In vitro studies of the anthelmintic activity of Picrolemma sprucei Hook. f. (Simaroubaceae)

• Autor(a) principal: Nunomura,Rita de Cássia Saraiva
• Data de Publicação: 2006
• Outros Autores: Silva,Ellen Cristina Costa da, Oliveira,Denilson Ferreira, Garcia,Adriana Mello, Boeloni,Jankerle Neves, Nunomura,Sergio Massayoshi, Pohlit,Adrian Martin
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Amazonica
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672006000300006
• topic: Picrolemma pseudocoffea Ducke; Haemonchus contortus; neosergeolide; isobrucein B; caferana

1300 ppm (1.3 g / L), water and ethanol extracts prepared from stems or roots of Picrolemma sprucei Hook. f. were lethal (85-90 % mortality) in vitro to Haemonchus contortus (Barber Pole Worm) larvae, a gastrointestinal nematode parasite found in domestic and wild ruminants. Neosergeolide and isobrucein B were isolated in 0.0083 and 0.0070 % yield from dry, ground P. sprucei stems (0.89 kg). Neosergeolide, isobrucein B and the anthelmintic drug standard levamisole all caused comparable mortality rates (68-77 %) in vitro to H. contortus at similar concentrations (81-86 ppm). The anthelmintic activity of P. sprucei infusions (teas), alcohol extracts, and neosergeolide and isobrucein B, has therefore been demonstrated for the first time.