Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos)
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/3232 |
Resumo: | The reaction of the gerbil’s skin to the Chemical induetion of tumors was studied, comparing the early morphologic alterations ocurring in the gerbil to the ones we have also studied in the mouse. Two models of carcinogenesis were used: the cumulative with methylcholanthrene and the biphasic using methylcolanthrene as initiator, followed by croton oil as promoter. The gross findings, such as thickening of the skin and hyperemia induced by the various experiments above, were less evident in the gerbils. The microscopic findings of hyperplasia and inflammatory reaction, were aIso less intense in the gerbii's skin. The cellular proliferation wassimulated, as shown by increased mitotic rate, without any recognizable progressiva hyperplasia of the epidermis with the cumulative modelelectron microscopy displayed a less evident dilatation of intercellular space in the interfollicular epidermis of gerbils than that observed in mice, and the induction of "dark cells" was not registered in gerbils, up to the 10th week of treatment. Gerbils did not show any "dark cell" with the biphasic model, and the initial minimal dilatation of the intercellular space disappeared despite the continuing treatment It has been demonstrated that the skin of the gerbil is more resistant to chemical carcinogenesis than that of the mouse. Gerbils did not develop any papiloma up to the 30th week of treatment with the biphasic model, while mice developed such tumors after a seven-week latency period. With the cumulative model, both gerbil and mouse each developed one papilloma, but the latter did so after ten weeks of treatment, while the former took fifteen weeks. The results suggest that the relative resistence of the gerbil’s skin to Chemical carcinogenesis in based upon and adaptation to the promotion process, specially with the croton oil. |
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Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos)Carcinogênese Química CutâneaModelo CumulativoModelo BifásicoGerbilhoChemical Skin CarcinogenesisCumulative ModelBiphasic ModelGerbilThe reaction of the gerbil’s skin to the Chemical induetion of tumors was studied, comparing the early morphologic alterations ocurring in the gerbil to the ones we have also studied in the mouse. Two models of carcinogenesis were used: the cumulative with methylcholanthrene and the biphasic using methylcolanthrene as initiator, followed by croton oil as promoter. The gross findings, such as thickening of the skin and hyperemia induced by the various experiments above, were less evident in the gerbils. The microscopic findings of hyperplasia and inflammatory reaction, were aIso less intense in the gerbii's skin. The cellular proliferation wassimulated, as shown by increased mitotic rate, without any recognizable progressiva hyperplasia of the epidermis with the cumulative modelelectron microscopy displayed a less evident dilatation of intercellular space in the interfollicular epidermis of gerbils than that observed in mice, and the induction of "dark cells" was not registered in gerbils, up to the 10th week of treatment. Gerbils did not show any "dark cell" with the biphasic model, and the initial minimal dilatation of the intercellular space disappeared despite the continuing treatment It has been demonstrated that the skin of the gerbil is more resistant to chemical carcinogenesis than that of the mouse. Gerbils did not develop any papiloma up to the 30th week of treatment with the biphasic model, while mice developed such tumors after a seven-week latency period. With the cumulative model, both gerbil and mouse each developed one papilloma, but the latter did so after ten weeks of treatment, while the former took fifteen weeks. The results suggest that the relative resistence of the gerbil’s skin to Chemical carcinogenesis in based upon and adaptation to the promotion process, specially with the croton oil.Foi estudada a resposta da pele de gerbilho à indução química de tumores, comparando-se as alterações morfológicas iniciais com aquelas que ocorrem na pele do camundongo. Dois modelos de carcinogenese foram aplicados: o cumulativo, utilizando metilcolantreno e o bifásico com metilcolantreno como iniciador e óleo de cróton como promotor. As alterações macroscópicas tais como espessamento da pele e hiperemia, induzidas com os dois tratamentos mencionados foram menos evidentes no gerbilho. A reação inflamatória e a hiperplasia, observadas microscopicamente, também foram de menor intensidade na pele de gerbilho, notando-se, durante os dois tratamentos, o paradoxo do estímulo permanente da proliferação celular, evidenciado pela elevação do índice mitotico, sem hiperplasia progressiva da epiderme. A nível ultra-estrutural, com o modelo cumulativo, na epiderme interfolicular do gerbilho, ocorreu dilatação do espaço intercelular menos evidente do que a registrada na do camundongo, e a indução de "células escuras" não foi observada até a 10ª semana de tratamento. Com o modelo bifásico, na epiderme interfolicular do gerbilho, nao houve indução de "células escuras" e a dilatação do espaço intercelular foi inicialmente, mímima, deixando