The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional do INPA |
Texto Completo: | https://repositorio.inpa.gov.br/handle/1/15978 |
Resumo: | The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis. The isolates were identified as Leishmania guyanensis, L. naiffi, and L. amazonensis. Most (64%) of the patients were male ranging in age from 18 to 58 years. Protein expression profiles of IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17 cytokines were shown to vary significantly between infected and noninfected (control group) individuals and according to the Leishmania species. Infection caused by L. guyanensis accounted for 73% of the cases and patients with this parasite also showed higher concentrations of IL-2, IFN-γ, IL-4, and IL-17 when compared to infection by L. amazonensis. Patients with infection caused by L. naiffi showed higher concentration of the cytokines analyzed when compared to uninfected patients; however, there was no statistically significant difference with the other species analyzed. © 2014 Thaís Tibery Espir et al. |
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Espir, Thaís TiberyFigueira, Luanda de PaulaNaiff, Maricleide de FariasCosta, Allyson Guimarães daRamalho-Ortigão, MarceloMalheiro, AdrianaFranco, A. M.2020-05-21T20:06:19Z2020-05-21T20:06:19Z2014https://repositorio.inpa.gov.br/handle/1/1597810.1155/2014/481750The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis. The isolates were identified as Leishmania guyanensis, L. naiffi, and L. amazonensis. Most (64%) of the patients were male ranging in age from 18 to 58 years. Protein expression profiles of IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17 cytokines were shown to vary significantly between infected and noninfected (control group) individuals and according to the Leishmania species. Infection caused by L. guyanensis accounted for 73% of the cases and patients with this parasite also showed higher concentrations of IL-2, IFN-γ, IL-4, and IL-17 when compared to infection by L. amazonensis. Patients with infection caused by L. naiffi showed higher concentration of the cytokines analyzed when compared to uninfected patients; however, there was no statistically significant difference with the other species analyzed. © 2014 Thaís Tibery Espir et al.Volume 2014Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessCytokineGamma InterferonInterleukin-10Interleukin-17Interleukin-2Interleukin-4Interleukin-6Tumor Necrosis Factor-alphaAutacoidCytokineGamma InterferonInterleukin-10Interleukin-17Interleukin-2Interleukin-4Interleukin-6Tumor Necrosis Factor-alphaAdultAntiinflammatory ActivityBrasilClinical Comparative StudyControlled StudyFemaleHumanLeishmaniaLeishmania NaiffiMaleNonhumanProtein Blood LevelProtein ExpressionSkin LeishmaniasisAdolescentBloodClassificationFlow CytometryHost Parasite InteractionImmunologyMiddle AgedParasitologyPhysiologySkin LeishmaniasisSpecies DifferenceYoung AdultAdolescentAdultBrasilCytokinesFemaleFlow CytometryHost-parasite InteractionsHumansInflammation MediatorsInterferon-gammaInterleukin-10Interleukin-17Interleukin-2Interleukin-4Interleukin-6LeishmaniaLeishmania GuyanensisLeishmaniasis, CutaneousMaleMiddle AgedSpecies SpecificityTumor Necrosis Factor-alphaYoung AdultThe Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJournal of Immunology Researchengreponame:Repositório Institucional do INPAinstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPAORIGINALartigo-inpa.pdfartigo-inpa.pdfapplication/pdf1447522https://repositorio.inpa.gov.br/bitstream/1/15978/1/artigo-inpa.pdf8b7632d9adf0e0facec056d44cd9e6f5MD511/159782020-07-14 11:27:22.364oai:repositorio:1/15978Repositório de PublicaçõesPUBhttps://repositorio.inpa.gov.br/oai/requestopendoar:2020-07-14T15:27:22Repositório Institucional do INPA - Instituto Nacional de Pesquisas da Amazônia (INPA)false |
dc.title.en.fl_str_mv |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
title |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
spellingShingle |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil Espir, Thaís Tibery Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Autacoid Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Adult Antiinflammatory Activity Brasil Clinical Comparative Study Controlled Study Female Human Leishmania Leishmania Naiffi Male Nonhuman Protein Blood Level Protein Expression Skin Leishmaniasis Adolescent Blood Classification Flow Cytometry Host Parasite Interaction Immunology Middle Aged Parasitology Physiology Skin Leishmaniasis Species Difference Young Adult Adolescent Adult Brasil Cytokines Female Flow Cytometry Host-parasite Interactions Humans Inflammation Mediators Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Leishmania Leishmania Guyanensis Leishmaniasis, Cutaneous Male Middle Aged Species Specificity Tumor Necrosis Factor-alpha Young Adult |
