Pulmonary Function in Long-Term Survivors of Childhood and Adolescence Osteosarcoma: Case Report
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/1345 |
Resumo: | Introduction: Chemotherapy used in osteosarcoma have the potential to cause lung damage. The objectives were to analyze lung volumes and capacities, and respiratory muscle strength of patients treated with chemotherapy and surgery for osteosarcoma. The study was designed as a prospective case-series of patients, through the analysis of spirometry, impulse, oscillometry, and manovacuometry tests. Case report: In twenty-one patients, the median age at diagnosis was 15 years, and at inclusion, 30 years. The median disease-free survival time was 10 years. Eight different chemotherapeutic agents were used: cisplatin, doxorubicin, methotrexate, carboplatin, ifophosphamide, epidoxorubicin, cyclophosphamide and etoposide. There were test abnormalities in 14 patients (66.6%), with mild obstructive disorders on spirometry in three patients (14.3%), and obstructive patterns on oscillometry in seven patients (33.3%). On spirometry, the mean ± standard deviation (SD) values of forced vital capacity (FVC) were 91.9%±12.2; for forced expiratory volume in one second (FEV1) were 87.4%±12.2 and FEV1/FVC ratios, 95.4%±7.9. On oscillometry, mean ± SD values for resistance at 5 Hz were 126.2%±36.2; for resistance at 20 Hz, 128.4%±32.4; reactance at 5 Hz, -0.75±0.68 kPa/L/s; for resonant frequency, 15.6±4.2 Hz. Nine patients (42.8%) had reduced maximum pressures on the manovacuometry: Maximum Expiratory Pressure (MEP) were reduced in eight patients, and inspiratory (MIP) in three. The mean ± SD MIP was 89.4±29.5; MEP, 88±37.7. Conclusion: Mild abnormalities in pulmonary function tests in this series of patients were observed years after treatment for osteosarcoma. |
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Pulmonary Function in Long-Term Survivors of Childhood and Adolescence Osteosarcoma: Case ReportFunción Pulmonar en Sobrevivientes de Osteosarcoma en la Infancia y la Adolescencia: Relato de CasoFunção Pulmonar em Sobreviventes de Osteossarcoma da Infância e Adolescência: Relato de CasoOsteossarcomaMedidas de Volume PulmonarEspirometriaOscilometriaAntineoplásicosOsteosarcomaLung Volume MeasurementsSpirometryOscillometryAntineoplastic AgentsOsteosarcomaMediciones del Volumen PulmonarEspirometríaOscilometríaAntineoplásicosIntroduction: Chemotherapy used in osteosarcoma have the potential to cause lung damage. The objectives were to analyze lung volumes and capacities, and respiratory muscle strength of patients treated with chemotherapy and surgery for osteosarcoma. The study was designed as a prospective case-series of patients, through the analysis of spirometry, impulse, oscillometry, and manovacuometry tests. Case report: In twenty-one patients, the median age at diagnosis was 15 years, and at inclusion, 30 years. The median disease-free survival time was 10 years. Eight different chemotherapeutic agents were used: cisplatin, doxorubicin, methotrexate, carboplatin, ifophosphamide, epidoxorubicin, cyclophosphamide and etoposide. There were test abnormalities in 14 patients (66.6%), with mild obstructive disorders on spirometry in three patients (14.3%), and obstructive patterns on oscillometry in seven patients (33.3%). On spirometry, the mean ± standard deviation (SD) values of forced vital capacity (FVC) were 91.9%±12.2; for forced expiratory volume in one second (FEV1) were 87.4%±12.2 and FEV1/FVC ratios, 95.4%±7.9. On oscillometry, mean ± SD values for resistance at 5 Hz were 126.2%±36.2; for resistance at 20 Hz, 128.4%±32.4; reactance at 5 Hz, -0.75±0.68 kPa/L/s; for resonant frequency, 15.6±4.2 Hz. Nine patients (42.8%) had reduced maximum pressures on the manovacuometry: Maximum Expiratory Pressure (MEP) were reduced in eight patients, and inspiratory (MIP) in three. The mean ± SD MIP was 89.4±29.5; MEP, 88±37.7. Conclusion: Mild abnormalities in pulmonary function tests in this series of patients were observed years after treatment for osteosarcoma.Introducción: La quimioterapia utilizada en osteosarcoma puede causar daño a los pulmones. Los objetivos de este trabajo fueron analizar los volúmenes y capacidades pulmonares y la fuerza respiratoria en pacientes tratados para osteosarcoma, en una serie prospectiva de casos, en un hospital de oncología pediátrica, mediante el