Review article: chromosomal diagnosis in rhabdomyosarcoma

Detalhes bibliográficos
Autor(a) principal: Cardoso, Plínio Cerqueira dos Santos
Data de Publicação: 2005
Outros Autores: Bahia, Marcelo de Oliveira, Baruffi, Marcelo Razera, Azevedo, Juliana Simão Nina de, Khayat, André Salim, Smith, Marilia de Arruda Cardoso, Assumpção, Paulo Pimentel de, Burbano, Rommel Rodríguez, Tone, Luiz Gonzaga
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1998
Resumo: Rhabdomyosarcomas (RMS) are considered clinically aggressive tumors, originated from immature mesenchymal cells and characterized by the presence of cells with an ill-defined differentiation. The use of conventional cytogenetic techniques has contributed considerably to distinguish the alveolar RMSs from the other types of solid tumors in children and adolescents. Besides that, it provides important prognostic informations about alveolar RMSs. Thus, the present work was aimed at reviewing the cytogenetic alterations observed in the different histological subtypes of RMS, focusing not only on the studies performed with conventional cytogenetics, but also on new approaches used in the study of neoplasms, such as FISH, CGH, SKY and M-FISH. These methodologies have contributed significantly to a better understanding of the karyotype heterogeneity observed in RMS.
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spelling Review article: chromosomal diagnosis in rhabdomyosarcomaArtigo de revisão: diagnóstico cromosômico em rabdomiossarcomaCromossomosCitogenéticaRabidomiossarcomaChromosomesCytogeneticsRhabdomyosarcomasRhabdomyosarcomas (RMS) are considered clinically aggressive tumors, originated from immature mesenchymal cells and characterized by the presence of cells with an ill-defined differentiation. The use of conventional cytogenetic techniques has contributed considerably to distinguish the alveolar RMSs from the other types of solid tumors in children and adolescents. Besides that, it provides important prognostic informations about alveolar RMSs. Thus, the present work was aimed at reviewing the cytogenetic alterations observed in the different histological subtypes of RMS, focusing not only on the studies performed with conventional cytogenetics, but also on new approaches used in the study of neoplasms, such as FISH, CGH, SKY and M-FISH. These methodologies have contributed significantly to a better understanding of the karyotype heterogeneity observed in RMS.Os rabdomiossarcomas (RMS) são considerados tumores clinicamente agressivos com origem a partir de células mesenquimais imaturas e que se caracterizam pela presença de células com diferenciação pouco definida. O emprego das técnicas citogenéticas convencionais em RMS vem contribuindo consideravelmente para a diferenciação entre os rabdomiossarcomas alveolares e os outros tumores de células pequenas e redondas, além de fornecer informações prognósticas importantes referente ao rabdomiossarcoma do tipo alveolar. Assim, este trabalho visa a realizar uma revisão das alterações citogenéticas observadas nos diferentes subtipos histológicos de RMS, enfocando não só os trabalhos de citogenética convencional, mas também novas abordagens utilizadas para o estudo de neoplasias tais como FISH, CGH, SKY e M-FISH. Tais metodologias vêm contribuindo de maneira significativa para a melhor compreensão da heterogeneidade cariotípica observada nos RMS.INCA2005-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/199810.32635/2176-9745.RBC.2005v51n1.1998Revista Brasileira de Cancerologia; Vol. 51 No. 1 (2005): Jan./Feb./Mar.; 59-65Revista Brasileira de Cancerologia; Vol. 51 Núm. 1 (2005): ene./feb./mar.; 59-65Revista Brasileira de Cancerologia; v. 51 n. 1 (2005): jan./fev./mar.; 59-652176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAenghttps://rbc.inca.gov.br/index.php/revista/article/view/1998/1221https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCardoso, Plínio Cerqueira dos Santos Bahia, Marcelo de Oliveira Baruffi, Marcelo Razera Azevedo, Juliana Simão Nina de Khayat, André Salim Smith, Marilia de Arruda Cardoso Assumpção, Paulo Pimentel de Burbano, Rommel Rodríguez Tone, Luiz Gonzaga 2023-07-25T15:02:13Zoai:rbc.inca.gov.br:article/1998Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-07-25T15:02:13Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Review article: chromosomal diagnosis in rhabdomyosarcoma
