Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - A review
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional do INPA |
Texto Completo: | https://repositorio.inpa.gov.br/handle/1/15994 |
Resumo: | Constant and extensive use of chemical insecticides has created a selection pressure and favored resistance development in many insect species worldwide. One of the most important pyrethroid resistance mechanisms is classified as target site insensitivity, due to conformational changes in the target site that impair a proper binding of the insecticide molecule. The voltage-gated sodium channel (NaV) is the target of pyrethroids and DDT insecticides, used to control insects of medical, agricultural and veterinary importance, such as anophelines. It has been reported that the presence of a few non-silent point mutations in the NaV gene are associated with pyrethroid resistance, termed as 'kdr' (knockdown resistance) for preventing the knockdown effect of these insecticides. The presence of these mutations, as well as their effects, has been thoroughly studied in Anopheles mosquitoes. So far, kdr mutations have already been detected in at least 13 species (Anopheles gambiae, Anopheles arabiensis, Anopheles sinensis, Anopheles stephensi, Anopheles subpictus, Anopheles sacharovi, Anopheles culicifacies, Anopheles sundaicus, Anopheles aconitus, Anopheles vagus, Anopheles paraliae, Anopheles peditaeniatus and Anopheles albimanus) from populations of African, Asian and, more recently, American continents. Seven mutational variants (L1014F, L1014S, L1014C, L1014W, N1013S, N1575Y and V1010L) were described, with the highest prevalence of L1014F, which occurs at the 1014 site in NaV IIS6 domain. The increase of frequency and distribution of kdr mutations clearly shows the importance of this mechanism in the process of pyrethroid resistance. In this sense, several species-specific and highly sensitive methods have been designed in order to genotype individual mosquitoes for kdr in large scale, which may serve as important tolls for monitoring the dynamics of pyrethroid resistance in natural populations. We also briefly discuss investigations concerning the course of Plasmodium infection in kdr individuals. Considering the limitation of insecticides available for employment in public health campaigns and the absence of a vaccine able to brake the life cycle of the malaria parasites, the use of pyrethroids is likely to remain as the main strategy against mosquitoes by either indoor residual spraying (IR) and insecticide treated nets (ITN). Therefore, monitoring insecticide resistance programs is a crucial need in malaria endemic countries. © 2014 Silva et al.; licensee BioMed Central Ltd. |
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Silva, Ana Paula B.Santos, Joselita Maria M.J, Martins, Ademir2020-05-21T21:37:09Z2020-05-21T21:37:09Z2014https://repositorio.inpa.gov.br/handle/1/1599410.1186/1756-3305-7-450Constant and extensive use of chemical insecticides has created a selection pressure and favored resistance development in many insect species worldwide. One of the most important pyrethroid resistance mechanisms is classified as target site insensitivity, due to conformational changes in the target site that impair a proper binding of the insecticide molecule. The voltage-gated sodium channel (NaV) is the target of pyrethroids and DDT insecticides, used to control insects of medical, agricultural and veterinary importance, such as anophelines. It has been reported that the presence of a few non-silent point mutations in the NaV gene are associated with pyrethroid resistance, termed as 'kdr' (knockdown resistance) for preventing the knockdown effect of these insecticides. The presence of these mutations, as well as their effects, has been thoroughly studied in Anopheles mosquitoes. So far, kdr mutations have already been detected in at least 13 species (Anopheles gambiae, Anopheles arabiensis, Anopheles sinensis, Anopheles stephensi, Anopheles subpictus, Anopheles sacharovi, Anopheles culicifacies, Anopheles sundaicus, Anopheles aconitus, Anopheles vagus, Anopheles paraliae, Anopheles peditaeniatus and Anopheles albimanus) from populations of African, Asian and, more recently, American continents. Seven mutational variants (L1014F, L1014S, L1014C, L1014W, N1013S, N1575Y and V1010L) were described, with the highest prevalence of L1014F, which occurs at the 1014 site in NaV IIS6 domain. The increase of frequency and distribution of kdr mutations clearly shows the importance of this mechanism in the process of pyrethroid resistance. In this sense, several species-specific and highly sensitive methods have been designed in order to genotype individual mosquitoes for kdr in large scale, which may serve as important tolls for monitoring the dynamics of pyrethroid resistance in natural populations. We also