Imunodetection of repair protein hMSH2 in actinic cheilitis and normal labial mucosa

Detalhes bibliográficos
Autor(a) principal: Pontes, Hélder Antônio Rebelo
Data de Publicação: 2005
Outros Autores: Aguiar, Maria Cássia Ferreira de, Mesquita, Ricardo Alves de, Pontes, Flávia Sirotheua Corrêa, Silveira Júnior, João Batista da
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1989
Resumo: The actinic cheilitis is a precancerous lesion of the lip. The exposure to direct sun light radiation has been indicated as the most important etiologic agent of both the actinic cheilitis and the squamous cells carcinoma of the lip. Thereby, other studies are necessary to help mapping the molecular events that contribute to the actinic cheilitis progession into a neoplasia. The hMSH2 protein of the DNA mismatch repair interacts with proteins that constitute the main repair pathways of the damage caused by ultraviolet radiation, nucleotide excision repair. Therefore, it is important to evaluate this protein in actinic cheilitis. The propose of this study was describe and to analyze the hMSH2 protein immunoexpression in samples of actinic cheilitis with different histological degrees (mild, moderate and severe), as well as in normal inferior lip epithelium. When actinic cheilitis with different histological degrees were compared among themselves, the results showed no statistical differences. There is no significant statistic differences among the actinic cheilitis and the normal lip mucosa. These results suggest that the hMSH2 protein does not participate on the actinic cheilitis development into squamous cell carcinoma of the lip, however other studies are necessary for a better understanding of DNA mismatch repair system participation at the context.
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spelling Imunodetection of repair protein hMSH2 in actinic cheilitis and normal labial mucosaImunoexpressão da proteína de reparo hMSH2 em queilite actínica e mucosa labial normalQueilite actínicaProteína hMSH2Reparo de bases mal pareadasActinic cheilitishMSH2 proteinMismatch repair systemThe actinic cheilitis is a precancerous lesion of the lip. The exposure to direct sun light radiation has been indicated as the most important etiologic agent of both the actinic cheilitis and the squamous cells carcinoma of the lip. Thereby, other studies are necessary to help mapping the molecular events that contribute to the actinic cheilitis progession into a neoplasia. The hMSH2 protein of the DNA mismatch repair interacts with proteins that constitute the main repair pathways of the damage caused by ultraviolet radiation, nucleotide excision repair. Therefore, it is important to evaluate this protein in actinic cheilitis. The propose of this study was describe and to analyze the hMSH2 protein immunoexpression in samples of actinic cheilitis with different histological degrees (mild, moderate and severe), as well as in normal inferior lip epithelium. When actinic cheilitis with different histological degrees were compared among themselves, the results showed no statistical differences. There is no significant statistic differences among the actinic cheilitis and the normal lip mucosa. These results suggest that the hMSH2 protein does not participate on the actinic cheilitis development into squamous cell carcinoma of the lip, however other studies are necessary for a better understanding of DNA mismatch repair system participation at the context.A queilite actínica é a principal lesão pré-neoplásica do lábio. A exposição crônica à radiação solar é apontada como o principal agente etiológico, tanto para a queilite actínica como para o carcinoma epidermóide do lábio. Porém, estudos complementares são necessários para ajudar a mapear os eventos moleculares indispensáveis para que ocorra a progressão da queilite actínica para esta neoplasia. A proteína hMSH2 do reparo de bases mal pareadas do DNA interage com algumas proteínas integrantes da principal via de reparo dos danos ocasionados pela radiação ultravioleta, o reparo de excisão de nucleotídeo. Portanto, é importante avaliar esta proteína em queilites actínicas. Este estudo teve como objetivo descrever e analisar a imunoexpressão da proteína hMSH2 em amostras de queilites actínicas com várias graduações histológicas (discreta, moderada e acentuada), assim como no epitélio do lábio inferior normal. Os resultados não mostraram diferenças estatísticas entre as várias graduações histológicas das queilites actínicas entre si, assim como não houve diferenças estatísticas significativas entre as amostras de queilite actínica e a mucosa labial normal. Esses resultados sugerem que a proteína hMSH2 não participa da progressão de queilite actínica para carcinoma epidermóide no