Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Amazonica |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000200015 |
Resumo: | Zanthoxylum rhoifolium Lam is a plant popularly used as antimicrobial, for malaria and inflammatory treatment. The essential oil of Z. rhoifolium was extracted and its cytotoxic effects against HeLa (human cervical carcinoma), A-549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), Vero (monkey kidney) cell lines and mice macrophages were evaluated. Some of the terpenes of its essential oil (ß-caryophyllene, alpha-humulene, alpha -pinene, myrcene and linalool) were also tested to verify their possible influence in the oil cytotoxic activity. The results obtained permitted to confirm that the essential oil is cytotoxic against tumoral cells (CD50 = 82.3, 90.7 and 113.6 µg/ml for A-549, HeLa e HT-29 cell lines, respectively), while it did not show cytotoxicity against non-tumoral cells (Vero and mice macrophages). Thus, the essential oil from Z. rhoifolium leaves seems to present a possible therapeuthic role due to its selective cytotoxic activity against tumoral cell lines. |
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Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leavesZanthoxylumEssential oilcytotoxicityß-caryophyllenealpha-humuleneZanthoxylum rhoifolium Lam is a plant popularly used as antimicrobial, for malaria and inflammatory treatment. The essential oil of Z. rhoifolium was extracted and its cytotoxic effects against HeLa (human cervical carcinoma), A-549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), Vero (monkey kidney) cell lines and mice macrophages were evaluated. Some of the terpenes of its essential oil (ß-caryophyllene, alpha-humulene, alpha -pinene, myrcene and linalool) were also tested to verify their possible influence in the oil cytotoxic activity. The results obtained permitted to confirm that the essential oil is cytotoxic against tumoral cells (CD50 = 82.3, 90.7 and 113.6 µg/ml for A-549, HeLa e HT-29 cell lines, respectively), while it did not show cytotoxicity against non-tumoral cells (Vero and mice macrophages). Thus, the essential oil from Z. rhoifolium leaves seems to present a possible therapeuthic role due to its selective cytotoxic activity against tumoral cell lines.Instituto Nacional de Pesquisas da Amazônia2007-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000200015Acta Amazonica v.37 n.2 2007reponame:Acta Amazonicainstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPA10.1590/S0044-59672007000200015info:eu-repo/semantics/openAccessSilva,Saulo Luis daFigueiredo,Patrícia MariaYano,Tomomasaeng2007-09-21T00:00:00Zoai:scielo:S0044-59672007000200015Revistahttps://acta.inpa.gov.br/PUBhttps://old.scielo.br/oai/scielo-oai.phpacta@inpa.gov.br||acta@inpa.gov.br1809-43920044-5967opendoar:2007-09-21T00:00Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA)false |
dc.title.none.fl_str_mv |
Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves |
title |
Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves |
spellingShingle |
Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves Silva,Saulo Luis da Zanthoxylum Essential oil cytotoxicity ß-caryophyllene alpha-humulene |
title_short |
Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves |
title_full |
Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves |
title_fullStr |
Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves |
title_full_unstemmed |
Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves |
title_sort |
Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves |
author |
Silva,Saulo Luis da |
author_facet |
Silva,Saulo Luis da Figueiredo,Patrícia Maria Yano,Tomomasa |
author_role |
author |
author2 |
Figueiredo,Patrícia Maria Yano,Tomomasa |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Silva,Saulo Luis da Figueiredo,Patrícia Maria Yano,Tomomasa |
dc.subject.por.fl_str_mv |
Zanthoxylum Essential oil cytotoxicity ß-caryophyllene alpha-humulene |
topic |
Zanthoxylum Essential oil cytotoxicity ß-caryophyllene alpha-humulene |
description |
Zanthoxylum rhoifolium Lam is a plant popularly used as antimicrobial, for malaria and inflammatory treatment. The essential oil of Z. rhoifolium was extracted and its cytotoxic effects against HeLa (human cervical carcinoma), A-549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), Vero (monkey kidney) cell lines and mice macrophages were evaluated. Some of the terpenes of its essential oil (ß-caryophyllene, alpha-humulene, alpha -pinene, myrcene and linalool) were also tested to verify their possible influence in the oil cytotoxic activity. The results obtained permitted to confirm that the essential oil is cytotoxic against tumoral cells (CD50 = 82.3, 90.7 and 113.6 µg/ml for A-549, HeLa e HT-29 cell lines, respectively), while it did not show cytotoxicity against non-tumoral cells (Vero and mice macrophages). Thus, the essential oil from Z. rhoifolium leaves seems to present a possible therapeuthic role due to its selective cytotoxic activity against tumoral cell lines. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000200015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000200015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0044-59672007000200015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Nacional de Pesquisas da Amazônia |
publisher.none.fl_str_mv |
Instituto Nacional de Pesquisas da Amazônia |
dc.source.none.fl_str_mv |
Acta Amazonica v.37 n.2 2007 reponame:Acta Amazonica instname:Instituto Nacional de Pesquisas da Amazônia (INPA) instacron:INPA |
instname_str |
Instituto Nacional de Pesquisas da Amazônia (INPA) |
instacron_str |
INPA |
institution |
INPA |
reponame_str |
Acta Amazonica |
collection |
Acta Amazonica |
repository.name.fl_str_mv |
Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA) |
repository.mail.fl_str_mv |
acta@inpa.gov.br||acta@inpa.gov.br |
_version_ |
1752129837351305216 |