Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos

Detalhes bibliográficos
Autor(a) principal: Cruz, Luiz Gustavo Balaguer
Data de Publicação: 2014
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da Uninove
Texto Completo: http://bibliotecatede.uninove.br/handle/tede/1314
Resumo: The skin is a coating tissue which undergoes permanent environmental action, often in aggressive forms, causing damage to this tissue. Generally, in the repair process structural changes occur which progress to the development of a scar. In this case the tissue may present morphological changes that interfere with its mechanical properties and this repair process produces a tissue with different properties than of the original tissue. Therefore, the use of therapies that favor this repair is important to seek a better scar quality. Low-level laser therapy appears as a resource used in the modulation of the inflammatory process helping the skin repair process. The objective of this study was evaluate the effect of low level laser (830nm) with 100 mW of potency us ing 1J or 3J of energy comparing to the effect of the topical sodium diclofenac on the repair process of the rat??s skin after induction of injury, analyzing the biomechanical behavior and histological changes of skin, 28 days after the harmful process. Male Wistar rats between 150g to 200g, 3 months old were used. The animals were anesthetized with association of xylazine hydrochloride and ketamine (90mg / kg and 10mg / kg, respectively, intraperitoneal injection). Once anesthetizd, 2 lesions were performed using a surgical scalpel at the dorsal area of the animal. The animals were divided into 5 groups of 7 animals: control (CTL), untreated scar (NT), scar + anti-inflammatory (DIC), scar + 1J laser (L1J) and scar + 3J laser (L3J). The pharmacological treatment and laser therapy were performed immediately after lesion induction and maintained daily irradiation until day 7. After 28 days, the animals were euthanized with an overdose of the same anesthetic and the tissue was immediately removed for histological analysis and traction trials. Results: Both the NT and group DIC showed a reduction of mechanical properties and alterations in histology analysis. L1J group showed significant improvement in mechanical properties and histological organization. We conclude that laser therapy improves certain mechanical properties of skin in this lesion model. However, more studies should be conducted to understand the proportion and organization of collagen fibers I and III biochemicaly. Either the study can be longer and evaluate the scars after the remodeling process.
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spelling Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Frigo, L??ciohttp://lattes.cnpq.br/8191788652250529Chavantes, Maria Cristinahttp://lattes.cnpq.br/9684711829191051http://lattes.cnpq.br/3204937441638378Cruz, Luiz Gustavo Balaguer2016-05-19T15:30:42Z2014-12-16Cruz, Luiz Gustavo Balaguer. Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos. 2014. 74 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1314The skin is a coating tissue which undergoes permanent environmental action, often in aggressive forms, causing damage to this tissue. Generally, in the repair process structural changes occur which progress to the development of a scar. In this case the tissue may present morphological changes that interfere with its mechanical properties and this repair process produces a tissue with different properties than of the original tissue. Therefore, the use of therapies that favor this repair is important to seek a better scar quality. Low-level laser therapy appears as a resource used in the modulation of the inflammatory process helping the skin repair process. The objective of this study was evaluate the effect of low level laser (830nm) with 100 mW of potency us ing 1J or 3J of energy comparing to the effect of the topical sodium diclofenac on the repair process of the rat??s skin after induction of injury, analyzing the biomechanical behavior and histological changes of skin, 28 days after the harmful process. Male Wistar rats between 150g to 200g, 3 months old were used. The animals were anesthetized with association of xylazine hydrochloride and ketamine (90mg / kg and 10mg / kg, respectively, intraperitoneal injection). Once anesthetizd, 2 lesions were performed using a surgical scalpel at the dorsal area of the animal. The animals were divided into 5 groups of 7 animals: control (CTL), untreated scar (NT), scar + anti-inflammatory (DIC), scar + 1J laser (L1J) and scar + 3J laser (L3J). The