Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/2624 |
Resumo: | Cohabitation is related to the act of living with people with certain diseases and there may be psychological, behavioral and immunological changes. Tendinopathies are changes in the tendon, usually difficult to treat, where photobiomodulation therapy has been shown to have good effects. The works relating changes in the cohabitation model and its reflex in tendon repair in the acute phase of inflammation are rare. In the same sense, a study of the effect of cranial photobiomodulation on the modulation of the peripheral inflammatory process as in tendinopathies is non-existent. The objective of this work was to evaluate the effect of photobiomodulation on the inflammatory process of the tendon in mice cohabited with animals with induced bladder tumor. Material and Methods: Forty female C57BL / 6 mice were divided into 4 groups: (Group 1): Animals with induced tendonitis, untreated and cohabited with healthy mice; (Group 2): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with healthy mice; (Group 3): Animals with induced tendonitis, untreated and cohabited with mice with bladder tumor; (Group 4): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with mice with tumor. Tendonitis was performed after 2 weeks of cohabitation. The 20 healthy animals were induced to tendinitis with collagenase injection (100ml / kg) in the region of the calcaneus tendon. The irradiation parameters were: (LED 810nm; 3J; 160mW; 30s). After 12 h of tendinitis induction, the animals of the 4 groups were euthanized with hyperdose of Xilasina and ketamine. The tendons were removed and stored for molecular and histological analysis. Results: Group 3 animals reduced COX-2 expression; IL1β; IL6 and increased NK-1. Similar results were observed with the animals of group 2. The inflammatory infiltrate was also reduced in groups 2, 3 and 4. Conclusion: Animals with tendinitis in cohabitation with animals with bladder tumor present a lower inflammatory scenario than animals that cohabited with healthy mice. Cranial photobiomodulation therapy using LED was effective in reducing tendinitis inflammation in cohabitated animals with healthy mice. However, further analysis is required to determine the mechanism of action involved. |
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Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Franco, Adriana Lino dos Santoshttp://lattes.cnpq.br/7295388304888384Lima, Mario de Oliveirahttp://lattes.cnpq.br/9922663048095344Makabe, Marcia Aparecida2021-10-26T20:35:37Z2019-02-06Makabe, Marcia Aparecida. Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido. 2019. 47 f. Dissertação( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2624Cohabitation is related to the act of living with people with certain diseases and there may be psychological, behavioral and immunological changes. Tendinopathies are changes in the tendon, usually difficult to treat, where photobiomodulation therapy has been shown to have good effects. The works relating changes in the cohabitation model and its reflex in tendon repair in the acute phase of inflammation are rare. In the same sense, a study of the effect of cranial photobiomodulation on the modulation of the peripheral inflammatory process as in tendinopathies is non-existent. The objective of this work was to evaluate the effect of photobiomodulation on the inflammatory process of the tendon in mice cohabited with animals with induced bladder tumor. Material and Methods: Forty female C57BL / 6 mice were divided into 4 groups: (Group 1): Animals with induced tendonitis, untreated and cohabited with healthy mice; (Group 2): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with healthy mice; (Group 3): Animals with induced tendonitis, untreated and cohabited with mice with bladder tumor; (Group 4): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with mice with tumor. Tendonitis was performed after 2 weeks of cohabitation. The 20 healthy animals were induced to tendinitis with collagenase injection (100ml / kg) in the region of the calcaneus tendon. The irradiation parameters were: (LED 810nm; 3J; 160mW; 30s). After 12 h of tendinitis induction, the animals of the 4 groups were euthanized with hyperdose of Xilasina and ketamine. The tendons were removed and stored for molecular and histological analysis. Results: Group 3 animals reduced COX-2 expression; IL1β; IL6 and increased NK-1. Similar results were observed with the animals of group 2. The inflammatory infiltrate was also reduced in groups 2, 3 and 4. Conclusion: Animals with tendinitis in cohabitation with animals with bladder tumor present a lower inflammatory scenario than animals that cohabited with healthy mice. Cranial photobiomodulation therapy using LED was effective in reducing tendinitis inflammation in cohabitated animals with healthy mice. However, further analysis is required to determine the mechanism of action involved.A Coabitação está relacionada ao ato de conviver com pessoas portadoras de determinadas doenças podendo