Cytokines in cerebrospinal fluid of children with West syndrome
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of epilepsy and clinical neurophysiology (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492012000200010 |
Resumo: | In this study we aimed to determine the levels of tumor necrosis factor beta (TNF-b), interleukin (IL) 1-beta (IL-1b), IL-5, IL-10, and interferon gamma (IFN-g ) in CSF from children during the onset of West syndrome (WS). We observed elevated levels of IL-1b and IFN-g correlated to clinical, EEG, therapeutic response, and follow-up suggesting the involvement of immune response in WS. These results suggest that inflammatory and immunologic mediators may play a role in the pathophysiologic mechanisms of infantile spasms. Our findings may explain the perfusion and cognitive disfunctions and actions of adrenocorticotropic hormone (ACTH), corticosteroids, and intravenous immunoglobulin (IVIg) observed in WS. In conclusion, WS results from association of neurophysiological mechanisms and structural abnormalities with participation of cytokines mainly in symptomatic group. |
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Journal of epilepsy and clinical neurophysiology (Online) |
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Cytokines in cerebrospinal fluid of children with West syndromeepilepsyWest syndromeinfantile spasmscytokinesIn this study we aimed to determine the levels of tumor necrosis factor beta (TNF-b), interleukin (IL) 1-beta (IL-1b), IL-5, IL-10, and interferon gamma (IFN-g ) in CSF from children during the onset of West syndrome (WS). We observed elevated levels of IL-1b and IFN-g correlated to clinical, EEG, therapeutic response, and follow-up suggesting the involvement of immune response in WS. These results suggest that inflammatory and immunologic mediators may play a role in the pathophysiologic mechanisms of infantile spasms. Our findings may explain the perfusion and cognitive disfunctions and actions of adrenocorticotropic hormone (ACTH), corticosteroids, and intravenous immunoglobulin (IVIg) observed in WS. In conclusion, WS results from association of neurophysiological mechanisms and structural abnormalities with participation of cytokines mainly in symptomatic group.Liga Brasileira de Epilepsia (LBE)2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492012000200010Journal of Epilepsy and Clinical Neurophysiology v.18 n.2 2012reponame:Journal of epilepsy and clinical neurophysiology (Online)instname:Liga Brasileira de Epilepsia (LBE)instacron:LBE10.1590/S1676-26492012000200010info:eu-repo/semantics/openAccessSousa,MA Dias deBonatti,RCFRodrigues Jr,VAzevedo,DSSantos,MHAPereira,ROLLeboreiro-Fernandez,Aeng2012-12-07T00:00:00Zoai:scielo:S1676-26492012000200010Revistahttp://epilepsia.org.br/publicacoes/ONGhttps://old.scielo.br/oai/scielo-oai.php||jecnpoa@terra.com.br1980-53651676-2649opendoar:2012-12-07T00:00Journal of epilepsy and clinical neurophysiology (Online) - Liga Brasileira de Epilepsia (LBE)false |
dc.title.none.fl_str_mv |
Cytokines in cerebrospinal fluid of children with West syndrome |
title |
Cytokines in cerebrospinal fluid of children with West syndrome |
spellingShingle |
Cytokines in cerebrospinal fluid of children with West syndrome Sousa,MA Dias de epilepsy West syndrome infantile spasms cytokines |
title_short |
Cytokines in cerebrospinal fluid of children with West syndrome |
title_full |
Cytokines in cerebrospinal fluid of children with West syndrome |
title_fullStr |
Cytokines in cerebrospinal fluid of children with West syndrome |
title_full_unstemmed |
Cytokines in cerebrospinal fluid of children with West syndrome |
title_sort |
Cytokines in cerebrospinal fluid of children with West syndrome |
author |
Sousa,MA Dias de |
author_facet |
Sousa,MA Dias de Bonatti,RCF Rodrigues Jr,V Azevedo,DS Santos,MHA Pereira,ROL Leboreiro-Fernandez,A |
author_role |
author |
author2 |
Bonatti,RCF Rodrigues Jr,V Azevedo,DS Santos,MHA Pereira,ROL Leboreiro-Fernandez,A |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Sousa,MA Dias de Bonatti,RCF Rodrigues Jr,V Azevedo,DS Santos,MHA Pereira,ROL Leboreiro-Fernandez,A |
dc.subject.por.fl_str_mv |
epilepsy West syndrome infantile spasms cytokines |
topic |
epilepsy West syndrome infantile spasms cytokines |
description |
In this study we aimed to determine the levels of tumor necrosis factor beta (TNF-b), interleukin (IL) 1-beta (IL-1b), IL-5, IL-10, and interferon gamma (IFN-g ) in CSF from children during the onset of West syndrome (WS). We observed elevated levels of IL-1b and IFN-g correlated to clinical, EEG, therapeutic response, and follow-up suggesting the involvement of immune response in WS. These results suggest that inflammatory and immunologic mediators may play a role in the pathophysiologic mechanisms of infantile spasms. Our findings may explain the perfusion and cognitive disfunctions and actions of adrenocorticotropic hormone (ACTH), corticosteroids, and intravenous immunoglobulin (IVIg) observed in WS. In conclusion, WS results from association of neurophysiological mechanisms and structural abnormalities with participation of cytokines mainly in symptomatic group. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492012000200010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492012000200010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1676-26492012000200010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Liga Brasileira de Epilepsia (LBE) |
publisher.none.fl_str_mv |
Liga Brasileira de Epilepsia (LBE) |
dc.source.none.fl_str_mv |
Journal of Epilepsy and Clinical Neurophysiology v.18 n.2 2012 reponame:Journal of epilepsy and clinical neurophysiology (Online) instname:Liga Brasileira de Epilepsia (LBE) instacron:LBE |
instname_str |
Liga Brasileira de Epilepsia (LBE) |
instacron_str |
LBE |
institution |
LBE |
reponame_str |
Journal of epilepsy and clinical neurophysiology (Online) |
collection |
Journal of epilepsy and clinical neurophysiology (Online) |
repository.name.fl_str_mv |
Journal of epilepsy and clinical neurophysiology (Online) - Liga Brasileira de Epilepsia (LBE) |
repository.mail.fl_str_mv |
||jecnpoa@terra.com.br |
_version_ |
1754734659789389824 |