pharmacological treatment and laser therapy were performed immediately after lesion induction and maintained daily irradiation until day 7. After 28 days, the animals were euthanized with an overdose of the same anesthetic and the tissue was immediately removed for histological analysis and traction trials. Results: Both the NT and group DIC showed a reduction of mechanical properties and alterations in histology analysis. L1J group showed significant improvement in mechanical properties and histological organization. We conclude that laser therapy improves certain mechanical properties of skin in this lesion model. However, more studies should be conducted to understand the proportion and organization of collagen fibers I and III biochemicaly. Either the study can be longer and evaluate the scars after the remodeling process.A pele ?? um tecido de revestimento que sofre permanente a????o do ambiente, muitas vezes de forma agressiva, levando a les??o deste tecido. Geralmente em seu processo de reparo ocorrem altera????es estruturais que evoluem para o desenvolvimento de uma cicatriz. Neste caso o tecido pode apresentar altera????es morfol??gicas que interferem em suas propriedades mec??nicas e este processo de reparo produz um tecido com propriedades diferentes do tecido original. Dessa forma, a utiliza????o de terapias que favore??am esta repara????o ?? importante para buscar uma qualidade melhor da cicatriz. A terapia com laser de baixa pot??ncia aparece como um recurso utilizado na modula????o do processo inflamat??rio auxiliando no processo de reparo da pele. O Objetivo deste trabalho foi avaliar o efeito da terapia com laser de baixa pot??ncia de 830nm, com 100mW de pot??ncia nas energias de um 1J e 3J comparativamente ao efeito do diclofenaco de s??dio t??pico no processo de reparo da pele de ratos, ap??s a indu????o de uma les??o controlada, observando aspectos histol??gicos e biomec??nicos. Foram utilizados ratos wistar, entre 150g ?? 200g, com 3 meses de idade. Os animais foram anestesiados com associa????o de cloridrato de quetamina e xilazina (90mg/Kg e 10mg/Kg respectivamente, inje????o intraperitoneal). Depois de anestesiados, foram realizadas 2 les??es cortantes utilizando um bisturi cir??rgico, no dorso do animal. Os animais foram divididos em 5 grupos de 5 animais: Controle (CTL), Cicatriz sem tratamento (NT), Cicatriz + Diclofenaco de s??dio t??pico (DIC), cicatriz + laser 1J (L1J) e cicatriz + laser 3J (L3J). O tratamento farmacol??gico e a terapia laser foram realizados imediatamente ap??s a indu????o da les??o e mantida a irradia????o di??ria at?? o s??timo dia. Ap??s 28 dias, os animais foram eutanasiados com hiperdosagem do mesmo anest??sico e o tecido foi imediatamente retirado para an??lises histol??gicas e de ensaios de tra????o. Resultados: Tanto o grupo NT quanto o grupo DIC apresentaram redu????o das propriedades mec??nicas e altera????es nas an??lises histol??gicas. O grupo tratado L1J e o grupo L3J apresentaram significativa melhora das propriedades mec??nicas e na organiza????o histol??gica. O grupo L1J apresentou resultados histol??gicos e biomec??nicos pr??ximos ao tecido saud??vel do grupo CTL. Conclus??o: Conclu??mos que a utiliza????o do diclofenaco de s??dio t??pico n??o conseguiu melhorar as caracter??sticas histol??gicas e biomec??nicas da pele ap??s a indu????o da les??o. A terapia com laser de baixa pot??ncia foi eficaz na melhora destas propriedades, sugerindo um melhor reparo tecidual. Por??m, mais estudos devem ser realizados visando entender a propor????o e organiza????o das fibras de col??geno ou mesmo o estudo de tempos de reparo superiores ao utilizados neste estudo.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-19T15:30:42Z No. of bitstreams: 1 Luiz Gustavo Balaguer.pdf: 2319004 bytes, checksum: 8ae6797553f9db1485a7a79e6cfa0616 (MD5)Made available in DSpace on 2016-05-19T15:30:42Z (GMT). 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dc.title.por.fl_str_mv Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos
dc.title.alternative.eng.fl_str_mv Comparison between the effect of the use of sodium diclofenac and the low level laser (830nm) an the wound healing process in rat skin: biomechanical and histological aspects
title Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos
spellingShingle Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos
Cruz, Luiz Gustavo Balaguer
cicatriz
laserterapia
col??geno
propriedades mec??nicas
diclofenaco de s??dio
scar
healing
LLLT
collagen
mechanical properties
sodiun diclofenac
CIENCIAS DA SAUDE
title_short Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos
title_full Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos
title_fullStr Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos
title_full_unstemmed Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos
title_sort Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos
author Cruz, Luiz Gustavo Balaguer
author_facet Cruz, Luiz Gustavo Balaguer
author_role author
dc.contributor.advisor1.fl_str_mv Marcos, Rodrigo Labat
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/2964112163504080
dc.contributor.referee1.fl_str_mv Marcos, Rodrigo Labat
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/2964112163504080
dc.contributor.referee2.fl_str_mv Frigo, L??cio
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/8191788652250529
dc.contributor.referee3.fl_str_mv Chavantes, Maria Cristina
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/9684711829191051
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3204937441638378
dc.contributor.author.fl_str_mv Cruz, Luiz Gustavo Balaguer
contributor_str_mv Marcos, Rodrigo Labat
Marcos, Rodrigo Labat
Frigo, L??cio
Chavantes, Maria Cristina
dc.subject.por.fl_str_mv cicatriz
laserterapia
col??geno
propriedades mec??nicas
diclofenaco de s??dio
topic cicatriz
laserterapia
col??geno
propriedades mec??nicas
diclofenaco de s??dio
scar
healing
LLLT
collagen
mechanical properties
sodiun diclofenac
CIENCIAS DA SAUDE
dc.subject.eng.fl_str_mv scar
healing
LLLT
collagen
mechanical properties
sodiun diclofenac
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE
description The skin is a coating tissue which undergoes permanent environmental action, often in aggressive forms, causing damage to this tissue. Generally, in the repair process structural changes occur which progress to the development of a scar. In this case the tissue may present morphological changes that interfere with its mechanical properties and this repair process produces a tissue with different properties than of the original tissue. Therefore, the use of therapies that favor this repair is important to seek a better scar quality. Low-level laser therapy appears as a resource used in the modulation of the inflammatory process helping the skin repair process. The objective of this study was evaluate the effect of low level laser (830nm) with 100 mW of potency us ing 1J or 3J of energy comparing to the effect of the topical sodium diclofenac on the repair process of the rat??s skin after induction of injury, analyzing the biomechanical behavior and histological changes of skin, 28 days after the harmful process. Male Wistar rats between 150g to 200g, 3 months old were used. The animals were anesthetized with association of xylazine hydrochloride and ketamine (90mg / kg and 10mg / kg, respectively, intraperitoneal injection). Once anesthetizd, 2 lesions were performed using a surgical scalpel at the dorsal area of the animal. The animals were divided into 5 groups of 7 animals: control (CTL), untreated scar (NT), scar + anti-inflammatory (DIC), scar + 1J laser (L1J) and scar + 3J laser (L3J). The pharmacological treatment and laser therapy were performed immediately after lesion induction and maintained daily irradiation until day 7. After 28 days, the animals were euthanized with an overdose of the same anesthetic and the tissue was immediately removed for histological analysis and traction trials. Results: Both the NT and group DIC showed a reduction of mechanical properties and alterations in histology analysis. L1J group showed significant improvement in mechanical properties and histological organization. We conclude that laser therapy improves certain mechanical properties of skin in this lesion model. However, more studies should be conducted to understand the proportion and organization of collagen fibers I and III biochemicaly. Either the study can be longer and evaluate the scars after the remodeling process.
publishDate 2014
dc.date.issued.fl_str_mv 2014-12-16
dc.date.accessioned.fl_str_mv 2016-05-19T15:30:42Z
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dc.identifier.citation.fl_str_mv Cruz, Luiz Gustavo Balaguer. Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos. 2014. 74 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo.
dc.identifier.uri.fl_str_mv http://bibliotecatede.uninove.br/handle/tede/1314
identifier_str_mv Cruz, Luiz Gustavo Balaguer. Compara????o entre o efeito do uso de diclofenaco de s??dio e o laser de baixa pot??ncia (830nm) no processo de cicatriza????o em pele de ratos: aspectos biomec??nicos e histol??gicos. 2014. 74 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo.
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