Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/2752 |
Resumo: | INTRODUCTION: The obesity is a pro-inflammatory disease that can also alter the intestinal barrier permeability that contributes to the imbalance of innate and acquired immunity, endothelial lesions and the consequent increased risk of cardiovascular disease. OBJECTIVE: To evaluate inflammatory and intestinal permeability biomarkers in obese adolescents compared to eutrophic adolescents and to evaluate the effect of the symbiotic intervention on such biomarkers in the obese group. METHODS: Prospective clinical study, which were studied 18 obese adolescents and 20 eutrophic adolescents. The following evaluations were carried out: 1) Body composition: bioimpedance (BIA) and BMI; 2) Marker of inflammation: IL6; 3) Evaluation of immune cells: CD4+ T lymphocytes, T reg lymphocytes and monocytes; 4) Intestinal permeability markers: Zonulina and Lipopolysaccharide (LPS). Obese adolescents received the symbiotic Simbioflora® for sixty days and after that were evaluated for the parameters described above. RESULTS: As expected, obese adolescents had a higher fat mass index, less fat-free mass, less dry lean mass and a higher BMI. Obese adolescents showed a significant increase in systolic blood pressure (109±9 vs. 101±9; p: 0,009); insulin (9,6±3,7 vs. 18,9±8,9; p:0,02); triglycerides (71±23 vs. 104±45; p:<0,01); lymphocyte CD4+ (8,9±7,5 vs. 18,0± 12,4; p:<0,01), IL6 (0,26±0,06 vs. 0,30±0,06; p:0,02), and LPS (0,08±0,05 vs. 0,18±0,15; p:<0,01). After intervention with symbiotics in obese adolescents, we observed a significant increase in CD4+ (18,0±12,4 vs. 29,6±10,6; p:0,002) and T reg lymphocytes (9,9±5,4 vs. 14,0±6,7; p:0,02). CONCLUSION: Obese adolescents present a deleterious anthropometric, biochemical and inflammatory changes that may in future contribute to a higher risk of diabetes and cardiovascular outcomes such as hypertension. The increase in serum LPS in this population may indicate the effect of the pathophysiological mechanism of obesity on the breakdown of the intestinal barrier, contributing to a state of microinflammation. Symbiotic supplementation was able to increase expression of T reg lymphocytes; that play anti-inflammatory effect. |
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Dalboni, Maria Aparecidahttp://lattes.cnpq.br/9818040147487320Dalboni, Maria Aparecidahttp://lattes.cnpq.br/9818040147487320Trombetta, Ivani Credidiohttp://lattes.cnpq.br/6691204901202886Dal Corso, Simonehttp://lattes.cnpq.br/9690847988531306Reis, Luciene Machado doshttp://lattes.cnpq.br/6070147721873955http://lattes.cnpq.br/3969208707880603Silveira, Cylmara Gargalak Aziz2021-11-18T14:32:07Z2020-06-26Silveira, Cylmara Gargalak Aziz. Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos. 2020. 77 f. Tese( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2752INTRODUCTION: The obesity is a pro-inflammatory disease that can also alter the intestinal barrier permeability that contributes to the imbalance of innate and acquired immunity, endothelial lesions and the consequent increased risk of cardiovascular disease. OBJECTIVE: To evaluate inflammatory and intestinal permeability biomarkers in obese adolescents compared to eutrophic adolescents and to evaluate the effect of the symbiotic intervention on such biomarkers in the obese group. METHODS: Prospective clinical study, which were studied 18 obese adolescents and 20 eutrophic adolescents. The following evaluations were carried out: 1) Body composition: bioimpedance (BIA) and BMI; 2) Marker of inflammation: IL6; 3) Evaluation of immune cells: CD4+ T lymphocytes, T reg lymphocytes and monocytes; 4) Intestinal permeability markers: Zonulina and Lipopolysaccharide (LPS). Obese adolescents received the symbiotic Simbioflora® for sixty days and after that were evaluated for the parameters described above. RESULTS: As expected, obese adolescents had a higher fat mass index, less fat-free mass, less dry lean mass and a higher BMI. Obese adolescents showed a significant increase in systolic blood pressure (109±9 vs. 101±9; p: 0,009); insulin (9,6±3,7 vs. 18,9±8,9; p:0,02); triglycerides (71±23 vs. 104±45; p:<0,01); lymphocyte CD4+ (8,9±7,5 vs. 18,0± 12,4; p:<0,01), IL6 (0,26±0,06 vs. 0,30±0,06; p:0,02), and LPS (0,08±0,05 vs. 0,18±0,15; p:<0,01). After intervention with symbiotics in obese adolescents, we observed a significant increase in CD4+ (18,0±12,4 vs. 29,6±10,6; p:0,002) and T reg lymphocytes (9,9±5,4 vs. 14,0±6,7; p:0,02). CONCLUSION: Obese adolescents present a deleterious anthropometric, biochemical and inflammatory changes that may in future contribute to a higher risk of diabetes