Intrinsic mechanical properties of the perfused armoured catfish heart with special reference to the effects of hypercapnic acidosis on maximum cardiac performance
Main Author: | |
---|---|
Publication Date: | 2009 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional do INPA |
Download full: | https://repositorio.inpa.gov.br/handle/1/15046 |
Summary: | The armoured catfish, Pterygoplichthys pardalis, is known to be extremely tolerant of environmental hypercarbia (elevated water CO2 tensions), which occurs in their natural environment. In addition, previous studies have demonstrated that during exposure to hypercarbia, P. pardalis does not exhibit extracellular pH compensation and thus the heart and other organs must continue to function despite a severe extracellular acidosis. We used an in situperfused heart preparation to determine the effects of an extracellular hypercapnic (elevated CO2 in the animal) acidosis (1-7.5% CO2) on heart function, specifically cardiac output, power output, heart rate and stroke volume. The present study is the first to comprehensively examine cardiac function in an acidosis- tolerant teleost. When compared with control conditions, maximum cardiac performance was unaffected at levels of CO2 as high as 5%, far exceeding the hypercapnic tolerance of other teleosts. Moreover, P. pardalis exhibited only a moderate decrease (~35%) in cardiac performance when exposed to 7.5% CO2, and full cardiac performance was restored in six out of seven hearts upon return to control conditions. Myocardial intracellular pH (pHi) was protected in situ, as has been found in vivo, and this protection extended to the highest level of CO2 (7.5%) investigated. Thus, maintained heart function during a hypercapnic acidosis in P. pardalis is probably associated with preferential pHi regulation of the heart, but ultimately is not sufficient to prevent loss of cardiac function. Our findings suggest the need for further study to elucidate the mechanisms behind this remarkable cardiac hypercapnic tolerance. |
id |
INPA-2_e40cdcb5488c3a20e78bc607f65c095e |
---|---|
oai_identifier_str |
oai:repositorio:1/15046 |
network_acronym_str |
INPA-2 |
network_name_str |
Repositório Institucional do INPA |
repository_id_str |
|
spelling |
Hanson, Linda M.Baker, Daniel W.Kuchel, Louise J.Farrell, Anthony Peter (Tony)Val, Adalberto LuisBrauner, Colin John2020-05-07T14:02:11Z2020-05-07T14:02:11Z2009https://repositorio.inpa.gov.br/handle/1/1504610.1242/jeb.022764The armoured catfish, Pterygoplichthys pardalis, is known to be extremely tolerant of environmental hypercarbia (elevated water CO2 tensions), which occurs in their natural environment. In addition, previous studies have demonstrated that during exposure to hypercarbia, P. pardalis does not exhibit extracellular pH compensation and thus the heart and other organs must continue to function despite a severe extracellular acidosis. We used an in situperfused heart preparation to determine the effects of an extracellular hypercapnic (elevated CO2 in the animal) acidosis (1-7.5% CO2) on heart function, specifically cardiac output, power output, heart rate and stroke volume. The present study is the first to comprehensively examine cardiac function in an acidosis- tolerant teleost. When compared with control conditions, maximum cardiac performance was unaffected at levels of CO2 as high as 5%, far exceeding the hypercapnic tolerance of other teleosts. Moreover, P. pardalis exhibited only a moderate decrease (~35%) in cardiac performance when exposed to 7.5% CO2, and full cardiac performance was restored in six out of seven hearts upon return to control conditions. Myocardial intracellular pH (pHi) was protected in situ, as has been found in vivo, and this protection extended to the highest level of CO2 (7.5%) investigated. Thus, maintained heart function during a hypercapnic acidosis in P. pardalis is probably associated with preferential pHi regulation of the heart, but ultimately is not sufficient to prevent loss of cardiac function. Our findings suggest the need for further study to elucidate the mechanisms behind this remarkable cardiac hypercapnic tolerance.Volume 212, Número 9, Pags. 1270-1276Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessCarbon DioxideAdaptationAnimalsBloodCatfishHeartIn Vitro StudyPhPhysiologyAdaptation, PhysiologicalAnimalCarbon DioxideCatfishesHeartHydrogen-ion ConcentrationAnimalsiaLiposarcus PardalisOligacanthorhynchusTeleosteiIntrinsic mechanical properties of the perfused armoured catfish heart with special reference to the effects of hypercapnic acidosis on maximum cardiac performanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJournal of Experimental Biologyengreponame:Repositório Institucional do INPAinstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPAORIGINALartigo-inpa.pdfapplication/pdf236693https://repositorio.inpa.gov.br/bitstream/1/15046/1/artigo-inpa.pdfb700bfab5768375f48e7e4452b73210cMD51CC-LICENSElicense_rdfapplication/octet-stream914https://repositorio.inpa.gov.br/bitstream/1/15046/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD521/150462020-07-14 10:42:10.296oai:repositorio:1/15046Repositório de PublicaçõesPUBhttps://repositorio.inpa.gov.br/oai/requestopendoar:2020-07-14T14:42:10Repositório Institucional do INPA - Instituto Nacional de Pesquisas da Amazônia (INPA)false |
dc.title.en.fl_str_mv |
Intrinsic mechanical properties of the perfused armoured catfish heart with special reference to the effects of hypercapnic acidosis on maximum cardiac performance |
title |
