Efeitos do treinamento f??sico aer??bico na fibrose pulmonar
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/1346 |
Resumo: | Background: Idiopathic pulmonary fibrosis (IPF) is characterized by decline of lung function, increased inflammation and fibrosis mainly in the pulmonary interstitium, with serotonin (5-HT) and Akt signaling presenting a role. Aerobic training (AT) reduces lung injury in different models of pulmonary diseases. However, the mechanisms underlying the effects of AT in a model of bleomycin-induced lung fibrosis is unknown. Thus, this study investigated the effects of AT in a model of bleomycin-induced pulmonary fibrosis, as well as the participation of 5HT/Akt signaling. Methods: Seventy-two C57Bl/6 male mice were distributed in Control (Co), Exercise (Ex), Fibrosis (Fi) and Fibrosis+Exercise (Fi+Ex) groups. Bleomycin (1.5UI/Kg) was administered on day 1 and treadmill AT began on day 14 during 4 weeks. Total and differential cells count in bronchoalveolar lavage (BAL), IL-1beta, IL-6, CXCL1/KC, IL-10, TNF-alpha and TGF-beta levels in BAL fluid, collagen content in the lung parenchyma, 5-HT levels in BAL fluid and in serum, and the expression of 5-HT2b receptor and Aktphosphorylation were evaluated. Results: AT reduced bleomycin-increased number of total cells (p<0.001), neutrophils (p<0.01), macrophages (p<0.01) and lymphocytes (p<0.05) in BAL. AT also reduced the levels of IL-1beta (p<0.01), IL-6 (p<0.05), CXCL1/KC (p<0.001), TNF-alpha (p<0.001) and TGF-beta (p<0.001), while increased the levels of IL-10 (p<0.001). Collagen fibers deposition was also reduced by AT (p<0.01). These findings were followed by AT-reduced bleomycin-increased 5-HT levels in BAL fluid (p<0.001) and in serum (p<0.05), as well as the expression of 5-HT2b receptor (p<0.01) and the Aktphosphorylation in lung tissue. Conclusions: We conclude that AT reduces lung inflammation and fibrosis in a model of bleomycin-induced lung fibrosis involving 5-HT/Akt signaling. |
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Vieira, Rodolfo de Paulahttp://lattes.cnpq.br/9213556008468472Vieira, Rodolfo de Paulahttp://lattes.cnpq.br/9213556008468472Prado, Carla M??ximohttp://lattes.cnpq.br/1740478426977844Oliveira, Ana Paula Ligeiro dehttp://lattes.cnpq.br/5700855351581023http://lattes.cnpq.br/8606568322082936Pereira, Paulo Rog??rio2016-05-25T17:34:07Z2014-12-15Pereira, Paulo Rog??rio. Efeitos do treinamento f??sico aer??bico na fibrose pulmonar. 2014. 62 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1346Background: Idiopathic pulmonary fibrosis (IPF) is characterized by decline of lung function, increased inflammation and fibrosis mainly in the pulmonary interstitium, with serotonin (5-HT) and Akt signaling presenting a role. Aerobic training (AT) reduces lung injury in different models of pulmonary diseases. However, the mechanisms underlying the effects of AT in a model of bleomycin-induced lung fibrosis is unknown. Thus, this study investigated the effects of AT in a model of bleomycin-induced pulmonary fibrosis, as well as the participation of 5HT/Akt signaling. Methods: Seventy-two C57Bl/6 male mice were distributed in Control (Co), Exercise (Ex), Fibrosis (Fi) and Fibrosis+Exercise (Fi+Ex) groups. Bleomycin (1.5UI/Kg) was administered on day 1 and treadmill AT began on day 14 during 4 weeks. Total and differential cells count in bronchoalveolar lavage (BAL), IL-1beta, IL-6, CXCL1/KC, IL-10, TNF-alpha and TGF-beta levels in BAL fluid, collagen content in the lung parenchyma, 5-HT levels in BAL fluid and in serum, and the expression of 5-HT2b receptor and Aktphosphorylation were evaluated. Results: AT reduced bleomycin-increased number of total cells (p<0.001), neutrophils (p<0.01), macrophages (p<0.01) and lymphocytes (p<0.05) in BAL. AT also reduced the levels of IL-1beta (p<0.01), IL-6 (p<0.05), CXCL1/KC (p<0.001), TNF-alpha (p<0.001) and TGF-beta (p<0.001), while increased the levels of IL-10 (p<0.001). Collagen fibers deposition was also reduced by AT (p<0.01). These findings were followed by AT-reduced bleomycin-increased 5-HT levels in BAL fluid (p<0.001) and in serum (p<0.05), as well as the expression of 5-HT2b receptor (p<0.01) and the Aktphosphorylation in lung tissue. Conclusions: We conclude that AT reduces lung inflammation and fibrosis in a model of bleomycin-induced lung fibrosis involving 5-HT/Akt signaling.Introdu????o: A fibrose pulmonar idiop??tica (FPI) ?? uma doen??a devastadora com pobre progn??stico e nenhum tratamento efetivo dispon??vel. Estudos recentes demonstram que a serotonina / 5-hidroxitriptamina (5-HT) desempenha um papel importante no