The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil

Detalhes bibliográficos
Autor(a) principal: Espir, Thaís Tibery
Data de Publicação: 2014
Outros Autores: Figueira, Luanda de Paula, Naiff, Maricleide de Farias, Costa, Allyson Guimarães da, Ramalho-Ortigão, Marcelo, Malheiro, Adriana, Franco, A. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional do INPA
Texto Completo: https://repositorio.inpa.gov.br/handle/1/15978
Resumo: The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis. The isolates were identified as Leishmania guyanensis, L. naiffi, and L. amazonensis. Most (64%) of the patients were male ranging in age from 18 to 58 years. Protein expression profiles of IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17 cytokines were shown to vary significantly between infected and noninfected (control group) individuals and according to the Leishmania species. Infection caused by L. guyanensis accounted for 73% of the cases and patients with this parasite also showed higher concentrations of IL-2, IFN-γ, IL-4, and IL-17 when compared to infection by L. amazonensis. Patients with infection caused by L. naiffi showed higher concentration of the cytokines analyzed when compared to uninfected patients; however, there was no statistically significant difference with the other species analyzed. © 2014 Thaís Tibery Espir et al.
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spelling Espir, Thaís TiberyFigueira, Luanda de PaulaNaiff, Maricleide de FariasCosta, Allyson Guimarães daRamalho-Ortigão, MarceloMalheiro, AdrianaFranco, A. M.2020-05-21T20:06:19Z2020-05-21T20:06:19Z2014https://repositorio.inpa.gov.br/handle/1/1597810.1155/2014/481750The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis. The isolates were identified as Leishmania guyanensis, L. naiffi, and L. amazonensis. Most (64%) of the patients were male ranging in age from 18 to 58 years. Protein expression profiles of IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17 cytokines were shown to vary significantly between infected and noninfected (control group) individuals and according to the Leishmania species. Infection caused by L. guyanensis accounted for 73% of the cases and patients with this parasite also showed higher concentrations of IL-2, IFN-γ, IL-4, and IL-17 when compared to infection by L. amazonensis. Patients with infection caused by L. naiffi showed higher concentration of the cytokines analyzed when compared to uninfected patients; however, there was no statistically significant difference with the other species analyzed. © 2014 Thaís Tibery Espir et al.Volume 2014Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessCytokineGamma InterferonInterleukin-10Interleukin-17Interleukin-2Interleukin-4Interleukin-6Tumor Necrosis Factor-alphaAutacoidCytokineGamma InterferonInterleukin-10Interleukin-17Interleukin-2Interleukin-4Interleukin-6Tumor Necrosis Factor-alphaAdultAntiinflammatory ActivityBrasilClinical Comparative StudyControlled StudyFemaleHumanLeishmaniaLeishmania NaiffiMaleNonhumanProtein Blood LevelProtein ExpressionSkin LeishmaniasisAdolescentBloodClassificationFlow CytometryHost Parasite InteractionImmunologyMiddle AgedParasitologyPhysiologySkin LeishmaniasisSpecies DifferenceYoung AdultAdolescentAdultBrasilCytokinesFemaleFlow CytometryHost-parasite InteractionsHumansInflammation MediatorsInterferon-gammaInterleukin-10Interleukin-17Interleukin-2Interleukin-4Interleukin-6LeishmaniaLeishmania GuyanensisLeishmaniasis, CutaneousMaleMiddle AgedSpecies SpecificityTumor Necrosis Factor-alphaYoung AdultThe Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJournal of Immunology Researchengreponame:Repositório Institucional do INPAinstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPAORIGINALartigo-inpa.pdfartigo-inpa.pdfapplication/pdf1447522https://repositorio.inpa.gov.br/bitstream/1/15978/1/artigo-inpa.pdf8b7632d9adf0e0facec056d44cd9e6f5MD511/159782020-07-14 11:27:22.364oai:repositorio:1/15978Repositório de PublicaçõesPUBhttps://repositorio.inpa.gov.br/oai/requestopendoar:2020-07-14T15:27:22Repositório Institucional do INPA - Instituto Nacional de Pesquisas da Amazônia (INPA)false
dc.title.en.fl_str_mv The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
title The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
spellingShingle The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
Espir, Thaís Tibery
Cytokine
Gamma Interferon
Interleukin-10
Interleukin-17
Interleukin-2
Interleukin-4
Interleukin-6
Tumor Necrosis Factor-alpha
Autacoid
Cytokine
Gamma Interferon
Interleukin-10
Interleukin-17
Interleukin-2
Interleukin-4
Interleukin-6
Tumor Necrosis Factor-alpha
Adult
Antiinflammatory Activity
Brasil
Clinical Comparative Study
Controlled Study
Female
Human
Leishmania
Leishmania Naiffi
Male
Nonhuman
Protein Blood Level
Protein Expression
Skin Leishmaniasis
Adolescent
Blood
Classification
Flow Cytometry
Host Parasite Interaction
Immunology
Middle Aged
Parasitology
Physiology
Skin Leishmaniasis
Species Difference
Young Adult
Adolescent
Adult
Brasil
Cytokines
Female
Flow Cytometry
Host-parasite Interactions
Humans
Inflammation Mediators
Interferon-gamma
Interleukin-10
Interleukin-17
Interleukin-2
Interleukin-4
Interleukin-6
Leishmania
Leishmania Guyanensis
Leishmaniasis, Cutaneous
Male
Middle Aged
Species Specificity
Tumor Necrosis Factor-alpha
Young Adult
title_short The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
title_full The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
title_fullStr The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
title_full_unstemmed The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
title_sort The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
author Espir, Thaís Tibery
author_facet Espir, Thaís Tibery
Figueira, Luanda de Paula
Naiff, Maricleide de Farias
Costa, Allyson Guimarães da
Ramalho-Ortigão, Marcelo
Malheiro, Adriana
Franco, A. M.
