POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENT
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Amadeus International Multidisciplinary Journal |
Texto Completo: | https://amadeusjournal.emnuvens.com.br/amadeus/article/view/36 |
Resumo: | Since the twentieth century, humanity has been experiencing a public health reality marked by numerous mosquito-borne diseases (belonging to the arthropod class), known as arboviruses. The Zika virus has become in recent years a risk to Brazilian and international public health due to its devastating effect due to its pathogenesis but also to fetal neurological development, causing serious health problems such as microcephaly and Guillain-Barré Syndrome, but also myelitis and meningoencephalitis. However, scientists studying the Zika virus have been trying to use the agent's ability to cause infections in healthy cells to attack and destroy cancer cells, such as the case of grade IV astrocytoma known as Gliobastoma Multiforme (GBM), which is a tumor of the very aggressive central nervous system and worse prognosis among primary cancers. As a result of effective therapy for GBM and the tropism of this etiological agent for brain cells, the hypothesis is that this virus would cause cell death in glioblastomas through metabolic alterations induced by the induced viral infection, but further studies must be carried out to demonstrate this therapeutic advantage in using the virus for the treatment of this malignant disease. Keywords: Zika virus; Gliobastoma Multiforme; Tumor of the Central Nervous System. |
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POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENTSince the twentieth century, humanity has been experiencing a public health reality marked by numerous mosquito-borne diseases (belonging to the arthropod class), known as arboviruses. The Zika virus has become in recent years a risk to Brazilian and international public health due to its devastating effect due to its pathogenesis but also to fetal neurological development, causing serious health problems such as microcephaly and Guillain-Barré Syndrome, but also myelitis and meningoencephalitis. However, scientists studying the Zika virus have been trying to use the agent's ability to cause infections in healthy cells to attack and destroy cancer cells, such as the case of grade IV astrocytoma known as Gliobastoma Multiforme (GBM), which is a tumor of the very aggressive central nervous system and worse prognosis among primary cancers. As a result of effective therapy for GBM and the tropism of this etiological agent for brain cells, the hypothesis is that this virus would cause cell death in glioblastomas through metabolic alterations induced by the induced viral infection, but further studies must be carried out to demonstrate this therapeutic advantage in using the virus for the treatment of this malignant disease. Keywords: Zika virus; Gliobastoma Multiforme; Tumor of the Central Nervous System.Instituto Persona de Educação Superior2018-07-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://amadeusjournal.emnuvens.com.br/amadeus/article/view/3610.14295/aimj.v2i4.36Amadeus International Multidisciplinary Journal; Vol. 2 No. 4 (2018); 106-111Amadeus International Multidisciplinary Journal; v. 2 n. 4 (2018); 106-1112525-8281reponame:Amadeus International Multidisciplinary Journalinstname:Instituto Persona de Educação Superiorinstacron:IPESenghttps://amadeusjournal.emnuvens.com.br/amadeus/article/view/36/94Copyright (c) 2018 Amadeus International Multidisciplinary Journalinfo:eu-repo/semantics/openAccessNascimento, Sâmia Israele Braz doSantos, Sheezara Teles Lira dosAlves, Bárbara TorquatoAguilera, Kevellyn CruzMenezes, Airton César Pinheiro deAlencar, Ana Maria CorreiaAndrade, Ana Maria Lima Carneiro deLeite, Daniel GonçalvesMelo, Antonio Marlos Duarte de2018-09-01T20:56:03Zoai:ojs.emnuvens.com.br:article/36Revistahttps://amadeusjournal.emnuvens.com.br/amadeus/indexPRIhttps://amadeusjournal.emnuvens.com.br/amadeus/oaiamadeusjournal@gmail.com2525-82812525-8281opendoar:2023-01-12T16:39:17.177317Amadeus International Multidisciplinary Journal - Instituto Persona de Educação Superiorfalse |
dc.title.none.fl_str_mv |
POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENT |
title |
POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENT |
spellingShingle |
POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENT Nascimento, Sâmia Israele Braz do |
title_short |
POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENT |
title_full |
POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENT |
title_fullStr |
POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENT |
title_full_unstemmed |
POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENT |
title_sort |
POTENTIAL THERAPEUTIC EFFECT OF ZIKA VIRUS IN GLIOBLASTOMA TREATMENT |
author |
Nascimento, Sâmia Israele Braz do |
author_facet |
Nascimento, Sâmia Israele Braz do Santos, Sheezara Teles Lira dos Alves, Bárbara Torquato Aguilera, Kevellyn Cruz Menezes, Airton César Pinheiro de Alencar, Ana Maria Correia Andrade, Ana Maria Lima Carneiro de Leite, Daniel Gonçalves Melo, Antonio Marlos Duarte de |
author_role |
author |
author2 |
Santos, Sheezara Teles Lira dos Alves, Bárbara Torquato Aguilera, Kevellyn Cruz Menezes, Airton César Pinheiro de Alencar, Ana Maria Correia Andrade, Ana Maria Lima Carneiro de Leite, Daniel Gonçalves Melo, Antonio Marlos Duarte de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nascimento, Sâmia Israele Braz do Santos, Sheezara Teles Lira dos Alves, Bárbara Torquato Aguilera, Kevellyn Cruz Menezes, Airton César Pinheiro de Alencar, Ana Maria Correia Andrade, Ana Maria Lima Carneiro de Leite, Daniel Gonçalves Melo, Antonio Marlos Duarte de |
description |
Since the twentieth century, humanity has been experiencing a public health reality marked by numerous mosquito-borne diseases (belonging to the arthropod class), known as arboviruses. The Zika virus has become in recent years a risk to Brazilian and international public health due to its devastating effect due to its pathogenesis but also to fetal neurological development, causing serious health problems such as microcephaly and Guillain-Barré Syndrome, but also myelitis and meningoencephalitis. However, scientists studying the Zika virus have been trying to use the agent's ability to cause infections in healthy cells to attack and destroy cancer cells, such as the case of grade IV astrocytoma known as Gliobastoma Multiforme (GBM), which is a tumor of the very aggressive central nervous system and worse prognosis among primary cancers. As a result of effective therapy for GBM and the tropism of this etiological agent for brain cells, the hypothesis is that this virus would cause cell death in glioblastomas through metabolic alterations induced by the induced viral infection, but further studies must be carried out to demonstrate this therapeutic advantage in using the virus for the treatment of this malignant disease. Keywords: Zika virus; Gliobastoma Multiforme; Tumor of the Central Nervous System. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://amadeusjournal.emnuvens.com.br/amadeus/article/view/36 10.14295/aimj.v2i4.36 |
url |
https://amadeusjournal.emnuvens.com.br/amadeus/article/view/36 |
identifier_str_mv |
10.14295/aimj.v2i4.36 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://amadeusjournal.emnuvens.com.br/amadeus/article/view/36/94 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Amadeus International Multidisciplinary Journal info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Amadeus International Multidisciplinary Journal |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Persona de Educação Superior |
publisher.none.fl_str_mv |
Instituto Persona de Educação Superior |
dc.source.none.fl_str_mv |
Amadeus International Multidisciplinary Journal; Vol. 2 No. 4 (2018); 106-111 Amadeus International Multidisciplinary Journal; v. 2 n. 4 (2018); 106-111 2525-8281 reponame:Amadeus International Multidisciplinary Journal instname:Instituto Persona de Educação Superior instacron:IPES |
instname_str |
Instituto Persona de Educação Superior |
instacron_str |
IPES |
institution |
IPES |
reponame_str |
Amadeus International Multidisciplinary Journal |
collection |
Amadeus International Multidisciplinary Journal |
repository.name.fl_str_mv |
Amadeus International Multidisciplinary Journal - Instituto Persona de Educação Superior |
repository.mail.fl_str_mv |
amadeusjournal@gmail.com |
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1797051333794070528 |