análisis de espirometría, oscilometría de impulsos y manuvacuometría. Relato de caso: En 21 pacientes, la mediana de edad al diagnóstico fue de 15 años y en la inclusión de 30 años. La supervivencia media libre de enfermedad fue de diez años. Hubo alteraciones en los exámenes en 14 pacientes (66,6%), con alteraciones obstructivas leves en la espirometría en tres (14,3%), y obstrucción en la oscilometría en siete (33,3%). En espirometría, las medias ± desviación estándar (DE) de la capacidad vital forzada (CVF) fueron 91,9%±12,2; para el volumen espiratorio forzado en el primer segundo (VEF1) fue 87,4%±12,2 y el cociente VEF1/CVF fue 95,4%±7,9. En oscilometría, los valores medios ± DE para la resistencia a 5 Hz fueron 126,2% ±36,2; para resistencia a 20 Hz, 128,4%±32,4; reactancia a 5 Hz, -0,75±0,68 kPa/L/s; para la frecuencia de resonancia, 15,6±4,2 Hz. En manuvacuometría, nueve pacientes (42,8%) mostraron una reducción de las presiones: las presiones espiratorias máximas (PEmáx) se redujeron en ocho pacientes y las presiones inspiratorias (PImáx) en tres. La media ± DE del PImáx fue 89,4 ± 29,5; PEmáx, 88±37,7. Conclusión: Se observaron ligeros cambios en las pruebas de función pulmonar anos después del tratamiento del osteosarcoma.Introdução: A quimioterapia usada no osteossarcoma tem potencial para causar danos aos pulmões. Os objetivos deste trabalho foram analisar os volumes e capacidades pulmonares e a forca respiratória de pacientes tratados com quimioterapia e cirurgia para osteossarcoma, em uma serie prospectiva de casos, em um hospital pediátrico oncológico, por meio da análise de espirometria, oscilometria de impulso e manovacuometria. Relato de caso: Em 21 pacientes, a mediana de idade ao diagnóstico foi de 15 anos e na inclusão de 30 anos. O tempo médio de sobrevida livre de doença foi de dez anos. Houve alterações nos exames em 14 pacientes (66,6%), com distúrbios obstrutivos leves na espirometria em três pacientes (14,3%) e padrões obstrutivos na oscilometria em sete pacientes (33,3%). Na espirometria, os valores de média ± desvio padrão (DP) da capacidade vital forcada (CVF) foram 91,9%±12,2; para o volume expiratório forcado no primeiro segundo (VEF1) foram 87,4%±12,2 e as relações VEF1/CVF, 95,4%±7,9. Na oscilometria, os valores médios ± DP para resistência em 5 Hz foram 126,2%±36,2; para resistência a 20 Hz, 128,4% ± 32,4; reatância a 5 Hz, -0,75 ± 0,68 kPa/L/s; para frequência de ressonância, 15,6±4,2 Hz. Na manovacuometria, nove pacientes (42,8%) apresentaram redução nas pressões: as pressões expiratórias máximas (PEmáx) foram reduzidas em oito pacientes e as inspiratórias (PImáx) em três. A média ± DP da PImáx foi 89,4±29,5; PEmáx, 88±37,7. Conclusão: Observaram-se alterações leves nos testes de função pulmonar anos após o tratamento do osteossarcoma.INCA2021-10-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/134510.32635/2176-9745.RBC.2021v67n4.1345Revista Brasileira de Cancerologia; Vol. 67 No. 4 (2021): Oct./Nov./Dec.; e-151345Revista Brasileira de Cancerologia; Vol. 67 Núm. 4 (2021): oct./nov./dic.; e-151345Revista Brasileira de Cancerologia; v. 67 n. 4 (2021): out./nov./dez.; e-1513452176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAenghttps://rbc.inca.gov.br/index.php/revista/article/view/1345/1524Copyright (c) 2021 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRibeiro, Erica Vieira de MeloAraujo, Orlei Ribeiro de Wandalsen, Gustavo FalboLima, Jales Henrique Pereira de Sousa , Rosa Massa Kikuchi de 2022-10-18T12:25:50Zoai:rbc.inca.gov.br:article/1345Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2022-10-18T12:25:50Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Pulmonary Function in Long-Term Survivors of Childhood and Adolescence Osteosarcoma: Case Report Función Pulmonar en Sobrevivientes de Osteosarcoma en la Infancia y la Adolescencia: Relato de Caso Função Pulmonar em Sobreviventes de Osteossarcoma da Infância e Adolescência: Relato de Caso |
title |
Pulmonary Function in Long-Term Survivors of Childhood and Adolescence Osteosarcoma: Case Report |
spellingShingle |
Pulmonary Function in Long-Term Survivors of Childhood and Adolescence Osteosarcoma: Case Report Ribeiro, Erica Vieira de Melo Osteossarcoma Medidas de Volume Pulmonar Espirometria Oscilometria Antineoplásicos Osteosarcoma Lung Volume Measurements Spirometry Oscillometry Antineoplastic Agents Osteosarcoma Mediciones del Volumen Pulmonar Espirometría Oscilometría Antineoplásicos |