title_short |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
title_full |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
title_fullStr |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
title_full_unstemmed |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
title_sort |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
author |
Espir, Thaís Tibery |
author_facet |
Espir, Thaís Tibery Figueira, Luanda de Paula Naiff, Maricleide de Farias Costa, Allyson Guimarães da Ramalho-Ortigão, Marcelo Malheiro, Adriana Franco, A. M. |
author_role |
author |
author2 |
Figueira, Luanda de Paula Naiff, Maricleide de Farias Costa, Allyson Guimarães da Ramalho-Ortigão, Marcelo Malheiro, Adriana Franco, A. M. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Espir, Thaís Tibery Figueira, Luanda de Paula Naiff, Maricleide de Farias Costa, Allyson Guimarães da Ramalho-Ortigão, Marcelo Malheiro, Adriana Franco, A. M. |
dc.subject.eng.fl_str_mv |
Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Autacoid Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Adult Antiinflammatory Activity Brasil Clinical Comparative Study Controlled Study Female Human Leishmania Leishmania Naiffi Male Nonhuman Protein Blood Level Protein Expression Skin Leishmaniasis Adolescent Blood Classification Flow Cytometry Host Parasite Interaction Immunology Middle Aged Parasitology Physiology Skin Leishmaniasis Species Difference Young Adult Adolescent Adult Brasil Cytokines Female Flow Cytometry Host-parasite Interactions Humans Inflammation Mediators Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Leishmania Leishmania Guyanensis Leishmaniasis, Cutaneous Male Middle Aged Species Specificity Tumor Necrosis Factor-alpha Young Adult |
topic |
Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Autacoid Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Adult Antiinflammatory Activity Brasil Clinical Comparative Study Controlled Study Female Human Leishmania Leishmania Naiffi Male Nonhuman Protein Blood Level Protein Expression Skin Leishmaniasis Adolescent Blood Classification Flow Cytometry Host Parasite Interaction Immunology Middle Aged Parasitology Physiology Skin Leishmaniasis Species Difference Young Adult Adolescent Adult Brasil Cytokines Female Flow Cytometry Host-parasite Interactions Humans Inflammation Mediators Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Leishmania Leishmania Guyanensis Leishmaniasis, Cutaneous Male Middle Aged Species Specificity Tumor Necrosis Factor-alpha Young Adult |
description |
The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis. The isolates were identified as Leishmania guyanensis, L. naiffi, and L. amazonensis. Most (64%) of the patients were male ranging in age from 18 to 58 years. Protein expression profiles of IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17 cytokines were shown to vary significantly between infected and noninfected (control group) individuals and according to the Leishmania species. Infection caused by L. guyanensis accounted for 73% of the cases and patients with this parasite also showed higher concentrations of IL-2, IFN-γ, IL-4, and IL-17 when compared to infection by L. amazonensis. Patients with infection caused by L. naiffi showed higher concentration of the cytokines analyzed when compared to uninfected patients; however, there was no statistically significant difference with the other species analyzed. © 2014 Thaís Tibery Espir et al. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2020-05-21T20:06:19Z |
dc.date.available.fl_str_mv |
2020-05-21T20:06:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.inpa.gov.br/handle/1/15978 |
dc.identifier.doi.none.fl_str_mv |
10.1155/2014/481750 |
url |
https://repositorio.inpa.gov.br/handle/1/15978 |
identifier_str_mv |
10.1155/2014/481750 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Volume 2014 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Journal of Immunology Research |
publisher.none.fl_str_mv |
Journal of Immunology Research |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional do INPA instname:Instituto Nacional de Pesquisas da Amazônia (INPA) instacron:INPA |
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Instituto Nacional de Pesquisas da Amazônia (INPA) |
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INPA |
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INPA |
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Repositório Institucional do INPA |
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Repositório Institucional do INPA |
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https://repositorio.inpa.gov.br/bitstream/1/15978/1/artigo-inpa.pdf |
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Repositório Institucional do INPA - Instituto Nacional de Pesquisas da Amazônia (INPA) |
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