Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/2641 |
Resumo: | Diabetes mellitus (DM) is a multifactorial chronic metabolic disease characterized mainly by the loss of glycemic homeostasis. Currently DM has a high worldwide incidence, being considered a serious health problem. In addition, several studies report other complications associated with DM that also make life difficult for patients, including problems affecting the oral cavity, such as gingivitis, periodontal disease, fungal, bacterial, viral infections, caries, hyposalivation. and xerostomia. The worsening of these manifestations is related to decreased flow and changes in salivary components, negatively impacting patients' quality of life. In order to investigate the relationship between diabetes and salivary gland dysfunction and changes in saliva composition, a randomized study was conducted with 47 patients, both genders, 18 to 65 years of age, with complaints related to oral health for example hyposalivation and xerostomia, using photobiomodulation. To detect oral manifestations, anamnesis, physical examination, salivary flow measurement, were performed by means of unstimulated and stimulated sialometry techniques, being two collections before therapy and two after, a self-perception questionnaire (OHIP). -14) was also applied. Irradiation was performed in the region of the major salivary glands, intra and extra orally, using an infrared Ecco Fibers-Quantum laser (λ = 808 nm), 120mW, 3.84J, 32s per point, being 3 extra oral and 3 bilateral intra oral points, totaling 12 points once a week for four weeks. Photobiomodulation caused significant improvement in salivary flow, in the radiometric parameters used in the group treated in the fourth week, when comparing the samples, not stimulated basal and stimulated laser, p = 0,0273. The results of calcium and total protein biochemistry showed a statistically significant change only in calcium when comparing the samples of the first and fourth week of treatment, stimulated basal and stimulated laser, p = 0,0136. It is concluded that photobiomodulation can be considered as a treatment to improve the salivary flow and composition of diabetic patients. |
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Deana, Alessandro MeloDeana, Alessandro MeloPrates, Renato Araujohttp://lattes.cnpq.br/7664790931310514Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Ribeiro, Martha Simõeshttp://lattes.cnpq.br/4996734160632011Ana, Patricia Aparecida dahttp://lattes.cnpq.br/2372516182094204http://lattes.cnpq.br/1471558216962199Sousa, Aline Silva2021-11-03T21:36:14Z2019-12-10Sousa, Aline Silva. Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia. 2019. 79 f. Tese( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2641Diabetes mellitus (DM) is a multifactorial chronic metabolic disease characterized mainly by the loss of glycemic homeostasis. Currently DM has a high worldwide incidence, being considered a serious health problem. In addition, several studies report other complications associated with DM that also make life difficult for patients, including problems affecting the oral cavity, such as gingivitis, periodontal disease, fungal, bacterial, viral infections, caries, hyposalivation. and xerostomia. The worsening of these manifestations is related to decreased flow and changes in salivary components, negatively impacting patients' quality of life. In order to investigate the relationship between diabetes and salivary gland dysfunction and changes in saliva composition, a randomized study was conducted with 47 patients, both genders, 18 to 65 years of age, with complaints related to oral health for example hyposalivation and xerostomia, using photobiomodulation. To detect oral manifestations, anamnesis, physical examination, salivary flow measurement, were performed by means of unstimulated and stimulated sialometry techniques, being two collections before therapy and two after, a self-perception questionnaire (OHIP). -14) was also applied. Irradiation was performed in the region of the major salivary glands, intra and extra orally, using an infrared Ecco Fibers-Quantum laser (λ = 808 nm), 120mW, 3.84J, 32s per point, being 3 extra oral and 3 bilateral intra oral points, totaling 12 points once a week for four weeks. Photobiomodulation caused significant improvement in salivary flow, in the radiometric parameters used in the group treated in the fourth week, when comparing the samples, not stimulated basal and stimulated laser, p = 0,0273. The results of calcium and total protein biochemistry showed a statistically significant change only in calcium when comparing the samples of the first and fourth week of treatment, stimulated