Granulosa cell tumors of the ovary: staging and treatment
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/2841 |
Resumo: | The purpose of this study was to analise the surgical and histoIogicaI resuIts which could help in the management for staging and treating patients with ovarian granulosa cell tumors. Eleven women with this type of tumor who were seen in the Center of Integral Assistance to Women's Health (University of Campinas - State of São Paulo) from January 1990 to Dezember 1994 were analised. Follow-up was done until August 1996. The mean age was 46 (18-67). Two patients underwent a bilateral salpingooforecromy with hysterectom) apendicectomy and omentectomy, and in seven the surgical procedure included also a pelvic and paraortic retroperitonial lymphadenectomy. Two patients had unressected intrabdominal disease. Concluding the surgical and histological analysis, five women had stage IJIC disease; one, stage IC, and five, stage IA. The histological review showed 10 adult-type neoplasm and juvenile-type one. In all cases there were diagnosed two or more histological granulosa cell tumor patterns, predominantely the solid type (7/11). Adjuvant cheinotherapy - six cycles of carboplatin (300 mg/m2) and ciclophosphamide (500 mg/ m2) - was done in al patients in stage IC or IIIC. At the last follow-up, 20 to 71 months after; all patients with localized, tumors were disease-free. On the other hand, three out five women with advanced cancer had persistent tumors in spite of adjuvant treatment. |
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Granulosa cell tumors of the ovary: staging and treatmentTumores de células da granulosa do ovário: estadiamento e tratamentoCirurgiaCélulas da GranulosaCâncer de OvárioSurgeryGranulosa CellsOvarian CancerThe purpose of this study was to analise the surgical and histoIogicaI resuIts which could help in the management for staging and treating patients with ovarian granulosa cell tumors. Eleven women with this type of tumor who were seen in the Center of Integral Assistance to Women's Health (University of Campinas - State of São Paulo) from January 1990 to Dezember 1994 were analised. Follow-up was done until August 1996. The mean age was 46 (18-67). Two patients underwent a bilateral salpingooforecromy with hysterectom) apendicectomy and omentectomy, and in seven the surgical procedure included also a pelvic and paraortic retroperitonial lymphadenectomy. Two patients had unressected intrabdominal disease. Concluding the surgical and histological analysis, five women had stage IJIC disease; one, stage IC, and five, stage IA. The histological review showed 10 adult-type neoplasm and juvenile-type one. In all cases there were diagnosed two or more histological granulosa cell tumor patterns, predominantely the solid type (7/11). Adjuvant cheinotherapy - six cycles of carboplatin (300 mg/m2) and ciclophosphamide (500 mg/ m2) - was done in al patients in stage IC or IIIC. At the last follow-up, 20 to 71 months after; all patients with localized, tumors were disease-free. On the other hand, three out five women with advanced cancer had persistent tumors in spite of adjuvant treatment.O objetivo deste trabalho foi o de analisar a importância dos achados cirúrgicos e histológicos para a definição dos estadiamento e tratamento dos tumores de células da camada granulosa do ovário. Foram avaliados o estadiamento e os resultados do tratamento de 11 pacientes, atendidas entre janeiro de 1990 e dezembro de 1994, no Centro de Atenção Integral à Saúde da Mulher, da Universidade Estadual de Campinas, no Estado de São Paulo. O seguimento foi atualizado em agosto de 1996. A idade das pacientes variou de 18 a 67 anos, com média de 46 anos. Duas pacientes foram submetidas à salpingo-ooforectomia bilateral, histerectomia total, apendicectomia e omentectoinia e, em sete, acrescentou-se a linfadenectomia retroperitoneal. Em dois casos a doença era irressecável. Cinco pacientes encontravam-se com tumor em estádio IIIC; uma, em estádio IC; e cinco, em estádio IA. A revisão histopatológica revelou 10 neoplasias do tipo adulto e uma do tipo juvenil. Em todos os casos encontrou-se mais de um tipo histopatológico de tumor de células granulosas, sendo dominante o tipo sólido (7/11 casos). o tratamento complementar com antiblásticos - seis ciclos de carboplatina (300 mg/ m2) e ciclofosfamida (500 mg/ m2) – foi aplicado nas pacientes com doença em estádios IC e IIIC. No último controle, com um seguimento variando de 20 a 71 meses, todas as pacientes com tumores no estádio inicial encontravam-se sem doença; contudo, das cinco pacientes com neoplasia em estádio IIIC, três apresentavam progressão da doença apesar do tratamento antiblástico.INCA2022-09-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/284110.32635/2176-9745.RBC.1997v43n2.2841Revista