lábio, no entanto, mais estudos são necessários para melhor compreensão da participação do reparo de bases mal pareadas neste processo.INCA2005-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/198910.32635/2176-9745.RBC.2005v51n1.1989Revista Brasileira de Cancerologia; Vol. 51 No. 1 (2005): Jan./Feb./Mar.; 23-30Revista Brasileira de Cancerologia; Vol. 51 Núm. 1 (2005): ene./feb./mar.; 23-30Revista Brasileira de Cancerologia; v. 51 n. 1 (2005): jan./fev./mar.; 23-302176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1989/1214Pontes, Hélder Antônio Rebelo Aguiar, Maria Cássia Ferreira de Mesquita, Ricardo Alves de Pontes, Flávia Sirotheua Corrêa Silveira Júnior, João Batista da info:eu-repo/semantics/openAccess2021-11-29T20:31:15Zoai:rbc.inca.gov.br:article/1989Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:31:15Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Imunodetection of repair protein hMSH2 in actinic cheilitis and normal labial mucosa
Imunoexpressão da proteína de reparo hMSH2 em queilite actínica e mucosa labial normal
title Imunodetection of repair protein hMSH2 in actinic cheilitis and normal labial mucosa
spellingShingle Imunodetection of repair protein hMSH2 in actinic cheilitis and normal labial mucosa
Pontes, Hélder Antônio Rebelo
Queilite actínica
Proteína hMSH2
Reparo de bases mal pareadas
Actinic cheilitis
hMSH2 protein
Mismatch repair system
title_short Imunodetection of repair protein hMSH2 in actinic cheilitis and normal labial mucosa
title_full Imunodetection of repair protein hMSH2 in actinic cheilitis and normal labial mucosa
title_fullStr Imunodetection of repair protein hMSH2 in actinic cheilitis and normal labial mucosa
title_full_unstemmed Imunodetection of repair protein hMSH2 in actinic cheilitis and normal labial mucosa
title_sort Imunodetection of repair protein hMSH2 in actinic cheilitis and normal labial mucosa
author Pontes, Hélder Antônio Rebelo
author_facet Pontes, Hélder Antônio Rebelo
Aguiar, Maria Cássia Ferreira de
Mesquita, Ricardo Alves de
Pontes, Flávia Sirotheua Corrêa
Silveira Júnior, João Batista da
author_role author
author2 Aguiar, Maria Cássia Ferreira de
Mesquita, Ricardo Alves de
Pontes, Flávia Sirotheua Corrêa
Silveira Júnior, João Batista da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pontes, Hélder Antônio Rebelo
Aguiar, Maria Cássia Ferreira de
Mesquita, Ricardo Alves de
Pontes, Flávia Sirotheua Corrêa
Silveira Júnior, João Batista da
dc.subject.por.fl_str_mv Queilite actínica
Proteína hMSH2
Reparo de bases mal pareadas
Actinic cheilitis
hMSH2 protein
Mismatch repair system
topic Queilite actínica
Proteína hMSH2
Reparo de bases mal pareadas
Actinic cheilitis
hMSH2 protein
Mismatch repair system
description The actinic cheilitis is a precancerous lesion of the lip. The exposure to direct sun light radiation has been indicated as the most important etiologic agent of both the actinic cheilitis and the squamous cells carcinoma of the lip. Thereby, other studies are necessary to help mapping the molecular events that contribute to the actinic cheilitis progession into a neoplasia. The hMSH2 protein of the DNA mismatch repair interacts with proteins that constitute the main repair pathways of the damage caused by ultraviolet radiation, nucleotide excision repair. Therefore, it is important to evaluate this protein in actinic cheilitis. The propose of this study was describe and to analyze the hMSH2 protein immunoexpression in samples of actinic cheilitis with different histological degrees (mild, moderate and severe), as well as in normal inferior lip epithelium. When actinic cheilitis with different histological degrees were compared among themselves, the results showed no statistical differences. There is no significant statistic differences among the actinic cheilitis and the normal lip mucosa. These results suggest that the hMSH2 protein does not participate on the actinic cheilitis development into squamous cell carcinoma of the lip, however other studies are necessary for a better understanding of DNA mismatch repair system participation at the context.
publishDate 2005
dc.date.none.fl_str_mv 2005-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1989
10.32635/2176-9745.RBC.2005v51n1.1989
url https://rbc.inca.gov.br/index.php/revista/article/view/1989
identifier_str_mv 10.32635/2176-9745.RBC.2005v51n1.1989
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1989/1214
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 51 No. 1 (2005): Jan./Feb./Mar.; 23-30
Revista Brasileira de Cancerologia; Vol. 51 Núm. 1 (2005): ene./feb./mar.; 23-30
Revista Brasileira de Cancerologia; v. 51 n. 1 (2005): jan./fev./mar.; 23-30
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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