Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.

Detalhes bibliográficos
Autor(a) principal: Silva,Ellen Cristina Costa da
Data de Publicação: 2009
Outros Autores: Amorim,Rodrigo César das Neves, Tadei,Wanderli Pedro, Pohlit,Adrian Martin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Amazonica
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672009000100026
Resumo: Quassinoids neosergeolide and isobrucein B, obtained from Picrolemma sprucei, have proven in vitro antitumor, antimalarial, anthelminthic, cytotoxic, insecticide and leishmanicidal activities. There is interest in the in vivo pharmacological study of these natural compounds and their semi-synthetic derivatives, however, the quantities obtained in previous extraction processes have been shown to be a limiting factor for continuation of these studies. Herein, we describe a method for obtaining grams of these quassinoids whose purification relies only on recrystallization.
id INPA-3_77436aae1a73171212a1e3229cddb957
oai_identifier_str oai:scielo:S0044-59672009000100026
network_acronym_str INPA-3
network_name_str Acta Amazonica
repository_id_str
spelling Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.CaferanaSimaroubaceaeQuassinoidRecrystallizationQuassinoids neosergeolide and isobrucein B, obtained from Picrolemma sprucei, have proven in vitro antitumor, antimalarial, anthelminthic, cytotoxic, insecticide and leishmanicidal activities. There is interest in the in vivo pharmacological study of these natural compounds and their semi-synthetic derivatives, however, the quantities obtained in previous extraction processes have been shown to be a limiting factor for continuation of these studies. Herein, we describe a method for obtaining grams of these quassinoids whose purification relies only on recrystallization.Instituto Nacional de Pesquisas da Amazônia2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672009000100026Acta Amazonica v.39 n.1 2009reponame:Acta Amazonicainstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPA10.1590/S0044-59672009000100026info:eu-repo/semantics/openAccessSilva,Ellen Cristina Costa daAmorim,Rodrigo César das NevesTadei,Wanderli PedroPohlit,Adrian Martineng2009-05-27T00:00:00Zoai:scielo:S0044-59672009000100026Revistahttps://acta.inpa.gov.br/PUBhttps://old.scielo.br/oai/scielo-oai.phpacta@inpa.gov.br||acta@inpa.gov.br1809-43920044-5967opendoar:2009-05-27T00:00Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA)false
dc.title.none.fl_str_mv Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.
title Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.
spellingShingle Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.
Silva,Ellen Cristina Costa da
Caferana
Simaroubaceae
Quassinoid
Recrystallization
title_short Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.
title_full Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.
title_fullStr Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.
title_full_unstemmed Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.
title_sort Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.
author Silva,Ellen Cristina Costa da
author_facet Silva,Ellen Cristina Costa da
Amorim,Rodrigo César das Neves
Tadei,Wanderli Pedro
Pohlit,Adrian Martin
author_role author
author2 Amorim,Rodrigo César das Neves
Tadei,Wanderli Pedro
Pohlit,Adrian Martin
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva,Ellen Cristina Costa da
Amorim,Rodrigo César das Neves
Tadei,Wanderli Pedro
Pohlit,Adrian Martin
dc.subject.por.fl_str_mv Caferana
Simaroubaceae
Quassinoid
Recrystallization
topic Caferana
Simaroubaceae
Quassinoid
Recrystallization
description Quassinoids neosergeolide and isobrucein B, obtained from Picrolemma sprucei, have proven in vitro antitumor, antimalarial, anthelminthic, cytotoxic, insecticide and leishmanicidal activities. There is interest in the in vivo pharmacological study of these natural compounds and their semi-synthetic derivatives, however, the quantities obtained in previous extraction processes have been shown to be a limiting factor for continuation of these studies. Herein, we describe a method for obtaining grams of these quassinoids whose purification relies only on recrystallization.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672009000100026
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672009000100026
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0044-59672009000100026
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Nacional de Pesquisas da Amazônia
publisher.none.fl_str_mv Instituto Nacional de Pesquisas da Amazônia
dc.source.none.fl_str_mv Acta Amazonica v.39 n.1 2009
reponame:Acta Amazonica
instname:Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron:INPA
instname_str Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron_str INPA
institution INPA
reponame_str Acta Amazonica
collection Acta Amazonica
repository.name.fl_str_mv Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA)
repository.mail.fl_str_mv acta@inpa.gov.br||acta@inpa.gov.br
_version_ 1752129838154514432

Registros relacionados