Effect of gamma radiation on polyvinylpyrrolidone hydrogels
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo de conferência |
Título da fonte: | Repositório Institucional do IPEN |
Texto Completo: | http://repositorio.ipen.br/handle/123456789/28349 |
Resumo: | Polyvinylpyrrolidone (PVP) hydrogels have been investigated as drug delivery matrices for the treatment of wounds, such as cutaneous leishmaniasis, and matrices with silver nanoparticles for chronic wounds and burns. The preparation of such hydrogels can occur by various cross-linking methods, such as gamma, chemical, physical, among others. The most feasible for wound dressings is gamma irradiation from cobalt-60, because gamma irradiation simultaneously promotes crosslinking and sterilization, leaving the wound dressing ready for use. The objective of this work was to investigate the effect on physico- chemical properties of gamma radiation on PVP hydrogel according to the radiation absorbed dose variation. The PVP hydrogels were irradiated with doses of 5, 15, 25, 35, 45, 55, 65, 75 and 95kGy at dose rate of 5 kGy/h and characterized by swelling, thermogravimetric and mechanical analysis. Results shown a favorable dose range window for processing of these hydrogels related to the application. The results showed that mechanical strength was affected at doses starting at 25 kGy. |
id |
IPEN_8794caa6dc55f5464ccd29792e542ad1 |
---|---|
oai_identifier_str |
oai:repositorio.ipen.br:123456789/28349 |
network_acronym_str |
IPEN |
network_name_str |
Repositório Institucional do IPEN |
repository_id_str |
4510 |
spelling |
2018-01-17T15:36:11Z2018-01-17T15:36:11ZOctober 22-27, 2017http://repositorio.ipen.br/handle/123456789/28349Polyvinylpyrrolidone (PVP) hydrogels have been investigated as drug delivery matrices for the treatment of wounds, such as cutaneous leishmaniasis, and matrices with silver nanoparticles for chronic wounds and burns. The preparation of such hydrogels can occur by various cross-linking methods, such as gamma, chemical, physical, among others. The most feasible for wound dressings is gamma irradiation from cobalt-60, because gamma irradiation simultaneously promotes crosslinking and sterilization, leaving the wound dressing ready for use. The objective of this work was to investigate the effect on physico- chemical properties of gamma radiation on PVP hydrogel according to the radiation absorbed dose variation. The PVP hydrogels were irradiated with doses of 5, 15, 25, 35, 45, 55, 65, 75 and 95kGy at dose rate of 5 kGy/h and characterized by swelling, thermogravimetric and mechanical analysis. Results shown a favorable dose range window for processing of these hydrogels related to the application. The results showed that mechanical strength was affected at doses starting at 25 kGy.Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2018-01-17T15:36:11Z No. of bitstreams: 1 24184.pdf: 658353 bytes, checksum: 1c629d75162a768ec0cc0fe118ece324 (MD5)Made available in DSpace on 2018-01-17T15:36:11Z (GMT). No. of bitstreams: 1 24184.pdf: 658353 bytes, checksum: 1c629d75162a768ec0cc0fe118ece324 (MD5)Associa????o Brasileira de Energia Nuclearabsorbed radiation doseschemical propertiescobalt 60differential thermal analysisdose ratesfourier transformationgamma radiationhydrogelsinfrared spectraphysical propertiespvpradiation effectsswellingtensile propertiesthermal gravimetric analysiswoundsEffect of gamma radiation on polyvinylpyrrolidone hydrogelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectINACIRio de Janeiro, RJBelo Horizonte, MGOLIVEIRA, M.J.A.VASQUEZ, P.A.S.ALCANTARA, M.T.S.MUNHOZ, M.M.L.LUGAO, A.B.INTERNATIONAL NUCLEAR ATLANTIC CONFERENCEinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN241842017OLIVEIRA, M.J.A.VASQUEZ, P.A.S.ALCANTARA, M.T.S.MUNHOZ, M.M.L.LUGAO, A.B.18-01Proceedings3310307522958585339OLIVEIRA, M.J.A.:3310:740:SVASQUEZ, P.A.S.:3075:240:NALCANTARA, M.T.S.:2295:740:NMUNHOZ, M.M.L.:8585:220:NLUGAO, A.B.:339:740:NORIGINAL24184.pdf24184.pdfapplication/pdf658353http://repositorio.ipen.br/bitstream/123456789/28349/1/24184.pdf1c629d75162a768ec0cc0fe118ece324MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/28349/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/283492020-08-28 19:41:32.309oai:repositorio.ipen.br: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Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102020-08-28T19:41:32Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false |