basal and stimulated laser, p = 0,0136. It is concluded that photobiomodulation can be considered as a treatment to improve the salivary flow and composition of diabetic patients.O Diabetes mellitus (DM) é uma doença metabólica crônica multifatorial, caracterizada principalmente pela perda da homeostasia glicêmica. Diversos estudos relatam outras complicações associadas ao DM que também dificultam sobremaneira a vida dos pacientes, entre as quais podemos citar os problemas que acometem a cavidade bucal, como: gengivite, doenças periodontais, infecções fúngicas, bacterianas, virais, cáries, hipossalivação e xerostomia. O agravamento dessas manifestações está relacionado com a diminuição do fluxo e alterações dos componentes salivares, impactando negativamente na qualidade de vida dos pacientes. Com o objetivo de investigar a relação do diabetes com a disfunção das glândulas salivares e alterações na composição da saliva, foi realizado um estudo, randomizado com 47 pacientes, ambos os gêneros, na faixa etária de 18 a 65 anos de idade, com queixas relacionadas a saúde bucal, como hipossalivação e xerostomia utilizando a fotobiomodulação. Para detecção das manifestações bucais, foi realizado anamnese, exame físico, mensuração do fluxo salivar, por meio de técnicas de sialometria, não estimulada e estimulada, sendo duas coletas antes da terapia e duas após, foi aplicado também um questionário de auto percepção (OHIP-14). A irradiação foi feita em região de glândulas salivares maiores, intra e extral oral, utilizando um laser Ecco Fibras- Quantum infravermelho (λ = 808nm), 120mW, 3.84J, 32s por ponto, sendo 3 pontos extra oral e 3 intra oral bilateral, totalizando 12 pontos, uma vez por semana, durante quatro semanas. A fotobiomodulação provocou melhora significativa no fluxo salivar, nos parâmetros radiométricos utilizados, no grupo tratado na quarta semana de tratamento quando comparado as amostras, não estimulada basal e estimulada laser, p = 0,0273. Já os resultados da bioquímica de Cálcio e Proteínas totais, foi notado alteração estatisticamente significante, somente no cálcio quando comparado as amostras da primeira e quarta semana de tratamento, estimulada basal e estimulada laser, p = 0,0136. Conclui-se que a fotobiomodulação pode ser considerada como um tratamento para melhora do fluxo e composição salivar de pacientes diabéticos.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-11-03T21:36:14Z No. of bitstreams: 1 Aline Silva Sousa.pdf: 2099051 bytes, checksum: 5ab255b74b3f977c8c9ff84a7bf35aba (MD5)Made available in DSpace on 2021-11-03T21:36:14Z (GMT). No. of bitstreams: 1 Aline Silva Sousa.pdf: 2099051 bytes, checksum: 5ab255b74b3f977c8c9ff84a7bf35aba (MD5) Previous issue date: 2019-12-10application/pdfporUniversidade Nove de JulhoPrograma de Pós-Graduação em Biofotônica Aplicada às Ciências da SaúdeUNINOVEBrasilSaúdediabetes mellituslaser vermelhoconcentração de cálcioglândulas salivareshipossalivaçãodiabetes mellitusred lasercalcium concentrationsalivary glandshyposalivationCIENCIAS DA SAUDEEfeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomiaEffect of photobiomodulation on larger salivary glands, pH and salivary biochemistry of diabetic patients with hyposalivation and xerostomyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALAline Silva Sousa.pdfAline Silva Sousa.pdfapplication/pdf2099051http://localhost:8080/tede/bitstream/tede/2641/2/Aline+Silva+Sousa.pdf5ab255b74b3f977c8c9ff84a7bf35abaMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2641/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/26412021-11-03 19:36:14.394oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2021-11-03T21:36:14Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia |
dc.title.alternative.eng.fl_str_mv |
Effect of photobiomodulation on larger salivary glands, pH and salivary biochemistry of diabetic patients with hyposalivation and xerostomy |
title |
Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia |
spellingShingle |
Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia Sousa, Aline Silva diabetes mellitus laser vermelho concentração de cálcio glândulas salivares hipossalivação diabetes mellitus red laser calcium concentration salivary glands hyposalivation CIENCIAS DA SAUDE |
title_short |
Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia |
title_full |
Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia |
title_fullStr |
Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia |
title_full_unstemmed |
Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia |
title_sort |
Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia |
author |
Sousa, Aline Silva |
author_facet |
