A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?

Detalhes bibliográficos
Autor(a) principal: Cust??dio, Ricardo Wesley Alberca
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da Uninove
Texto Completo: http://bibliotecatede.uninove.br/handle/tede/1347
Resumo: Leukotrienes (LTs) play a central role in the pathophysiology of asthma. Aerobic exercise has been shown to be capable of reducing asthmatic inflammation. Therefore, this study investigated whether the anti-inflammatory effects of aerobic exercise are due to inhibition of the pathway of LTs. Forty BALB / c mice were divided into four groups: Control, Exercise, OVA and OVA + Exercise. The mice were sensitized and challenged with ovalbumin. Aerobic training was performed on a adapted treadmill, at low intensity, 5x / week, 1h / session for 4 weeks, after the establishment of airway inflammation. Total and differential cells were analized in bronchoalveolar lavage (BAL), cytokine levels in BAL, the number of lymphocytes and macrophages in the airway wall, the airway remodeling (collagen and elastic fibers, mucous production and thickness of bronchial smooth muscle), bronchial hyperresponsiveness, beyond the levels of leukotriene B4 (LTB4) and leukotriene C4 (LTC4) in BAL. In addition, immunohistochemistry was performed for 5-lipoxygenase (5-LO) LTA4 hydrolase (LTA4H) CysLT1 receptor, CysLT2 receptor, LTC4 synthase, LTB4 receptor 2 (BLT2). The results demonstrated that aerobic exercise reduced the total number of cells (p <0.05), eosinophils (p <0.05), neutrophils (p <0.001), lymphocytes (p <0.001) and macrophage (p <0.01) in BAL and the number of lymphocytes (p <0.05) and macrophages (p <0.01) in the airway wall. In addition, the accumulation of collagen fibers (p <0.01), elastic fibers (p <0.01) and mucus production (p <0.01) and the thickness of bronchial smooth muscle (P <0.05) and bronchial hyperresponsiveness levels at 25 MCh (p <0.05) and 50 MCh (p <0.01) were reduced in mice sensitized and trained. Furthermore, BAL IL-5 (p <0.05) were reduced, and the levels of LTB4 (p <0.05). The expression of 5-LO (p <0.05) LTA4H (p <0.05), the CysLT 1 receptor (p <0.05), CysLT 2 receptor (p <0.05), LTC4 synthase (p <0.05) and BLT2 (p <0.05) in peribronchial leukocytes were reduced by exercise and expression of 5-LO (p <0.05) LTA4H (p <0.05), the CysLT 1 receptor (p <0.05), CysLT 2 receptor (p <0.05), LTC4 synthase (p <0.05) and BLT2 (p <0.05) in the bronchial epithelium. We conclude that the low intensity aerobic exercise reduces phenotype of asthma by inhibiting the leukotriene pathway.
