Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional do INMETRO |
Texto Completo: | http://hdl.handle.net/10926/1982 |
Resumo: | Orofacial clefts (OFC) are common congenital malformations that affect family quality of life. The identification of risk factors involved with OFC would contribute to the implementation of public health programs. A hospital based case-control study was conducted with non-syndromic OFC cases (n=150) and unaffected controls (n=150) in Rio de Janeiro, Brazil, to identify the association of OFC with risk factors. The relation, of gender, ethnicity, systemic history of relatives, family history of oral clefts, alcohol, tobacco use and passive maternal tabagism during pregnancy and the mother's residence were evaluated. Differences between orofacial cleft cases and controls and between types of orofacial clefts were analyzed. According to the study, the main associations relating to OFCs were a positive family history of OFC (or: 20.34, 95% CI: 5.86-84.42; p=0.000), alcohol use during pregnancy (OR: 3.75, 95% CI: 1.62-8.92; p=0.001), tobacco use during pregnancy (OR: 3.65, 95% CI: 1.82-7.44; p=0.000) and mother's residence (rural) (OR: 2.41, 95% CI: 1.04-5.69; p=0.025). Also a family of OFC individuals presented a higher risk for renal diseases (OR: 2.99, 95% CI 0.84-11.64; p=0.058). The study conclued that exposure to some environmental risk factors during pregnancy increase the risk for OFC. |
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info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRisk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil20112013-01-18T11:57:18Z2013-01-18T11:57:18ZOrofacial clefts (OFC) are common congenital malformations that affect family quality of life. The identification of risk factors involved with OFC would contribute to the implementation of public health programs. A hospital based case-control study was conducted with non-syndromic OFC cases (n=150) and unaffected controls (n=150) in Rio de Janeiro, Brazil, to identify the association of OFC with risk factors. The relation, of gender, ethnicity, systemic history of relatives, family history of oral clefts, alcohol, tobacco use and passive maternal tabagism during pregnancy and the mother's residence were evaluated. Differences between orofacial cleft cases and controls and between types of orofacial clefts were analyzed. According to the study, the main associations relating to OFCs were a positive family history of OFC (or: 20.34, 95% CI: 5.86-84.42; p=0.000), alcohol use during pregnancy (OR: 3.75, 95% CI: 1.62-8.92; p=0.001), tobacco use during pregnancy (OR: 3.65, 95% CI: 1.82-7.44; p=0.000) and mother's residence (rural) (OR: 2.41, 95% CI: 1.04-5.69; p=0.025). Also a family of OFC individuals presented a higher risk for renal diseases (OR: 2.99, 95% CI 0.84-11.64; p=0.058). The study conclued that exposure to some environmental risk factors during pregnancy increase the risk for OFC.7 p. : il., tab.Submitted by Lívia Oliveira (livia.oliveira2@hotmail.com) on 2012-07-18T16:44:24Z No. of bitstreams: 1 Granjeiro3_2011.pdf: 141707 bytes, checksum: a2c7812b2d947b7bfc741f75c0d8feea (MD5)Approved for entry into archive by Regina Mello(mrmello@inmetro.gov.br) on 2013-01-18T11:57:18Z (GMT) No. of bitstreams: 1 Granjeiro3_2011.pdf: 141707 bytes, checksum: a2c7812b2d947b7bfc741f75c0d8feea (MD5)Made available in DSpace on 2013-01-18T11:57:18Z (GMT). No. of bitstreams: 1 Granjeiro3_2011.pdf: 141707 bytes, checksum: a2c7812b2d947b7bfc741f75c0d8feea (MD5) Previous issue date: 2011enghttp://hdl.handle.net/10926/1982DMD_hdl_10926/1982ANTUNES, Leonardo dos Santos et al. Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil. International Journal of Dentistry, v. 10, n. 1, p. 20-25, 2011.Antunes, Leonardo dos SantosKüchler, Erika CalvanoMotta, Luise Gomes daCosta, Marcelo de CastroGranjeiro, José MauroOlej, Beniinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do INMETROinstname:Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO)instacron:INMETROAntunes_2011.pdfhttp://xrepo01s.inmetro.gov.br/bitstream/10926/1982/1/Antunes_2011.pdfapplication/pdf141707http://xrepo01s.inmetro.gov.br/bitstream/10926/1982/1/Antunes_2011.pdfa2c7812b2d947b7bfc741f75c0d8feeaMD510926_1982_1Antunes_2011.pdf.txthttp://xrepo01s.inmetro.gov.br/bitstream/10926/1982/7/Antunes_2011.pdf.txttext/plain22630http://xrepo01s.inmetro.gov.br/bitstream/10926/1982/7/Antunes_2011.pdf.txt16e9a10b8d9e1e1ead1c56a00a7e4fb0MD510926_1982_72024-06-10T15:24:54Zoai:xrepo01s.inmetro.gov.br:10926/1982Repositório de Publicaçõeshttp://repositorios.inmetro.gov.br/oai/requestopendoar:2013-03-28T17:51:03Repositório Institucional do INMETRO - Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO)false |
dc.title.none.fl_str_mv |
Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil |
title |
Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil |
spellingShingle |
Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil Antunes, Leonardo dos Santos |
title_short |
Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil |
title_full |
Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil |
title_fullStr |
Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil |
title_full_unstemmed |
Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil |
title_sort |
Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil |
author |
Antunes, Leonardo dos Santos |
author_facet |
Antunes, Leonardo dos Santos Küchler, Erika Calvano Motta, Luise Gomes da Costa, Marcelo de Castro Granjeiro, José Mauro Olej, Beni |
author_role |
author |
author2 |
Küchler, Erika Calvano Motta, Luise Gomes da Costa, Marcelo de Castro Granjeiro, José Mauro Olej, Beni |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Antunes, Leonardo dos Santos Küchler, Erika Calvano Motta, Luise Gomes da Costa, Marcelo de Castro Granjeiro, José Mauro Olej, Beni |
description |
Orofacial clefts (OFC) are common congenital malformations that affect family quality of life. The identification of risk factors involved with OFC would contribute to the implementation of public health programs. A hospital based case-control study was conducted with non-syndromic OFC cases (n=150) and unaffected controls (n=150) in Rio de Janeiro, Brazil, to identify the association of OFC with risk factors. The relation, of gender, ethnicity, systemic history of relatives, family history of oral clefts, alcohol, tobacco use and passive maternal tabagism during pregnancy and the mother's residence were evaluated. Differences between orofacial cleft cases and controls and between types of orofacial clefts were analyzed. According to the study, the main associations relating to OFCs were a positive family history of OFC (or: 20.34, 95% CI: 5.86-84.42; p=0.000), alcohol use during pregnancy (OR: 3.75, 95% CI: 1.62-8.92; p=0.001), tobacco use during pregnancy (OR: 3.65, 95% CI: 1.82-7.44; p=0.000) and mother's residence (rural) (OR: 2.41, 95% CI: 1.04-5.69; p=0.025). Also a family of OFC individuals presented a higher risk for renal diseases (OR: 2.99, 95% CI 0.84-11.64; p=0.058). The study conclued that exposure to some environmental risk factors during pregnancy increase the risk for OFC. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.available.fl_str_mv |
2013-01-18T11:57:18Z |
dc.date.accessioned.fl_str_mv |
2013-01-18T11:57:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10926/1982 DMD_hdl_10926/1982 |
dc.identifier.citation.fl_str_mv |
ANTUNES, Leonardo dos Santos et al. Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil. International Journal of Dentistry, v. 10, n. 1, p. 20-25, 2011. |
url |
http://hdl.handle.net/10926/1982 |
identifier_str_mv |
DMD_hdl_10926/1982 ANTUNES, Leonardo dos Santos et al. Risk factors for orofacial clefts: case-control study in non-syndromic individuals in Rio de Janeiro, Brazil. International Journal of Dentistry, v. 10, n. 1, p. 20-25, 2011. |
dc.language.iso.fl_str_mv |
eng |
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eng |
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Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO) |
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