Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/2760 |
Resumo: | Introduction: There is a direct interaction of the central nervous system and the autonomic nervous system with lipid and glycidic metabolism. Thus, glucose and free fatty acid (FFA) mobilization is greatly influenced by the autonomic nervous system, especially the sympathetic nervous system. FFA exhibit a wide range of functions, from immune regulation to metabolism in a variety of tissues and organs. Fatty acid concentration is increased in stress states, when vasoconstrictor hormones (norepinephrine, adrenaline) will be released and associated hemodynamic changes Objective: To evaluate hemodynamic, autonomic and metabolic changes in response to the association of acute stress (physical and mental) in healthy individuals. Methods In this study, 15 subjects, 31±7 years old, of both sexes, were evaluated 3 times: before and after the application of two test sessions, combining physical (isometric exercise test) and mental (Stroop color test) stress at 30 min intervals. Blood pressure, heart rate, systemic vascular resistance and distensibility of the large and small arteries obtained with HDI were analyzed (Hypertension Diagnosis Incorporation, CR2000, Eagan, USA); heart rate variability parameters recorded with Polar RS800 and analyzed with Kubios software. Blood samples were collected for measurement of fatty acids glucose, insulin and catecholamines. The ANOVA test was used to compare the parameters at the different evaluation moments; Linear regression analysis was used to verify the effect of hemodynamic variables on metabolic changes. The significance of p established was <0.05. Results: Compared to baseline, after the first stimulus there was a significant increase (p <0.05) in diastolic blood pressure (5.1%), peripheral vascular resistance (6.1%), and large distensibility (14%). and small arteries (25%) and FFA levels (24%). These changes were even more evident after the second stimulus. Compared to baseline, noradrenaline values increased significantly after the second stimulus (18,7%). Hemodynamic changes were not directly related to changes in FFA. Conclusion: The organism of healthy young people, when challenged by a combination of physical and mental stress, responds with changes in the sympathetic nervous system, which influence the hemodynamic profile. The metabolic changes that accompany this response, especially the increase in free fatty acid rates, are rapid and proportional to the stimuli applied, and appear to occur independently of the observed hemodynamic changes. |
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Consolim-Colombo, Fernanda Marcianohttp://lattes.cnpq.br/8102854014364848Consolim-Colombo, Fernanda Marcianohttp://lattes.cnpq.br/8102854014364848Dellê, Humbertohttp://lattes.cnpq.br/7435662740477057Silva Junior, Jose Antoniohttp://lattes.cnpq.br/1990427833073161http://lattes.cnpq.br/9935465239560464Motta, Josiane Motta e2021-11-18T19:24:53Z2019-12-19Motta, Josiane Motta e. Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto. 2019. 64 f. Tese( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2760Introduction: There is a direct interaction of the central nervous system and the autonomic nervous system with lipid and glycidic metabolism. Thus, glucose and free fatty acid (FFA) mobilization is greatly influenced by the autonomic nervous system, especially the sympathetic nervous system. FFA exhibit a wide range of functions, from immune regulation to metabolism in a variety of tissues and organs. Fatty acid concentration is increased in stress states, when vasoconstrictor hormones (norepinephrine, adrenaline) will be released and associated hemodynamic changes Objective: To evaluate hemodynamic, autonomic and metabolic changes in response to the association of acute stress (physical and mental) in healthy individuals. Methods In this study, 15 subjects, 31±7 years old, of both sexes, were evaluated 3 times: before and after the application of two test sessions, combining physical (isometric exercise test) and mental (Stroop color test) stress at 30 min intervals. Blood pressure, heart rate, systemic vascular resistance and distensibility of the large and small arteries obtained with HDI were analyzed (Hypertension Diagnosis Incorporation, CR2000, Eagan, USA); heart rate variability parameters recorded with Polar RS800 and analyzed with Kubios software. Blood samples were collected for measurement of fatty acids glucose, insulin and catecholamines. The ANOVA test was used to compare the parameters at the different evaluation moments; Linear regression analysis was used to verify the effect of