Cancer Immunosurveillance and Immunoediting: Clinical Implications and Therapeutic Potential

Detalhes bibliográficos
Autor(a) principal: Torrezini, Thaissa
Data de Publicação: 2008
Outros Autores: Athanazio, Daniel Abensur
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1762
Resumo: Cancer is one of the three main causes of death worldwide. Understanding the mechanisms of cell transformation and tumor progression is a crucial issue for the development of new therapeutic tools, particularly in the context of advanced malignant tumors for which the current options are inefficient. The concept of immunosurveillance was originally proposed as the immune system's ability to recognize and inhibit tumor growth. Recent advances in basic immunology suggest an additional concept of immunoediting to describe the selective pressures that shape tumor immunogenicity. A complex array of signaling pathways and cells including NK, NKT, and T-lymphocytes are involved in this process. Immunosurveillance and immunoediting can be reproduced in experimental models, but the two processes cannot be easily confirmed in humans due to methodological limitations. Thus, the present work reviews the history of these hypotheses as well as the current experimental and human data on this theme.
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spelling Cancer Immunosurveillance and Immunoediting: Clinical Implications and Therapeutic PotentialImunovigilância e Imunoedição de Neoplasias: Implicações Clínicas e Potencial TerapêuticoNeoplasiasImunovigilânciaImunoediçãoRegressão espontâneaInflamação crônicaNeoplasmImmunosurveillanceImmunoeditingSpontaneous regressionChronic inflammationCancer is one of the three main causes of death worldwide. Understanding the mechanisms of cell transformation and tumor progression is a crucial issue for the development of new therapeutic tools, particularly in the context of advanced malignant tumors for which the current options are inefficient. The concept of immunosurveillance was originally proposed as the immune system's ability to recognize and inhibit tumor growth. Recent advances in basic immunology suggest an additional concept of immunoediting to describe the selective pressures that shape tumor immunogenicity. A complex array of signaling pathways and cells including NK, NKT, and T-lymphocytes are involved in this process. Immunosurveillance and immunoediting can be reproduced in experimental models, but the two processes cannot be easily confirmed in humans due to methodological limitations. Thus, the present work reviews the history of these hypotheses as well as the current experimental and human data on this theme.Neoplasias representam uma das três principais causas de morte no mundo. A compreensão dos mecanismos de transformação e progressão tumorais é fundamental para o desenvolvimento de novas estratégias de tratamento, especialmente no contexto de neoplasias em estágios avançados cujos tratamentos atuais são ineficientes. O conceito de imunovigilância foi originalmente proposto como a capacidade do sistema imune de reconhecer e inibir o processo neoplásico. Recentes avanços no campo da Imunologia básica acrescentam o conceito complementar da imunoedição, no qual a pressão seletiva do sistema imune molda o perfil antigênico dos tumores. Uma complexa rede de vias de sinalização de células, incluindo linfócitos NK, NKT, T e macrófagos, está envolvida neste processo. As hipóteses da imunovigilância e imunoedição são demonstradas em diversos modelos experimentais; no entanto, sua comprovação em humanos é complicada por uma série de limitações metodológicas. Assim, o presente trabalho revisa o histórico e as principais observações experimentais, assim como discute os achados em humanos mais relevantes sobre o tema.INCA2008-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/176210.32635/2176-9745.RBC.2008v54n1.1762Revista Brasileira de Cancerologia; Vol. 54 No. 1 (2008): Jan./Feb./Mar.; 63-77Revista Brasileira de Cancerologia; Vol. 54 Núm. 1 (2008): ene./feb./mar.; 63-77Revista Brasileira de Cancerologia; v. 54 n. 1 (2008): jan./fev./mar.; 63-772176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1762/1050Torrezini, Thaissa Athanazio, Daniel Abensur info:eu-repo/semantics/openAccess2021-11-29T20:23:56Zoai:rbc.inca.gov.br:article/1762Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:23:56Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Cancer Immunosurveillance and Immunoediting: Clinical Implications and Therapeutic Potential
Imunovigilância e Imunoedição de Neoplasias: Implicações Clínicas e Potencial Terapêutico
title Cancer Immunosurveillance and Immunoediting: Clinical Implications and Therapeutic Potential
spellingShingle Cancer Immunosurveillance and Immunoediting: Clinical Implications and Therapeutic Potential
Torrezini, Thaissa
Neoplasias
Imunovigilância
Imunoedição
Regressão espontânea
Inflamação crônica
Neoplasm
Immunosurveillance
Immunoediting
Spontaneous regression
Chronic inflammation
title_short Cancer Immunosurveillance and Immunoediting: Clinical Implications and Therapeutic Potential
title_full Cancer Immunosurveillance and Immunoediting: Clinical Implications and Therapeutic Potential
title_fullStr Cancer Immunosurveillance and Immunoediting: Clinical Implications and Therapeutic Potential
title_full_unstemmed Cancer Immunosurveillance and Immunoediting: Clinical Implications and Therapeutic Potential
title_sort Cancer Immunosurveillance and Immunoediting: Clinical Implications and Therapeutic Potential
author Torrezini, Thaissa
author_facet Torrezini, Thaissa
Athanazio, Daniel Abensur
author_role author
author2 Athanazio, Daniel Abensur
author2_role author
dc.contributor.author.fl_str_mv Torrezini, Thaissa
Athanazio, Daniel Abensur
dc.subject.por.fl_str_mv Neoplasias
Imunovigilância
Imunoedição
Regressão espontânea
Inflamação crônica
Neoplasm
Immunosurveillance
Immunoediting
Spontaneous regression
Chronic inflammation
topic Neoplasias
Imunovigilância
Imunoedição
Regressão espontânea
Inflamação crônica
Neoplasm
Immunosurveillance
Immunoediting
Spontaneous regression
Chronic inflammation
description Cancer is one of the three main causes of death worldwide. Understanding the mechanisms of cell transformation and tumor progression is a crucial issue for the development of new therapeutic tools, particularly in the context of advanced malignant tumors for which the current options are inefficient. The concept of immunosurveillance was originally proposed as the immune system's ability to recognize and inhibit tumor growth. Recent advances in basic immunology suggest an additional concept of immunoediting to describe the selective pressures that shape tumor immunogenicity. A complex array of signaling pathways and cells including NK, NKT, and T-lymphocytes are involved in this process. Immunosurveillance and immunoediting can be reproduced in experimental models, but the two processes cannot be easily confirmed in humans due to methodological limitations. Thus, the present work reviews the history of these hypotheses as well as the current experimental and human data on this theme.
publishDate 2008
dc.date.none.fl_str_mv 2008-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1762
10.32635/2176-9745.RBC.2008v54n1.1762
url https://rbc.inca.gov.br/index.php/revista/article/view/1762
identifier_str_mv 10.32635/2176-9745.RBC.2008v54n1.1762
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1762/1050
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 54 No. 1 (2008): Jan./Feb./Mar.; 63-77
Revista Brasileira de Cancerologia; Vol. 54 Núm. 1 (2008): ene./feb./mar.; 63-77
Revista Brasileira de Cancerologia; v. 54 n. 1 (2008): jan./fev./mar.; 63-77
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
_version_ 1797042248072822784

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