PHYTOCHEMICAL STUDY AND ANTICHOLINESTERASIC ACTIVITY OF SPECIES Plantago major L.

• Main Author: de Sousa Oliveira Silva, Amanda Cristina
• Publication Date: 2022
• Other Authors: Rodrigues da Silva Neto, Antonio, Reis Camboim, Luiz Fernando, Rodrigues da Silva, João Paulo, Martins Maia Filho, Antônio Luiz, Rodrigues Leal, Francisco, Crisóstomo Bezerra Costa, Clara Andrezza, Duarte de Freitas, Johnnatan, Duarte de Freitas, Jennifer McLaine, Mendes Feitosa, Chistiane, Brandim Marques, Rosemarie, Teixeira Uchôa, Valdiléia
• Format: Article
• Language: por
• Source: Scientia Generalis
• Download full: https://scientiageneralis.com.br/index.php/SG/article/view/440
• topic: Phytochemical profile; Acetylcholinesterase enzyme; Metabolites; Chromatography; Plantago major L.; Perfil fitoquímico; Enzima acetilcolinesterasa; Metabolitos; Cromatografía; Plantago mayor L.; Perfil fitoquímico; Enzima Acetilcolinesterásica; Metabólitos; Cromatografia; Plantago major L.

Plantago major L. is a plant of medicinal interest belonging to the Plantaginaceae family, popularly known as plantain, its leaves are used to treat boils, earache, hoarseness, antiseptic, antibacterial and so on. This work aimed to study the hexane and ethanolic extracts of P. major leaves, identifying the main chemical constituents through chromatographic tests and their anticholinesterase action. The ethanolic and hexane extracts of the leaves were submitted to phytochemical prospection, chromatographic studies and the enzyme assay of acetylcholinesterase inhibition was performed according to the methodology proposed by Ellman. The results of the phytochemical analysis of the extracts showed a variety of secondary metabolites. The acetylcholinesterase enzyme inhibition tests of the leaf extracts showed inhibition percentages of 84.20%, 83.04% for the ethanolic extract and 70.86% for the hexane extract, being satisfactory in relation to the reference values found in the literature.