Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of epilepsy and clinical neurophysiology (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492007000200005 |
Resumo: | INTRODUCTION: In this study the authors review the outcomes of 22 patients with medically refractory epilepsy and slow growth brain tumors. OBJECTIVES: Evaluate the clinical, electrophysiological, operative, and histopathological features. PATIENTS AND RESULTS: The majority of the tumors were located in the temporal lobe (n = 20) and involved the cortical gray matter. The most frequent tumors were gangliogliomas (n = 9), astrocytomas grade I and II (n = 6), dysembryoplastic neuroepithelial tumors (n = 5) and ganglioneuroma (n = 2). The biological behavior of the tumors was strikingly indolent, as indicated by a long preoperative history of chronic seizures (mean, 14 years). Mean follow-up time after resection was 27 months, and according to Engels classification, 85% were seizure-free, 10% showed a reduction of seizure frequency of at least 90%, and 5% had reduction in seizure frequency at least 75%. CONCLUSION: The data indicate that neoplasms associated with pharmacoresistent epilepsy constitute a distinct clinicopathological group of tumors that arise in young patients, involve the cortex, and exhibit indolent biological behavior for many years. Complete surgical removal of these tumors, including the epileptogenic area, can achieve excellent seizure control. |
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Journal of epilepsy and clinical neurophysiology (Online) |
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Clinical features and surgical outcome of patients with indolent brain tumors and epilepsyindolent brain tumorsepilepsysurgical outcomeINTRODUCTION: In this study the authors review the outcomes of 22 patients with medically refractory epilepsy and slow growth brain tumors. OBJECTIVES: Evaluate the clinical, electrophysiological, operative, and histopathological features. PATIENTS AND RESULTS: The majority of the tumors were located in the temporal lobe (n = 20) and involved the cortical gray matter. The most frequent tumors were gangliogliomas (n = 9), astrocytomas grade I and II (n = 6), dysembryoplastic neuroepithelial tumors (n = 5) and ganglioneuroma (n = 2). The biological behavior of the tumors was strikingly indolent, as indicated by a long preoperative history of chronic seizures (mean, 14 years). Mean follow-up time after resection was 27 months, and according to Engels classification, 85% were seizure-free, 10% showed a reduction of seizure frequency of at least 90%, and 5% had reduction in seizure frequency at least 75%. CONCLUSION: The data indicate that neoplasms associated with pharmacoresistent epilepsy constitute a distinct clinicopathological group of tumors that arise in young patients, involve the cortex, and exhibit indolent biological behavior for many years. Complete surgical removal of these tumors, including the epileptogenic area, can achieve excellent seizure control.Liga Brasileira de Epilepsia (LBE)2007-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492007000200005Journal of Epilepsy and Clinical Neurophysiology v.13 n.2 2007reponame:Journal of epilepsy and clinical neurophysiology (Online)instname:Liga Brasileira de Epilepsia (LBE)instacron:LBE10.1590/S1676-26492007000200005info:eu-repo/semantics/openAccessMelo,Julieta G. S. P.Centeno,Ricardo S.Malheiros,Suzana M. F.Ferraz,Fernando A. P.Stávale,João N.Carrete,Henrique H.Sakamoto,Américo C.Yacubian,Elza Márcia T.eng2007-08-14T00:00:00Zoai:scielo:S1676-26492007000200005Revistahttp://epilepsia.org.br/publicacoes/ONGhttps://old.scielo.br/oai/scielo-oai.php||jecnpoa@terra.com.br1980-53651676-2649opendoar:2007-08-14T00:00Journal of epilepsy and clinical neurophysiology (Online) - Liga Brasileira de Epilepsia (LBE)false |
dc.title.none.fl_str_mv |
Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy |
title |
Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy |
spellingShingle |
Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy Melo,Julieta G. S. P. indolent brain tumors epilepsy surgical outcome |
title_short |
Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy |
title_full |
Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy |
title_fullStr |
Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy |
title_full_unstemmed |
Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy |
title_sort |
Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy |
author |
Melo,Julieta G. S. P. |
author_facet |
Melo,Julieta G. S. P. Centeno,Ricardo S. Malheiros,Suzana M. F. Ferraz,Fernando A. P. Stávale,João N. Carrete,Henrique H. Sakamoto,Américo C. Yacubian,Elza Márcia T. |
author_role |
author |
author2 |
Centeno,Ricardo S. Malheiros,Suzana M. F. Ferraz,Fernando A. P. Stávale,João N. Carrete,Henrique H. Sakamoto,Américo C. Yacubian,Elza Márcia T. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Melo,Julieta G. S. P. Centeno,Ricardo S. Malheiros,Suzana M. F. Ferraz,Fernando A. P. Stávale,João N. Carrete,Henrique H. Sakamoto,Américo C. Yacubian,Elza Márcia T. |
dc.subject.por.fl_str_mv |
indolent brain tumors epilepsy surgical outcome |
topic |
indolent brain tumors epilepsy surgical outcome |
description |
INTRODUCTION: In this study the authors review the outcomes of 22 patients with medically refractory epilepsy and slow growth brain tumors. OBJECTIVES: Evaluate the clinical, electrophysiological, operative, and histopathological features. PATIENTS AND RESULTS: The majority of the tumors were located in the temporal lobe (n = 20) and involved the cortical gray matter. The most frequent tumors were gangliogliomas (n = 9), astrocytomas grade I and II (n = 6), dysembryoplastic neuroepithelial tumors (n = 5) and ganglioneuroma (n = 2). The biological behavior of the tumors was strikingly indolent, as indicated by a long preoperative history of chronic seizures (mean, 14 years). Mean follow-up time after resection was 27 months, and according to Engels classification, 85% were seizure-free, 10% showed a reduction of seizure frequency of at least 90%, and 5% had reduction in seizure frequency at least 75%. CONCLUSION: The data indicate that neoplasms associated with pharmacoresistent epilepsy constitute a distinct clinicopathological group of tumors that arise in young patients, involve the cortex, and exhibit indolent biological behavior for many years. Complete surgical removal of these tumors, including the epileptogenic area, can achieve excellent seizure control. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492007000200005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492007000200005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1676-26492007000200005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Liga Brasileira de Epilepsia (LBE) |
publisher.none.fl_str_mv |
Liga Brasileira de Epilepsia (LBE) |
dc.source.none.fl_str_mv |
Journal of Epilepsy and Clinical Neurophysiology v.13 n.2 2007 reponame:Journal of epilepsy and clinical neurophysiology (Online) instname:Liga Brasileira de Epilepsia (LBE) instacron:LBE |
instname_str |
Liga Brasileira de Epilepsia (LBE) |
instacron_str |
LBE |
institution |
LBE |
reponame_str |
Journal of epilepsy and clinical neurophysiology (Online) |
collection |
Journal of epilepsy and clinical neurophysiology (Online) |
repository.name.fl_str_mv |
Journal of epilepsy and clinical neurophysiology (Online) - Liga Brasileira de Epilepsia (LBE) |
repository.mail.fl_str_mv |
||jecnpoa@terra.com.br |
_version_ |
1754734659142418432 |