author_role author
author2 Figueira, Luanda de Paula
Naiff, Maricleide de Farias
Costa, Allyson Guimarães da
Ramalho-Ortigão, Marcelo
Malheiro, Adriana
Franco, A. M.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Espir, Thaís Tibery
Figueira, Luanda de Paula
Naiff, Maricleide de Farias
Costa, Allyson Guimarães da
Ramalho-Ortigão, Marcelo
Malheiro, Adriana
Franco, A. M.
dc.subject.eng.fl_str_mv Cytokine
Gamma Interferon
Interleukin-10
Interleukin-17
Interleukin-2
Interleukin-4
Interleukin-6
Tumor Necrosis Factor-alpha
Autacoid
Cytokine
Gamma Interferon
Interleukin-10
Interleukin-17
Interleukin-2
Interleukin-4
Interleukin-6
Tumor Necrosis Factor-alpha
Adult
Antiinflammatory Activity
Brasil
Clinical Comparative Study
Controlled Study
Female
Human
Leishmania
Leishmania Naiffi
Male
Nonhuman
Protein Blood Level
Protein Expression
Skin Leishmaniasis
Adolescent
Blood
Classification
Flow Cytometry
Host Parasite Interaction
Immunology
Middle Aged
Parasitology
Physiology
Skin Leishmaniasis
Species Difference
Young Adult
Adolescent
Adult
Brasil
Cytokines
Female
Flow Cytometry
Host-parasite Interactions
Humans
Inflammation Mediators
Interferon-gamma
Interleukin-10
Interleukin-17
Interleukin-2
Interleukin-4
Interleukin-6
Leishmania
Leishmania Guyanensis
Leishmaniasis, Cutaneous
Male
Middle Aged
Species Specificity
Tumor Necrosis Factor-alpha
Young Adult
topic Cytokine
Gamma Interferon
Interleukin-10
Interleukin-17
Interleukin-2
Interleukin-4
Interleukin-6
Tumor Necrosis Factor-alpha
Autacoid
Cytokine
Gamma Interferon
Interleukin-10
Interleukin-17
Interleukin-2
Interleukin-4
Interleukin-6
Tumor Necrosis Factor-alpha
Adult
Antiinflammatory Activity
Brasil
Clinical Comparative Study
Controlled Study
Female
Human
Leishmania
Leishmania Naiffi
Male
Nonhuman
Protein Blood Level
Protein Expression
Skin Leishmaniasis
Adolescent
Blood
Classification
Flow Cytometry
Host Parasite Interaction
Immunology
Middle Aged
Parasitology
Physiology
Skin Leishmaniasis
Species Difference
Young Adult
Adolescent
Adult
Brasil
Cytokines
Female
Flow Cytometry
Host-parasite Interactions
Humans
Inflammation Mediators
Interferon-gamma
Interleukin-10
Interleukin-17
Interleukin-2
Interleukin-4
Interleukin-6
Leishmania
Leishmania Guyanensis
Leishmaniasis, Cutaneous
Male
Middle Aged
Species Specificity
Tumor Necrosis Factor-alpha
Young Adult
description The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis. The isolates were identified as Leishmania guyanensis, L. naiffi, and L. amazonensis. Most (64%) of the patients were male ranging in age from 18 to 58 years. Protein expression profiles of IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17 cytokines were shown to vary significantly between infected and noninfected (control group) individuals and according to the Leishmania species. Infection caused by L. guyanensis accounted for 73% of the cases and patients with this parasite also showed higher concentrations of IL-2, IFN-γ, IL-4, and IL-17 when compared to infection by L. amazonensis. Patients with infection caused by L. naiffi showed higher concentration of the cytokines analyzed when compared to uninfected patients; however, there was no statistically significant difference with the other species analyzed. © 2014 Thaís Tibery Espir et al.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2020-05-21T20:06:19Z
dc.date.available.fl_str_mv 2020-05-21T20:06:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.inpa.gov.br/handle/1/15978
dc.identifier.doi.none.fl_str_mv 10.1155/2014/481750
url https://repositorio.inpa.gov.br/handle/1/15978
identifier_str_mv 10.1155/2014/481750
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Volume 2014
dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Journal of Immunology Research
publisher.none.fl_str_mv Journal of Immunology Research
dc.source.none.fl_str_mv reponame:Repositório Institucional do INPA
instname:Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron:INPA
instname_str Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron_str INPA
institution INPA
reponame_str Repositório Institucional do INPA
collection Repositório Institucional do INPA
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