processo de fibrose pulmonar. Entretanto, alguns estudos demonstram que o tratamento n??o farmacol??gico, como programas de reabilita????o pulmonar para pacientes com FPI resulta em melhora da qualidade de vida e do manejo da doen??a, mas os efeitos sobre os pulm??es e os poss??veis mecanismos desses efeitos n??o s??o conhecidos. Objetivos: Portanto, o presente estudo investigou os efeitos do treinamento f??sico aer??bio na resposta pulmonar em um modelo de fibrose pulmonar induzida por bleomicina em camundongos, e os poss??veis efeitos moduladores do exerc??cio sobre os n??veis de 5-HT. Materiais e m??todos: Foram utilizados setenta e dois camundongos machos C57/Bl6, os quais foram distribu??dos em Controle (Co), Exerc??cio (Ex), Fibrose (Fi) e Fibrose + Exerc??cio (Fi + Ex). Vinte e quatro horas ap??s o ??ltimo teste f??sico na esteira, a inflama????o pulmonar foi avaliada atrav??s da avalia????o do lavado broncoalveolar (contagem de c??lulas e medidas de citocinas: IL-1beta, IL-6, CXCL1/KC, IL-10, TNF-alfa, TGF-beta), e o remodelamento pulmonar atrav??s do ac??mulo de fibras col??genas no par??nquima pulmonar. Foram avaliados tamb??m os n??veis de 5-HT no sobrenadante do lavado broncoalveolar e no soro. Al??m disso, a express??o do receptor para 5-HT (5-HT2B) tamb??m foi avaliado no tecido pulmonar. Por fim, a express??o da forma integral e fosforilada da Akt tamb??m foi avaliada no tecido pulmonar. Resultados: Os resultados demonstraram que o treinamento aer??bio reduziu o n??mero de c??lulas totais (p<0.001), de neutr??filos (p<0.01), de macr??fagos (p<0.01) e de linf??citos (p<0.05) no lavado broncoalveolar, assim como reduziu os n??veis de IL-1beta (p<0.01), IL-6 (p<0.05), CXCL1/KC (p<0.001), TNF-alfa (p<0.001) e TGF-beta (p<0.001) no lavado broncoalveolar, enquanto aumentou os n??veis da citocina anti-inflamat??ria IL-10 (p<0.001). O treinamento f??sico tamb??m reduziu a deposi????o de fibras de col??geno no par??nquima pulmonar (p<0.001). Os n??veis de 5-HT no sobrenadante do lavado broncoalveolar (p<0.001) e no soro (p<0.05) e a express??o do receptor 5HT2B (p<0.01) no tecido pulmonar demonstraram-se reduzidos no grupo submetido ao treinamento f??sico. A express??o de Akt na forma total n??o foi alterada pelo treinamento f??sico, enquanto que a forma fosforilada foi reduzida pelo treinamento f??sico (p<0.01). Conclus??es: Os resultados do presente estudo demonstram claramente que o treinamento f??sico aer??bio ?? capaz de reduzir a inflama????o e a fibrose pulmonar em um modelo experimental de fibrose pulmonar induzida pela bleomicina. Os resultados tamb??m demonstram que pelo menos em parte, esses efeitos ben??ficos do treinamento f??sico aer??bio pode ter sido mediado pelo aumento da libera????o de IL-10, assim como pela redu????o da exacerba????o dos n??veis de serotonina, levando a uma redu????o da express??o do receptor de serotonina 5-HT2B, e tamb??m da redu????o da ativa????o da prote??na Akt.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-25T17:34:07Z No. of bitstreams: 1 Paulo Rogerio Pereira.pdf: 773654 bytes, checksum: 098c4df44754fb146e1a3739b5cb13f0 (MD5)Made available in DSpace on 2016-05-25T17:34:07Z (GMT). No. of bitstreams: 1 Paulo Rogerio Pereira.pdf: 773654 bytes, checksum: 098c4df44754fb146e1a3739b5cb13f0 (MD5) Previous issue date: 2014-12-15application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Ci??ncias da Reabilita????oUNINOVEBrasilSa??deidiopathic pulmonary fibrosisexercise immunologyphysical trainingserotonincytokinesCIENCIAS DA SAUDEEfeitos do treinamento f??sico aer??bico na fibrose pulmonarEffects of aerobic exercise training on pulmonary fibrosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALPaulo Rogerio Pereira.pdfPaulo Rogerio Pereira.pdfapplication/pdf773654http://localhost:8080/tede/bitstream/tede/1346/2/Paulo+Rogerio+Pereira.pdf098c4df44754fb146e1a3739b5cb13f0MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/1346/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/13462016-05-25 14:34:07.112oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2016-05-25T17:34:07Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Efeitos do treinamento f??sico aer??bico na fibrose pulmonar |
dc.title.alternative.eng.fl_str_mv |
Effects of aerobic exercise training on pulmonary fibrosis |
title |
Efeitos do treinamento f??sico aer??bico na fibrose pulmonar |
spellingShingle |
Efeitos do treinamento f??sico aer??bico na fibrose pulmonar Pereira, Paulo Rog??rio idiopathic pulmonary fibrosis exercise immunology physical training serotonin cytokines CIENCIAS DA SAUDE |
title_short |
Efeitos do treinamento f??sico aer??bico na fibrose pulmonar |
