Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Amazonica |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000100053 |
Resumo: | ABSTRACT Copaiba oleoresin, extracted from the Copaifera reticulata tree, has been used as a remedy in popular medicine in the Brazilian Amazon for various purposes, including reducing drug abuse. Yet no studies evaluated the effect of repeated administration of copaiba oil on alcohol consumption in animals. To evaluate this effect, we divided adult male Wistar rats into a) an alcohol group in which the animals had free access to choose between two bottles: one containing alcohol solution (20%) and another containing vehicle solution (0.2% saccharin); and b) a control group with access to two bottles containing vehicle solution. Rats were free to drink 24 h per day, for 35 days. Daily alcohol consumption and weekly body weight gain and food intake were monitored. From day 22, half of the rats in each group received 600 mg kg-1 copaiba oleoresin and the other received vehicle, subcutaneously, once a day, for three days. On day 35, rats were evaluated in an open-field test. The results showed that copaiba oil decreased voluntary alcohol intake and preference between days 2 and 6 after the last administration. Copaiba treatment also decreased the food intake and body weight gain in both alcohol and control groups without changing behaviors in the open-field test. Therefore, copaiba oil was able to reduce voluntary alcohol consumption in rats and could be tested in humans as an adjuvant to treat alcohol use disorder. |
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Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in ratsessential oilethanolnatural productsdrug addictionABSTRACT Copaiba oleoresin, extracted from the Copaifera reticulata tree, has been used as a remedy in popular medicine in the Brazilian Amazon for various purposes, including reducing drug abuse. Yet no studies evaluated the effect of repeated administration of copaiba oil on alcohol consumption in animals. To evaluate this effect, we divided adult male Wistar rats into a) an alcohol group in which the animals had free access to choose between two bottles: one containing alcohol solution (20%) and another containing vehicle solution (0.2% saccharin); and b) a control group with access to two bottles containing vehicle solution. Rats were free to drink 24 h per day, for 35 days. Daily alcohol consumption and weekly body weight gain and food intake were monitored. From day 22, half of the rats in each group received 600 mg kg-1 copaiba oleoresin and the other received vehicle, subcutaneously, once a day, for three days. On day 35, rats were evaluated in an open-field test. The results showed that copaiba oil decreased voluntary alcohol intake and preference between days 2 and 6 after the last administration. Copaiba treatment also decreased the food intake and body weight gain in both alcohol and control groups without changing behaviors in the open-field test. Therefore, copaiba oil was able to reduce voluntary alcohol consumption in rats and could be tested in humans as an adjuvant to treat alcohol use disorder.Instituto Nacional de Pesquisas da Amazônia2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000100053Acta Amazonica v.52 n.1 2022reponame:Acta Amazonicainstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPA10.1590/1809-4392202102342info:eu-repo/semantics/openAccessPULCINELLI,Rianne RemusGIUSTINA,Clara Lindenmayer DellaBANDIERA,SolangeALMEIDA,Felipe BorgesIZOLAN,Lucas dos ReisNIN,Mauricio SchulerLEAL,Mirna BainyGOMEZ,Rosaneeng2022-03-11T00:00:00Zoai:scielo:S0044-59672022000100053Revistahttps://acta.inpa.gov.br/PUBhttps://old.scielo.br/oai/scielo-oai.phpacta@inpa.gov.br||acta@inpa.gov.br1809-43920044-5967opendoar:2022-03-11T00:00Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA)false |
dc.title.none.fl_str_mv |
Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats |
title |
Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats |
spellingShingle |
Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats PULCINELLI,Rianne Remus essential oil ethanol natural products drug addiction |
title_short |
Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats |
title_full |
Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats |
title_fullStr |
Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats |
title_full_unstemmed |
Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats |
title_sort |
Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats |
author |
PULCINELLI,Rianne Remus |
author_facet |
PULCINELLI,Rianne Remus GIUSTINA,Clara Lindenmayer Della BANDIERA,Solange ALMEIDA,Felipe Borges IZOLAN,Lucas dos Reis NIN,Mauricio Schuler LEAL,Mirna Bainy GOMEZ,Rosane |
author_role |
author |
author2 |
GIUSTINA,Clara Lindenmayer Della BANDIERA,Solange ALMEIDA,Felipe Borges IZOLAN,Lucas dos Reis NIN,Mauricio Schuler LEAL,Mirna Bainy GOMEZ,Rosane |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
PULCINELLI,Rianne Remus GIUSTINA,Clara Lindenmayer Della BANDIERA,Solange ALMEIDA,Felipe Borges IZOLAN,Lucas dos Reis NIN,Mauricio Schuler LEAL,Mirna Bainy GOMEZ,Rosane |
dc.subject.por.fl_str_mv |
essential oil ethanol natural products drug addiction |
topic |
essential oil ethanol natural products drug addiction |
description |
ABSTRACT Copaiba oleoresin, extracted from the Copaifera reticulata tree, has been used as a remedy in popular medicine in the Brazilian Amazon for various purposes, including reducing drug abuse. Yet no studies evaluated the effect of repeated administration of copaiba oil on alcohol consumption in animals. To evaluate this effect, we divided adult male Wistar rats into a) an alcohol group in which the animals had free access to choose between two bottles: one containing alcohol solution (20%) and another containing vehicle solution (0.2% saccharin); and b) a control group with access to two bottles containing vehicle solution. Rats were free to drink 24 h per day, for 35 days. Daily alcohol consumption and weekly body weight gain and food intake were monitored. From day 22, half of the rats in each group received 600 mg kg-1 copaiba oleoresin and the other received vehicle, subcutaneously, once a day, for three days. On day 35, rats were evaluated in an open-field test. The results showed that copaiba oil decreased voluntary alcohol intake and preference between days 2 and 6 after the last administration. Copaiba treatment also decreased the food intake and body weight gain in both alcohol and control groups without changing behaviors in the open-field test. Therefore, copaiba oil was able to reduce voluntary alcohol consumption in rats and could be tested in humans as an adjuvant to treat alcohol use disorder. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000100053 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000100053 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1809-4392202102342 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Nacional de Pesquisas da Amazônia |
publisher.none.fl_str_mv |
Instituto Nacional de Pesquisas da Amazônia |
dc.source.none.fl_str_mv |
Acta Amazonica v.52 n.1 2022 reponame:Acta Amazonica instname:Instituto Nacional de Pesquisas da Amazônia (INPA) instacron:INPA |
instname_str |
Instituto Nacional de Pesquisas da Amazônia (INPA) |
instacron_str |
INPA |
institution |
INPA |
reponame_str |
Acta Amazonica |
collection |
Acta Amazonica |
repository.name.fl_str_mv |
Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA) |
repository.mail.fl_str_mv |
acta@inpa.gov.br||acta@inpa.gov.br |
_version_ |
1752129841565532160 |