Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells

• Autor(a) principal: Oliveira, Felipe Leite de
• Data de Publicação: 2009
• Outros Autores: Chammas, Roger, Ricon, Lauremília, Fermino, Marise Lopes, Bernardes, Emerson Soares, Hsu, Daniel Kaiyuan, Liu, Fu-Tong, Borojevic, Radovan, El-Cheikh, Márcia Cury
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional do INMETRO
• Texto Completo: http://hdl.handle.net/10926/1549

Extracellular galectin-3 participates in the control of B2 lymphocytemigration and adhesion and of their differentiation into plasma cells. Here, we analyzed the role of galectin- 3 in B1-cell physiology and the balance between B1a and B1b lymphocytes in the peritoneal cavity. In galectin-3−/− mice, the total number of B1a lymphocytes was lower, while B1b lymphocyte number was higher as compared to wild-type mice. The differentiation of B1a cells into plasma cells was associated with their abnormal adhesion and location on the mesentery. The B220 and CD43, constitutively expressed by B1 lymphocytes, were respectively up- and downregulated in galectin-3−/− mice. Mononuclear cells were strongly adhered to the mesenteric membranes of both CD43−/− and galectin-3−/− mice, but in contrast to CD43−/− mice, the accumulation of B1 cells in peritoneal membranes in galectin- 3−/− mice was accompanied by their functional differentiation into plasma cells.We have shown that in the absence of galectin-3, B1-cell differentiation into plasma cells is favored and the dynamic equilibrium of B1-cell populations in the peritoneum is maintained through a compensatory increase in B1b lymphocytes.