Pharmaceutical Assistance to Oncological Patients Using Monoclonal Antibodies in a Reference Hospital in the west of Santa Catarina
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/2316 |
Resumo: | Introduction: The use of monoclonal antibodies has been incorporated into cancer treatment protocols, once their effectiveness has been proven. This type of therapy is costly and its acquisition is still an obstacle for the patient. Objective: To describe the use of monoclonal antibodies in the perspective of purchasing, regulation and judicialization, adverse effects and causes of therapy discontinuation. Method: Descriptive study evaluating patients (n=169) undergoing treatment for cancer in a public hospital, from August 1, 2017 to July 31, 2019. Results: The population investigated consisted mostly of females (n=115). The main neoplasms found were breast (n=64, 36.16%), lymphomas (n=53, 29.94%) and plasma cell/plasmacytoma multiple myeloma (n=25, 14.12%). The most used monoclonal antibodies were trastuzumab (n=65, 35.71%) and rituximab (n=54, 29.67%). Four forms of drug purchase were observed. The purchases through the National Health System (SUS) (n=103, 56.59%) and law-mandated (n=72, 39.56%) prevailed. Most patients had no therapy-related adverse effects (60.3%), but among those who did, the main effects were vomiting and nausea, asthenia, diarrhea, pain, neutropenia and mucositis. Adverse effects/toxicity (n=15), lack of medication (n=11) and delayed approval (n=10) were the most common causes of treatment discontinuation. Conclusion: Monoclonal antibodies are more specific and have lesser effects. For drugs unavailable at SUS, judicialization is an important tool. |
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Pharmaceutical Assistance to Oncological Patients Using Monoclonal Antibodies in a Reference Hospital in the west of Santa CatarinaAsistencia Farmacéutica a Pacientes Oncológicos que Utilizan Anticuerpos Monoclonales en un Hospital de Referencia en el Oeste de Santa CatarinaAssistência Farmacêutica a Pacientes Oncológicos em Uso de Anticorpos Monoclonais em um Hospital de Referência do Oeste de Santa Catarinaassistência farmacêuticaanticorpos monoclonais/uso terapêuticoanticorpos monoclonais/efeitos adversosneoplasias/ tratamento farmacológicojudicialização da saúdepharmaceutical servicesantibodies, monoclonal/therapeutic useantibodies, monoclonal/adverse effectsneoplasms/drug therapyhealth’s judicializationservicios farmacéuticosanticuerpos monoclonales/uso terapéuticoanticuerpos monoclonales/efectos adversosneoplasias/tratamiento farmacológicojudicialización de la saludIntroduction: The use of monoclonal antibodies has been incorporated into cancer treatment protocols, once their effectiveness has been proven. This type of therapy is costly and its acquisition is still an obstacle for the patient. Objective: To describe the use of monoclonal antibodies in the perspective of purchasing, regulation and judicialization, adverse effects and causes of therapy discontinuation. Method: Descriptive study evaluating patients (n=169) undergoing treatment for cancer in a public hospital, from August 1, 2017 to July 31, 2019. Results: The population investigated consisted mostly of females (n=115). The main neoplasms found were breast (n=64, 36.16%), lymphomas (n=53, 29.94%) and plasma cell/plasmacytoma multiple myeloma (n=25, 14.12%). The most used monoclonal antibodies were trastuzumab (n=65, 35.71%) and rituximab (n=54, 29.67%). Four forms of drug purchase were observed. The purchases through the National Health System (SUS) (n=103, 56.59%) and law-mandated (n=72, 39.56%) prevailed. Most patients had no therapy-related adverse effects (60.3%), but among those who did, the main effects were vomiting and nausea, asthenia, diarrhea, pain, neutropenia and mucositis. Adverse effects/toxicity (n=15), lack of medication (n=11) and delayed approval (n=10) were the most common causes of treatment discontinuation. Conclusion: Monoclonal antibodies are more specific and have lesser effects. For drugs unavailable at SUS, judicialization is an important tool.Introducción: El uso de anticuerpos monoclonales se ha incorporado a los protocolos de tratamiento del cáncer, una vez comprobada su eficacia. Este tipo de terapia es costosa y su adquisición sigue siendo un obstáculo para el paciente. Objetivo: Describir el uso de anticuerpos monoclonales en términos de adquisición, regulación y judicialización, efectos adversos y causas de interrupción de la terapia. Método: Estudio descriptivo que evaluó a pacientes (n=169) en tratamiento por cáncer, en un hospital público, desde el 1 de agosto de 2017 al 31 de julio de 2019. Resultados: La población estudiada fue mayoritariamente femenina (n=115). Las principales