Sousa, Aline Silva |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Deana, Alessandro Melo |
dc.contributor.referee1.fl_str_mv |
Deana, Alessandro Melo |
dc.contributor.referee2.fl_str_mv |
Prates, Renato Araujo |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7664790931310514 |
dc.contributor.referee3.fl_str_mv |
Marcos, Rodrigo Labat |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/2964112163504080 |
dc.contributor.referee4.fl_str_mv |
Ribeiro, Martha Simões |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/4996734160632011 |
dc.contributor.referee5.fl_str_mv |
Ana, Patricia Aparecida da |
dc.contributor.referee5Lattes.fl_str_mv |
http://lattes.cnpq.br/2372516182094204 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1471558216962199 |
dc.contributor.author.fl_str_mv |
Sousa, Aline Silva |
contributor_str_mv |
Deana, Alessandro Melo Deana, Alessandro Melo Prates, Renato Araujo Marcos, Rodrigo Labat Ribeiro, Martha Simões Ana, Patricia Aparecida da |
dc.subject.por.fl_str_mv |
diabetes mellitus laser vermelho concentração de cálcio glândulas salivares hipossalivação |
topic |
diabetes mellitus laser vermelho concentração de cálcio glândulas salivares hipossalivação diabetes mellitus red laser calcium concentration salivary glands hyposalivation CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
diabetes mellitus red laser calcium concentration salivary glands hyposalivation |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Diabetes mellitus (DM) is a multifactorial chronic metabolic disease characterized mainly by the loss of glycemic homeostasis. Currently DM has a high worldwide incidence, being considered a serious health problem. In addition, several studies report other complications associated with DM that also make life difficult for patients, including problems affecting the oral cavity, such as gingivitis, periodontal disease, fungal, bacterial, viral infections, caries, hyposalivation. and xerostomia. The worsening of these manifestations is related to decreased flow and changes in salivary components, negatively impacting patients' quality of life. In order to investigate the relationship between diabetes and salivary gland dysfunction and changes in saliva composition, a randomized study was conducted with 47 patients, both genders, 18 to 65 years of age, with complaints related to oral health for example hyposalivation and xerostomia, using photobiomodulation. To detect oral manifestations, anamnesis, physical examination, salivary flow measurement, were performed by means of unstimulated and stimulated sialometry techniques, being two collections before therapy and two after, a self-perception questionnaire (OHIP). -14) was also applied. Irradiation was performed in the region of the major salivary glands, intra and extra orally, using an infrared Ecco Fibers-Quantum laser (λ = 808 nm), 120mW, 3.84J, 32s per point, being 3 extra oral and 3 bilateral intra oral points, totaling 12 points once a week for four weeks. Photobiomodulation caused significant improvement in salivary flow, in the radiometric parameters used in the group treated in the fourth week, when comparing the samples, not stimulated basal and stimulated laser, p = 0,0273. The results of calcium and total protein biochemistry showed a statistically significant change only in calcium when comparing the samples of the first and fourth week of treatment, stimulated basal and stimulated laser, p = 0,0136. It is concluded that photobiomodulation can be considered as a treatment to improve the salivary flow and composition of diabetic patients. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-12-10 |
dc.date.accessioned.fl_str_mv |
2021-11-03T21:36:14Z |
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info:eu-repo/semantics/publishedVersion |
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dc.identifier.citation.fl_str_mv |
Sousa, Aline Silva. Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia. 2019. 79 f. Tese( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2641 |
identifier_str_mv |
Sousa, Aline Silva. Efeito da fotobiomodulação em glândulas salivares maiores, pH e bioquímica salivar de pacientes diabéticos com hipossalivação e xerostomia. 2019. 79 f. Tese( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/2641 |
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Universidade Nove de Julho |
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Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde |
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UNINOVE |
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Saúde |
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Universidade Nove de Julho |
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