Flutamide: a review of its pharmacological and physico-chemical properties. Methods for analysis of pharmaceutical formulas

Detalhes bibliográficos
Autor(a) principal: Marona, Hérida Regina Nunes
Data de Publicação: 2004
Outros Autores: Storti, Madge Patrícia Betto, Lucca Neto, Vicente Alexandre de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2057
Resumo: Flutamide, 2-metil-N-[4-nitro-3-(trifluorometyl)phenyl]propanamide, á,á,á-trifluoro-2-methil-4'-nitro-mpropionotoluidide or 4'-nitro-3'-trifluoromethylisobutyranilide, is a nonsteroidal antiandrogenic drug devoid of hormonal agonist activity, used in treatment of advanced prostate cancer. It inihibits the binding of testosterone or the dihydrotestosterone to nuclear and cytoplasmic receptors in target cells. Flutamide is completely absorbed from the gastrointestinal tract and rapidly converted to a variety of metabolites. Is 94% to 96% bound to plasma proteins. The parent drug and metabolites are primarily eliminated by the urine. The principal side effects are gynecomastia and diarrhea. In bulk or pharmaceutical dosage forms, flutamide can be estimated by polarography, spectrophotometry, gas chromatography and high performance liquid chromatography. The present communication reports pharmacological and physico-chemical properties of flutamide and analytical methods for its estimation.
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spelling Flutamide: a review of its pharmacological and physico-chemical properties. Methods for analysis of pharmaceutical formulasFlutamida: Revisão de suas propriedades farmacológicas e físicoquímicas. Métodos de análise em formulações farmacêuticasNeoplasias ProstáticasFlutamidaAntiandrógenosFarmacocinéticaTerapiaEfeitos AdversosProstatic NeoplasmsFlutamideAntiandrogenPharmacokineticsTherapyAdverse EffectsFlutamide, 2-metil-N-[4-nitro-3-(trifluorometyl)phenyl]propanamide, á,á,á-trifluoro-2-methil-4'-nitro-mpropionotoluidide or 4'-nitro-3'-trifluoromethylisobutyranilide, is a nonsteroidal antiandrogenic drug devoid of hormonal agonist activity, used in treatment of advanced prostate cancer. It inihibits the binding of testosterone or the dihydrotestosterone to nuclear and cytoplasmic receptors in target cells. Flutamide is completely absorbed from the gastrointestinal tract and rapidly converted to a variety of metabolites. Is 94% to 96% bound to plasma proteins. The parent drug and metabolites are primarily eliminated by the urine. The principal side effects are gynecomastia and diarrhea. In bulk or pharmaceutical dosage forms, flutamide can be estimated by polarography, spectrophotometry, gas chromatography and high performance liquid chromatography. The present communication reports pharmacological and physico-chemical properties of flutamide and analytical methods for its estimation.A flutamida, 2-metil-N-[4-nitro-3-(trifluorometil)fenil]propanamida, á,á,á-trifluoro-2-metil-4'-nitro-mpropionotoluidida ou 4'-nitro-3'-trifluorometilisobutiranilida, é um fármaco antiandrógeno não-esteróide, destituída de atividade hormonal, utilizada no tratamento do câncer avançado de próstata. Atua inibindo a ligação da testosterona ou da diidrotestosterona aos receptores nucleares e citoplasmáticos nas células-alvo. A flutamida é completamente absorvida pelo trato gastrintestinal, e rapidamente convertida em vários metabólitos. A ligação às proteínas plasmáticas é de 94% a 96%. O fármaco e seus metabólitos são excretados principalmente na urina. As principais reações adversas relacionadas ao uso da flutamida são a ginecomastia e a diarréia leve. Sob a forma de matéria-prima ou em formulações farmacêuticas, a flutamida pode ser determinada por métodos como polarografia, espectrofotometria, cromatografia gasosa e cromatografia líquida de alta eficiência. O presente trabalho discorre sobre as propriedades farmacológicas e físico-químicas da flutamida, bem como os métodos de análise aplicados à determinação do fármaco.INCA2004-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/205710.32635/2176-9745.RBC.2004v50n1.2057Revista Brasileira de Cancerologia; Vol. 50 No. 1 (2004): Jan./Feb./Mar.; 37-44Revista Brasileira de Cancerologia; Vol. 50 Núm. 1 (2004): ene./feb./mar.; 37-44Revista Brasileira de Cancerologia; v. 50 n. 1 (2004): jan./fev./mar.; 37-442176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2057/1275Marona, Hérida Regina Nunes Storti, Madge Patrícia Betto Lucca Neto, Vicente Alexandre de info:eu-repo/semantics/openAccess2021-11-29T20:33:52Zoai:rbc.inca.gov.br:article/2057Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:33:52Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Flutamide: a review of its pharmacological and physico-chemical properties. Methods for analysis of pharmaceutical formulas