de existir posteriormente, apesar da continuidade do tratamento. A pele do gerbilho, quando comparada com a de camundongo, mostrou-se relativamente resistente a carcinogenese química. Se no camundongo, com o modelo bifásico, após um período de latência de sete semanas, houve a formação de vários papilomas, no gerbilho não houve desenvolvimento de tumor até à 304 semana, com o modelo cumulativo, tanto no camundongo como no gerbilho, houve desenvolvimento de um papiloma; o período de latência no camundongo foi de dez semanas, enquanto que no gerbilho foi de quinze semanas. Os resultados obtidos sugerem que a relativa resistência da pele de gerbilho à carcinogênese química parece residir em um fenômeno de adaptação ao processo de promoção tumoral, particularmente com óleo de cróton.INCA2023-08-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/323210.32635/2176-9745.RBC.1986v32n1.3232Revista Brasileira de Cancerologia; Vol. 32 No. 1 (1986): Mar.; 31-42Revista Brasileira de Cancerologia; Vol. 32 Núm. 1 (1986): mar.; 31-42Revista Brasileira de Cancerologia; v. 32 n. 1 (1986): mar.; 31-422176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/3232/2089https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGuzmán Silva, Maria AngélicaGuimarães, Jorge S. P.2023-08-07T18:56:10Zoai:rbc.inca.gov.br:article/3232Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-08-07T18:56:10Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos) |
title |
Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos) |
spellingShingle |
Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos) Guzmán Silva, Maria Angélica Carcinogênese Química Cutânea Modelo Cumulativo Modelo Bifásico Gerbilho Chemical Skin Carcinogenesis Cumulative Model Biphasic Model Gerbil |
title_short |
Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos) |
title_full |
Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos) |
title_fullStr |
Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos) |
title_full_unstemmed |
Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos) |
title_sort |
Análise Morfológica Comparativa da Carcinogênese Química Cutânea entre Camundongo (Mus Musculus) e Gerbilho (Meriones Unguiculatos) |
author |
Guzmán Silva, Maria Angélica |
author_facet |
Guzmán Silva, Maria Angélica Guimarães, Jorge S. P. |
author_role |
author |
author2 |
Guimarães, Jorge S. P. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Guzmán Silva, Maria Angélica Guimarães, Jorge S. P. |
dc.subject.por.fl_str_mv |
Carcinogênese Química Cutânea Modelo Cumulativo Modelo Bifásico Gerbilho Chemical Skin Carcinogenesis Cumulative Model Biphasic Model Gerbil |
topic |
Carcinogênese Química Cutânea Modelo Cumulativo Modelo Bifásico Gerbilho Chemical Skin Carcinogenesis Cumulative Model Biphasic Model Gerbil |
description |
The reaction of the gerbil’s skin to the Chemical induetion of tumors was studied, comparing the early morphologic alterations ocurring in the gerbil to the ones we have also studied in the mouse. Two models of carcinogenesis were used: the cumulative with methylcholanthrene and the biphasic using methylcolanthrene as initiator, followed by croton oil as promoter. The gross findings, such as thickening of the skin and hyperemia induced by the various experiments above, were less evident in the gerbils. The microscopic findings of hyperplasia and inflammatory reaction, were aIso less intense in the gerbii's skin. The cellular proliferation wassimulated, as shown by increased mitotic rate, without any recognizable progressiva hyperplasia of the epidermis with the cumulative modelelectron microscopy displayed a less evident dilatation of intercellular space in the interfollicular epidermis of gerbils than that observed in mice, and the induction of "dark cells" was not registered in gerbils, up to the 10th week of treatment. Gerbils did not show any "dark cell" with the biphasic model, and the initial minimal dilatation of the intercellular space disappeared despite the continuing treatment It has been demonstrated that the skin of the gerbil is more resistant to chemical carcinogenesis than that of the mouse. Gerbils did not develop any papiloma up to the 30th week of treatment with the biphasic model, while mice developed such tumors after a seven-week latency period. With the cumulative model, both gerbil and mouse each developed one papilloma, but the latter did so after ten weeks of treatment, while the former took fifteen weeks. The results suggest that the relative resistence of the gerbil’s skin to Chemical carcinogenesis in based upon and adaptation to the promotion process, specially with the croton oil. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-07 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3232 10.32635/2176-9745.RBC.1986v32n1.3232 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/3232 |
identifier_str_mv |
10.32635/2176-9745.RBC.1986v32n1.3232 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3232/2089 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 32 No. 1 (1986): Mar.; 31-42 Revista Brasileira de Cancerologia; Vol. 32 Núm. 1 (1986): mar.; 31-42 Revista Brasileira de Cancerologia; v. 32 n. 1 (1986): mar.; 31-42 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042234813579264 |