Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido

Detalhes bibliográficos
Autor(a) principal: Makabe, Marcia Aparecida
Data de Publicação: 2019
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da Uninove
Texto Completo: http://bibliotecatede.uninove.br/handle/tede/2624
Resumo: Cohabitation is related to the act of living with people with certain diseases and there may be psychological, behavioral and immunological changes. Tendinopathies are changes in the tendon, usually difficult to treat, where photobiomodulation therapy has been shown to have good effects. The works relating changes in the cohabitation model and its reflex in tendon repair in the acute phase of inflammation are rare. In the same sense, a study of the effect of cranial photobiomodulation on the modulation of the peripheral inflammatory process as in tendinopathies is non-existent. The objective of this work was to evaluate the effect of photobiomodulation on the inflammatory process of the tendon in mice cohabited with animals with induced bladder tumor. Material and Methods: Forty female C57BL / 6 mice were divided into 4 groups: (Group 1): Animals with induced tendonitis, untreated and cohabited with healthy mice; (Group 2): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with healthy mice; (Group 3): Animals with induced tendonitis, untreated and cohabited with mice with bladder tumor; (Group 4): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with mice with tumor. Tendonitis was performed after 2 weeks of cohabitation. The 20 healthy animals were induced to tendinitis with collagenase injection (100ml / kg) in the region of the calcaneus tendon. The irradiation parameters were: (LED 810nm; 3J; 160mW; 30s). After 12 h of tendinitis induction, the animals of the 4 groups were euthanized with hyperdose of Xilasina and ketamine. The tendons were removed and stored for molecular and histological analysis. Results: Group 3 animals reduced COX-2 expression; IL1β; IL6 and increased NK-1. Similar results were observed with the animals of group 2. The inflammatory infiltrate was also reduced in groups 2, 3 and 4. Conclusion: Animals with tendinitis in cohabitation with animals with bladder tumor present a lower inflammatory scenario than animals that cohabited with healthy mice. Cranial photobiomodulation therapy using LED was effective in reducing tendinitis inflammation in cohabitated animals with healthy mice. However, further analysis is required to determine the mechanism of action involved.
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spelling Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Franco, Adriana Lino dos Santoshttp://lattes.cnpq.br/7295388304888384Lima, Mario de Oliveirahttp://lattes.cnpq.br/9922663048095344Makabe, Marcia Aparecida2021-10-26T20:35:37Z2019-02-06Makabe, Marcia Aparecida. Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido. 2019. 47 f. Dissertação( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2624Cohabitation is related to the act of living with people with certain diseases and there may be psychological, behavioral and immunological changes. Tendinopathies are changes in the tendon, usually difficult to treat, where photobiomodulation therapy has been shown to have good effects. The works relating changes in the cohabitation model and its reflex in tendon repair in the acute phase of inflammation are rare. In the same sense, a study of the effect of cranial photobiomodulation on the modulation of the peripheral inflammatory process as in tendinopathies is non-existent. The objective of this work was to evaluate the effect of photobiomodulation on the inflammatory process of the tendon in mice cohabited with animals with induced bladder tumor. Material and Methods: Forty female C57BL / 6 mice were divided into 4 groups: (Group 1): Animals with induced tendonitis, untreated and cohabited with healthy mice; (Group 2): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with healthy mice; (Group 3): Animals with induced tendonitis, untreated and cohabited with mice with bladder tumor; (Group 4): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with mice with tumor. Tendonitis was performed after 2 weeks of cohabitation. The 20 healthy animals were induced to tendinitis with collagenase injection (100ml / kg) in the region of the calcaneus tendon. The irradiation parameters were: (LED 810nm; 3J; 160mW; 30s). After 12 h of tendinitis induction, the animals of the 4 groups were euthanized with hyperdose of Xilasina and ketamine. The tendons were removed and stored for molecular and histological analysis. Results: Group 3 animals reduced COX-2 expression; IL1β; IL6 and increased NK-1. Similar results were observed with the animals of group 2. The inflammatory infiltrate was also reduced in groups 2, 3 and 4. Conclusion: Animals with tendinitis in cohabitation with animals with bladder tumor present a lower inflammatory scenario than animals that cohabited with healthy mice. Cranial photobiomodulation therapy using LED was effective in reducing tendinitis inflammation in cohabitated animals with healthy mice. However, further analysis is required to determine the mechanism of action involved.A Coabitação está relacionada ao ato de conviver com pessoas portadoras de determinadas doenças podendo haver alterações psicológicas, comportamentais e imunológicas. As tendinopatias são alterações no tendão, geralmente difíceis de serem tratadas, onde a terapia por fotobiomodulação vem apresentando bons efeitos. São raros os trabalhos relacionando alterações no modelo de coabitação e seu reflexo no reparo tendíneo na fase aguda da inflamação. No mesmo sentido, estudo do efeito da fotobiomodulação craniana na modulação do processo inflamatório periférico como nas tendinopatias são inexistentes. O objetivo deste trabalho foi avaliar o efeito da fotobiomodulação sobre o processo inflamatório do tendão em camundongos coabitados com animais com tumor de bexiga induzido. Material e Métodos: Quarenta camundongos C57BL/6 fêmeas foram distribuídas em 4 grupos: (Grupo 1): Animais com tendinite induzida, sem tratamento e coabitado com camundongos saudáveis; (Grupo 2): Animais com tendinite induzida, tratado com LEDterapia craniana e coabitado com camundongos saudaveis; (Grupo 3): Animais com tendinite induzida, sem tratamento e coabitado com camundongos com tumor de bexiga; (Grupo 4): Animais com tendinite induzida, tratado com LEDterapia craniana e coabitado com camundongos com tumor. A tendinite foi realizada após 2 semanas de coabitação. Os 20 