Synthesis of hybrid AuFe nanoparticles by photoreduction and methyl aminoluvinate

Detalhes bibliográficos
Autor(a) principal: GON??ALVES, KARINA de O.
Data de Publicação: 2019
Outros Autores: SILVA, FLAVIA R. de O., VIEIRA, DANIEL P., COURROL, LILIA C., SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE
Tipo de documento: Artigo de conferência
Título da fonte: Repositório Institucional do IPEN
Texto Completo: http://repositorio.ipen.br/handle/123456789/30138
Resumo: The nanohybrid gold/iron (AuFe) system is particularly interesting for biomedical applications such as targeted drug delivery, hyperthermia and photodynamic therapy (PDT) mainly due to its magnetic combined to the plasmonic properties. In this study, we aimed to synthesize nanohybrids to be used as a vehicle to deliver Methyl Aminoluvinate (MAL) for selective and efficient PDT. MAL is a prodrug that is metabolized to protoporphyrin IX (PpIX), photosensitizer in PDT. The nanohybrids were synthesized by photoreduction of solutions containing iron powder, polyethylene glycol (PEG), chloroauric acid (HAuCl4) and MAL as a reducing agent in water solution. The products were characterized by UV-Vis, zeta potential and transmission electron microscopy. The synthesized nanoparticles had the optical properties of metallic nanoparticles and the magnetic properties of iron nanoparticles. Their characteristic absorption bands, in the visible light range, became become broader and red???shifted in the presence of iron nanoparticles. Cell viability of cancer cell lines in the presence of nanohybrids studies were performed.
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spelling 2019-08-30T13:28:33Z2019-08-30T13:28:33ZOctober 08-10, 2018http://repositorio.ipen.br/handle/123456789/3013810.1109/SBFoton-IOPC.2018.86109500000-0002-0007-534XThe nanohybrid gold/iron (AuFe) system is particularly interesting for biomedical applications such as targeted drug delivery, hyperthermia and photodynamic therapy (PDT) mainly due to its magnetic combined to the plasmonic properties. In this study, we aimed to synthesize nanohybrids to be used as a vehicle to deliver Methyl Aminoluvinate (MAL) for selective and efficient PDT. MAL is a prodrug that is metabolized to protoporphyrin IX (PpIX), photosensitizer in PDT. The nanohybrids were synthesized by photoreduction of solutions containing iron powder, polyethylene glycol (PEG), chloroauric acid (HAuCl4) and MAL as a reducing agent in water solution. The products were characterized by UV-Vis, zeta potential and transmission electron microscopy. The synthesized nanoparticles had the optical properties of metallic nanoparticles and the magnetic properties of iron nanoparticles. Their characteristic absorption bands, in the visible light range, became become broader and red???shifted in the presence of iron nanoparticles. Cell viability of cancer cell lines in the presence of nanohybrids studies were performed.Submitted by Pedro Silva Filho (pfsilva@ipen.br) on 2019-08-30T13:28:33Z No. of bitstreams: 1 25932.pdf: 700379 bytes, checksum: 1687d6f63c186771b8121a1bd5d35c75 (MD5)Made available in DSpace on 2019-08-30T13:28:33Z (GMT). No. of bitstreams: 1 25932.pdf: 700379 bytes, checksum: 1687d6f63c186771b8121a1bd5d35c75 (MD5)Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP)FAPESP: 14/06960-9IEEESynthesis of hybrid AuFe nanoparticles by photoreduction and methyl aminoluvinateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectSBFoton IOPCIPiscataway, NJ, USACampinas, SP59103158600600GON??ALVES, KARINA de O.SILVA, FLAVIA R. de O.VIEIRA, DANIEL P.COURROL, LILIA C.SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCEinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN259322018VIEIRA, DANIEL P.SILVA, FLAVIA R. de O.19-08Proceedings31585910VIEIRA, DANIEL P.:3158:810:NSILVA, FLAVIA R. de O.:5910:820:NORIGINAL25932.pdf25932.pdfapplication/pdf700379http://repositorio.ipen.br/bitstream/123456789/30138/1/25932.pdf1687d6f63c186771b8121a1bd5d35c75MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/30138/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/301382019-08-30 13:28:33.681oai:repositorio.ipen.br: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Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102019-08-30T13:28:33Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false
dc.title.pt_BR.fl_str_mv Synthesis of hybrid AuFe nanoparticles by photoreduction and methyl aminoluvinate
title Synthesis of hybrid AuFe nanoparticles by photoreduction and methyl aminoluvinate
spellingShingle Synthesis of hybrid AuFe nanoparticles by photoreduction and methyl aminoluvinate
GON??ALVES, KARINA de O.