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spelling Vieira, Rodolfo de Paulahttp://lattes.cnpq.br/9213556008468472Vieira, Rodolfo de Paulahttp://lattes.cnpq.br/9213556008468472Carvalho, Fl??vio Aimbire Soares dehttp://lattes.cnpq.br/8216583445045638Oliveira, Lu??s Vicente Franco dehttp://lattes.cnpq.br/3644494034569111http://lattes.cnpq.br/7214720727458365Cust??dio, Ricardo Wesley Alberca2016-05-25T17:51:42Z2015-01-21Cust??dio, Ricardo Wesley Alberca. A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?. 2015. 96 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1347Leukotrienes (LTs) play a central role in the pathophysiology of asthma. Aerobic exercise has been shown to be capable of reducing asthmatic inflammation. Therefore, this study investigated whether the anti-inflammatory effects of aerobic exercise are due to inhibition of the pathway of LTs. Forty BALB / c mice were divided into four groups: Control, Exercise, OVA and OVA + Exercise. The mice were sensitized and challenged with ovalbumin. Aerobic training was performed on a adapted treadmill, at low intensity, 5x / week, 1h / session for 4 weeks, after the establishment of airway inflammation. Total and differential cells were analized in bronchoalveolar lavage (BAL), cytokine levels in BAL, the number of lymphocytes and macrophages in the airway wall, the airway remodeling (collagen and elastic fibers, mucous production and thickness of bronchial smooth muscle), bronchial hyperresponsiveness, beyond the levels of leukotriene B4 (LTB4) and leukotriene C4 (LTC4) in BAL. In addition, immunohistochemistry was performed for 5-lipoxygenase (5-LO) LTA4 hydrolase (LTA4H) CysLT1 receptor, CysLT2 receptor, LTC4 synthase, LTB4 receptor 2 (BLT2). The results demonstrated that aerobic exercise reduced the total number of cells (p <0.05), eosinophils (p <0.05), neutrophils (p <0.001), lymphocytes (p <0.001) and macrophage (p <0.01) in BAL and the number of lymphocytes (p <0.05) and macrophages (p <0.01) in the airway wall. In addition, the accumulation of collagen fibers (p <0.01), elastic fibers (p <0.01) and mucus production (p <0.01) and the thickness of bronchial smooth muscle (P <0.05) and bronchial hyperresponsiveness levels at 25 MCh (p <0.05) and 50 MCh (p <0.01) were reduced in mice sensitized and trained. Furthermore, BAL IL-5 (p <0.05) were reduced, and the levels of LTB4 (p <0.05). The expression of 5-LO (p <0.05) LTA4H (p <0.05), the CysLT 1 receptor (p <0.05), CysLT 2 receptor (p <0.05), LTC4 synthase (p <0.05) and BLT2 (p <0.05) in peribronchial leukocytes were reduced by exercise and expression of 5-LO (p <0.05) LTA4H (p <0.05), the CysLT 1 receptor (p <0.05), CysLT 2 receptor (p <0.05), LTC4 synthase (p <0.05) and BLT2 (p <0.05) in the bronchial epithelium. We conclude that the low intensity aerobic exercise reduces phenotype of asthma by inhibiting the leukotriene pathway.Os leucotrienos (LTs) desempenham um papel central na fisiopatologia da asma. O exerc??cio f??sico aer??bico tem demonstrado ser capaz de reduzir a inflama????o asm??tica. Portanto, este estudo investigou se os efeitos anti-inflamat??rios do exerc??cio aer??bico ocorrem devido ?? inibi????o da via dos LTs. Quarenta camundongos BALB/c machos foram distribu??dos em quatro grupos: Controle, Exerc??cio, OVA e OVA+Exerc??cio. Os camundongos foram sensibilizados e desafiados com ovalbumina. O treinamento aer??bico foi realizado em uma esteira adaptada, em intensidade leve, 5x/semana, 1h/sess??o, durante 4 semanas, ap??s o estabelecimento da inflama????o das vias a??reas. C??lulas totais e diferenciais foram analisas no lavado bronco-alveolar (BAL), os n??veis de citocinas no BAL, o n??mero de linf??citos e macr??fagos na parede das vias a??reas, o remodelamento das