title_full |
Efeitos do treinamento f??sico aer??bico na fibrose pulmonar |
title_fullStr |
Efeitos do treinamento f??sico aer??bico na fibrose pulmonar |
title_full_unstemmed |
Efeitos do treinamento f??sico aer??bico na fibrose pulmonar |
title_sort |
Efeitos do treinamento f??sico aer??bico na fibrose pulmonar |
author |
Pereira, Paulo Rog??rio |
author_facet |
Pereira, Paulo Rog??rio |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Vieira, Rodolfo de Paula |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9213556008468472 |
dc.contributor.referee1.fl_str_mv |
Vieira, Rodolfo de Paula |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/9213556008468472 |
dc.contributor.referee2.fl_str_mv |
Prado, Carla M??ximo |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/1740478426977844 |
dc.contributor.referee3.fl_str_mv |
Oliveira, Ana Paula Ligeiro de |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/5700855351581023 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8606568322082936 |
dc.contributor.author.fl_str_mv |
Pereira, Paulo Rog??rio |
contributor_str_mv |
Vieira, Rodolfo de Paula Vieira, Rodolfo de Paula Prado, Carla M??ximo Oliveira, Ana Paula Ligeiro de |
dc.subject.eng.fl_str_mv |
idiopathic pulmonary fibrosis exercise immunology physical training serotonin cytokines |
topic |
idiopathic pulmonary fibrosis exercise immunology physical training serotonin cytokines CIENCIAS DA SAUDE |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Background: Idiopathic pulmonary fibrosis (IPF) is characterized by decline of lung function, increased inflammation and fibrosis mainly in the pulmonary interstitium, with serotonin (5-HT) and Akt signaling presenting a role. Aerobic training (AT) reduces lung injury in different models of pulmonary diseases. However, the mechanisms underlying the effects of AT in a model of bleomycin-induced lung fibrosis is unknown. Thus, this study investigated the effects of AT in a model of bleomycin-induced pulmonary fibrosis, as well as the participation of 5HT/Akt signaling. Methods: Seventy-two C57Bl/6 male mice were distributed in Control (Co), Exercise (Ex), Fibrosis (Fi) and Fibrosis+Exercise (Fi+Ex) groups. Bleomycin (1.5UI/Kg) was administered on day 1 and treadmill AT began on day 14 during 4 weeks. Total and differential cells count in bronchoalveolar lavage (BAL), IL-1beta, IL-6, CXCL1/KC, IL-10, TNF-alpha and TGF-beta levels in BAL fluid, collagen content in the lung parenchyma, 5-HT levels in BAL fluid and in serum, and the expression of 5-HT2b receptor and Aktphosphorylation were evaluated. Results: AT reduced bleomycin-increased number of total cells (p<0.001), neutrophils (p<0.01), macrophages (p<0.01) and lymphocytes (p<0.05) in BAL. AT also reduced the levels of IL-1beta (p<0.01), IL-6 (p<0.05), CXCL1/KC (p<0.001), TNF-alpha (p<0.001) and TGF-beta (p<0.001), while increased the levels of IL-10 (p<0.001). Collagen fibers deposition was also reduced by AT (p<0.01). These findings were followed by AT-reduced bleomycin-increased 5-HT levels in BAL fluid (p<0.001) and in serum (p<0.05), as well as the expression of 5-HT2b receptor (p<0.01) and the Aktphosphorylation in lung tissue. Conclusions: We conclude that AT reduces lung inflammation and fibrosis in a model of bleomycin-induced lung fibrosis involving 5-HT/Akt signaling. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-12-15 |
dc.date.accessioned.fl_str_mv |
2016-05-25T17:34:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Pereira, Paulo Rog??rio. Efeitos do treinamento f??sico aer??bico na fibrose pulmonar. 2014. 62 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1346 |
identifier_str_mv |
Pereira, Paulo Rog??rio. Efeitos do treinamento f??sico aer??bico na fibrose pulmonar. 2014. 62 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/1346 |
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por |
language |
por |
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8765449414823306929 |
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600 |
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openAccess |
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Universidade Nove de Julho |
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Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o |
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UNINOVE |
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Brasil |
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Sa??de |
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Universidade Nove de Julho |
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