Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo de conferência |
Título da fonte: | Repositório Institucional do IPEN |
Texto Completo: | http://repositorio.ipen.br/handle/123456789/30584 |
Resumo: | BACKGROUND: Radiatiotherapy is often associated with a wide range of significant side effects. These side effects are commonly classified as acute or delayed according to when they manifest in relation to treatment. METHODS: This study aimed to evaluate acute toxicity in patients with prostate cancer treated with conformational radiotherapy (3D) in an Oncology Unit in Eastern Minas Gerais. A prospective, observational, cohort study was performed through a non-probabilistic sampling of convenience, totalazing 45 patients. Patients included in the study were followed from the start of treatment to 3 months after external beam radiation therapy (EBRT). RESULTS: Demographic Characteristics - Of the 45 patients included, mean age was 70.6 ?? 8.3 (SD) years, and predominantly white (44.0 %). The majority were married (75.6 %). Considering the risk classification, there was a homogeneous distribution between the low (33.3 %), intermediate (31.1 %) and high (35.6 %) levels. The majority of the patients (57.8 %) had a low risk (T1) classification, followed by intermediate risk classification (33.3%) and high risk (8.9 %). In the Gleason score, 44.4 % presented values below 6 (low), 40.0 % intermediate, and 15.5 % high. 62.2 % had a PSA level less than 10 ng.mL-1, 22.2 % had an intermediate level, from 10 to 20 ng.mL-1 and 15.6%, above 20 ng.mL-1. Manifestation of acute toxicity - It was observed that the majority (59.1 %) of the acute effects manifested during the first consultation, prevailing the symptom of urinary frequency (64.1 %). Regarding the symptoms of acute effects most prevalent during the three consultations, we highlight the urinary frequency with 44.0 %, followed by the urinary residue (20.0 %). CONCLUSION: 80.0 % of the patients presented acute effects during radiotherapy, being the urinary frequency the event more frequent (44.0 %), followed by urinary residue (20.0 %). Eighteen patients (40.0 %) presented only one acute effect and 59.1 % of the effects were observed at the first visit. |
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2020-01-07T13:20:59Z2020-01-07T13:20:59ZOctober 21-25, 2019http://repositorio.ipen.br/handle/123456789/305840000-0003-2943-60970000-0002-7303-6720BACKGROUND: Radiatiotherapy is often associated with a wide range of significant side effects. These side effects are commonly classified as acute or delayed according to when they manifest in relation to treatment. METHODS: This study aimed to evaluate acute toxicity in patients with prostate cancer treated with conformational radiotherapy (3D) in an Oncology Unit in Eastern Minas Gerais. A prospective, observational, cohort study was performed through a non-probabilistic sampling of convenience, totalazing 45 patients. Patients included in the study were followed from the start of treatment to 3 months after external beam radiation therapy (EBRT). RESULTS: Demographic Characteristics - Of the 45 patients included, mean age was 70.6 ?? 8.3 (SD) years, and predominantly white (44.0 %). The majority were married (75.6 %). Considering the risk classification, there was a homogeneous distribution between the low (33.3 %), intermediate (31.1 %) and high (35.6 %) levels. The majority of the patients (57.8 %) had a low risk (T1) classification, followed by intermediate risk classification (33.3%) and high risk (8.9 %). In the Gleason score, 44.4 % presented values below 6 (low), 40.0 % intermediate, and 15.5 % high. 62.2 % had a PSA level less than 10 ng.mL-1, 22.2 % had an intermediate level, from 10 to 20 ng.mL-1 and 15.6%, above 20 ng.mL-1. Manifestation of acute toxicity - It was observed that the majority (59.1 %) of the acute effects manifested during the first consultation, prevailing the symptom of urinary frequency (64.1 %). Regarding the symptoms of acute effects most prevalent during the three consultations, we highlight the urinary frequency with 44.0 %, followed by the urinary residue (20.0 %). CONCLUSION: 80.0 % of the patients presented acute effects during radiotherapy, being the urinary frequency the event more frequent (44.0 %), followed by urinary residue (20.0 %). Eighteen patients (40.0 %) presented only one acute effect and 59.1 % of the effects were observed at the first visit.Submitted by Celia Satomi Uehara (celia.u-topservice@ipen.br) on 2020-01-07T13:20:59Z No. of bitstreams: 1 26234.pdf: 341747 bytes, checksum: d247d3a095d1aacc0d16cc58558e9522 (MD5)Made available in DSpace on 2020-01-07T13:20:59Z (GMT). No. of bitstreams: 1 26234.pdf: 341747 bytes, checksum: d247d3a095d1aacc0d16cc58558e9522 (MD5)1797-1809Associa????o Brasileira de Energia Nuclearexternal beam radiation