Brasileira de Cancerologia; Vol. 43 No. 2 (1997): Apr./May/June; 107-110Revista Brasileira de Cancerologia; Vol. 43 Núm. 2 (1997): abr./mayo/jun.; 107-110Revista Brasileira de Cancerologia; v. 43 n. 2 (1997): abr./maio/jun.; 107-1102176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2841/1717https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDerchain, Sophie Françoise MauricetteTeixeira, Luiz CarlosTorres, José Carlos CamposAndrade, Liliana A.L.A.2023-01-18T14:49:40Zoai:rbc.inca.gov.br:article/2841Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-01-18T14:49:40Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Granulosa cell tumors of the ovary: staging and treatment Tumores de células da granulosa do ovário: estadiamento e tratamento |
title |
Granulosa cell tumors of the ovary: staging and treatment |
spellingShingle |
Granulosa cell tumors of the ovary: staging and treatment Derchain, Sophie Françoise Mauricette Cirurgia Células da Granulosa Câncer de Ovário Surgery Granulosa Cells Ovarian Cancer |
title_short |
Granulosa cell tumors of the ovary: staging and treatment |
title_full |
Granulosa cell tumors of the ovary: staging and treatment |
title_fullStr |
Granulosa cell tumors of the ovary: staging and treatment |
title_full_unstemmed |
Granulosa cell tumors of the ovary: staging and treatment |
title_sort |
Granulosa cell tumors of the ovary: staging and treatment |
author |
Derchain, Sophie Françoise Mauricette |
author_facet |
Derchain, Sophie Françoise Mauricette Teixeira, Luiz Carlos Torres, José Carlos Campos Andrade, Liliana A.L.A. |
author_role |
author |
author2 |
Teixeira, Luiz Carlos Torres, José Carlos Campos Andrade, Liliana A.L.A. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Derchain, Sophie Françoise Mauricette Teixeira, Luiz Carlos Torres, José Carlos Campos Andrade, Liliana A.L.A. |
dc.subject.por.fl_str_mv |
Cirurgia Células da Granulosa Câncer de Ovário Surgery Granulosa Cells Ovarian Cancer |
topic |
Cirurgia Células da Granulosa Câncer de Ovário Surgery Granulosa Cells Ovarian Cancer |
description |
The purpose of this study was to analise the surgical and histoIogicaI resuIts which could help in the management for staging and treating patients with ovarian granulosa cell tumors. Eleven women with this type of tumor who were seen in the Center of Integral Assistance to Women's Health (University of Campinas - State of São Paulo) from January 1990 to Dezember 1994 were analised. Follow-up was done until August 1996. The mean age was 46 (18-67). Two patients underwent a bilateral salpingooforecromy with hysterectom) apendicectomy and omentectomy, and in seven the surgical procedure included also a pelvic and paraortic retroperitonial lymphadenectomy. Two patients had unressected intrabdominal disease. Concluding the surgical and histological analysis, five women had stage IJIC disease; one, stage IC, and five, stage IA. The histological review showed 10 adult-type neoplasm and juvenile-type one. In all cases there were diagnosed two or more histological granulosa cell tumor patterns, predominantely the solid type (7/11). Adjuvant cheinotherapy - six cycles of carboplatin (300 mg/m2) and ciclophosphamide (500 mg/ m2) - was done in al patients in stage IC or IIIC. At the last follow-up, 20 to 71 months after; all patients with localized, tumors were disease-free. On the other hand, three out five women with advanced cancer had persistent tumors in spite of adjuvant treatment. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
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https://rbc.inca.gov.br/index.php/revista/article/view/2841 10.32635/2176-9745.RBC.1997v43n2.2841 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/2841 |
identifier_str_mv |
10.32635/2176-9745.RBC.1997v43n2.2841 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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https://rbc.inca.gov.br/index.php/revista/article/view/2841/1717 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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INCA |
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INCA |
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Revista Brasileira de Cancerologia; Vol. 43 No. 2 (1997): Apr./May/June; 107-110 Revista Brasileira de Cancerologia; Vol. 43 Núm. 2 (1997): abr./mayo/jun.; 107-110 Revista Brasileira de Cancerologia; v. 43 n. 2 (1997): abr./maio/jun.; 107-110 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
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Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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INCA |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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rbc@inca.gov.br |
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