Synthesis of polymeric gels crosslinked by ionizing radiation for treatment of cutaneous leishmaniasis

• Autor(a) principal: OLIVEIRA, MARIA J.A. de
• Data de Publicação: 2020
• Outros Autores: MOREIRA, EDSON G., SALVADOR, PABLO A.V., ALCANTARA, MARA T.S., LUGAO, ADEMAR B., INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
• Tipo de documento: Artigo de conferência
• Título da fonte: Repositório Institucional do IPEN
• Texto Completo: http://repositorio.ipen.br/handle/123456789/30622
• topic: cobalt 60; cross-linking; gels; nanoparticles; neutron activation analysis; polymers; protozoa; silver; skin diseases; therapeutic uses; transmission electron microscopy

Ionizing radiation is a very efficient, versatile and clean tool for modifying polymers for various applications, including in the biomedical area. The advantages of using radiation include the ability to process materials in any physical form, at a convenient temperature, often at room temperature. There is no need for the use of initiators or other chemicals and it is easily carried out with high reliability and does not generate any waste. In the research support area, several materials have been treated in order to find correlations between the applied dose and some property of the material susceptible to be modified with gamma radiation. This study proposes the development of polymeric gels (cream) with Glucantime (Sb V) and gel (cream) with silver nanoparticles, for alternative treatment of cutaneous Leishmaniasis. A cobalt-60 gamma irradiation source was used for crosslinking the polymers, forming the silver nanoparticles and simultaneous sterilization, leaving the product ready for use. Polymeric gels were characterized by physico-chemical techniques, instrumental n??utron activation analysis (INAA), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).