Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/1351 |
Resumo: | Introduction: One of the most common diseases in the present century, COPD (Chronic Obstructive Pulmonary Disease) has its mark on pulmonary inflammation, characterized by a number of cells such as macrophages, lymphocytes and neutrophils mainly degrading elastic fibers and release a series of inflammatory mediators that recruit other cells that act in defense in the lung. Objective: To develop a COPD model with passive inhalation of cigarette smoke in a 45 day period and promote the treatment of the disease with low-power laser. Methodology: the animals were organized into groups, control (breathing room air without cigarette smoke), the COPD group (45 days of passive inhalation of cigarette smoke) and Laser (45 days of passive inhalation + 15 days of application low power laser) .Results: Total and differential cell counts as well as histological and biochemical analysis shows the presence of COPD. Data from low-power laser-treated group shows that there was a reduction in the number of inflammatory cells and the concentration of the inflammatory mediators present in animal tissue in COPD. Conclusion: The passive inhalation of cigarette smoke for 45 days resulted in COPD, and the low-power laser was effective in the treatment because it took the reduction of inflammatory mediators and cells present in this lung disease. |
id |
NOVE_2e560d4c4cdd7277c0010a16a3a80ea2 |
---|---|
oai_identifier_str |
oai:localhost:tede/1351 |
network_acronym_str |
NOVE |
network_name_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
repository_id_str |
|
spelling |
Corr??a, Jo??o Carlos Ferrarihttp://lattes.cnpq.br/7430706253523346Corr??a, Jo??o Carlos FerrariJo??o Carlos Ferrari Corr??aCarvalho, Fl??vio Aimbire Soares dehttp://lattes.cnpq.br/8216583445045638Costa, Maricilia Silvahttp://lattes.cnpq.br/7963390052508784Jorge, Luciana Maria Malosa Sampaiohttp://lattes.cnpq.br/2970138065407046Carvalho, Paulo de Tarso Camillo dehttp://lattes.cnpq.br/2378784910179477http://lattes.cnpq.br/5825688891229777Alves, Wellington dos Santos2016-05-25T18:51:15Z2015-02-26Alves, Wellington dos Santos. Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos. 2015. 81 f. Tese( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1351Introduction: One of the most common diseases in the present century, COPD (Chronic Obstructive Pulmonary Disease) has its mark on pulmonary inflammation, characterized by a number of cells such as macrophages, lymphocytes and neutrophils mainly degrading elastic fibers and release a series of inflammatory mediators that recruit other cells that act in defense in the lung. Objective: To develop a COPD model with passive inhalation of cigarette smoke in a 45 day period and promote the treatment of the disease with low-power laser. Methodology: the animals were organized into groups, control (breathing room air without cigarette smoke), the COPD group (45 days of passive inhalation of cigarette smoke) and Laser (45 days of passive inhalation + 15 days of application low power laser) .Results: Total and differential cell counts as well as histological and biochemical analysis shows the presence of COPD. Data from low-power laser-treated group shows that there was a reduction in the number of inflammatory cells and the concentration of the inflammatory mediators present in animal tissue in COPD. Conclusion: The passive inhalation of cigarette smoke for 45 days resulted in COPD, and the low-power laser was effective in the treatment because it took the reduction of inflammatory mediators and cells present in this lung disease.Introdu????o: Uma das doen??as mais comuns no s??culo atual , a DPOC (Doen??a Pulmonar Obstrutiva Cr??nica) tem a sua marca na inflama????o pulmonar, caracterizada por uma s??rie de c??lulas como os macr??fagos, linf??citos e principalmente os neutr??filos que degradam as fibras el??sticas e liberam uma s??rie de mediadores inflamat??rios que recrutam outras c??lulas que atuam na defesa a n??vel pulmonar. Objetivo: desenvolver um modelo de DPOC com inala????o passiva de fuma??a de cigarro num per??odo de 45 dias e promover o tratamento da doen??a com o laser de baixa pot??ncia. Metodologia: os animais foram organizados em grupos, o controle (respira o ar ambiente sem fuma??a de cigarro), o grupo DPOC (45 dias de inala????o passiva de fuma??a de cigarro) e Laser (45 dias de inala????o passiva + 15 dias de aplica????o do laser de baixa pot??ncia). Resultados: A contagem total e diferencial das c??lulas, bem como as an??lises histol??gicas e bioqu??micas mostra a presen??a da DPOC. Os dados do grupo tratado com laser de baixa pot??ncia mostra que houve redu????o do n??mero de c??lulas inflamat??rias e da concentra????o dos mediadores inflamat??rios presentes na DPOC nos tecidos animais. Conclus??o: A inala????o passiva de fuma??a de cigarro por 45 dias ocasionou a DPOC, e o laser de baixa pot??ncia foi eficaz no seu tratamento pois levou a redu????o dos mediadores inflamat??rios e c??lulas presentes nesta doen??a pulmonar.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-25T18:51:15Z No. of bitstreams: 1 Wellignton dos Santos Alves.pdf: 1612582 bytes, checksum: 2e50043705c6562fcff36b21898a815f (MD5)Made available in DSpace on 2016-05-25T18:51:15Z (GMT). No. of bitstreams: 1 Wellignton dos Santos Alves.pdf: 1612582 bytes, checksum: 2e50043705c6562fcff36b21898a815f (MD5) Previous issue date: 2015-02-26application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Ci??ncias da Reabilita????oUNINOVEBrasilSa??dereabilita????o pulmonarlaser de baixa pot??nciaDPOCpulmonary rehabilitationlaser low powerCOPDCIENCIAS DA SAUDEEstudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratosLow intensity laser action study on cell recruitment and pulmonary inflammatory mediators of experimental COPD in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALWellignton dos Santos Alves.pdfWellignton dos Santos Alves.pdfapplication/pdf1612582http://localhost:8080/tede/bitstream/tede/1351/2/Wellignton+dos+Santos+Alves.pdf2e50043705c6562fcff36b21898a815fMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/1351/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/13512016-05-25 15:51:15.652oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2016-05-25T18:51:15Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos |
dc.title.alternative.eng.fl_str_mv |
Low intensity laser action study on cell recruitment and pulmonary inflammatory mediators of experimental COPD in rats |
title |
Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos |
spellingShingle |
Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos Alves, Wellington dos Santos reabilita????o pulmonar laser de baixa pot??ncia DPOC pulmonary rehabilitation laser low power COPD CIENCIAS DA SAUDE |
title_short |
Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos |
title_full |
Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos |
title_fullStr |
Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos |
title_full_unstemmed |
Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos |
title_sort |
Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos |
author |
Alves, Wellington dos Santos |
author_facet |
Alves, Wellington dos Santos |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Corr??a, Jo??o Carlos Ferrari |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7430706253523346 |
dc.contributor.referee1.fl_str_mv |
Corr??a, Jo??o Carlos Ferrari |
dc.contributor.referee1Lattes.fl_str_mv |
Jo??o Carlos Ferrari Corr??a |
dc.contributor.referee2.fl_str_mv |
Carvalho, Fl??vio Aimbire Soares de |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/8216583445045638 |
dc.contributor.referee3.fl_str_mv |
Costa, Maricilia Silva |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/7963390052508784 |
dc.contributor.referee4.fl_str_mv |
Jorge, Luciana Maria Malosa Sampaio |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/2970138065407046 |
dc.contributor.referee5.fl_str_mv |
Carvalho, Paulo de Tarso Camillo de |
dc.contributor.referee5Lattes.fl_str_mv |
http://lattes.cnpq.br/2378784910179477 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5825688891229777 |
dc.contributor.author.fl_str_mv |
Alves, Wellington dos Santos |
contributor_str_mv |
Corr??a, Jo??o Carlos Ferrari Corr??a, Jo??o Carlos Ferrari Carvalho, Fl??vio Aimbire Soares de Costa, Maricilia Silva Jorge, Luciana Maria Malosa Sampaio Carvalho, Paulo de Tarso Camillo de |
dc.subject.por.fl_str_mv |
reabilita????o pulmonar laser de baixa pot??ncia DPOC |
topic |
reabilita????o pulmonar laser de baixa pot??ncia DPOC pulmonary rehabilitation laser low power COPD CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
pulmonary rehabilitation laser low power COPD |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Introduction: One of the most common diseases in the present century, COPD (Chronic Obstructive Pulmonary Disease) has its mark on pulmonary inflammation, characterized by a number of cells such as macrophages, lymphocytes and neutrophils mainly degrading elastic fibers and release a series of inflammatory mediators that recruit other cells that act in defense in the lung. Objective: To develop a COPD model with passive inhalation of cigarette smoke in a 45 day period and promote the treatment of the disease with low-power laser. Methodology: the animals were organized into groups, control (breathing room air without cigarette smoke), the COPD group (45 days of passive inhalation of cigarette smoke) and Laser (45 days of passive inhalation + 15 days of application low power laser) .Results: Total and differential cell counts as well as histological and biochemical analysis shows the presence of COPD. Data from low-power laser-treated group shows that there was a reduction in the number of inflammatory cells and the concentration of the inflammatory mediators present in animal tissue in COPD. Conclusion: The passive inhalation of cigarette smoke for 45 days resulted in COPD, and the low-power laser was effective in the treatment because it took the reduction of inflammatory mediators and cells present in this lung disease. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-02-26 |
dc.date.accessioned.fl_str_mv |
2016-05-25T18:51:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Alves, Wellington dos Santos. Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos. 2015. 81 f. Tese( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1351 |
identifier_str_mv |
Alves, Wellington dos Santos. Estudo da a????o do laser de baixa intensidade sobre o recrutamento celular e os mediadores inflamat??rios pulmonares na DPOC experimental em ratos. 2015. 81 f. Tese( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/1351 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
8765449414823306929 |
dc.relation.confidence.fl_str_mv |
600 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.publisher.program.fl_str_mv |
Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o |
dc.publisher.initials.fl_str_mv |
UNINOVE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Sa??de |
publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da Uninove instname:Universidade Nove de Julho (UNINOVE) instacron:UNINOVE |
instname_str |
Universidade Nove de Julho (UNINOVE) |
instacron_str |
UNINOVE |
institution |
UNINOVE |
reponame_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
collection |
Biblioteca Digital de Teses e Dissertações da Uninove |
bitstream.url.fl_str_mv |
http://localhost:8080/tede/bitstream/tede/1351/2/Wellignton+dos+Santos+Alves.pdf http://localhost:8080/tede/bitstream/tede/1351/1/license.txt |
bitstream.checksum.fl_str_mv |
2e50043705c6562fcff36b21898a815f bd3efa91386c1718a7f26a329fdcb468 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE) |
repository.mail.fl_str_mv |
bibliotecatede@uninove.br||bibliotecatede@uninove.br |
_version_ |
1811016859142586368 |