Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy

Detalhes bibliográficos
Autor(a) principal: CARLECH, HIGOR S.
Data de Publicação: 2020
Outros Autores: LISBOA, ANA C.V.C., VITAL, MARCILIO L., ZEITUNI, CARLOS A., ROSTELATO, MARIA E.C.M., INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
Tipo de documento: Artigo de conferência
Título da fonte: Repositório Institucional do IPEN
Texto Completo: http://repositorio.ipen.br/handle/123456789/30584
Resumo: BACKGROUND: Radiatiotherapy is often associated with a wide range of significant side effects. These side effects are commonly classified as acute or delayed according to when they manifest in relation to treatment. METHODS: This study aimed to evaluate acute toxicity in patients with prostate cancer treated with conformational radiotherapy (3D) in an Oncology Unit in Eastern Minas Gerais. A prospective, observational, cohort study was performed through a non-probabilistic sampling of convenience, totalazing 45 patients. Patients included in the study were followed from the start of treatment to 3 months after external beam radiation therapy (EBRT). RESULTS: Demographic Characteristics - Of the 45 patients included, mean age was 70.6 ?? 8.3 (SD) years, and predominantly white (44.0 %). The majority were married (75.6 %). Considering the risk classification, there was a homogeneous distribution between the low (33.3 %), intermediate (31.1 %) and high (35.6 %) levels. The majority of the patients (57.8 %) had a low risk (T1) classification, followed by intermediate risk classification (33.3%) and high risk (8.9 %). In the Gleason score, 44.4 % presented values below 6 (low), 40.0 % intermediate, and 15.5 % high. 62.2 % had a PSA level less than 10 ng.mL-1, 22.2 % had an intermediate level, from 10 to 20 ng.mL-1 and 15.6%, above 20 ng.mL-1. Manifestation of acute toxicity - It was observed that the majority (59.1 %) of the acute effects manifested during the first consultation, prevailing the symptom of urinary frequency (64.1 %). Regarding the symptoms of acute effects most prevalent during the three consultations, we highlight the urinary frequency with 44.0 %, followed by the urinary residue (20.0 %). CONCLUSION: 80.0 % of the patients presented acute effects during radiotherapy, being the urinary frequency the event more frequent (44.0 %), followed by urinary residue (20.0 %). Eighteen patients (40.0 %) presented only one acute effect and 59.1 % of the effects were observed at the first visit.
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spelling 2020-01-07T13:20:59Z2020-01-07T13:20:59ZOctober 21-25, 2019http://repositorio.ipen.br/handle/123456789/305840000-0003-2943-60970000-0002-7303-6720BACKGROUND: Radiatiotherapy is often associated with a wide range of significant side effects. These side effects are commonly classified as acute or delayed according to when they manifest in relation to treatment. METHODS: This study aimed to evaluate acute toxicity in patients with prostate cancer treated with conformational radiotherapy (3D) in an Oncology Unit in Eastern Minas Gerais. A prospective, observational, cohort study was performed through a non-probabilistic sampling of convenience, totalazing 45 patients. Patients included in the study were followed from the start of treatment to 3 months after external beam radiation therapy (EBRT). RESULTS: Demographic Characteristics - Of the 45 patients included, mean age was 70.6 ?? 8.3 (SD) years, and predominantly white (44.0 %). The majority were married (75.6 %). Considering the risk classification, there was a homogeneous distribution between the low (33.3 %), intermediate (31.1 %) and high (35.6 %) levels. The majority of the patients (57.8 %) had a low risk (T1) classification, followed by intermediate risk classification (33.3%) and high risk (8.9 %). In the Gleason score, 44.4 % presented values below 6 (low), 40.0 % intermediate, and 15.5 % high. 62.2 % had a PSA level less than 10 ng.mL-1, 22.2 % had an intermediate level, from 10 to 20 ng.mL-1 and 15.6%, above 20 ng.mL-1. Manifestation of acute toxicity - It was observed that the majority (59.1 %) of the acute effects manifested during the first consultation, prevailing the symptom of urinary frequency (64.1 %). Regarding the symptoms of acute effects most prevalent during the three consultations, we highlight the urinary frequency with 44.0 %, followed by the urinary residue (20.0 %). CONCLUSION: 80.0 % of the patients presented acute effects during radiotherapy, being the urinary frequency the event more frequent (44.0 %), followed by urinary residue (20.0 %). Eighteen patients (40.0 %) presented only one acute effect and 59.1 % of the effects were observed at the first visit.Submitted by Celia Satomi Uehara (celia.u-topservice@ipen.br) on 2020-01-07T13:20:59Z No. of bitstreams: 1 26234.pdf: 341747 bytes, checksum: d247d3a095d1aacc0d16cc58558e9522 (MD5)Made available in DSpace on 2020-01-07T13:20:59Z (GMT). No. of bitstreams: 1 26234.pdf: 341747 bytes, checksum: d247d3a095d1aacc0d16cc58558e9522 (MD5)1797-1809Associa????o Brasileira de Energia Nuclearexternal beam radiation therapyneoplasmspatientsprostateradiotherapyside effectstoxicityurinary tractEvaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectINACIRio de JaneiroSantos, SP146919447600600600CARLECH, HIGOR S.LISBOA, ANA C.V.C.VITAL, MARCILIO L.ZEITUNI, CARLOS A.ROSTELATO, MARIA E.C.M.INTERNATIONAL NUCLEAR ATLANTIC CONFERENCEinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN262342019ROSTELATO, MARIA E.C.M.ZEITUNI, CARLOS A.CARLECH, HIGOR S.20-01Proceedings794414691choort with 45 patientsROSTELATO, MARIA E.C.M.:7:230:NZEITUNI, CARLOS A.:944:230:NCARLECH, HIGOR S.:14691:230:SORIGINAL26234.pdf26234.pdfapplication/pdf341747http://repositorio.ipen.br/bitstream/123456789/30584/1/26234.pdfd247d3a095d1aacc0d16cc58558e9522MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/30584/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/305842020-04-06 14:00:53.199oai:repositorio.ipen.br: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Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102020-04-06T14:00:53Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false
dc.title.pt_BR.fl_str_mv Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy
title Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy
spellingShingle Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy
CARLECH, HIGOR S.
external beam radiation therapy
neoplasms
patients
prostate
radiotherapy
side effects
toxicity
urinary tract
title_short Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy
title_full Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy
title_fullStr Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy
title_full_unstemmed Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy
title_sort Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy
author CARLECH, HIGOR S.
author_facet CARLECH, HIGOR S.
LISBOA, ANA C.V.C.
VITAL, MARCILIO L.
ZEITUNI, CARLOS A.
ROSTELATO, MARIA E.C.M.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
author_role author
author2 LISBOA, ANA C.V.C.
VITAL, MARCILIO L.
ZEITUNI, CARLOS A.
ROSTELATO, MARIA E.C.M.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv CARLECH, HIGOR S.
LISBOA, ANA C.V.C.
VITAL, MARCILIO L.
ZEITUNI, CARLOS A.
ROSTELATO, MARIA E.C.M.
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
dc.subject.por.fl_str_mv external beam radiation therapy
neoplasms
patients
prostate
radiotherapy
side effects
toxicity
urinary tract
topic external beam radiation therapy
neoplasms
patients
prostate
radiotherapy
side effects
toxicity
urinary tract
description BACKGROUND: Radiatiotherapy is often associated with a wide range of significant side effects. These side effects are commonly classified as acute or delayed according to when they manifest in relation to treatment. METHODS: This study aimed to evaluate acute toxicity in patients with prostate cancer treated with conformational radiotherapy (3D) in an Oncology Unit in Eastern Minas Gerais. A prospective, observational, cohort study was performed through a non-probabilistic sampling of convenience, totalazing 45 patients. Patients included in the study were followed from the start of treatment to 3 months after external beam radiation therapy (EBRT). RESULTS: Demographic Characteristics - Of the 45 patients included, mean age was 70.6 ?? 8.3 (SD) years, and predominantly white (44.0 %). The majority were married (75.6 %). Considering the risk classification, there was a homogeneous distribution between the low (33.3 %), intermediate (31.1 %) and high (35.6 %) levels. The majority of the patients (57.8 %) had a low risk (T1) classification, followed by intermediate risk classification (33.3%) and high risk (8.9 %). In the Gleason score, 44.4 % presented values below 6 (low), 40.0 % intermediate, and 15.5 % high. 62.2 % had a PSA level less than 10 ng.mL-1, 22.2 % had an intermediate level, from 10 to 20 ng.mL-1 and 15.6%, above 20 ng.mL-1. Manifestation of acute toxicity - It was observed that the majority (59.1 %) of the acute effects manifested during the first consultation, prevailing the symptom of urinary frequency (64.1 %). Regarding the symptoms of acute effects most prevalent during the three consultations, we highlight the urinary frequency with 44.0 %, followed by the urinary residue (20.0 %). CONCLUSION: 80.0 % of the patients presented acute effects during radiotherapy, being the urinary frequency the event more frequent (44.0 %), followed by urinary residue (20.0 %). Eighteen patients (40.0 %) presented only one acute effect and 59.1 % of the effects were observed at the first visit.
publishDate 2020
dc.date.evento.pt_BR.fl_str_mv October 21-25, 2019
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