Intrinsic mechanical properties of the perfused armoured catfish heart with special reference to the effects of hypercapnic acidosis on maximum cardiac performance |
spellingShingle |
Intrinsic mechanical properties of the perfused armoured catfish heart with special reference to the effects of hypercapnic acidosis on maximum cardiac performance Hanson, Linda M. Carbon Dioxide Adaptation Animals Blood Catfish Heart In Vitro Study Ph Physiology Adaptation, Physiological Animal Carbon Dioxide Catfishes Heart Hydrogen-ion Concentration Animalsia Liposarcus Pardalis Oligacanthorhynchus Teleostei |
title_short |
Intrinsic mechanical properties of the perfused armoured catfish heart with special reference to the effects of hypercapnic acidosis on maximum cardiac performance |
title_full |
Intrinsic mechanical properties of the perfused armoured catfish heart with special reference to the effects of hypercapnic acidosis on maximum cardiac performance |
title_fullStr |
Intrinsic mechanical properties of the perfused armoured catfish heart with special reference to the effects of hypercapnic acidosis on maximum cardiac performance |
title_full_unstemmed |
Intrinsic mechanical properties of the perfused armoured catfish heart with special reference to the effects of hypercapnic acidosis on maximum cardiac performance |
title_sort |
Intrinsic mechanical properties of the perfused armoured catfish heart with special reference to the effects of hypercapnic acidosis on maximum cardiac performance |
author |
Hanson, Linda M. |
author_facet |
Hanson, Linda M. Baker, Daniel W. Kuchel, Louise J. Farrell, Anthony Peter (Tony) Val, Adalberto Luis Brauner, Colin John |
author_role |
author |
author2 |
Baker, Daniel W. Kuchel, Louise J. Farrell, Anthony Peter (Tony) Val, Adalberto Luis Brauner, Colin John |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Hanson, Linda M. Baker, Daniel W. Kuchel, Louise J. Farrell, Anthony Peter (Tony) Val, Adalberto Luis Brauner, Colin John |
dc.subject.eng.fl_str_mv |
Carbon Dioxide Adaptation Animals Blood Catfish Heart In Vitro Study Ph Physiology Adaptation, Physiological Animal Carbon Dioxide Catfishes Heart Hydrogen-ion Concentration Animalsia Liposarcus Pardalis Oligacanthorhynchus Teleostei |
topic |
Carbon Dioxide Adaptation Animals Blood Catfish Heart In Vitro Study Ph Physiology Adaptation, Physiological Animal Carbon Dioxide Catfishes Heart Hydrogen-ion Concentration Animalsia Liposarcus Pardalis Oligacanthorhynchus Teleostei |
description |
The armoured catfish, Pterygoplichthys pardalis, is known to be extremely tolerant of environmental hypercarbia (elevated water CO2 tensions), which occurs in their natural environment. In addition, previous studies have demonstrated that during exposure to hypercarbia, P. pardalis does not exhibit extracellular pH compensation and thus the heart and other organs must continue to function despite a severe extracellular acidosis. We used an in situperfused heart preparation to determine the effects of an extracellular hypercapnic (elevated CO2 in the animal) acidosis (1-7.5% CO2) on heart function, specifically cardiac output, power output, heart rate and stroke volume. The present study is the first to comprehensively examine cardiac function in an acidosis- tolerant teleost. When compared with control conditions, maximum cardiac performance was unaffected at levels of CO2 as high as 5%, far exceeding the hypercapnic tolerance of other teleosts. Moreover, P. pardalis exhibited only a moderate decrease (~35%) in cardiac performance when exposed to 7.5% CO2, and full cardiac performance was restored in six out of seven hearts upon return to control conditions. Myocardial intracellular pH (pHi) was protected in situ, as has been found in vivo, and this protection extended to the highest level of CO2 (7.5%) investigated. Thus, maintained heart function during a hypercapnic acidosis in P. pardalis is probably associated with preferential pHi regulation of the heart, but ultimately is not sufficient to prevent loss of cardiac function. Our findings suggest the need for further study to elucidate the mechanisms behind this remarkable cardiac hypercapnic tolerance. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2020-05-07T14:02:11Z |
dc.date.available.fl_str_mv |
2020-05-07T14:02:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.inpa.gov.br/handle/1/15046 |
dc.identifier.doi.none.fl_str_mv |
10.1242/jeb.022764 |
url |
https://repositorio.inpa.gov.br/handle/1/15046 |
identifier_str_mv |
10.1242/jeb.022764 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Volume 212, Número 9, Pags. 1270-1276 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Journal of Experimental Biology |
publisher.none.fl_str_mv |
Journal of Experimental Biology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional do INPA instname:Instituto Nacional de Pesquisas da Amazônia (INPA) instacron:INPA |
instname_str |
Instituto Nacional de Pesquisas da Amazônia (INPA) |
instacron_str |
INPA |
institution |
INPA |
reponame_str |
Repositório Institucional do INPA |
collection |
Repositório Institucional do INPA |
bitstream.url.fl_str_mv |
https://repositorio.inpa.gov.br/bitstream/1/15046/1/artigo-inpa.pdf https://repositorio.inpa.gov.br/bitstream/1/15046/2/license_rdf |
bitstream.checksum.fl_str_mv |
b700bfab5768375f48e7e4452b73210c 4d2950bda3d176f570a9f8b328dfbbef |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional do INPA - Instituto Nacional de Pesquisas da Amazônia (INPA) |
repository.mail.fl_str_mv |
|
_version_ |
1801499119359885312 |