vias a??reas (fibras col??genas e el??sticas, produ????o de muco e da espessura do m??sculo liso br??nquico), a hiperresponsividade bronquica, al??m dos n??veis de leucotrieno B4 (LTB4) e leucotrieno C4 (LTC4) no BAL. Adicionalmente, foi realizada a imuno-histoqu??mica para 5-lipoxigenase (5-LO), LTA4-hidrolase (LTA4H), receptor de CysLT1, receptor de CysLT2, LTC4-sintase, receptor 2 de LTB4 (BLT2). Os resultados demonstraram que o exerc??cio aer??bico diminuiu o n??mero total de c??lulas (p<0.05), eosin??filos (p<0.05), neutr??filos (p<0.001), linf??citos (p<0.001) e macr??fagos (p<0.01) no BAL, bem como o n??mero de linf??citos (p<0.05) e os macr??fagos (p<0.01) na parede das vias a??reas. Al??m disso, o ac??mulo de fibras col??genas (p<0.01), fibras el??sticas (p<0.01) e produ????o de muco (p<0.01) e da espessura do m??sculo liso br??nquico (p<0.05) e os n??veis de hiperresponsividade br??nquica com 25 MCh(p<0.05) e 50 MCh (p<0.01) foi reduzida nos camundongos sensibilizados e treinados. Al??m disso, os n??veis de BAL de IL-5 (p <0,05), foram reduzidos, bem como os n??veis de LTB4 (p <0,05). A express??o da 5-LO (p <0,05), LTA4H (p <0,05), o receptor de CysLT1 (p <0,05), receptor de CysLT2 (p <0,05), LTC4-sintase (p <0,05) e BLT2 (p <0,05) nos leuc??citos peribr??nquicos foram reduzidos pelo exerc??cio e a express??o da 5-LO (p <0,05), LTA4H (p <0,05), o receptor de CysLT1 (p <0,05), o receptor de CysLT2 (p <0,05), LTC4-sintase (p <0,05) e BLT2 (p <0,05) no epit??lio br??nquico. Conclu??mos que o treinamento de intensidade leve reduz fen??tipo da asma por inibi????o da via dos leucotrienos.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-25T17:51:42Z No. of bitstreams: 1 Ricardo Wesley Alberca Custodio.pdf: 1719201 bytes, checksum: dde8d630cb7ae3e178cab55eaac0dd13 (MD5)Made available in DSpace on 2016-05-25T17:51:42Z (GMT). No. of bitstreams: 1 Ricardo Wesley Alberca Custodio.pdf: 1719201 bytes, checksum: dde8d630cb7ae3e178cab55eaac0dd13 (MD5) Previous issue date: 2015-01-21application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Ci??ncias da Reabilita????oUNINOVEBrasilSa??deasmaleucotrienosexerc??cioimunologiainflama????oasthmaleukotrienesexerciseimmunologyinflammationCIENCIAS DA SAUDEA via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?Leukotriene pathway are involved in the anti-inflammatory effects of aerobic exercise on asthma?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALRicardo Wesley Alberca Custodio.pdfRicardo Wesley Alberca Custodio.pdfapplication/pdf1730975http://localhost:8080/tede/bitstream/tede/1347/2/Ricardo+Wesley+Alberca+Custodio.pdfc894faa8fb022df3ea6c6402da12bcdaMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/1347/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/13472016-07-15 16:14:56.681oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2016-07-15T19:14:56Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false
dc.title.por.fl_str_mv A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?
dc.title.alternative.por.fl_str_mv Leukotriene pathway are involved in the anti-inflammatory effects of aerobic exercise on asthma?
title A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?
spellingShingle A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?
Cust??dio, Ricardo Wesley Alberca
asma
leucotrienos
exerc??cio
imunologia
inflama????o
asthma
leukotrienes
exercise
immunology
inflammation
CIENCIAS DA SAUDE
title_short A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?
title_full A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?
title_fullStr A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?
title_full_unstemmed A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?
title_sort A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?