hemodynamic variables on metabolic changes. The significance of p established was <0.05. Results: Compared to baseline, after the first stimulus there was a significant increase (p <0.05) in diastolic blood pressure (5.1%), peripheral vascular resistance (6.1%), and large distensibility (14%). and small arteries (25%) and FFA levels (24%). These changes were even more evident after the second stimulus. Compared to baseline, noradrenaline values increased significantly after the second stimulus (18,7%). Hemodynamic changes were not directly related to changes in FFA. Conclusion: The organism of healthy young people, when challenged by a combination of physical and mental stress, responds with changes in the sympathetic nervous system, which influence the hemodynamic profile. The metabolic changes that accompany this response, especially the increase in free fatty acid rates, are rapid and proportional to the stimuli applied, and appear to occur independently of the observed hemodynamic changes.Introdução: Existe uma interação direta do sistema nervoso autônomo com o metabolismo lipídico e glicídico, de modo que a mobilização de glicose e de ácidos graxos livres (AGLs) sofre grande influência em especial do sistema nervoso simpático. Os AGLs exibem uma ampla gama de funções, desde a regulação imune até o metabolismo em uma variedade de tecidos e órgãos. A concentração de ácidos graxos é aumentada em estados crônicos de estresse, podendo estar relacionados a liberação de hormônios vasoconstritores (noradrenalina, adrenalina) e alterações hemodinâmicas associadas. Objetivo: Avaliar alterações hemodinâmicas, autonômicas e metabólicas em resposta a associação de estresse agudo (físico e mental) em indivíduos saudáveis. Métodos: Nesse estudo, 15 indivíduos, de 31±7 anos, de ambos os sexos, foram avaliados em três momentos: antes e após a aplicação de duas sessões de testes, combinando estresse físico (teste de exercício isométrico) e mental (teste das cores), com intervalos de 30 min. Foram analisados: pressão arterial, frequência cardíaca, resistência vascular sistêmica e distensibilidade das grandes e pequenas artérias obtidos com o HDI (Hypertension Diagnosis Incorporation, CR2000, Eagan, USA); parâmetros de variabilidade da frequência cardíaca registrados com o Polar RS800 e analisados com o software Kubios. Amostras de sangue foram coletadas para dosagem de ácidos graxos glicose, insulina e catecolaminas. O teste de ANOVA foi usado para comparar os parâmetros nos diferentes momentos de avaliação; análise de regressão linear foi utilizada para verificar o efeito de variáveis hemodinâmicas sobre alterações metabólicas. A significância de p estabelecida foi <0,05. Resultados: Comparado ao basal, após o primeiro estímulo, houve aumento significativo (p<0,05) na pressão arterial diastólica (5,1%), na resistência vascular periférica (6,1%), na distensibilidade das grandes (14%) e pequenas artérias (25%) e nos níveis de AGLs, 24%). Essas alterações foram ainda mais evidentes, após o segundo estímulo. Em relação ao basal, os valores de noradrenalina aumentaram de forma significativa após o segundo estímulo (18,7%). Alterações hemodinâmicas não tiveram relação direta com as alterações nos AGLs. Conclusão: O organismo de jovens saudáveis, quando desafiado por uma combinação de estresse físico e mental, responde com alterações no sistema nervoso simpático, que influenciam no perfil hemodinâmico. As alterações metabólicas que acompanham essa resposta, em especial o aumento das taxas de ácidos graxos livres, são rápidas e proporcionais aos estímulos aplicados, e parecem ocorrer a independentemente das alterações hemodinâmicas observadas.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-11-18T19:24:53Z No. of bitstreams: 1 Josiane Motta.pdf: 831174 bytes, checksum: 35b44d831b19ea1ed4f3e0ba6b940b95 (MD5)Made available in DSpace on 2021-11-18T19:24:53Z (GMT). No. of bitstreams: 1 Josiane Motta.pdf: 831174 bytes, checksum: 35b44d831b19ea1ed4f3e0ba6b940b95 (MD5) Previous issue date: 2019-12-19application/pdfporUniversidade Nove de JulhoPrograma de Mestrado em MedicinaUNINOVEBrasilSaúdeestresseácidos graxospressão arterialfrequência cardíacaresistência vascularstressfatty acidsblood pressureheart ratevascular resistanceCIENCIAS DA SAUDEResposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo pilotoAcute metabolic hormonal and hemodynamic modulation against physical and mental stress in normal subjects: pilot studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALJosiane Motta.pdfJosiane