therapyneoplasmspatientsprostateradiotherapyside effectstoxicityurinary tractEvaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectINACIRio de JaneiroSantos, SP146919447600600600CARLECH, HIGOR S.LISBOA, ANA C.V.C.VITAL, MARCILIO L.ZEITUNI, CARLOS A.ROSTELATO, MARIA E.C.M.INTERNATIONAL NUCLEAR ATLANTIC CONFERENCEinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN262342019ROSTELATO, MARIA E.C.M.ZEITUNI, CARLOS A.CARLECH, HIGOR S.20-01Proceedings794414691choort with 45 patientsROSTELATO, MARIA E.C.M.:7:230:NZEITUNI, CARLOS A.:944:230:NCARLECH, HIGOR S.:14691:230:SORIGINAL26234.pdf26234.pdfapplication/pdf341747http://repositorio.ipen.br/bitstream/123456789/30584/1/26234.pdfd247d3a095d1aacc0d16cc58558e9522MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/30584/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/305842020-04-06 14:00:53.199oai:repositorio.ipen.br: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Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102020-04-06T14:00:53Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false |
dc.title.pt_BR.fl_str_mv |
Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy |
title |
Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy |
spellingShingle |
Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy CARLECH, HIGOR S. external beam radiation therapy neoplasms patients prostate radiotherapy side effects toxicity urinary tract |
title_short |
Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy |
title_full |
Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy |
title_fullStr |
Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy |
title_full_unstemmed |
Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy |
title_sort |
Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy |
author |
CARLECH, HIGOR S. |
author_facet |
CARLECH, HIGOR S. LISBOA, ANA C.V.C. VITAL, MARCILIO L. ZEITUNI, CARLOS A. ROSTELATO, MARIA E.C.M. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
author_role |
author |
author2 |
LISBOA, ANA C.V.C. VITAL, MARCILIO L. ZEITUNI, CARLOS A. ROSTELATO, MARIA E.C.M. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
CARLECH, HIGOR S. LISBOA, ANA C.V.C. VITAL, MARCILIO L. ZEITUNI, CARLOS A. ROSTELATO, MARIA E.C.M. INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE |
dc.subject.por.fl_str_mv |
external beam radiation therapy neoplasms patients prostate radiotherapy side effects toxicity urinary tract |
topic |
external beam radiation therapy neoplasms patients prostate radiotherapy side effects toxicity urinary tract |
description |
BACKGROUND: Radiatiotherapy is often associated with a wide range of significant side effects. These side effects are commonly classified as acute or delayed according to when they manifest in relation to treatment. METHODS: This study aimed to evaluate acute toxicity in patients with prostate cancer treated with conformational radiotherapy (3D) in an Oncology Unit in Eastern Minas Gerais. A prospective, observational, cohort study was performed through a non-probabilistic sampling of convenience, totalazing 45 patients. Patients included in the study were followed from the start of treatment to 3 months after external beam radiation therapy (EBRT). RESULTS: Demographic Characteristics - Of the 45 patients included, mean age was 70.6 ?? 8.3 (SD) years, and predominantly white (44.0 %). The majority were married (75.6 %). Considering the risk classification, there was a homogeneous distribution between the low (33.3 %), intermediate (31.1 %) and high (35.6 %) levels. The majority of the patients (57.8 %) had a low risk (T1) classification, followed by intermediate risk classification (33.3%) and high risk (8.9 %). In the Gleason score, 44.4 % presented values below 6 (low), 40.0 % intermediate, and 15.5 % high. 62.2 % had a PSA level less than 10 ng.mL-1, 22.2 % had an intermediate level, from 10 to 20 ng.mL-1 and 15.6%, above 20 ng.mL-1. Manifestation of acute toxicity - It was observed that the majority (59.1 %) of the acute effects manifested during the first consultation, prevailing the symptom of urinary frequency (64.1 %). Regarding the symptoms of acute effects most prevalent during the three consultations, we highlight the urinary frequency with 44.0 %, followed by the urinary residue (20.0 %). CONCLUSION: 80.0 % of the patients presented acute effects during radiotherapy, being the urinary frequency the event more frequent (44.0 %), followed by urinary residue (20.0 %). Eighteen patients (40.0 %) presented only one acute effect and 59.1 % of the effects were observed at the first visit. |
publishDate |
2020 |
dc.date.evento.pt_BR.fl_str_mv |
October 21-25, 2019 |
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2020-01-07T13:20:59Z |
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2020-01-07T13:20:59Z |
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