neoplasias encontradas fueron mama (n=64, 36,16%), linfomas (n=53, 29,94%) y mieloma múltiple de células plasmáticas/plasmocitomas (n=25, 14,16%). Los anticuerpos monoclonales más utilizados fueron trastuzumab (n=65, 35,71%) y rituximab (n=54, 29,67%). Se observaron cuatro formas de adquisición de fármacos. Predominaron las adquisiciones a través del Sistema Único de Salud (SUS) (n=103, 56,59%) y judiciales (n=72, 39,56%). La mayoría de los pacientes no presentaron efectos adversos a la terapia (60,3%), pero entre los que sí los tuvieron, los principales efectos fueron vómitos y náuseas, astenia, diarrea, dolor, neutropenia y mucositis. Los efectos adversos/toxicidad (n=15), la falta de medicación (n=11) y la liberación retardada (n=10) fueron las causas más frecuentes de interrupción del tratamiento. Conclusión: Los anticuerpos monoclonales son más específicos y tienen menos efectos. Para los medicamentos no disponibles en el SUS, la judicialización es una herramienta importante.Introdução: A utilização dos anticorpos monoclonais vem sendo incorporada aos protocolos de tratamento para câncer, uma vez comprovada sua eficácia. Essa modalidade de terapia é onerosa, e sua aquisição ainda constitui um obstáculo para o paciente. Objetivo: Descrever a utilização de anticorpos monoclonais no que tange à forma de aquisição, regulação e judicialização, efeitos adversos e causas de interrupção da terapia. Método: Estudo descritivo com avaliação de pacientes (n=169) em tratamento para câncer, em um hospital público, no período de 1 de agosto de 2017 a 31 de julho de 2019. Resultados: A população estudada foi majoritariamente feminina (n=115). As principais neoplasias encontradas foram de mama (n=64, 36,16%), linfomas (n=53, 29,94%) e mieloma múltiplo de plasmócito/plasmocitoma (n=25, 14,12%). Os anticorpos monoclonais mais utilizados foram o trastuzumabe (n=65, 35,71%) e rituximabe (n=54, 29,67%). Foram observadas quatro formas de aquisição dos fármacos. As aquisições por meio do Sistema Único de Saúde (SUS) (n=103, 56,59%) e judicial (n=72, 39,56%) prevaleceram. A maioria dos pacientes não apresentou efeitos adversos à terapia (60,3%); mas, entre os que apresentaram, os principais efeitos foram vômitos e náuseas, astenia, diarreia, dor, neutropenia e mucosite. Efeitos adversos/toxicidade (n=15), falta de medicamento (n=11) e atraso na liberação (n=10) foram as causas mais comuns de interrupção do tratamento. Conclusão: Os anticorpos monoclonais são mais específicos e apresentam menores efeitos. Aos fármacos indisponíveis pelo SUS, a judicialização mostra-se como uma ferramenta importante.INCA2022-08-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdftext/htmlhttps://rbc.inca.gov.br/index.php/revista/article/view/231610.32635/2176-9745.RBC.2022v68n3.2316Revista Brasileira de Cancerologia; Vol. 68 No. 3 (2022): July/Aug./Sept.; e-152316Revista Brasileira de Cancerologia; Vol. 68 Núm. 3 (2022): jul./ago./sept; e-152316Revista Brasileira de Cancerologia; v. 68 n. 3 (2022): jul./ago./set.; e-1523162176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/2316/2061https://rbc.inca.gov.br/index.php/revista/article/view/2316/2655https://rbc.inca.gov.br/index.php/revista/article/view/2316/2270Copyright (c) 2022 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLeonel, Renan MartinelliReis, Flávia Medeiros DutraAndolfatto, DanielOliveira, Gabriela Gonçalves de2023-02-09T13:29:29Zoai:rbc.inca.gov.br:article/2316Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-02-09T13:29:29Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Pharmaceutical Assistance to Oncological Patients Using Monoclonal Antibodies in a Reference Hospital in the west of Santa Catarina Asistencia Farmacéutica a Pacientes Oncológicos que Utilizan Anticuerpos Monoclonales en un Hospital de Referencia en el Oeste de Santa Catarina Assistência Farmacêutica a Pacientes Oncológicos em Uso de Anticorpos Monoclonais em um Hospital de Referência do Oeste de Santa Catarina |
title |
Pharmaceutical Assistance to Oncological Patients Using Monoclonal Antibodies in a Reference Hospital in the west of Santa Catarina |
spellingShingle |
Pharmaceutical Assistance to Oncological Patients Using Monoclonal Antibodies in a Reference Hospital in the west of Santa Catarina Leonel, Renan Martinelli assistência farmacêutica anticorpos monoclonais/uso terapêutico anticorpos monoclonais/efeitos adversos neoplasias/ tratamento farmacológico judicialização da saúde pharmaceutical services antibodies, monoclonal/therapeutic use antibodies, monoclonal/adverse effects neoplasms/drug therapy health’s judicialization servicios farmacéuticos anticuerpos monoclonales/uso terapéutico anticuerpos monoclonales/efectos adversos neoplasias/tratamiento farmacológico judicialización de la salud |
