Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy

Detalhes bibliográficos
Autor(a) principal: Melo,Julieta G. S. P.
Data de Publicação: 2007
Outros Autores: Centeno,Ricardo S., Malheiros,Suzana M. F., Ferraz,Fernando A. P., Stávale,João N., Carrete,Henrique H., Sakamoto,Américo C., Yacubian,Elza Márcia T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of epilepsy and clinical neurophysiology (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492007000200005
Resumo: INTRODUCTION: In this study the authors review the outcomes of 22 patients with medically refractory epilepsy and slow growth brain tumors. OBJECTIVES: Evaluate the clinical, electrophysiological, operative, and histopathological features. PATIENTS AND RESULTS: The majority of the tumors were located in the temporal lobe (n = 20) and involved the cortical gray matter. The most frequent tumors were gangliogliomas (n = 9), astrocytomas grade I and II (n = 6), dysembryoplastic neuroepithelial tumors (n = 5) and ganglioneuroma (n = 2). The biological behavior of the tumors was strikingly indolent, as indicated by a long preoperative history of chronic seizures (mean, 14 years). Mean follow-up time after resection was 27 months, and according to Engel’s classification, 85% were seizure-free, 10% showed a reduction of seizure frequency of at least 90%, and 5% had reduction in seizure frequency at least 75%. CONCLUSION: The data indicate that neoplasms associated with pharmacoresistent epilepsy constitute a distinct clinicopathological group of tumors that arise in young patients, involve the cortex, and exhibit indolent biological behavior for many years. Complete surgical removal of these tumors, including the epileptogenic area, can achieve excellent seizure control.
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spelling Clinical features and surgical outcome of patients with indolent brain tumors and epilepsyindolent brain tumorsepilepsysurgical outcomeINTRODUCTION: In this study the authors review the outcomes of 22 patients with medically refractory epilepsy and slow growth brain tumors. OBJECTIVES: Evaluate the clinical, electrophysiological, operative, and histopathological features. PATIENTS AND RESULTS: The majority of the tumors were located in the temporal lobe (n = 20) and involved the cortical gray matter. The most frequent tumors were gangliogliomas (n = 9), astrocytomas grade I and II (n = 6), dysembryoplastic neuroepithelial tumors (n = 5) and ganglioneuroma (n = 2). The biological behavior of the tumors was strikingly indolent, as indicated by a long preoperative history of chronic seizures (mean, 14 years). Mean follow-up time after resection was 27 months, and according to Engel’s classification, 85% were seizure-free, 10% showed a reduction of seizure frequency of at least 90%, and 5% had reduction in seizure frequency at least 75%. CONCLUSION: The data indicate that neoplasms associated with pharmacoresistent epilepsy constitute a distinct clinicopathological group of tumors that arise in young patients, involve the cortex, and exhibit indolent biological behavior for many years. Complete surgical removal of these tumors, including the epileptogenic area, can achieve excellent seizure control.Liga Brasileira de Epilepsia (LBE)2007-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492007000200005Journal of Epilepsy and Clinical Neurophysiology v.13 n.2 2007reponame:Journal of epilepsy and clinical neurophysiology (Online)instname:Liga Brasileira de Epilepsia (LBE)instacron:LBE10.1590/S1676-26492007000200005info:eu-repo/semantics/openAccessMelo,Julieta G. S. P.Centeno,Ricardo S.Malheiros,Suzana M. F.Ferraz,Fernando A. P.Stávale,João N.Carrete,Henrique H.Sakamoto,Américo C.Yacubian,Elza Márcia T.eng2007-08-14T00:00:00Zoai:scielo:S1676-26492007000200005Revistahttp://epilepsia.org.br/publicacoes/ONGhttps://old.scielo.br/oai/scielo-oai.php||jecnpoa@terra.com.br1980-53651676-2649opendoar:2007-08-14T00:00Journal of epilepsy and clinical neurophysiology (Online) - Liga Brasileira de Epilepsia (LBE)false
dc.title.none.fl_str_mv Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy
title Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy
spellingShingle Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy
Melo,Julieta G. S. P.
indolent brain tumors
epilepsy
surgical outcome
title_short Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy
title_full Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy
title_fullStr Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy
title_full_unstemmed Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy
title_sort Clinical features and surgical outcome of patients with indolent brain tumors and epilepsy
author Melo,Julieta G. S. P.
author_facet Melo,Julieta G. S. P.
Centeno,Ricardo S.
Malheiros,Suzana M. F.
Ferraz,Fernando A. P.
Stávale,João N.
Carrete,Henrique H.
Sakamoto,Américo C.
Yacubian,Elza Márcia T.
author_role author
author2 Centeno,Ricardo S.
Malheiros,Suzana M. F.
Ferraz,Fernando A. P.
Stávale,João N.
Carrete,Henrique H.
Sakamoto,Américo C.
Yacubian,Elza Márcia T.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Melo,Julieta G. S. P.
Centeno,Ricardo S.
Malheiros,Suzana M. F.
Ferraz,Fernando A. P.
Stávale,João N.
Carrete,Henrique H.
Sakamoto,Américo C.
Yacubian,Elza Márcia T.
dc.subject.por.fl_str_mv indolent brain tumors
epilepsy
surgical outcome
topic indolent brain tumors
epilepsy
surgical outcome
description INTRODUCTION: In this study the authors review the outcomes of 22 patients with medically refractory epilepsy and slow growth brain tumors. OBJECTIVES: Evaluate the clinical, electrophysiological, operative, and histopathological features. PATIENTS AND RESULTS: The majority of the tumors were located in the temporal lobe (n = 20) and involved the cortical gray matter. The most frequent tumors were gangliogliomas (n = 9), astrocytomas grade I and II (n = 6), dysembryoplastic neuroepithelial tumors (n = 5) and ganglioneuroma (n = 2). The biological behavior of the tumors was strikingly indolent, as indicated by a long preoperative history of chronic seizures (mean, 14 years). Mean follow-up time after resection was 27 months, and according to Engel’s classification, 85% were seizure-free, 10% showed a reduction of seizure frequency of at least 90%, and 5% had reduction in seizure frequency at least 75%. CONCLUSION: The data indicate that neoplasms associated with pharmacoresistent epilepsy constitute a distinct clinicopathological group of tumors that arise in young patients, involve the cortex, and exhibit indolent biological behavior for many years. Complete surgical removal of these tumors, including the epileptogenic area, can achieve excellent seizure control.
publishDate 2007
dc.date.none.fl_str_mv 2007-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492007000200005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492007000200005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1676-26492007000200005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Liga Brasileira de Epilepsia (LBE)
publisher.none.fl_str_mv Liga Brasileira de Epilepsia (LBE)
dc.source.none.fl_str_mv Journal of Epilepsy and Clinical Neurophysiology v.13 n.2 2007
reponame:Journal of epilepsy and clinical neurophysiology (Online)
instname:Liga Brasileira de Epilepsia (LBE)
instacron:LBE
instname_str Liga Brasileira de Epilepsia (LBE)
instacron_str LBE
institution LBE
reponame_str Journal of epilepsy and clinical neurophysiology (Online)
collection Journal of epilepsy and clinical neurophysiology (Online)
repository.name.fl_str_mv Journal of epilepsy and clinical neurophysiology (Online) - Liga Brasileira de Epilepsia (LBE)
repository.mail.fl_str_mv ||jecnpoa@terra.com.br
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