iodine ingestion has also been suggested. Despite multimodal intervention attempts, prognosis is poor. Case report: A 41 year-old female patient underwent a total thyroidectomy because of to the rapid growth of a thyroid mass, associated with radiological suspicion of malignancy. The macroscopic evaluation showed that the tumor had a lobulated shape, necrotic and hemorrhagic areas, and poorly-defined margins. Microscopic findings confirmed an anaplastic thyroid carcinoma, characterized by the proliferation of spindle and osteoclast-like multinucleated cells, associated with a well differentiated papillary thyroid carcinoma. Conclusion: Despite its rarity, the anaplastic carcinoma should be thought as a possibility when evaluating a thyroid neoplasia, and differential diagnosis must be considered cautiously, since it can be misleading for other tumors, such as lymphomas and sarcomas. In addition, it is important to point out the necessity to admit it even when the patient does not belong to the typical epidemiological group.Introducción: El carcinoma anaplásico de tiroides es un tumor agresivo poco común y afecta principalmente a mujeres mayores de 60 años, siendo menos común en adultos más jóvenes. Se cree que este tumor surge debido a la perdida de diferenciación en carcinomas tiroideos bien diferenciados. También se ha implicado una baja ingestión de yodo. A pesar de los intentos de intervención multimodal, el pronóstico es malo. Reporte del caso: Paciente de 41 años fue sometida a tiroidectomía total por rápido crecimiento de una masa tiroidea, asociada a sospecha radiológica de malignidad. La evaluación macroscópica mostro que un tumor voluminoso con áreas necróticas y hemorrágicas y márgenes mal definidos. Los hallazgos microscópicos confirmaron un carcinoma anaplásico de tiroides, caracterizado por la proliferación de células multinucleadas fusiformes y similares a los osteoclastos, asociado con un carcinoma papilar de tiroides bien diferenciado. Conclusión: A pesar de su rareza, el carcinoma anaplásico debe considerarse una posibilidad al evaluar la neoplasia tiroidea. Se deben considerar cuidadosamente los diferentes diagnósticos, ya que pueden confundirse con otros canceres, como linfomas y sarcomas. Además, es importante señalar la necesidad de considerarlo incluso cuando el paciente no pertenece al grupo epidemiológico habitual.Introdução: O carcinoma anaplásico da tireoide e um tumor raro e agressivo, que afeta principalmente mulheres com idade acima de 60 anos, sendo menos comum em pessoas mais jovens. Acredita-se que esse tumor surja em razão da perda de diferenciação em carcinomas bem diferenciados de tireoide. Uma baixa ingestão de iodo também foi sugerida. Apesar das tentativas de intervenção multimodal, o prognostico e ruim. Relato do caso: Paciente do sexo feminino, 41 anos, submetida a tireoidectomia total, por causa do rápido crescimento de massa tireoidiana, associada a suspeita radiológica de malignidade. A avaliação macroscópica mostrou que o tumor apresentava formato lobulado, áreas necróticas e hemorrágicas e margens mal definidas. Os achados microscópicos confirmaram um carcinoma anaplásico de tireoide, caracterizado pela proliferação de células multinucleadas fusiformes e osteoclásticas, associadas a um carcinoma papilar de tireoide bem diferenciado. Conclusão: Apesar de sua raridade, o carcinoma anaplásico deve ser considerado uma possibilidade na avaliação de uma neoplasia tireoidiana, e o diagnostico diferencial deve ser levado em conta com cautela, pois pode ser confundido com outros tumores, como linfomas e sarcomas. Além disso, e importante ressaltar a necessidade de considera-la mesmo quando o paciente nao pertence ao grupo epidemiológico usual.INCA2022-05-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoapplication/pdfapplication/pdftext/htmlhttps://rbc.inca.gov.br/index.php/revista/article/view/186010.32635/2176-9745.RBC.2022v68n2.1860Revista Brasileira de Cancerologia; Vol. 68 No. 2 (2022): Apr./May/June; e-051860Revista Brasileira de Cancerologia; Vol. 68 Núm. 2 (2022): abr./mayo/jun.; e-051860Revista Brasileira de Cancerologia; v. 68 n. 2 (2022): abr./maio./jun.; e-0518602176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/1860/1612https://rbc.inca.gov.br/index.php/revista/article/view/1860/2022https://rbc.inca.gov.br/index.php/revista/article/view/1860/1638Copyright (c) 2022 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBoscoli, Sofia de Souza Pereira, Ighor Ramon Pallu Doro Segalla, Mara Rejane Rodrigues Correa Castro, Eduardo Morais de 2022-08-10T16:24:55Zoai:rbc.inca.gov.br:article/1860Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2022-08-10T16:24:55Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Anaplastic Thyroid Carcinoma in a Young Woman: Case Report