briefly discuss investigations concerning the course of Plasmodium infection in kdr individuals. Considering the limitation of insecticides available for employment in public health campaigns and the absence of a vaccine able to brake the life cycle of the malaria parasites, the use of pyrethroids is likely to remain as the main strategy against mosquitoes by either indoor residual spraying (IR) and insecticide treated nets (ITN). Therefore, monitoring insecticide resistance programs is a crucial need in malaria endemic countries. © 2014 Silva et al.; licensee BioMed Central Ltd.Volume 7, Número 1Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessPyrethroidVoltage Gated Sodium ChannelInsecticidePyrethroidSodium ChannelAnophelesAnopheles AconitusAnopheles AlbimanusAnopheles ArabiensisAnopheles CulicifaciesAnopheles GambiaeAnopheles ParaliaeAnopheles PeditaeniatusAnopheles SacharoviAnopheles SinensisAnopheles StephensiAnopheles SubpictusAnopheles SundaicusAnopheles VagusGeneGene ExpressionGenetic AssociationGenetic VariabilityGenotypeHumanIndoor Residual SprayingInsecticide ResistanceInsecticide Treated NetKdr GeneLife Cycle StagesNav GeneNonhumanPlasmodium BergheiPlasmodium FalciparumPoint MutationPopulation DynamicsReviewAmino Acid SubstitutionAnimalsAnophelesDisease CarrierDrug EffectsGene FrequencyGeneticsGeographyInsecticide ResistanceMalariaPoint MutationTransmissionAmino Acid SubstitutionAnimalAnophelesGene FrequencyGenotypeGeographyHumansInsect VectorsInsecticide ResistanceInsecticidesMalariaPoint MutationPyrethrinsSodium ChannelsMutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - A reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleParasites and Vectorsengreponame:Repositório Institucional do INPAinstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPAORIGINALartigo-inpa.pdfartigo-inpa.pdfapplication/pdf650087https://repositorio.inpa.gov.br/bitstream/1/15994/1/artigo-inpa.pdf462450c5d7082c990e90a3446869f029MD511/159942020-07-14 11:28:01.354oai:repositorio:1/15994Repositório de PublicaçõesPUBhttps://repositorio.inpa.gov.br/oai/requestopendoar:2020-07-14T15:28:01Repositório Institucional do INPA - Instituto Nacional de Pesquisas da Amazônia (INPA)false |
dc.title.en.fl_str_mv |
Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - A review |
title |
Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - A review |
spellingShingle |
Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - A review Silva, Ana Paula B. Pyrethroid Voltage Gated Sodium Channel Insecticide Pyrethroid Sodium Channel Anopheles Anopheles Aconitus Anopheles Albimanus Anopheles Arabiensis Anopheles Culicifacies Anopheles Gambiae Anopheles Paraliae Anopheles Peditaeniatus Anopheles Sacharovi Anopheles Sinensis Anopheles Stephensi Anopheles Subpictus Anopheles Sundaicus Anopheles Vagus Gene Gene Expression Genetic Association Genetic Variability Genotype Human Indoor Residual Spraying Insecticide Resistance Insecticide Treated Net Kdr Gene Life Cycle Stages Nav Gene Nonhuman Plasmodium Berghei Plasmodium Falciparum Point Mutation Population Dynamics Review Amino Acid Substitution Animals Anopheles Disease Carrier Drug Effects Gene Frequency Genetics Geography Insecticide Resistance Malaria Point Mutation Transmission Amino Acid Substitution Animal Anopheles Gene Frequency Genotype Geography Humans Insect Vectors Insecticide Resistance Insecticides Malaria Point Mutation Pyrethrins Sodium Channels |
title_short |
Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - A review |
title_full |
Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - A review |
title_fullStr |
Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - A review |
title_full_unstemmed |
Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - A review |
title_sort |
Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - A review |
author |
Silva, Ana Paula B. |
author_facet |
Silva, Ana Paula B. Santos, Joselita Maria M. J, Martins, Ademir |
author_role |
author |
author2 |
Santos, Joselita Maria M. J, Martins, Ademir |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Silva, Ana Paula B. Santos, Joselita Maria M. J, Martins, Ademir |
dc.subject.eng.fl_str_mv |
Pyrethroid Voltage Gated Sodium Channel Insecticide Pyrethroid Sodium Channel Anopheles Anopheles Aconitus Anopheles Albimanus Anopheles Arabiensis Anopheles Culicifacies Anopheles Gambiae Anopheles Paraliae Anopheles Peditaeniatus Anopheles Sacharovi Anopheles Sinensis Anopheles Stephensi Anopheles Subpictus Anopheles Sundaicus Anopheles Vagus Gene Gene Expression Genetic Association Genetic Variability Genotype Human Indoor Residual Spraying Insecticide Resistance Insecticide Treated Net Kdr Gene Life Cycle Stages Nav Gene Nonhuman Plasmodium Berghei Plasmodium Falciparum Point Mutation Population Dynamics Review Amino Acid Substitution Animals Anopheles Disease Carrier Drug Effects Gene Frequency Genetics Geography Insecticide Resistance Malaria Point Mutation Transmission Amino Acid Substitution Animal Anopheles Gene Frequency Genotype Geography Humans Insect Vectors Insecticide Resistance Insecticides Malaria Point Mutation Pyrethrins Sodium Channels |
