The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG

Detalhes bibliográficos
Autor(a) principal: SOARES, JAQUELINE J.S.
Data de Publicação: 2018
Outros Autores: JACOVONE, RAYNARA M.S., SANTOS, PAULO S., ZAIM, MARCIO H., FARIA, DALVA L.A. de, SAKATA, SOLANGE K., INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
Tipo de documento: Artigo de conferência
Título da fonte: Repositório Institucional do IPEN
Texto Completo: http://repositorio.ipen.br/handle/123456789/28340
Resumo: The functionalization of graphene oxide (GO) with polyethylene glycol (PEG) has been widely used in drug delivery systems. This nanocomposite exhibits excellent stability in the presence of high concentrations of salts and proteins and shows to be less toxic than its raw form in vitro and in vivo. However, it must be sterilized before use in the medical field and the gamma irradiation shows a promising option for this purpose. Sterilization by ionizing energy through gamma rays, generated by Cobalt-60 self-disintegration, consists in exposing the materials to short electromagnetic waves. The irradiation process provides substantial advantages when compared to thermal and chemical processes such as more precise control of the process, production of products with superior qualities, lower energy consumption and less environmental pollution. In this work the effect of gamma radiation on the structure of GO and GO functionalized com Amino-PEG (GO-PEG-NH2) irradiated with different doses (15, 25, 35 and 50 kGy) and rate dose 7.31 kGy.h-1 was evaluated. The analyses were performed by Fourier-transform infrared spectroscopy (FT-IR) and Raman spectroscopy. The results showed that the methods for the synthesis of GO and GO-PEG-NH2 was effective since there was confirmation of the surface oxidation of materials and functionalization with the PEG-NH2 and the sterilization by gamma radiation does not caused any defects on materials.
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spelling 2018-01-17T11:41:11Z2018-01-17T11:41:11ZOctober 22-27, 2017http://repositorio.ipen.br/handle/123456789/28340The functionalization of graphene oxide (GO) with polyethylene glycol (PEG) has been widely used in drug delivery systems. This nanocomposite exhibits excellent stability in the presence of high concentrations of salts and proteins and shows to be less toxic than its raw form in vitro and in vivo. However, it must be sterilized before use in the medical field and the gamma irradiation shows a promising option for this purpose. Sterilization by ionizing energy through gamma rays, generated by Cobalt-60 self-disintegration, consists in exposing the materials to short electromagnetic waves. The irradiation process provides substantial advantages when compared to thermal and chemical processes such as more precise control of the process, production of products with superior qualities, lower energy consumption and less environmental pollution. In this work the effect of gamma radiation on the structure of GO and GO functionalized com Amino-PEG (GO-PEG-NH2) irradiated with different doses (15, 25, 35 and 50 kGy) and rate dose 7.31 kGy.h-1 was evaluated. The analyses were performed by Fourier-transform infrared spectroscopy (FT-IR) and Raman spectroscopy. The results showed that the methods for the synthesis of GO and GO-PEG-NH2 was effective since there was confirmation of the surface oxidation of materials and functionalization with the PEG-NH2 and the sterilization by gamma radiation does not caused any defects on materials.Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2018-01-17T11:41:11Z No. of bitstreams: 1 24175.pdf: 644012 bytes, checksum: 56aff8fc1f9aefb96fd714aca36253c9 (MD5)Made available in DSpace on 2018-01-17T11:41:11Z (GMT). No. of bitstreams: 1 24175.pdf: 644012 bytes, checksum: 56aff8fc1f9aefb96fd714aca36253c9 (MD5)Associa????o Brasileira de Energia Nuclearcobalt 60dose ratesfourier transformationgamma radiationgrapheneinfrared spectrapolyethylene glycolsradiation dosesradiation effectsraman spectroscopysterilizationsynthesisThe effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEGinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectINACIRio de Janeiro, RJBelo Horizonte, MGSOARES, JAQUELINE J.S.JACOVONE, RAYNARA M.S.SANTOS, PAULO S.ZAIM, MARCIO H.FARIA, DALVA L.A. deSAKATA, SOLANGE K.INTERNATIONAL NUCLEAR ATLANTIC CONFERENCEinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN241752017SOARES, JAQUELINE J.S.JACOVONE, RAYNARA M.S.SANTOS, PAULO S.SAKATA, SOLANGE K.18-01Proceedings143131430040747038SOARES, JAQUELINE J.S.:14313:220:SJACOVONE, RAYNARA M.S.:14300:220:NSANTOS, PAULO S.:4074:240:NSAKATA, SOLANGE K.:7038:220:NORIGINAL24175.pdf24175.pdfapplication/pdf644012http://repositorio.ipen.br/bitstream/123456789/28340/1/24175.pdf56aff8fc1f9aefb96fd714aca36253c9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/28340/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/283402022-08-10 13:34:13.879oai:repositorio.ipen.br:123456789/28340Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102022-08-10T13:34:13Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false
dc.title.pt_BR.fl_str_mv The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG
title The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG
spellingShingle The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG
SOARES, JAQUELINE J.S.
