PLANT SPECIES IN THE TREATMENT OF ANXIETY: SYSTEMATIC REVIEW OF CLINICAL AND EXPERIMENTAL STUDIES

• Autor(a) principal: de Jesus Silva Diniz, Raquel
• Data de Publicação: 2022
• Outros Autores: Rose de Maria Oliveira Moreira, Lucy, Drummond Viera da Silva, Fabricio, Trindade Marinho Santana, Heliana
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Scientia Generalis
• Texto Completo: https://scientiageneralis.com.br/index.php/SG/article/view/219
• topic: Ansiedad; Plantas medicinales; Trastornos de ansiedad; Anxiety; Medicinal plants; Anxiety Disorders; Ansiedade; Plantas medicinais; Transtornos de ansiedade

Anxiety is the second most prevalent mental disorder in the world, being associated with negative repercussions for the individual, limiting and hindering their ability to adapt. The significant increase in the use of natural remedies as an alternative to the conventional treatment of this disorder culminates in the use of plant species and their preparations. The objective of this systematic exploratory review was to investigate and analyze the activity of plant species in improving symptoms related to anxiety. A search for clinical and experimental articles was carried out in the Pubmed, MEDLINE and Scielo databases, using the descriptors "medicinal plants and anxiety" and "medicinal plants and anti-anxiety agents". Of the 411 papers found, 22 experimental articles and only 1 clinical one were selected. Twenty-seven plant species were identified in the recovered articles. The leaf was the most widely used pharmacogen in isolation (50%), followed by the bark, aerial part / branch and root (7.14%, each). The aqueous extract was mostly used (38.46%) and maceration and hydrodistillation were the most cited extraction methods, appearing in 54.55% and 18.18% of the studies, respectively. A remarkable number of plant species exerts anxiolytic effects proven in experimental studies, whose main mechanism of action is the participation of the GABAA receptor in the mediation of anxiolytic activity. Most of the evaluated plants do not modify the motor performance of the animals, which represents an advantage to the detriment of what is observed in conventional anxiety pharmacotherapy.