Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review

Detalhes bibliográficos
Autor(a) principal: Mainenti, Pietro
Data de Publicação: 2008
Outros Autores: Rosa, Luiz Eduardo Blumer
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1746
Resumo: Objective: The most frequent neoplasms in experimental carcinogenesis of the salivary glands in animals are carcinomas and sarcomas, whether alone or in association. The diagnosis of carcinosarcoma has only been mentioned in more recent research. Literature review: 7,12-dimethylbenz[a]anthracene is the most common carcinogenic substance used in laboratory animals. This compound belongs to the polycyclic aromatic hydrocarbon group and is reported as the substance of choice in salivary gland experimental oncogenesis. Material and Methods: A literature review was performed to evaluate the data on animals suitable for carcinogenesis, carcinogen concentration, and tumor development related to salivary glands. Discussion and conclusion: The results showed both a lack of consensus among the authors and the need for standardization of the classification and nomenclature of DMBA induced glandular neoplasms.
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spelling Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review Carcinogênese Química Experimental em Glândulas Salivares - Revisão da Literatura Neoplasias das glândulas salivaresCarcinógenos9,10-dimetil-1,2-benzantracenoGlândulas salivaresSalivary gland neoplasmsCarcinogens9,10-dimethyl-1,2-benzanthraceneSalivary glandsObjective: The most frequent neoplasms in experimental carcinogenesis of the salivary glands in animals are carcinomas and sarcomas, whether alone or in association. The diagnosis of carcinosarcoma has only been mentioned in more recent research. Literature review: 7,12-dimethylbenz[a]anthracene is the most common carcinogenic substance used in laboratory animals. This compound belongs to the polycyclic aromatic hydrocarbon group and is reported as the substance of choice in salivary gland experimental oncogenesis. Material and Methods: A literature review was performed to evaluate the data on animals suitable for carcinogenesis, carcinogen concentration, and tumor development related to salivary glands. Discussion and conclusion: The results showed both a lack of consensus among the authors and the need for standardization of the classification and nomenclature of DMBA induced glandular neoplasms.Introdução: As neoplasias malignas mais encontradas em carcinogênese experimental de glândulas salivares animais são os carcinomas e os sarcomas, associados ou não. O diagnóstico de carcinossarcomas somente foi aludido em estudos recentes. Revisão da literatura: O carcinógeno mais utilizado em carcinogênese química é o 7,12 - dimetilbenzantraceno. Esta substância, pertencente ao grupo dos hidrocarbonetos policíclicos aromáticos, é considerada a droga de escolha em oncogênese de glândulas salivares. Material e Método: Por meio de uma revisão de literatura, foram avaliados os dados relativos aos experimentos em animais, às concentrações dos carcinógenos e ao desenvolvimento de tumores induzidos em glândulas salivares submandibulares. Discussão e Conclusão: Os resultados de nosso referencial teórico evidenciaram pouca congruência entre os autores e suas conclusões. Ficou clara a necessidade de adequação e padronização da classificação e nomenclatura das neoplasias glandulares induzidas por DMBA.INCA2008-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/174610.32635/2176-9745.RBC.2008v54n2.1746Revista Brasileira de Cancerologia; Vol. 54 No. 2 (2008): Apr./May/June; 167-174Revista Brasileira de Cancerologia; Vol. 54 Núm. 2 (2008): abr./mayo/jun.; 167-174Revista Brasileira de Cancerologia; v. 54 n. 2 (2008): abr./maio/jun.; 167-1742176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1746/1036Mainenti, PietroRosa, Luiz Eduardo Blumer info:eu-repo/semantics/openAccess2021-11-29T20:23:16Zoai:rbc.inca.gov.br:article/1746Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:23:16Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review
Carcinogênese Química Experimental em Glândulas Salivares - Revisão da Literatura
title Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review
spellingShingle Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review
Mainenti, Pietro
Neoplasias das glândulas salivares
Carcinógenos
9,10-dimetil-1,2-benzantraceno
Glândulas salivares
Salivary gland neoplasms
Carcinogens
9,10-dimethyl-1,2-benzanthracene
Salivary glands
title_short Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review
title_full Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review
title_fullStr Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review
title_full_unstemmed Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review
title_sort Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review
author Mainenti, Pietro
author_facet Mainenti, Pietro
Rosa, Luiz Eduardo Blumer
author_role author
author2 Rosa, Luiz Eduardo Blumer
author2_role author
dc.contributor.author.fl_str_mv Mainenti, Pietro
Rosa, Luiz Eduardo Blumer
dc.subject.por.fl_str_mv Neoplasias das glândulas salivares
Carcinógenos
9,10-dimetil-1,2-benzantraceno
Glândulas salivares
Salivary gland neoplasms
Carcinogens
9,10-dimethyl-1,2-benzanthracene
Salivary glands
topic Neoplasias das glândulas salivares
Carcinógenos
9,10-dimetil-1,2-benzantraceno
Glândulas salivares
Salivary gland neoplasms
Carcinogens
9,10-dimethyl-1,2-benzanthracene
Salivary glands
description Objective: The most frequent neoplasms in experimental carcinogenesis of the salivary glands in animals are carcinomas and sarcomas, whether alone or in association. The diagnosis of carcinosarcoma has only been mentioned in more recent research. Literature review: 7,12-dimethylbenz[a]anthracene is the most common carcinogenic substance used in laboratory animals. This compound belongs to the polycyclic aromatic hydrocarbon group and is reported as the substance of choice in salivary gland experimental oncogenesis. Material and Methods: A literature review was performed to evaluate the data on animals suitable for carcinogenesis, carcinogen concentration, and tumor development related to salivary glands. Discussion and conclusion: The results showed both a lack of consensus among the authors and the need for standardization of the classification and nomenclature of DMBA induced glandular neoplasms.
publishDate 2008
dc.date.none.fl_str_mv 2008-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1746
10.32635/2176-9745.RBC.2008v54n2.1746
url https://rbc.inca.gov.br/index.php/revista/article/view/1746
identifier_str_mv 10.32635/2176-9745.RBC.2008v54n2.1746
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1746/1036
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 54 No. 2 (2008): Apr./May/June; 167-174
Revista Brasileira de Cancerologia; Vol. 54 Núm. 2 (2008): abr./mayo/jun.; 167-174
Revista Brasileira de Cancerologia; v. 54 n. 2 (2008): abr./maio/jun.; 167-174
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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