Artigo de revisão: diagnóstico cromosômico em rabdomiossarcoma
title Review article: chromosomal diagnosis in rhabdomyosarcoma
spellingShingle Review article: chromosomal diagnosis in rhabdomyosarcoma
Cardoso, Plínio Cerqueira dos Santos
Cromossomos
Citogenética
Rabidomiossarcoma
Chromosomes
Cytogenetics
Rhabdomyosarcomas
title_short Review article: chromosomal diagnosis in rhabdomyosarcoma
title_full Review article: chromosomal diagnosis in rhabdomyosarcoma
title_fullStr Review article: chromosomal diagnosis in rhabdomyosarcoma
title_full_unstemmed Review article: chromosomal diagnosis in rhabdomyosarcoma
title_sort Review article: chromosomal diagnosis in rhabdomyosarcoma
author Cardoso, Plínio Cerqueira dos Santos
author_facet Cardoso, Plínio Cerqueira dos Santos
Bahia, Marcelo de Oliveira
Baruffi, Marcelo Razera
Azevedo, Juliana Simão Nina de
Khayat, André Salim
Smith, Marilia de Arruda Cardoso
Assumpção, Paulo Pimentel de
Burbano, Rommel Rodríguez
Tone, Luiz Gonzaga
author_role author
author2 Bahia, Marcelo de Oliveira
Baruffi, Marcelo Razera
Azevedo, Juliana Simão Nina de
Khayat, André Salim
Smith, Marilia de Arruda Cardoso
Assumpção, Paulo Pimentel de
Burbano, Rommel Rodríguez
Tone, Luiz Gonzaga
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Plínio Cerqueira dos Santos
Bahia, Marcelo de Oliveira
Baruffi, Marcelo Razera
Azevedo, Juliana Simão Nina de
Khayat, André Salim
Smith, Marilia de Arruda Cardoso
Assumpção, Paulo Pimentel de
Burbano, Rommel Rodríguez
Tone, Luiz Gonzaga
dc.subject.por.fl_str_mv Cromossomos
Citogenética
Rabidomiossarcoma
Chromosomes
Cytogenetics
Rhabdomyosarcomas
topic Cromossomos
Citogenética
Rabidomiossarcoma
Chromosomes
Cytogenetics
Rhabdomyosarcomas
description Rhabdomyosarcomas (RMS) are considered clinically aggressive tumors, originated from immature mesenchymal cells and characterized by the presence of cells with an ill-defined differentiation. The use of conventional cytogenetic techniques has contributed considerably to distinguish the alveolar RMSs from the other types of solid tumors in children and adolescents. Besides that, it provides important prognostic informations about alveolar RMSs. Thus, the present work was aimed at reviewing the cytogenetic alterations observed in the different histological subtypes of RMS, focusing not only on the studies performed with conventional cytogenetics, but also on new approaches used in the study of neoplasms, such as FISH, CGH, SKY and M-FISH. These methodologies have contributed significantly to a better understanding of the karyotype heterogeneity observed in RMS.
publishDate 2005
dc.date.none.fl_str_mv 2005-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1998
10.32635/2176-9745.RBC.2005v51n1.1998
url https://rbc.inca.gov.br/index.php/revista/article/view/1998
identifier_str_mv 10.32635/2176-9745.RBC.2005v51n1.1998
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1998/1221
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 51 No. 1 (2005): Jan./Feb./Mar.; 59-65
Revista Brasileira de Cancerologia; Vol. 51 Núm. 1 (2005): ene./feb./mar.; 59-65
Revista Brasileira de Cancerologia; v. 51 n. 1 (2005): jan./fev./mar.; 59-65
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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