Flutamida: Revisão de suas propriedades farmacológicas e físicoquímicas. Métodos de análise em formulações farmacêuticas
title Flutamide: a review of its pharmacological and physico-chemical properties. Methods for analysis of pharmaceutical formulas
spellingShingle Flutamide: a review of its pharmacological and physico-chemical properties. Methods for analysis of pharmaceutical formulas
Marona, Hérida Regina Nunes
Neoplasias Prostáticas
Flutamida
Antiandrógenos
Farmacocinética
Terapia
Efeitos Adversos
Prostatic Neoplasms
Flutamide
Antiandrogen
Pharmacokinetics
Therapy
Adverse Effects
title_short Flutamide: a review of its pharmacological and physico-chemical properties. Methods for analysis of pharmaceutical formulas
title_full Flutamide: a review of its pharmacological and physico-chemical properties. Methods for analysis of pharmaceutical formulas
title_fullStr Flutamide: a review of its pharmacological and physico-chemical properties. Methods for analysis of pharmaceutical formulas
title_full_unstemmed Flutamide: a review of its pharmacological and physico-chemical properties. Methods for analysis of pharmaceutical formulas
title_sort Flutamide: a review of its pharmacological and physico-chemical properties. Methods for analysis of pharmaceutical formulas
author Marona, Hérida Regina Nunes
author_facet Marona, Hérida Regina Nunes
Storti, Madge Patrícia Betto
Lucca Neto, Vicente Alexandre de
author_role author
author2 Storti, Madge Patrícia Betto
Lucca Neto, Vicente Alexandre de
author2_role author
author
dc.contributor.author.fl_str_mv Marona, Hérida Regina Nunes
Storti, Madge Patrícia Betto
Lucca Neto, Vicente Alexandre de
dc.subject.por.fl_str_mv Neoplasias Prostáticas
Flutamida
Antiandrógenos
Farmacocinética
Terapia
Efeitos Adversos
Prostatic Neoplasms
Flutamide
Antiandrogen
Pharmacokinetics
Therapy
Adverse Effects
topic Neoplasias Prostáticas
Flutamida
Antiandrógenos
Farmacocinética
Terapia
Efeitos Adversos
Prostatic Neoplasms
Flutamide
Antiandrogen
Pharmacokinetics
Therapy
Adverse Effects
description Flutamide, 2-metil-N-[4-nitro-3-(trifluorometyl)phenyl]propanamide, á,á,á-trifluoro-2-methil-4'-nitro-mpropionotoluidide or 4'-nitro-3'-trifluoromethylisobutyranilide, is a nonsteroidal antiandrogenic drug devoid of hormonal agonist activity, used in treatment of advanced prostate cancer. It inihibits the binding of testosterone or the dihydrotestosterone to nuclear and cytoplasmic receptors in target cells. Flutamide is completely absorbed from the gastrointestinal tract and rapidly converted to a variety of metabolites. Is 94% to 96% bound to plasma proteins. The parent drug and metabolites are primarily eliminated by the urine. The principal side effects are gynecomastia and diarrhea. In bulk or pharmaceutical dosage forms, flutamide can be estimated by polarography, spectrophotometry, gas chromatography and high performance liquid chromatography. The present communication reports pharmacological and physico-chemical properties of flutamide and analytical methods for its estimation.
publishDate 2004
dc.date.none.fl_str_mv 2004-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2057
10.32635/2176-9745.RBC.2004v50n1.2057
url https://rbc.inca.gov.br/index.php/revista/article/view/2057
identifier_str_mv 10.32635/2176-9745.RBC.2004v50n1.2057
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2057/1275
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 50 No. 1 (2004): Jan./Feb./Mar.; 37-44
Revista Brasileira de Cancerologia; Vol. 50 Núm. 1 (2004): ene./feb./mar.; 37-44
Revista Brasileira de Cancerologia; v. 50 n. 1 (2004): jan./fev./mar.; 37-44
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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