cobalt 60
dose rates
fourier transformation
gamma radiation
graphene
infrared spectra
polyethylene glycols
radiation doses
radiation effects
raman spectroscopy
sterilization
synthesis
title_short The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG
title_full The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG
title_fullStr The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG
title_full_unstemmed The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG
title_sort The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG
author SOARES, JAQUELINE J.S.
author_facet SOARES, JAQUELINE J.S.
JACOVONE, RAYNARA M.S.
SANTOS, PAULO S.
ZAIM, MARCIO H.
FARIA, DALVA L.A. de
SAKATA, SOLANGE K.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
author_role author
author2 JACOVONE, RAYNARA M.S.
SANTOS, PAULO S.
ZAIM, MARCIO H.
FARIA, DALVA L.A. de
SAKATA, SOLANGE K.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv SOARES, JAQUELINE J.S.
JACOVONE, RAYNARA M.S.
SANTOS, PAULO S.
ZAIM, MARCIO H.
FARIA, DALVA L.A. de
SAKATA, SOLANGE K.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
dc.subject.por.fl_str_mv cobalt 60
dose rates
fourier transformation
gamma radiation
graphene
infrared spectra
polyethylene glycols
radiation doses
radiation effects
raman spectroscopy
sterilization
synthesis
topic cobalt 60
dose rates
fourier transformation
gamma radiation
graphene
infrared spectra
polyethylene glycols
radiation doses
radiation effects
raman spectroscopy
sterilization
synthesis
description The functionalization of graphene oxide (GO) with polyethylene glycol (PEG) has been widely used in drug delivery systems. This nanocomposite exhibits excellent stability in the presence of high concentrations of salts and proteins and shows to be less toxic than its raw form in vitro and in vivo. However, it must be sterilized before use in the medical field and the gamma irradiation shows a promising option for this purpose. Sterilization by ionizing energy through gamma rays, generated by Cobalt-60 self-disintegration, consists in exposing the materials to short electromagnetic waves. The irradiation process provides substantial advantages when compared to thermal and chemical processes such as more precise control of the process, production of products with superior qualities, lower energy consumption and less environmental pollution. In this work the effect of gamma radiation on the structure of GO and GO functionalized com Amino-PEG (GO-PEG-NH2) irradiated with different doses (15, 25, 35 and 50 kGy) and rate dose 7.31 kGy.h-1 was evaluated. The analyses were performed by Fourier-transform infrared spectroscopy (FT-IR) and Raman spectroscopy. The results showed that the methods for the synthesis of GO and GO-PEG-NH2 was effective since there was confirmation of the surface oxidation of materials and functionalization with the PEG-NH2 and the sterilization by gamma radiation does not caused any defects on materials.
publishDate 2018
dc.date.evento.pt_BR.fl_str_mv October 22-27, 2017
dc.date.accessioned.fl_str_mv 2018-01-17T11:41:11Z
dc.date.available.fl_str_mv 2018-01-17T11:41:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://repositorio.ipen.br/handle/123456789/28340
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Associa????o Brasileira de Energia Nuclear
publisher.none.fl_str_mv Associa????o Brasileira de Energia Nuclear
dc.source.none.fl_str_mv reponame:Repositório Institucional do IPEN
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