title_short |
Pharmaceutical Assistance to Oncological Patients Using Monoclonal Antibodies in a Reference Hospital in the west of Santa Catarina |
title_full |
Pharmaceutical Assistance to Oncological Patients Using Monoclonal Antibodies in a Reference Hospital in the west of Santa Catarina |
title_fullStr |
Pharmaceutical Assistance to Oncological Patients Using Monoclonal Antibodies in a Reference Hospital in the west of Santa Catarina |
title_full_unstemmed |
Pharmaceutical Assistance to Oncological Patients Using Monoclonal Antibodies in a Reference Hospital in the west of Santa Catarina |
title_sort |
Pharmaceutical Assistance to Oncological Patients Using Monoclonal Antibodies in a Reference Hospital in the west of Santa Catarina |
author |
Leonel, Renan Martinelli |
author_facet |
Leonel, Renan Martinelli Reis, Flávia Medeiros Dutra Andolfatto, Daniel Oliveira, Gabriela Gonçalves de |
author_role |
author |
author2 |
Reis, Flávia Medeiros Dutra Andolfatto, Daniel Oliveira, Gabriela Gonçalves de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Leonel, Renan Martinelli Reis, Flávia Medeiros Dutra Andolfatto, Daniel Oliveira, Gabriela Gonçalves de |
dc.subject.por.fl_str_mv |
assistência farmacêutica anticorpos monoclonais/uso terapêutico anticorpos monoclonais/efeitos adversos neoplasias/ tratamento farmacológico judicialização da saúde pharmaceutical services antibodies, monoclonal/therapeutic use antibodies, monoclonal/adverse effects neoplasms/drug therapy health’s judicialization servicios farmacéuticos anticuerpos monoclonales/uso terapéutico anticuerpos monoclonales/efectos adversos neoplasias/tratamiento farmacológico judicialización de la salud |
topic |
assistência farmacêutica anticorpos monoclonais/uso terapêutico anticorpos monoclonais/efeitos adversos neoplasias/ tratamento farmacológico judicialização da saúde pharmaceutical services antibodies, monoclonal/therapeutic use antibodies, monoclonal/adverse effects neoplasms/drug therapy health’s judicialization servicios farmacéuticos anticuerpos monoclonales/uso terapéutico anticuerpos monoclonales/efectos adversos neoplasias/tratamiento farmacológico judicialización de la salud |
description |
Introduction: The use of monoclonal antibodies has been incorporated into cancer treatment protocols, once their effectiveness has been proven. This type of therapy is costly and its acquisition is still an obstacle for the patient. Objective: To describe the use of monoclonal antibodies in the perspective of purchasing, regulation and judicialization, adverse effects and causes of therapy discontinuation. Method: Descriptive study evaluating patients (n=169) undergoing treatment for cancer in a public hospital, from August 1, 2017 to July 31, 2019. Results: The population investigated consisted mostly of females (n=115). The main neoplasms found were breast (n=64, 36.16%), lymphomas (n=53, 29.94%) and plasma cell/plasmacytoma multiple myeloma (n=25, 14.12%). The most used monoclonal antibodies were trastuzumab (n=65, 35.71%) and rituximab (n=54, 29.67%). Four forms of drug purchase were observed. The purchases through the National Health System (SUS) (n=103, 56.59%) and law-mandated (n=72, 39.56%) prevailed. Most patients had no therapy-related adverse effects (60.3%), but among those who did, the main effects were vomiting and nausea, asthenia, diarrhea, pain, neutropenia and mucositis. Adverse effects/toxicity (n=15), lack of medication (n=11) and delayed approval (n=10) were the most common causes of treatment discontinuation. Conclusion: Monoclonal antibodies are more specific and have lesser effects. For drugs unavailable at SUS, judicialization is an important tool. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2316 10.32635/2176-9745.RBC.2022v68n3.2316 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/2316 |
identifier_str_mv |
10.32635/2176-9745.RBC.2022v68n3.2316 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2316/2061 https://rbc.inca.gov.br/index.php/revista/article/view/2316/2655 https://rbc.inca.gov.br/index.php/revista/article/view/2316/2270 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf text/html |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 68 No. 3 (2022): July/Aug./Sept.; e-152316 Revista Brasileira de Cancerologia; Vol. 68 Núm. 3 (2022): jul./ago./sept; e-152316 Revista Brasileira de Cancerologia; v. 68 n. 3 (2022): jul./ago./set.; e-152316 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
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Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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INCA |
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INCA |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042232315871232 |