Anorexia-cachexia syndrome in cancer patients

Detalhes bibliográficos
Autor(a) principal: Silva, Manuela Pacheco Nunes da
Data de Publicação: 2006
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1910
Resumo: The cancer anorexia-cachexia syndrome (CACS) is a common complication in advanced cancer patients. It is characterized by massive wasting of skeletal muscle and adipose tissue with involuntary weight loss, anemia, asthenia, and negative nitrogen balance due to immunological, physiological and metabolic changes. CACS is intensified by alterations in nutrient metabolism (carbohydrates, proteins, and lipids), hormonal changes (leptin, neuropeptide-Y, melanocortin, ghrelin), and increased serum cytokine levels (TNFa, IL-1, IL-6, IFN-g). Tumors produce factors that alter the patient's perception of food, particularly taste and smell, and cancer treatment contributes to CACS. Nutritional treatment uses special nutrients such as polyunsaturated fatty acids (EPA and DHA), the amino acids glutamine and arginine, and nucleotides. Nutritional and pharmacological treatment with appetite-stimulating drugs has yielded more positive results in patients with CACS.
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spelling Anorexia-cachexia syndrome in cancer patientsSíndrome da anorexia-caquexia em portadores de câncerAnorexiaCaquexiaCâncerNutriçãoAnorexiaCachexiaCancerNutritionThe cancer anorexia-cachexia syndrome (CACS) is a common complication in advanced cancer patients. It is characterized by massive wasting of skeletal muscle and adipose tissue with involuntary weight loss, anemia, asthenia, and negative nitrogen balance due to immunological, physiological and metabolic changes. CACS is intensified by alterations in nutrient metabolism (carbohydrates, proteins, and lipids), hormonal changes (leptin, neuropeptide-Y, melanocortin, ghrelin), and increased serum cytokine levels (TNFa, IL-1, IL-6, IFN-g). Tumors produce factors that alter the patient's perception of food, particularly taste and smell, and cancer treatment contributes to CACS. Nutritional treatment uses special nutrients such as polyunsaturated fatty acids (EPA and DHA), the amino acids glutamine and arginine, and nucleotides. Nutritional and pharmacological treatment with appetite-stimulating drugs has yielded more positive results in patients with CACS.A síndrome da anorexia-caquexia (SAC) é uma complicação freqüente no paciente portador de uma neoplasia maligna em estado avançado. Caracteriza-se por um intenso consumo dos tecidos muscular e adiposo, com conseqüente perda involuntária de peso, além de anemia, astenia, balanço nitrogenado negativo, devido alterações fisiológicas, metabólicas e imunológicas. A SAC é intensificada pelas alterações no metabolismo dos nutrientes (carboidratos, proteínas e lipídios), alterações hormonais (leptina, NPY, MC, grelina), além do aumento das citocinas circulantes (TNFa, IL-1, IL-6, IFN). Mudanças na percepção de paladar e olfato ocorridas com a progressão tumoral e com o tratamento oncológico, também contribuem com a anorexia e, conseqüentemente, com a SAC. O tratamento nutricional é realizado com a utilização de nutrientes especiais, como os ácidos graxos polinsaturados EPA e DHA, os aminoácidos glutamina e arginina e os nucleotídeos. A nutrição deve ser seguida junto ao tratamento farmacológico, com estimulantes do apetite, devido maiores resultados positivos para o paciente com SAC.INCA2006-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/191010.32635/2176-9745.RBC.2006v52n1.1910Revista Brasileira de Cancerologia; Vol. 52 No. 1 (2006): Jan./Feb./Mar.; 59-77Revista Brasileira de Cancerologia; Vol. 52 Núm. 1 (2006): ene./feb./mar.; 59-77Revista Brasileira de Cancerologia; v. 52 n. 1 (2006): jan./fev./mar.; 59-772176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1910/1161Silva, Manuela Pacheco Nunes dainfo:eu-repo/semantics/openAccess2021-11-29T20:28:35Zoai:rbc.inca.gov.br:article/1910Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:28:35Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Anorexia-cachexia syndrome in cancer patients
Síndrome da anorexia-caquexia em portadores de câncer
title Anorexia-cachexia syndrome in cancer patients
spellingShingle Anorexia-cachexia syndrome in cancer patients
Silva, Manuela Pacheco Nunes da
Anorexia
Caquexia
Câncer
Nutrição
Anorexia
Cachexia
Cancer
Nutrition
title_short Anorexia-cachexia syndrome in cancer patients
title_full Anorexia-cachexia syndrome in cancer patients
title_fullStr Anorexia-cachexia syndrome in cancer patients
title_full_unstemmed Anorexia-cachexia syndrome in cancer patients
title_sort Anorexia-cachexia syndrome in cancer patients
author Silva, Manuela Pacheco Nunes da
author_facet Silva, Manuela Pacheco Nunes da
author_role author
dc.contributor.author.fl_str_mv Silva, Manuela Pacheco Nunes da
dc.subject.por.fl_str_mv Anorexia
Caquexia
Câncer
Nutrição
Anorexia
Cachexia
Cancer
Nutrition
topic Anorexia
Caquexia
Câncer
Nutrição
Anorexia
Cachexia
Cancer
Nutrition
description The cancer anorexia-cachexia syndrome (CACS) is a common complication in advanced cancer patients. It is characterized by massive wasting of skeletal muscle and adipose tissue with involuntary weight loss, anemia, asthenia, and negative nitrogen balance due to immunological, physiological and metabolic changes. CACS is intensified by alterations in nutrient metabolism (carbohydrates, proteins, and lipids), hormonal changes (leptin, neuropeptide-Y, melanocortin, ghrelin), and increased serum cytokine levels (TNFa, IL-1, IL-6, IFN-g). Tumors produce factors that alter the patient's perception of food, particularly taste and smell, and cancer treatment contributes to CACS. Nutritional treatment uses special nutrients such as polyunsaturated fatty acids (EPA and DHA), the amino acids glutamine and arginine, and nucleotides. Nutritional and pharmacological treatment with appetite-stimulating drugs has yielded more positive results in patients with CACS.
publishDate 2006
dc.date.none.fl_str_mv 2006-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1910
10.32635/2176-9745.RBC.2006v52n1.1910
url https://rbc.inca.gov.br/index.php/revista/article/view/1910
identifier_str_mv 10.32635/2176-9745.RBC.2006v52n1.1910
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1910/1161
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 52 No. 1 (2006): Jan./Feb./Mar.; 59-77
Revista Brasileira de Cancerologia; Vol. 52 Núm. 1 (2006): ene./feb./mar.; 59-77
Revista Brasileira de Cancerologia; v. 52 n. 1 (2006): jan./fev./mar.; 59-77
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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