title_short Synthesis of hybrid AuFe nanoparticles by photoreduction and methyl aminoluvinate
title_full Synthesis of hybrid AuFe nanoparticles by photoreduction and methyl aminoluvinate
title_fullStr Synthesis of hybrid AuFe nanoparticles by photoreduction and methyl aminoluvinate
title_full_unstemmed Synthesis of hybrid AuFe nanoparticles by photoreduction and methyl aminoluvinate
title_sort Synthesis of hybrid AuFe nanoparticles by photoreduction and methyl aminoluvinate
author GON??ALVES, KARINA de O.
author_facet GON??ALVES, KARINA de O.
SILVA, FLAVIA R. de O.
VIEIRA, DANIEL P.
COURROL, LILIA C.
SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE
author_role author
author2 SILVA, FLAVIA R. de O.
VIEIRA, DANIEL P.
COURROL, LILIA C.
SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE
author2_role author
author
author
author
dc.contributor.author.fl_str_mv GON??ALVES, KARINA de O.
SILVA, FLAVIA R. de O.
VIEIRA, DANIEL P.
COURROL, LILIA C.
SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE
description The nanohybrid gold/iron (AuFe) system is particularly interesting for biomedical applications such as targeted drug delivery, hyperthermia and photodynamic therapy (PDT) mainly due to its magnetic combined to the plasmonic properties. In this study, we aimed to synthesize nanohybrids to be used as a vehicle to deliver Methyl Aminoluvinate (MAL) for selective and efficient PDT. MAL is a prodrug that is metabolized to protoporphyrin IX (PpIX), photosensitizer in PDT. The nanohybrids were synthesized by photoreduction of solutions containing iron powder, polyethylene glycol (PEG), chloroauric acid (HAuCl4) and MAL as a reducing agent in water solution. The products were characterized by UV-Vis, zeta potential and transmission electron microscopy. The synthesized nanoparticles had the optical properties of metallic nanoparticles and the magnetic properties of iron nanoparticles. Their characteristic absorption bands, in the visible light range, became become broader and red???shifted in the presence of iron nanoparticles. Cell viability of cancer cell lines in the presence of nanohybrids studies were performed.
publishDate 2019
dc.date.evento.pt_BR.fl_str_mv October 08-10, 2018
dc.date.accessioned.fl_str_mv 2019-08-30T13:28:33Z
dc.date.available.fl_str_mv 2019-08-30T13:28:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ipen.br/handle/123456789/30138
dc.identifier.doi.pt_BR.fl_str_mv 10.1109/SBFoton-IOPC.2018.8610950
dc.identifier.orcid.pt_BR.fl_str_mv 0000-0002-0007-534X
url http://repositorio.ipen.br/handle/123456789/30138
identifier_str_mv 10.1109/SBFoton-IOPC.2018.8610950
0000-0002-0007-534X
dc.relation.authority.fl_str_mv 5910
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dc.relation.confidence.fl_str_mv 600
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.coverage.pt_BR.fl_str_mv I
dc.publisher.none.fl_str_mv IEEE
publisher.none.fl_str_mv IEEE
dc.source.none.fl_str_mv reponame:Repositório Institucional do IPEN
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