Motta.pdfapplication/pdf831174http://localhost:8080/tede/bitstream/tede/2760/2/Josiane+Motta.pdf35b44d831b19ea1ed4f3e0ba6b940b95MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2760/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/27602021-11-18 17:24:53.173oai:localhost:tede/2760Tk9UQTogQ09MT1FVRSBBUVVJIEEgU1VBIFBSw5NQUklBIExJQ0VOw4dBCkVzdGEgbGljZW7Dp2EgZGUgZXhlbXBsbyDDqSBmb3JuZWNpZGEgYXBlbmFzIHBhcmEgZmlucyBpbmZvcm1hdGl2b3MuCgpMSUNFTsOHQSBERSBESVNUUklCVUnDh8ODTyBOw4NPLUVYQ0xVU0lWQQoKQ29tIGEgYXByZXNlbnRhw6fDo28gZGVzdGEgbGljZW7Dp2EsIHZvY8OqIChvIGF1dG9yIChlcykgb3UgbyB0aXR1bGFyIGRvcyBkaXJlaXRvcyBkZSBhdXRvcikgY29uY2VkZSDDoCBVbml2ZXJzaWRhZGUgClhYWCAoU2lnbGEgZGEgVW5pdmVyc2lkYWRlKSBvIGRpcmVpdG8gbsOjby1leGNsdXNpdm8gZGUgcmVwcm9kdXppciwgIHRyYWR1emlyIChjb25mb3JtZSBkZWZpbmlkbyBhYmFpeG8pLCBlL291IApkaXN0cmlidWlyIGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0csO0bmljbyBlIAplbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mgw6F1ZGlvIG91IHbDrWRlby4KClZvY8OqIGNvbmNvcmRhIHF1ZSBhIFNpZ2xhIGRlIFVuaXZlcnNpZGFkZSBwb2RlLCBzZW0gYWx0ZXJhciBvIGNvbnRlw7pkbywgdHJhbnNwb3IgYSBzdWEgdGVzZSBvdSBkaXNzZXJ0YcOnw6NvIApwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHDp8Ojby4KClZvY8OqIHRhbWLDqW0gY29uY29yZGEgcXVlIGEgU2lnbGEgZGUgVW5pdmVyc2lkYWRlIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPDs3BpYSBhIHN1YSB0ZXNlIG91IApkaXNzZXJ0YcOnw6NvIHBhcmEgZmlucyBkZSBzZWd1cmFuw6dhLCBiYWNrLXVwIGUgcHJlc2VydmHDp8Ojby4KClZvY8OqIGRlY2xhcmEgcXVlIGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyDDqSBvcmlnaW5hbCBlIHF1ZSB2b2PDqiB0ZW0gbyBwb2RlciBkZSBjb25jZWRlciBvcyBkaXJlaXRvcyBjb250aWRvcyAKbmVzdGEgbGljZW7Dp2EuIFZvY8OqIHRhbWLDqW0gZGVjbGFyYSBxdWUgbyBkZXDDs3NpdG8gZGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyBuw6NvLCBxdWUgc2VqYSBkZSBzZXUgCmNvbmhlY2ltZW50bywgaW5mcmluZ2UgZGlyZWl0b3MgYXV0b3JhaXMgZGUgbmluZ3XDqW0uCgpDYXNvIGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyBjb250ZW5oYSBtYXRlcmlhbCBxdWUgdm9jw6ogbsOjbyBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2PDqiAKZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc8OjbyBpcnJlc3RyaXRhIGRvIGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBwYXJhIGNvbmNlZGVyIMOgIFNpZ2xhIGRlIFVuaXZlcnNpZGFkZSAKb3MgZGlyZWl0b3MgYXByZXNlbnRhZG9zIG5lc3RhIGxpY2Vuw6dhLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIAppZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250ZcO6ZG8gZGEgdGVzZSBvdSBkaXNzZXJ0YcOnw6NvIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFRFU0UgT1UgRElTU0VSVEHDh8ODTyBPUkEgREVQT1NJVEFEQSBURU5IQSBTSURPIFJFU1VMVEFETyBERSBVTSBQQVRST0PDjU5JTyBPVSAKQVBPSU8gREUgVU1BIEFHw4pOQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PIFFVRSBOw4NPIFNFSkEgQSBTSUdMQSBERSAKVU5JVkVSU0lEQURFLCBWT0PDiiBERUNMQVJBIFFVRSBSRVNQRUlUT1UgVE9ET1MgRSBRVUFJU1FVRVIgRElSRUlUT1MgREUgUkVWSVPDg08gQ09NTyAKVEFNQsOJTSBBUyBERU1BSVMgT0JSSUdBw4fDlUVTIEVYSUdJREFTIFBPUiBDT05UUkFUTyBPVSBBQ09SRE8uCgpBIFNpZ2xhIGRlIFVuaXZlcnNpZGFkZSBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lIChzKSBvdSBvKHMpIG5vbWUocykgZG8ocykgCmRldGVudG9yKGVzKSBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgZGEgdGVzZSBvdSBkaXNzZXJ0YcOnw6NvLCBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIGFsw6ltIGRhcXVlbGFzIApjb25jZWRpZGFzIHBvciBlc3RhIGxpY2Vuw6dhLgo=Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2021-11-18T19:24:53Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto |
dc.title.alternative.eng.fl_str_mv |
Acute metabolic hormonal and hemodynamic modulation against physical and mental stress in normal subjects: pilot study |
title |
Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto |
spellingShingle |
Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto Motta, Josiane Motta e estresse ácidos graxos pressão arterial frequência cardíaca resistência vascular stress fatty acids blood pressure heart rate vascular resistance CIENCIAS DA SAUDE |
title_short |
Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto |
title_full |
Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto |
title_fullStr |
Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto |
title_full_unstemmed |
Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto |
title_sort |
Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto |
author |
Motta, Josiane Motta e |
author_facet |
Motta, Josiane Motta e |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Consolim-Colombo, Fernanda Marciano |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/8102854014364848 |
dc.contributor.referee1.fl_str_mv |
Consolim-Colombo, Fernanda Marciano |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/8102854014364848 |
dc.contributor.referee2.fl_str_mv |
Dellê, Humberto |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7435662740477057 |
dc.contributor.referee3.fl_str_mv |
