Formulation development and evaluation of Silybum marianum tablets

Detalhes bibliográficos
Autor(a) principal: Cianchino,Valeria Andrea
Data de Publicação: 2020
Outros Autores: Favier,Laura Silvina, Ortega,Claudia Alicia, Peralta,Cecilia, Cifuente,Diego Alberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Rodriguésia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2175-78602020000100706
Resumo: Abstract In popular medicine Silybum marianum is used as a hepatoprotective agent. Silymarin is the major constituent. The present work deals with the formulation and evaluation of S. marianum tablets from ethanolic extract by direct compression. The ethanolic extract was obtained from seeds by soxhlet extraction. Two pharmaceutical formulations were prepared using fluid extract as an active principle, and Aeroperl® 300 Pharma as a carrier. In order to improve flow ability and compressibility, co-processed excipients MicroceLac® 100 and FlowLac® 90 were employed. Pre-compression and post-compression parameters were evaluated according to USP 34-NF 29. Besides, silymarin was determined by NMR spectral data. Both formulations showed excellent rheological properties and the best biopharmaceutical parameters were observed in F2 (S. marianum ethanolic extract, aeroperl® 300 Pharma, flowLac® 90, glycolate starch and magnesium stearate) in terms of the friability (0.82 %) and the disintegration time (8.05 min).
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spelling Formulation development and evaluation of Silybum marianum tabletsdirect compressionethanolic extractherbal tabletsquality controlsSilybum marianumAbstract In popular medicine Silybum marianum is used as a hepatoprotective agent. Silymarin is the major constituent. The present work deals with the formulation and evaluation of S. marianum tablets from ethanolic extract by direct compression. The ethanolic extract was obtained from seeds by soxhlet extraction. Two pharmaceutical formulations were prepared using fluid extract as an active principle, and Aeroperl® 300 Pharma as a carrier. In order to improve flow ability and compressibility, co-processed excipients MicroceLac® 100 and FlowLac® 90 were employed. Pre-compression and post-compression parameters were evaluated according to USP 34-NF 29. Besides, silymarin was determined by NMR spectral data. Both formulations showed excellent rheological properties and the best biopharmaceutical parameters were observed in F2 (S. marianum ethanolic extract, aeroperl® 300 Pharma, flowLac® 90, glycolate starch and magnesium stearate) in terms of the friability (0.82 %) and the disintegration time (8.05 min).Instituto de Pesquisas Jardim Botânico do Rio de Janeiro2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2175-78602020000100706Rodriguésia v.71 2020reponame:Rodriguésia (Online)instname:Instituto de Pesquisas Jardim Botânico do Rio de Janeiro (JBRJ)instacron:JBRJ10.1590/2175-7860202071044info:eu-repo/semantics/openAccessCianchino,Valeria AndreaFavier,Laura SilvinaOrtega,Claudia AliciaPeralta,CeciliaCifuente,Diego Albertoeng2020-07-17T00:00:00Zoai:scielo:S2175-78602020000100706Revistahttp://rodriguesia.jbrj.gov.br/https://old.scielo.br/oai/scielo-oai.phprodriguesia@jbrj.gov.br2175-78600370-6583opendoar:2020-07-17T00:00Rodriguésia (Online) - Instituto de Pesquisas Jardim Botânico do Rio de Janeiro (JBRJ)false
dc.title.none.fl_str_mv Formulation development and evaluation of Silybum marianum tablets
title Formulation development and evaluation of Silybum marianum tablets
spellingShingle Formulation development and evaluation of Silybum marianum tablets
Cianchino,Valeria Andrea
direct compression
ethanolic extract
herbal tablets
quality controls
Silybum marianum
title_short Formulation development and evaluation of Silybum marianum tablets
title_full Formulation development and evaluation of Silybum marianum tablets
title_fullStr Formulation development and evaluation of Silybum marianum tablets
title_full_unstemmed Formulation development and evaluation of Silybum marianum tablets
title_sort Formulation development and evaluation of Silybum marianum tablets
author Cianchino,Valeria Andrea
author_facet Cianchino,Valeria Andrea
Favier,Laura Silvina
Ortega,Claudia Alicia
Peralta,Cecilia
Cifuente,Diego Alberto
author_role author
author2 Favier,Laura Silvina
Ortega,Claudia Alicia
Peralta,Cecilia
Cifuente,Diego Alberto
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cianchino,Valeria Andrea
Favier,Laura Silvina
Ortega,Claudia Alicia
Peralta,Cecilia
Cifuente,Diego Alberto
dc.subject.por.fl_str_mv direct compression
ethanolic extract
herbal tablets
quality controls
Silybum marianum
topic direct compression
ethanolic extract
herbal tablets
quality controls
Silybum marianum
description Abstract In popular medicine Silybum marianum is used as a hepatoprotective agent. Silymarin is the major constituent. The present work deals with the formulation and evaluation of S. marianum tablets from ethanolic extract by direct compression. The ethanolic extract was obtained from seeds by soxhlet extraction. Two pharmaceutical formulations were prepared using fluid extract as an active principle, and Aeroperl® 300 Pharma as a carrier. In order to improve flow ability and compressibility, co-processed excipients MicroceLac® 100 and FlowLac® 90 were employed. Pre-compression and post-compression parameters were evaluated according to USP 34-NF 29. Besides, silymarin was determined by NMR spectral data. Both formulations showed excellent rheological properties and the best biopharmaceutical parameters were observed in F2 (S. marianum ethanolic extract, aeroperl® 300 Pharma, flowLac® 90, glycolate starch and magnesium stearate) in terms of the friability (0.82 %) and the disintegration time (8.05 min).
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2175-78602020000100706
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2175-78602020000100706
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/2175-7860202071044
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Pesquisas Jardim Botânico do Rio de Janeiro
publisher.none.fl_str_mv Instituto de Pesquisas Jardim Botânico do Rio de Janeiro
dc.source.none.fl_str_mv Rodriguésia v.71 2020
reponame:Rodriguésia (Online)
instname:Instituto de Pesquisas Jardim Botânico do Rio de Janeiro (JBRJ)
instacron:JBRJ
instname_str Instituto de Pesquisas Jardim Botânico do Rio de Janeiro (JBRJ)
instacron_str JBRJ
institution JBRJ
reponame_str Rodriguésia (Online)
collection Rodriguésia (Online)
repository.name.fl_str_mv Rodriguésia (Online) - Instituto de Pesquisas Jardim Botânico do Rio de Janeiro (JBRJ)
repository.mail.fl_str_mv rodriguesia@jbrj.gov.br
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