Carcinoma Anaplásico de Tiroides en una Mujer Joven: Reporte de Caso
Carcinoma Anaplásico de Tireoide em uma Paciente Jovem: Relato de Caso
title Anaplastic Thyroid Carcinoma in a Young Woman: Case Report
spellingShingle Anaplastic Thyroid Carcinoma in a Young Woman: Case Report
Boscoli, Sofia de Souza
neoplasias da glândula tireoide
carcinoma anaplásico da tireoide/patologia
câncer papilífero da tireoide
neoplasias
thyroid neoplasms
thyroid carcinoma, anaplastic/pathology
thyroid cancer, papillary
neoplasms
neoplasias de la tiroides
carcinoma anaplásico de tiroides/ patología
cáncer papilar tiroideo
neoplasias
title_short Anaplastic Thyroid Carcinoma in a Young Woman: Case Report
title_full Anaplastic Thyroid Carcinoma in a Young Woman: Case Report
title_fullStr Anaplastic Thyroid Carcinoma in a Young Woman: Case Report
title_full_unstemmed Anaplastic Thyroid Carcinoma in a Young Woman: Case Report
title_sort Anaplastic Thyroid Carcinoma in a Young Woman: Case Report
author Boscoli, Sofia de Souza
author_facet Boscoli, Sofia de Souza
Pereira, Ighor Ramon Pallu Doro
Segalla, Mara Rejane Rodrigues Correa
Castro, Eduardo Morais de
author_role author
author2 Pereira, Ighor Ramon Pallu Doro
Segalla, Mara Rejane Rodrigues Correa
Castro, Eduardo Morais de
author2_role author
author
author
dc.contributor.author.fl_str_mv Boscoli, Sofia de Souza
Pereira, Ighor Ramon Pallu Doro
Segalla, Mara Rejane Rodrigues Correa
Castro, Eduardo Morais de
dc.subject.por.fl_str_mv neoplasias da glândula tireoide
carcinoma anaplásico da tireoide/patologia
câncer papilífero da tireoide
neoplasias
thyroid neoplasms
thyroid carcinoma, anaplastic/pathology
thyroid cancer, papillary
neoplasms
neoplasias de la tiroides
carcinoma anaplásico de tiroides/ patología
cáncer papilar tiroideo
neoplasias
topic neoplasias da glândula tireoide
carcinoma anaplásico da tireoide/patologia
câncer papilífero da tireoide
neoplasias
thyroid neoplasms
thyroid carcinoma, anaplastic/pathology
thyroid cancer, papillary
neoplasms
neoplasias de la tiroides
carcinoma anaplásico de tiroides/ patología
cáncer papilar tiroideo
neoplasias
description Introduction: The anaplastic thyroid carcinoma is a rare, aggressive tumor, and it affects mainly women over the age of 60 years, being less common in younger people. It is believed that this tumor appears due to the loss of differentiation in well differentiated thyroid carcinomas. Low iodine ingestion has also been suggested. Despite multimodal intervention attempts, prognosis is poor. Case report: A 41 year-old female patient underwent a total thyroidectomy because of to the rapid growth of a thyroid mass, associated with radiological suspicion of malignancy. The macroscopic evaluation showed that the tumor had a lobulated shape, necrotic and hemorrhagic areas, and poorly-defined margins. Microscopic findings confirmed an anaplastic thyroid carcinoma, characterized by the proliferation of spindle and osteoclast-like multinucleated cells, associated with a well differentiated papillary thyroid carcinoma. Conclusion: Despite its rarity, the anaplastic carcinoma should be thought as a possibility when evaluating a thyroid neoplasia, and differential diagnosis must be considered cautiously, since it can be misleading for other tumors, such as lymphomas and sarcomas. In addition, it is important to point out the necessity to admit it even when the patient does not belong to the typical epidemiological group.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Relato de Caso
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1860
10.32635/2176-9745.RBC.2022v68n2.1860
url https://rbc.inca.gov.br/index.php/revista/article/view/1860
identifier_str_mv 10.32635/2176-9745.RBC.2022v68n2.1860
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1860/1612
https://rbc.inca.gov.br/index.php/revista/article/view/1860/2022
https://rbc.inca.gov.br/index.php/revista/article/view/1860/1638
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
text/html
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 68 No. 2 (2022): Apr./May/June; e-051860
Revista Brasileira de Cancerologia; Vol. 68 Núm. 2 (2022): abr./mayo/jun.; e-051860
Revista Brasileira de Cancerologia; v. 68 n. 2 (2022): abr./maio./jun.; e-051860
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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