Experimental design technique applied to the validation of an instrumental neutron activation analysis procedure

Detalhes bibliográficos
Autor(a) principal: SANTOS, UANDA P. de M. dos
Data de Publicação: 2018
Outros Autores: MOREIRA, EDSON G., INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
Tipo de documento: Artigo de conferência
Título da fonte: Repositório Institucional do IPEN
Texto Completo: http://repositorio.ipen.br/handle/123456789/28317
Resumo: In this study optimization of procedures and standardization of Instrumental Neutron Activation Analysis (INAA) method were carried out for the determination of the elements bromine, chlorine, magnesium, manganese, potassium, sodium and vanadium in biological matrix materials using short irradiations at a pneumatic system. 2k experimental designs were applied for evaluation of the individual contribution of selected variables of the analytical procedure in the final mass fraction result. The chosen experimental designs were the 23 and the 24, depending on the radionuclide half life. Different certified reference materials and multi-element comparators were analyzed considering the following variables: sample decay time, irradiation time, counting time and sample distance to detector. Comparator concentration, sample mass and irradiation time were maintained constant in this procedure. By means of the statistical analysis and theoretical and experimental considerations, it was determined the optimized experimental conditions for the analytical methods that will be adopted for the validation procedure of INAA methods in the Neutron Activation Analysis Laboratory (LAN) of the Research Reactor Center (CRPq) at the Nuclear and Energy Research Institute (IPEN ??? CNEN/SP). Optimized conditions were estimated based on the results of z-score tests, main effect, interaction effects and better irradiation conditions.
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spelling 2018-01-15T15:30:50Z2018-01-15T15:30:50ZOctober 22-27, 2017http://repositorio.ipen.br/handle/123456789/28317In this study optimization of procedures and standardization of Instrumental Neutron Activation Analysis (INAA) method were carried out for the determination of the elements bromine, chlorine, magnesium, manganese, potassium, sodium and vanadium in biological matrix materials using short irradiations at a pneumatic system. 2k experimental designs were applied for evaluation of the individual contribution of selected variables of the analytical procedure in the final mass fraction result. The chosen experimental designs were the 23 and the 24, depending on the radionuclide half life. Different certified reference materials and multi-element comparators were analyzed considering the following variables: sample decay time, irradiation time, counting time and sample distance to detector. Comparator concentration, sample mass and irradiation time were maintained constant in this procedure. By means of the statistical analysis and theoretical and experimental considerations, it was determined the optimized experimental conditions for the analytical methods that will be adopted for the validation procedure of INAA methods in the Neutron Activation Analysis Laboratory (LAN) of the Research Reactor Center (CRPq) at the Nuclear and Energy Research Institute (IPEN ??? CNEN/SP). Optimized conditions were estimated based on the results of z-score tests, main effect, interaction effects and better irradiation conditions.Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2018-01-15T15:30:50Z No. of bitstreams: 1 24152.pdf: 256040 bytes, checksum: bae1e92fecfb0bc9f0e4048365f815e6 (MD5)Made available in DSpace on 2018-01-15T15:30:50Z (GMT). No. of bitstreams: 1 24152.pdf: 256040 bytes, checksum: bae1e92fecfb0bc9f0e4048365f815e6 (MD5)Associa????o Brasileira de Energia Nuclearbiological materialsconcentration ratioelementsexperimental datahigh-purity ge detectorsneutron activation analysisoptimizationstandardizationvalidationExperimental design technique applied to the validation of an instrumental neutron activation analysis procedureinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectINACIRio de Janeiro, RJBelo Horizonte, MGSANTOS, UANDA P. de M. dosMOREIRA, EDSON G.INTERNATIONAL NUCLEAR ATLANTIC CONFERENCEinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN241522017SANTOS, UANDA P. de M. dosMOREIRA, EDSON G.18-01Proceedings11659860SANTOS, UANDA P. DE M. 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dc.title.pt_BR.fl_str_mv Experimental design technique applied to the validation of an instrumental neutron activation analysis procedure
title Experimental design technique applied to the validation of an instrumental neutron activation analysis procedure
spellingShingle Experimental design technique applied to the validation of an instrumental neutron activation analysis procedure
SANTOS, UANDA P. de M. dos
biological materials
concentration ratio
elements
experimental data
high-purity ge detectors
neutron activation analysis
optimization
standardization
validation
title_short Experimental design technique applied to the validation of an instrumental neutron activation analysis procedure
title_full Experimental design technique applied to the validation of an instrumental neutron activation analysis procedure
title_fullStr Experimental design technique applied to the validation of an instrumental neutron activation analysis procedure
title_full_unstemmed Experimental design technique applied to the validation of an instrumental neutron activation analysis procedure
title_sort Experimental design technique applied to the validation of an instrumental neutron activation analysis procedure
author SANTOS, UANDA P. de M. dos
author_facet SANTOS, UANDA P. de M. dos
MOREIRA, EDSON G.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
author_role author
author2 MOREIRA, EDSON G.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
author2_role author
author
dc.contributor.author.fl_str_mv SANTOS, UANDA P. de M. dos
MOREIRA, EDSON G.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
dc.subject.por.fl_str_mv biological materials
concentration ratio
elements
experimental data
high-purity ge detectors
neutron activation analysis
optimization
standardization
validation
topic biological materials
concentration ratio
elements
experimental data
high-purity ge detectors
neutron activation analysis
optimization
standardization
validation
description In this study optimization of procedures and standardization of Instrumental Neutron Activation Analysis (INAA) method were carried out for the determination of the elements bromine, chlorine, magnesium, manganese, potassium, sodium and vanadium in biological matrix materials using short irradiations at a pneumatic system. 2k experimental designs were applied for evaluation of the individual contribution of selected variables of the analytical procedure in the final mass fraction result. The chosen experimental designs were the 23 and the 24, depending on the radionuclide half life. Different certified reference materials and multi-element comparators were analyzed considering the following variables: sample decay time, irradiation time, counting time and sample distance to detector. Comparator concentration, sample mass and irradiation time were maintained constant in this procedure. By means of the statistical analysis and theoretical and experimental considerations, it was determined the optimized experimental conditions for the analytical methods that will be adopted for the validation procedure of INAA methods in the Neutron Activation Analysis Laboratory (LAN) of the Research Reactor Center (CRPq) at the Nuclear and Energy Research Institute (IPEN ??? CNEN/SP). Optimized conditions were estimated based on the results of z-score tests, main effect, interaction effects and better irradiation conditions.
publishDate 2018
dc.date.evento.pt_BR.fl_str_mv October 22-27, 2017
dc.date.accessioned.fl_str_mv 2018-01-15T15:30:50Z
dc.date.available.fl_str_mv 2018-01-15T15:30:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://repositorio.ipen.br/handle/123456789/28317
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dc.publisher.none.fl_str_mv Associa????o Brasileira de Energia Nuclear
publisher.none.fl_str_mv Associa????o Brasileira de Energia Nuclear
dc.source.none.fl_str_mv reponame:Repositório Institucional do IPEN
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instname_str Instituto de Pesquisas Energéticas e Nucleares (IPEN)
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