Silva Junior, Jose Antonio |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/1990427833073161 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9935465239560464 |
dc.contributor.author.fl_str_mv |
Motta, Josiane Motta e |
contributor_str_mv |
Consolim-Colombo, Fernanda Marciano Consolim-Colombo, Fernanda Marciano Dellê, Humberto Silva Junior, Jose Antonio |
dc.subject.por.fl_str_mv |
estresse ácidos graxos pressão arterial frequência cardíaca resistência vascular |
topic |
estresse ácidos graxos pressão arterial frequência cardíaca resistência vascular stress fatty acids blood pressure heart rate vascular resistance CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
stress fatty acids blood pressure heart rate vascular resistance |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Introduction: There is a direct interaction of the central nervous system and the autonomic nervous system with lipid and glycidic metabolism. Thus, glucose and free fatty acid (FFA) mobilization is greatly influenced by the autonomic nervous system, especially the sympathetic nervous system. FFA exhibit a wide range of functions, from immune regulation to metabolism in a variety of tissues and organs. Fatty acid concentration is increased in stress states, when vasoconstrictor hormones (norepinephrine, adrenaline) will be released and associated hemodynamic changes Objective: To evaluate hemodynamic, autonomic and metabolic changes in response to the association of acute stress (physical and mental) in healthy individuals. Methods In this study, 15 subjects, 31±7 years old, of both sexes, were evaluated 3 times: before and after the application of two test sessions, combining physical (isometric exercise test) and mental (Stroop color test) stress at 30 min intervals. Blood pressure, heart rate, systemic vascular resistance and distensibility of the large and small arteries obtained with HDI were analyzed (Hypertension Diagnosis Incorporation, CR2000, Eagan, USA); heart rate variability parameters recorded with Polar RS800 and analyzed with Kubios software. Blood samples were collected for measurement of fatty acids glucose, insulin and catecholamines. The ANOVA test was used to compare the parameters at the different evaluation moments; Linear regression analysis was used to verify the effect of hemodynamic variables on metabolic changes. The significance of p established was <0.05. Results: Compared to baseline, after the first stimulus there was a significant increase (p <0.05) in diastolic blood pressure (5.1%), peripheral vascular resistance (6.1%), and large distensibility (14%). and small arteries (25%) and FFA levels (24%). These changes were even more evident after the second stimulus. Compared to baseline, noradrenaline values increased significantly after the second stimulus (18,7%). Hemodynamic changes were not directly related to changes in FFA. Conclusion: The organism of healthy young people, when challenged by a combination of physical and mental stress, responds with changes in the sympathetic nervous system, which influence the hemodynamic profile. The metabolic changes that accompany this response, especially the increase in free fatty acid rates, are rapid and proportional to the stimuli applied, and appear to occur independently of the observed hemodynamic changes. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-12-19 |
dc.date.accessioned.fl_str_mv |
2021-11-18T19:24:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/doctoralThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Motta, Josiane Motta e. Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto. 2019. 64 f. Tese( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2760 |
identifier_str_mv |
Motta, Josiane Motta e. Resposta hemodinâmica e metabólica ao estresse físico e mental em indivíduos normais: estudo piloto. 2019. 64 f. Tese( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/2760 |
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por |
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por |
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8765449414823306929 |
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600 |
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openAccess |
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Universidade Nove de Julho |
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Programa de Mestrado em Medicina |
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UNINOVE |
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Brasil |
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Saúde |
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Universidade Nove de Julho |
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