animais saudáveis foram induzidos a tendinite com injeção de colagenase (100ml/kg) na região do tendão calcâneo. Os parâmetros de irradiação foram: (LED 810nm; 3J; 160mW; 30s). Após 12h da indução da tendinite, os animais dos 4 grupos foram eutanasiados com hiperdose de Xilasina e quetamina. Os tendões foram removidos e armazenados para analises moleculares e histológicos. Resultados: Os animais do grupo 3 reduziram a expressão de COX-2; IL1β; IL6 e aumentaram NK-1. Resultados similares foram observados com os animais do grupo 2. O infiltrado inflamatório também foi reduzido nos grupos 2, 3 e 4. Conclusão: Animais com tendinite em coabitação com animais com tumor de bexiga apresentam menor cenário inflamatório que os animais que coabitaram com camundongos saudáveis. A terapia por fotobiomodulacão craniana utilizando LED foi eficaz na redução da inflamação tendinea em animais coabitados com camundongos saudáveis. No entanto são necessários outras analises para a determinação do mecanismo de ação envolvido.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-10-26T20:35:37Z No. of bitstreams: 1 Márcia Aparecida Makabe.pdf: 1469331 bytes, checksum: 8dc82fa8085edf22f906e26657faa462 (MD5)Made available in DSpace on 2021-10-26T20:35:37Z (GMT). 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dc.title.por.fl_str_mv Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido
title Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido
spellingShingle Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido
Makabe, Marcia Aparecida
coabitação
tendinite
fotobiomodulação
laser de baixa intensidade
mediadores inflamatórios
cohabitation
tendonitis
photobiomodulation
low intensity laser
inflammatory mediators
CIENCIAS DA SAUDE
title_short Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido
title_full Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido
title_fullStr Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido
title_full_unstemmed Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido
title_sort Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido
author Makabe, Marcia Aparecida
author_facet Makabe, Marcia Aparecida
author_role author
dc.contributor.advisor1.fl_str_mv Marcos, Rodrigo Labat
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/2964112163504080
dc.contributor.referee1.fl_str_mv Marcos, Rodrigo Labat
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/2964112163504080
dc.contributor.referee2.fl_str_mv Franco, Adriana Lino dos Santos
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/7295388304888384
dc.contributor.referee3.fl_str_mv Lima, Mario de Oliveira
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/9922663048095344
dc.contributor.author.fl_str_mv Makabe, Marcia Aparecida
contributor_str_mv Marcos, Rodrigo Labat
Marcos, Rodrigo Labat
Franco, Adriana Lino dos Santos
Lima, Mario de Oliveira
dc.subject.por.fl_str_mv coabitação
tendinite
fotobiomodulação
laser de baixa intensidade
mediadores inflamatórios
topic coabitação
tendinite
fotobiomodulação
laser de baixa intensidade
mediadores inflamatórios
cohabitation
tendonitis
photobiomodulation
low intensity laser
inflammatory mediators
CIENCIAS DA SAUDE
dc.subject.eng.fl_str_mv cohabitation
tendonitis
photobiomodulation
low intensity laser
inflammatory mediators
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE
description Cohabitation is related to the act of living with people with certain diseases and there may be psychological, behavioral and immunological changes. Tendinopathies are changes in the tendon, usually difficult to treat, where photobiomodulation therapy has been shown to have good effects. The works relating changes in the cohabitation model and its reflex in tendon repair in the acute phase of inflammation are rare. In the same sense, a study of the effect of cranial photobiomodulation on the modulation of the peripheral inflammatory process as in tendinopathies is non-existent. The objective of this work was to evaluate the effect of photobiomodulation on the inflammatory process of the tendon in mice cohabited with animals with induced bladder tumor. Material and Methods: Forty female C57BL / 6 mice were divided into 4 groups: (Group 1): Animals with induced tendonitis, untreated and cohabited with healthy mice; (Group 2): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with healthy mice; (Group 3): Animals with induced tendonitis, untreated and cohabited with mice with bladder tumor; (Group 4): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with mice with tumor. Tendonitis was performed after 2 weeks of cohabitation. The 20 healthy animals were induced to tendinitis with collagenase injection (100ml / kg) in the region of the calcaneus tendon. The irradiation parameters were: (LED 810nm; 3J; 160mW; 30s). After 12 h of tendinitis induction, the animals of the 4 groups were euthanized with hyperdose of Xilasina and ketamine. The tendons were removed and stored for molecular and histological analysis. Results: Group 3 animals reduced COX-2 expression; IL1β; IL6 and increased NK-1. Similar results were observed with the animals of group 2. The inflammatory infiltrate was also reduced in groups 2, 3 and 4. Conclusion: Animals with tendinitis in cohabitation with animals with bladder tumor present a lower inflammatory scenario than animals that cohabited with healthy mice. Cranial photobiomodulation therapy using LED was effective in reducing tendinitis inflammation in cohabitated animals with healthy mice. However, further analysis is required to determine the mechanism of action involved.
publishDate 2019
dc.date.issued.fl_str_mv 2019-02-06
dc.date.accessioned.fl_str_mv 2021-10-26T20:35:37Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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dc.identifier.citation.fl_str_mv Makabe, Marcia Aparecida. Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido. 2019. 47 f. Dissertação( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo.
dc.identifier.uri.fl_str_mv http://bibliotecatede.uninove.br/handle/tede/2624
identifier_str_mv Makabe, Marcia Aparecida. Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido. 2019. 47 f. Dissertação( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo.
url http://bibliotecatede.uninove.br/handle/tede/2624
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dc.publisher.initials.fl_str_mv UNINOVE
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Saúde
publisher.none.fl_str_mv Universidade Nove de Julho
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