author Cust??dio, Ricardo Wesley Alberca
author_facet Cust??dio, Ricardo Wesley Alberca
author_role author
dc.contributor.advisor1.fl_str_mv Vieira, Rodolfo de Paula
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/9213556008468472
dc.contributor.referee1.fl_str_mv Vieira, Rodolfo de Paula
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/9213556008468472
dc.contributor.referee2.fl_str_mv Carvalho, Fl??vio Aimbire Soares de
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/8216583445045638
dc.contributor.referee3.fl_str_mv Oliveira, Lu??s Vicente Franco de
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/3644494034569111
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/7214720727458365
dc.contributor.author.fl_str_mv Cust??dio, Ricardo Wesley Alberca
contributor_str_mv Vieira, Rodolfo de Paula
Vieira, Rodolfo de Paula
Carvalho, Fl??vio Aimbire Soares de
Oliveira, Lu??s Vicente Franco de
dc.subject.por.fl_str_mv asma
leucotrienos
exerc??cio
imunologia
inflama????o
topic asma
leucotrienos
exerc??cio
imunologia
inflama????o
asthma
leukotrienes
exercise
immunology
inflammation
CIENCIAS DA SAUDE
dc.subject.eng.fl_str_mv asthma
leukotrienes
exercise
immunology
inflammation
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE
description Leukotrienes (LTs) play a central role in the pathophysiology of asthma. Aerobic exercise has been shown to be capable of reducing asthmatic inflammation. Therefore, this study investigated whether the anti-inflammatory effects of aerobic exercise are due to inhibition of the pathway of LTs. Forty BALB / c mice were divided into four groups: Control, Exercise, OVA and OVA + Exercise. The mice were sensitized and challenged with ovalbumin. Aerobic training was performed on a adapted treadmill, at low intensity, 5x / week, 1h / session for 4 weeks, after the establishment of airway inflammation. Total and differential cells were analized in bronchoalveolar lavage (BAL), cytokine levels in BAL, the number of lymphocytes and macrophages in the airway wall, the airway remodeling (collagen and elastic fibers, mucous production and thickness of bronchial smooth muscle), bronchial hyperresponsiveness, beyond the levels of leukotriene B4 (LTB4) and leukotriene C4 (LTC4) in BAL. In addition, immunohistochemistry was performed for 5-lipoxygenase (5-LO) LTA4 hydrolase (LTA4H) CysLT1 receptor, CysLT2 receptor, LTC4 synthase, LTB4 receptor 2 (BLT2). The results demonstrated that aerobic exercise reduced the total number of cells (p <0.05), eosinophils (p <0.05), neutrophils (p <0.001), lymphocytes (p <0.001) and macrophage (p <0.01) in BAL and the number of lymphocytes (p <0.05) and macrophages (p <0.01) in the airway wall. In addition, the accumulation of collagen fibers (p <0.01), elastic fibers (p <0.01) and mucus production (p <0.01) and the thickness of bronchial smooth muscle (P <0.05) and bronchial hyperresponsiveness levels at 25 MCh (p <0.05) and 50 MCh (p <0.01) were reduced in mice sensitized and trained. Furthermore, BAL IL-5 (p <0.05) were reduced, and the levels of LTB4 (p <0.05). The expression of 5-LO (p <0.05) LTA4H (p <0.05), the CysLT 1 receptor (p <0.05), CysLT 2 receptor (p <0.05), LTC4 synthase (p <0.05) and BLT2 (p <0.05) in peribronchial leukocytes were reduced by exercise and expression of 5-LO (p <0.05) LTA4H (p <0.05), the CysLT 1 receptor (p <0.05), CysLT 2 receptor (p <0.05), LTC4 synthase (p <0.05) and BLT2 (p <0.05) in the bronchial epithelium. We conclude that the low intensity aerobic exercise reduces phenotype of asthma by inhibiting the leukotriene pathway.
publishDate 2015
dc.date.issued.fl_str_mv 2015-01-21
dc.date.accessioned.fl_str_mv 2016-05-25T17:51:42Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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dc.identifier.citation.fl_str_mv Cust??dio, Ricardo Wesley Alberca. A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?. 2015. 96 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo.
dc.identifier.uri.fl_str_mv http://bibliotecatede.uninove.br/handle/tede/1347
identifier_str_mv Cust??dio, Ricardo Wesley Alberca. A via dos leucotrienos contribui para os efeitos antiinflamat??rios do treinamento f??sico aer??bio na asma?. 2015. 96 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo.
url http://bibliotecatede.uninove.br/handle/tede/1347
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dc.publisher.none.fl_str_mv Universidade Nove de Julho
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dc.publisher.initials.fl_str_mv UNINOVE
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Sa??de
publisher.none.fl_str_mv Universidade Nove de Julho
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repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)
repository.mail.fl_str_mv bibliotecatede@uninove.br||bibliotecatede@uninove.br
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