topic |
Pyrethroid Voltage Gated Sodium Channel Insecticide Pyrethroid Sodium Channel Anopheles Anopheles Aconitus Anopheles Albimanus Anopheles Arabiensis Anopheles Culicifacies Anopheles Gambiae Anopheles Paraliae Anopheles Peditaeniatus Anopheles Sacharovi Anopheles Sinensis Anopheles Stephensi Anopheles Subpictus Anopheles Sundaicus Anopheles Vagus Gene Gene Expression Genetic Association Genetic Variability Genotype Human Indoor Residual Spraying Insecticide Resistance Insecticide Treated Net Kdr Gene Life Cycle Stages Nav Gene Nonhuman Plasmodium Berghei Plasmodium Falciparum Point Mutation Population Dynamics Review Amino Acid Substitution Animals Anopheles Disease Carrier Drug Effects Gene Frequency Genetics Geography Insecticide Resistance Malaria Point Mutation Transmission Amino Acid Substitution Animal Anopheles Gene Frequency Genotype Geography Humans Insect Vectors Insecticide Resistance Insecticides Malaria Point Mutation Pyrethrins Sodium Channels |
description |
Constant and extensive use of chemical insecticides has created a selection pressure and favored resistance development in many insect species worldwide. One of the most important pyrethroid resistance mechanisms is classified as target site insensitivity, due to conformational changes in the target site that impair a proper binding of the insecticide molecule. The voltage-gated sodium channel (NaV) is the target of pyrethroids and DDT insecticides, used to control insects of medical, agricultural and veterinary importance, such as anophelines. It has been reported that the presence of a few non-silent point mutations in the NaV gene are associated with pyrethroid resistance, termed as 'kdr' (knockdown resistance) for preventing the knockdown effect of these insecticides. The presence of these mutations, as well as their effects, has been thoroughly studied in Anopheles mosquitoes. So far, kdr mutations have already been detected in at least 13 species (Anopheles gambiae, Anopheles arabiensis, Anopheles sinensis, Anopheles stephensi, Anopheles subpictus, Anopheles sacharovi, Anopheles culicifacies, Anopheles sundaicus, Anopheles aconitus, Anopheles vagus, Anopheles paraliae, Anopheles peditaeniatus and Anopheles albimanus) from populations of African, Asian and, more recently, American continents. Seven mutational variants (L1014F, L1014S, L1014C, L1014W, N1013S, N1575Y and V1010L) were described, with the highest prevalence of L1014F, which occurs at the 1014 site in NaV IIS6 domain. The increase of frequency and distribution of kdr mutations clearly shows the importance of this mechanism in the process of pyrethroid resistance. In this sense, several species-specific and highly sensitive methods have been designed in order to genotype individual mosquitoes for kdr in large scale, which may serve as important tolls for monitoring the dynamics of pyrethroid resistance in natural populations. We also briefly discuss investigations concerning the course of Plasmodium infection in kdr individuals. Considering the limitation of insecticides available for employment in public health campaigns and the absence of a vaccine able to brake the life cycle of the malaria parasites, the use of pyrethroids is likely to remain as the main strategy against mosquitoes by either indoor residual spraying (IR) and insecticide treated nets (ITN). Therefore, monitoring insecticide resistance programs is a crucial need in malaria endemic countries. © 2014 Silva et al.; licensee BioMed Central Ltd. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2020-05-21T21:37:09Z |
dc.date.available.fl_str_mv |
2020-05-21T21:37:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.inpa.gov.br/handle/1/15994 |
dc.identifier.doi.none.fl_str_mv |
10.1186/1756-3305-7-450 |
url |
https://repositorio.inpa.gov.br/handle/1/15994 |
identifier_str_mv |
10.1186/1756-3305-7-450 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Volume 7, Número 1 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Parasites and Vectors |
publisher.none.fl_str_mv |
Parasites and Vectors |
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reponame:Repositório Institucional do INPA instname:Instituto Nacional de Pesquisas da Amazônia (INPA) instacron:INPA |
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INPA |
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INPA |
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Repositório Institucional do INPA |
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Repositório Institucional do INPA |
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