title_short |
Pulmonary Function in Long-Term Survivors of Childhood and Adolescence Osteosarcoma: Case Report |
title_full |
Pulmonary Function in Long-Term Survivors of Childhood and Adolescence Osteosarcoma: Case Report |
title_fullStr |
Pulmonary Function in Long-Term Survivors of Childhood and Adolescence Osteosarcoma: Case Report |
title_full_unstemmed |
Pulmonary Function in Long-Term Survivors of Childhood and Adolescence Osteosarcoma: Case Report |
title_sort |
Pulmonary Function in Long-Term Survivors of Childhood and Adolescence Osteosarcoma: Case Report |
author |
Ribeiro, Erica Vieira de Melo |
author_facet |
Ribeiro, Erica Vieira de Melo Araujo, Orlei Ribeiro de Wandalsen, Gustavo Falbo Lima, Jales Henrique Pereira de Sousa , Rosa Massa Kikuchi de |
author_role |
author |
author2 |
Araujo, Orlei Ribeiro de Wandalsen, Gustavo Falbo Lima, Jales Henrique Pereira de Sousa , Rosa Massa Kikuchi de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ribeiro, Erica Vieira de Melo Araujo, Orlei Ribeiro de Wandalsen, Gustavo Falbo Lima, Jales Henrique Pereira de Sousa , Rosa Massa Kikuchi de |
dc.subject.por.fl_str_mv |
Osteossarcoma Medidas de Volume Pulmonar Espirometria Oscilometria Antineoplásicos Osteosarcoma Lung Volume Measurements Spirometry Oscillometry Antineoplastic Agents Osteosarcoma Mediciones del Volumen Pulmonar Espirometría Oscilometría Antineoplásicos |
topic |
Osteossarcoma Medidas de Volume Pulmonar Espirometria Oscilometria Antineoplásicos Osteosarcoma Lung Volume Measurements Spirometry Oscillometry Antineoplastic Agents Osteosarcoma Mediciones del Volumen Pulmonar Espirometría Oscilometría Antineoplásicos |
description |
Introduction: Chemotherapy used in osteosarcoma have the potential to cause lung damage. The objectives were to analyze lung volumes and capacities, and respiratory muscle strength of patients treated with chemotherapy and surgery for osteosarcoma. The study was designed as a prospective case-series of patients, through the analysis of spirometry, impulse, oscillometry, and manovacuometry tests. Case report: In twenty-one patients, the median age at diagnosis was 15 years, and at inclusion, 30 years. The median disease-free survival time was 10 years. Eight different chemotherapeutic agents were used: cisplatin, doxorubicin, methotrexate, carboplatin, ifophosphamide, epidoxorubicin, cyclophosphamide and etoposide. There were test abnormalities in 14 patients (66.6%), with mild obstructive disorders on spirometry in three patients (14.3%), and obstructive patterns on oscillometry in seven patients (33.3%). On spirometry, the mean ± standard deviation (SD) values of forced vital capacity (FVC) were 91.9%±12.2; for forced expiratory volume in one second (FEV1) were 87.4%±12.2 and FEV1/FVC ratios, 95.4%±7.9. On oscillometry, mean ± SD values for resistance at 5 Hz were 126.2%±36.2; for resistance at 20 Hz, 128.4%±32.4; reactance at 5 Hz, -0.75±0.68 kPa/L/s; for resonant frequency, 15.6±4.2 Hz. Nine patients (42.8%) had reduced maximum pressures on the manovacuometry: Maximum Expiratory Pressure (MEP) were reduced in eight patients, and inspiratory (MIP) in three. The mean ± SD MIP was 89.4±29.5; MEP, 88±37.7. Conclusion: Mild abnormalities in pulmonary function tests in this series of patients were observed years after treatment for osteosarcoma. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Relato de Caso |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1345 10.32635/2176-9745.RBC.2021v67n4.1345 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/1345 |
identifier_str_mv |
10.32635/2176-9745.RBC.2021v67n4.1345 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1345/1524 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 67 No. 4 (2021): Oct./Nov./Dec.; e-151345 Revista Brasileira de Cancerologia; Vol. 67 Núm. 4 (2021): oct./nov./dic.; e-151345 Revista Brasileira de Cancerologia; v. 67 n. 4 (2021): out./nov./dez.; e-151345 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
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Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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INCA |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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rbc@inca.gov.br |
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