dc.title.pt_BR.fl_str_mv |
Effect of gamma radiation on polyvinylpyrrolidone hydrogels |
title |
Effect of gamma radiation on polyvinylpyrrolidone hydrogels |
spellingShingle |
Effect of gamma radiation on polyvinylpyrrolidone hydrogels OLIVEIRA, M.J.A. absorbed radiation doses chemical properties cobalt 60 differential thermal analysis dose rates fourier transformation gamma radiation hydrogels infrared spectra physical properties pvp radiation effects swelling tensile properties thermal gravimetric analysis wounds |
title_short |
Effect of gamma radiation on polyvinylpyrrolidone hydrogels |
title_full |
Effect of gamma radiation on polyvinylpyrrolidone hydrogels |
title_fullStr |
Effect of gamma radiation on polyvinylpyrrolidone hydrogels |
title_full_unstemmed |
Effect of gamma radiation on polyvinylpyrrolidone hydrogels |
title_sort |
Effect of gamma radiation on polyvinylpyrrolidone hydrogels |
author |
OLIVEIRA, M.J.A. |
author_facet |
OLIVEIRA, M.J.A. VASQUEZ, P.A.S. ALCANTARA, M.T.S. MUNHOZ, M.M.L. LUGAO, A.B. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
author_role |
author |
author2 |
VASQUEZ, P.A.S. ALCANTARA, M.T.S. MUNHOZ, M.M.L. LUGAO, A.B. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
OLIVEIRA, M.J.A. VASQUEZ, P.A.S. ALCANTARA, M.T.S. MUNHOZ, M.M.L. LUGAO, A.B. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
dc.subject.por.fl_str_mv |
absorbed radiation doses chemical properties cobalt 60 differential thermal analysis dose rates fourier transformation gamma radiation hydrogels infrared spectra physical properties pvp radiation effects swelling tensile properties thermal gravimetric analysis wounds |
topic |
absorbed radiation doses chemical properties cobalt 60 differential thermal analysis dose rates fourier transformation gamma radiation hydrogels infrared spectra physical properties pvp radiation effects swelling tensile properties thermal gravimetric analysis wounds |
description |
Polyvinylpyrrolidone (PVP) hydrogels have been investigated as drug delivery matrices for the treatment of wounds, such as cutaneous leishmaniasis, and matrices with silver nanoparticles for chronic wounds and burns. The preparation of such hydrogels can occur by various cross-linking methods, such as gamma, chemical, physical, among others. The most feasible for wound dressings is gamma irradiation from cobalt-60, because gamma irradiation simultaneously promotes crosslinking and sterilization, leaving the wound dressing ready for use. The objective of this work was to investigate the effect on physico- chemical properties of gamma radiation on PVP hydrogel according to the radiation absorbed dose variation. The PVP hydrogels were irradiated with doses of 5, 15, 25, 35, 45, 55, 65, 75 and 95kGy at dose rate of 5 kGy/h and characterized by swelling, thermogravimetric and mechanical analysis. Results shown a favorable dose range window for processing of these hydrogels related to the application. The results showed that mechanical strength was affected at doses starting at 25 kGy. |
publishDate |
2018 |
dc.date.evento.pt_BR.fl_str_mv |
October 22-27, 2017 |
dc.date.accessioned.fl_str_mv |
2018-01-17T15:36:11Z |
dc.date.available.fl_str_mv |
2018-01-17T15:36:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ipen.br/handle/123456789/28349 |
url |
http://repositorio.ipen.br/handle/123456789/28349 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.coverage.pt_BR.fl_str_mv |
I |
dc.publisher.none.fl_str_mv |
Associa????o Brasileira de Energia Nuclear |
publisher.none.fl_str_mv |
Associa????o Brasileira de Energia Nuclear |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional do IPEN instname:Instituto de Pesquisas Energéticas e Nucleares (IPEN) instacron:IPEN |
instname_str |
Instituto de Pesquisas Energéticas e Nucleares (IPEN) |
instacron_str |
IPEN |
institution |
IPEN |
reponame_str |
Repositório Institucional do IPEN |
collection |
Repositório Institucional do IPEN |
bitstream.url.fl_str_mv |
http://repositorio.ipen.br/bitstream/123456789/28349/1/24184.pdf http://repositorio.ipen.br/bitstream/123456789/28349/2/license.txt |
bitstream.checksum.fl_str_mv |
1c629d75162a768ec0cc0fe118ece324 8a4605be74aa9ea9d79846c1fba20a33 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN) |
repository.mail.fl_str_mv |
bibl@ipen.br |
_version_ |
1767254244325326848 |