and cardiovascular outcomes such as hypertension. The increase in serum LPS in this population may indicate the effect of the pathophysiological mechanism of obesity on the breakdown of the intestinal barrier, contributing to a state of microinflammation. Symbiotic supplementation was able to increase expression of T reg lymphocytes; that play anti-inflammatory effect.INTRODUÇÃO: A obesidade é uma doença pró-inflamatória que pode alterar a microbiota intestinal, o que contribui para o desequilíbrio da imunidade inata e adquirida, lesões endoteliais e consequente aumento de risco de doenças cardiovasculares. OBJETIVO: Avaliar biomarcadores inflamatórios e de permeabilidade intestinal em adolescentes obesos comparados a adolescentes eutróficos e avaliar o efeito da intervenção com simbiótico sobre tais biomarcadores no grupo obeso. MÉTODOS: Estudo clínico prospectivo, que estudou 18 adolescentes obesos e 20 adolescentes eutróficos. Foram realizadas as seguintes avaliações: 1) Composição corporal: bioimpedância (BIA) e IMC; 2) Marcador de inflamação: IL6; 3) Avaliação de células imunes: linfócitos T CD4+, linfócitos T reg e monócitos; 4) Marcadores de permeabilidade intestinal: Zonulina e Lipopolissacarídeo (LPS). Os adolescentes obesos receberam por sessenta dias o simbiótico Simbioflora®, o conteúdo de 1 sachê ao dia e foram reavaliados novamente para os parâmetros descritos acima. RESULTADOS: Como esperado, os adolescentes obesos apresentaram maior índice de massa de gordura, menor massa livre de gordura, menor massa magra seca e maior IMC. Os adolescentes obesos apresentaram aumento significante da pressão arterial sistólica (109±9 vs. 101 ±9; p: 0,009); da insulina (9,6±3,7 vs. 18,9±8,9; p:0,02); triglicérides (71±23 vs. 104±45; p:< 0,01); linfócito CD4+ (8,9±7,5 vs. 18,0± 12,4; p:< 0,01), IL6 (0,26±0,06 vs. 0,30±0,06; p:0,02), e LPS (0,08± 0,05 vc. 0,18± 0,15; p:< 0,01) comparado com os adolescentes eutróficos, respectivamente. Após a intervenção com simbióticos nos adolescentes obesos, observamos aumento significante dos Linfócitos CD4+ (18,0±12,4 vs. 29,6±10,6; p:0,002) e Linfócitos T reguladores (T reg) (9,9±5,4 vs. 14,0±6,7; p:0,02). CONCLUSÃO: Adolescentes obesos apresentam alterações antropométricas, bioquímicas e inflamatórias importantes que podem futuramente contribuir para maior risco de diabetes e desfechos cardiovasculares como hipertensão. O aumento do LPS sérico nessa população pode indicar o efeito do mecanismo fisiopatológico da obesidade sobre o desarranjo da barreira intestinal, contribuindo para um estado de microinflamação. A suplementação com simbiótico aumentou a expressão de linfócitos T reg que têm efeito anti-inflamatório.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-11-18T14:32:07Z No. of bitstreams: 1 Cylmara Gargalak Aziz Silveira.pdf: 5728926 bytes, checksum: 5877e32a1c8fad52ece4f6d302e12b3a (MD5)Made available in DSpace on 2021-11-18T14:32:07Z (GMT). No. of bitstreams: 1 Cylmara Gargalak Aziz Silveira.pdf: 5728926 bytes, checksum: 5877e32a1c8fad52ece4f6d302e12b3a (MD5) Previous issue date: 2020-06-26application/pdfporUniversidade Nove de JulhoPrograma de Mestrado em MedicinaUNINOVEBrasilSaúdeobesidadeadolescentesinflamaçãopermeabilidade intestinalobesityadolescentsinflammationintestinal permeabilityCIENCIAS DA SAUDEAvaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesosEvaluation of biomarkes of inflammation and intestinal permeability in obese adolescentsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVELICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2752/3/license.txtbd3efa91386c1718a7f26a329fdcb468MD53ORIGINALCylmara Gargalak Aziz Silveira.pdfCylmara Gargalak Aziz Silveira.pdfapplication/pdf5728926http://localhost:8080/tede/bitstream/tede/2752/2/Cylmara+Gargalak+Aziz+Silveira.pdf5877e32a1c8fad52ece4f6d302e12b3aMD52tede/27522021-11-18 12:32:07.737oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2021-11-18T14:32:07Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos |
dc.title.alternative.eng.fl_str_mv |
Evaluation of biomarkes of inflammation and intestinal permeability in obese adolescents |
title |
Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos |
spellingShingle |
Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos Silveira, Cylmara Gargalak Aziz obesidade adolescentes inflamação permeabilidade intestinal obesity adolescents inflammation intestinal permeability CIENCIAS DA SAUDE |
title_short |
Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos |
title_full |
Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos |
title_fullStr |
Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos |
title_full_unstemmed |
Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos |
title_sort |
Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos |
author |
Silveira, Cylmara Gargalak Aziz |
author_facet |
Silveira, Cylmara Gargalak Aziz |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Dalboni, Maria Aparecida |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9818040147487320 |
dc.contributor.referee1.fl_str_mv |
Dalboni, Maria Aparecida |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/9818040147487320 |
dc.contributor.referee2.fl_str_mv |
Trombetta, Ivani Credidio |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/6691204901202886 |
dc.contributor.referee3.fl_str_mv |
Dal Corso, Simone |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/9690847988531306 |
dc.contributor.referee4.fl_str_mv |
Reis, Luciene Machado dos |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/6070147721873955 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3969208707880603 |
dc.contributor.author.fl_str_mv |
Silveira, Cylmara Gargalak Aziz |
contributor_str_mv |
Dalboni, Maria Aparecida Dalboni, Maria Aparecida Trombetta, Ivani Credidio Dal Corso, Simone Reis, Luciene Machado dos |
dc.subject.por.fl_str_mv |
obesidade adolescentes inflamação permeabilidade intestinal |
topic |
obesidade adolescentes inflamação permeabilidade intestinal obesity adolescents inflammation intestinal permeability CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
obesity adolescents inflammation intestinal permeability |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
INTRODUCTION: The obesity is a pro-inflammatory disease that can also alter the intestinal barrier permeability that contributes to the imbalance of innate and acquired immunity, endothelial lesions and the consequent increased risk of cardiovascular disease. OBJECTIVE: To evaluate inflammatory and intestinal permeability biomarkers in obese adolescents compared to eutrophic adolescents and to evaluate the effect of the symbiotic intervention on such biomarkers in the obese group. METHODS: Prospective clinical study, which were studied 18 obese adolescents and 20 eutrophic adolescents. The following evaluations were carried out: 1) Body composition: bioimpedance (BIA) and BMI; 2) Marker of inflammation: IL6; 3) Evaluation of immune cells: CD4+ T lymphocytes, T reg lymphocytes and monocytes; 4) Intestinal permeability markers: Zonulina and Lipopolysaccharide (LPS). Obese adolescents received the symbiotic Simbioflora® for sixty days and after that were evaluated for the parameters described above. RESULTS: As expected, obese adolescents had a higher fat mass index, less fat-free mass, less dry lean mass and a higher BMI. Obese adolescents showed a significant increase in systolic blood pressure (109±9 vs. 101±9; p: 0,009); insulin (9,6±3,7 vs. 18,9±8,9; p:0,02); triglycerides (71±23 vs. 104±45; p:<0,01); lymphocyte CD4+ (8,9±7,5 vs. 18,0± 12,4; p:<0,01), IL6 (0,26±0,06 vs. 0,30±0,06; p:0,02), and LPS (0,08±0,05 vs. 0,18±0,15; p:<0,01). After intervention with symbiotics in obese adolescents, we observed a significant increase in CD4+ (18,0±12,4 vs. 29,6±10,6; p:0,002) and T reg lymphocytes (9,9±5,4 vs. 14,0±6,7; p:0,02). CONCLUSION: Obese adolescents present a deleterious anthropometric, biochemical and inflammatory changes that may in future contribute to a higher risk of diabetes and cardiovascular outcomes such as hypertension. The increase in serum LPS in this population may indicate the effect of the pathophysiological mechanism of obesity on the breakdown of the intestinal barrier, contributing to a state of microinflammation. Symbiotic supplementation was able to increase expression of T reg lymphocytes; that play anti-inflammatory effect. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-06-26 |
dc.date.accessioned.fl_str_mv |
2021-11-18T14:32:07Z |
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doctoralThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Silveira, Cylmara Gargalak Aziz. Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos. 2020. 77 f. Tese( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2752 |
identifier_str_mv |
Silveira, Cylmara Gargalak Aziz. Avaliação de biomarcadores de inflamação e de permeabilidade intestinal em adolescentes obesos. 2020. 77 f. Tese( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/2752 |
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por |
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UNINOVE |
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Saúde |
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Universidade Nove de Julho |
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