Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves

Detalhes bibliográficos
Autor(a) principal: Silva,Saulo Luis da
Data de Publicação: 2007
Outros Autores: Figueiredo,Patrícia Maria, Yano,Tomomasa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Amazonica
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000200015
Resumo: Zanthoxylum rhoifolium Lam is a plant popularly used as antimicrobial, for malaria and inflammatory treatment. The essential oil of Z. rhoifolium was extracted and its cytotoxic effects against HeLa (human cervical carcinoma), A-549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), Vero (monkey kidney) cell lines and mice macrophages were evaluated. Some of the terpenes of its essential oil (ß-caryophyllene, alpha-humulene, alpha -pinene, myrcene and linalool) were also tested to verify their possible influence in the oil cytotoxic activity. The results obtained permitted to confirm that the essential oil is cytotoxic against tumoral cells (CD50 = 82.3, 90.7 and 113.6 µg/ml for A-549, HeLa e HT-29 cell lines, respectively), while it did not show cytotoxicity against non-tumoral cells (Vero and mice macrophages). Thus, the essential oil from Z. rhoifolium leaves seems to present a possible therapeuthic role due to its selective cytotoxic activity against tumoral cell lines.
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spelling Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leavesZanthoxylumEssential oilcytotoxicityß-caryophyllenealpha-humuleneZanthoxylum rhoifolium Lam is a plant popularly used as antimicrobial, for malaria and inflammatory treatment. The essential oil of Z. rhoifolium was extracted and its cytotoxic effects against HeLa (human cervical carcinoma), A-549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), Vero (monkey kidney) cell lines and mice macrophages were evaluated. Some of the terpenes of its essential oil (ß-caryophyllene, alpha-humulene, alpha -pinene, myrcene and linalool) were also tested to verify their possible influence in the oil cytotoxic activity. The results obtained permitted to confirm that the essential oil is cytotoxic against tumoral cells (CD50 = 82.3, 90.7 and 113.6 µg/ml for A-549, HeLa e HT-29 cell lines, respectively), while it did not show cytotoxicity against non-tumoral cells (Vero and mice macrophages). Thus, the essential oil from Z. rhoifolium leaves seems to present a possible therapeuthic role due to its selective cytotoxic activity against tumoral cell lines.Instituto Nacional de Pesquisas da Amazônia2007-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000200015Acta Amazonica v.37 n.2 2007reponame:Acta Amazonicainstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPA10.1590/S0044-59672007000200015info:eu-repo/semantics/openAccessSilva,Saulo Luis daFigueiredo,Patrícia MariaYano,Tomomasaeng2007-09-21T00:00:00Zoai:scielo:S0044-59672007000200015Revistahttps://acta.inpa.gov.br/PUBhttps://old.scielo.br/oai/scielo-oai.phpacta@inpa.gov.br||acta@inpa.gov.br1809-43920044-5967opendoar:2007-09-21T00:00Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA)false
dc.title.none.fl_str_mv Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves
title Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves
spellingShingle Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves
Silva,Saulo Luis da
Zanthoxylum
Essential oil
cytotoxicity
ß-caryophyllene
alpha-humulene
title_short Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves
title_full Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves
title_fullStr Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves
title_full_unstemmed Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves
title_sort Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves
author Silva,Saulo Luis da
author_facet Silva,Saulo Luis da
Figueiredo,Patrícia Maria
Yano,Tomomasa
author_role author
author2 Figueiredo,Patrícia Maria
Yano,Tomomasa
author2_role author
author
dc.contributor.author.fl_str_mv Silva,Saulo Luis da
Figueiredo,Patrícia Maria
Yano,Tomomasa
dc.subject.por.fl_str_mv Zanthoxylum
Essential oil
cytotoxicity
ß-caryophyllene
alpha-humulene
topic Zanthoxylum
Essential oil
cytotoxicity
ß-caryophyllene
alpha-humulene
description Zanthoxylum rhoifolium Lam is a plant popularly used as antimicrobial, for malaria and inflammatory treatment. The essential oil of Z. rhoifolium was extracted and its cytotoxic effects against HeLa (human cervical carcinoma), A-549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), Vero (monkey kidney) cell lines and mice macrophages were evaluated. Some of the terpenes of its essential oil (ß-caryophyllene, alpha-humulene, alpha -pinene, myrcene and linalool) were also tested to verify their possible influence in the oil cytotoxic activity. The results obtained permitted to confirm that the essential oil is cytotoxic against tumoral cells (CD50 = 82.3, 90.7 and 113.6 µg/ml for A-549, HeLa e HT-29 cell lines, respectively), while it did not show cytotoxicity against non-tumoral cells (Vero and mice macrophages). Thus, the essential oil from Z. rhoifolium leaves seems to present a possible therapeuthic role due to its selective cytotoxic activity against tumoral cell lines.
publishDate 2007
dc.date.none.fl_str_mv 2007-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000200015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000200015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0044-59672007000200015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Nacional de Pesquisas da Amazônia
publisher.none.fl_str_mv Instituto Nacional de Pesquisas da Amazônia
dc.source.none.fl_str_mv Acta Amazonica v.37 n.2 2007
reponame:Acta Amazonica
instname:Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron:INPA
instname_str Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron_str INPA
institution INPA
reponame_str Acta Amazonica
collection Acta Amazonica
repository.name.fl_str_mv Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA)
repository.mail.fl_str_mv acta@inpa.gov.br||acta@inpa.gov.br
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