haver alterações psicológicas, comportamentais e imunológicas. As tendinopatias são alterações no tendão, geralmente difíceis de serem tratadas, onde a terapia por fotobiomodulação vem apresentando bons efeitos. São raros os trabalhos relacionando alterações no modelo de coabitação e seu reflexo no reparo tendíneo na fase aguda da inflamação. No mesmo sentido, estudo do efeito da fotobiomodulação craniana na modulação do processo inflamatório periférico como nas tendinopatias são inexistentes. O objetivo deste trabalho foi avaliar o efeito da fotobiomodulação sobre o processo inflamatório do tendão em camundongos coabitados com animais com tumor de bexiga induzido. Material e Métodos: Quarenta camundongos C57BL/6 fêmeas foram distribuídas em 4 grupos: (Grupo 1): Animais com tendinite induzida, sem tratamento e coabitado com camundongos saudáveis; (Grupo 2): Animais com tendinite induzida, tratado com LEDterapia craniana e coabitado com camundongos saudaveis; (Grupo 3): Animais com tendinite induzida, sem tratamento e coabitado com camundongos com tumor de bexiga; (Grupo 4): Animais com tendinite induzida, tratado com LEDterapia craniana e coabitado com camundongos com tumor. A tendinite foi realizada após 2 semanas de coabitação. Os 20 animais saudáveis foram induzidos a tendinite com injeção de colagenase (100ml/kg) na região do tendão calcâneo. Os parâmetros de irradiação foram: (LED 810nm; 3J; 160mW; 30s). Após 12h da indução da tendinite, os animais dos 4 grupos foram eutanasiados com hiperdose de Xilasina e quetamina. Os tendões foram removidos e armazenados para analises moleculares e histológicos. Resultados: Os animais do grupo 3 reduziram a expressão de COX-2; IL1β; IL6 e aumentaram NK-1. Resultados similares foram observados com os animais do grupo 2. O infiltrado inflamatório também foi reduzido nos grupos 2, 3 e 4. Conclusão: Animais com tendinite em coabitação com animais com tumor de bexiga apresentam menor cenário inflamatório que os animais que coabitaram com camundongos saudáveis. A terapia por fotobiomodulacão craniana utilizando LED foi eficaz na redução da inflamação tendinea em animais coabitados com camundongos saudáveis. No entanto são necessários outras analises para a determinação do mecanismo de ação envolvido.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-10-26T20:35:37Z No. of bitstreams: 1 Márcia Aparecida Makabe.pdf: 1469331 bytes, checksum: 8dc82fa8085edf22f906e26657faa462 (MD5)Made available in DSpace on 2021-10-26T20:35:37Z (GMT). No. of bitstreams: 1 Márcia Aparecida Makabe.pdf: 1469331 bytes, checksum: 8dc82fa8085edf22f906e26657faa462 (MD5) Previous issue date: 2019-02-06application/pdfporUniversidade Nove de JulhoPrograma de Pós-Graduação em Biofotônica Aplicada às Ciências da SaúdeUNINOVEBrasilSaúdecoabitaçãotendinitefotobiomodulaçãolaser de baixa intensidademediadores inflamatórioscohabitationtendonitisphotobiomodulationlow intensity laserinflammatory mediatorsCIENCIAS DA SAUDEEstudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzidoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALMárcia Aparecida Makabe.pdfMárcia Aparecida Makabe.pdfapplication/pdf1469331http://localhost:8080/tede/bitstream/tede/2624/2/M%C3%A1rcia+Aparecida+Makabe.pdf8dc82fa8085edf22f906e26657faa462MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2624/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/26242021-10-26 18:35:37.666oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2021-10-26T20:35:37Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido |
title |
Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido |
spellingShingle |
Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido Makabe, Marcia Aparecida coabitação tendinite fotobiomodulação laser de baixa intensidade mediadores inflamatórios cohabitation tendonitis photobiomodulation low intensity laser inflammatory mediators CIENCIAS DA SAUDE |
title_short |
Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido |
title_full |
Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido |
title_fullStr |
Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido |
title_full_unstemmed |
Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido |
title_sort |
Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido |
author |
Makabe, Marcia Aparecida |
author_facet |
Makabe, Marcia Aparecida |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Marcos, Rodrigo Labat |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2964112163504080 |
dc.contributor.referee1.fl_str_mv |
Marcos, Rodrigo Labat |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2964112163504080 |
dc.contributor.referee2.fl_str_mv |
Franco, Adriana Lino dos Santos |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7295388304888384 |
dc.contributor.referee3.fl_str_mv |
Lima, Mario de Oliveira |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9922663048095344 |
dc.contributor.author.fl_str_mv |
Makabe, Marcia Aparecida |
contributor_str_mv |
Marcos, Rodrigo Labat Marcos, Rodrigo Labat Franco, Adriana Lino dos Santos Lima, Mario de Oliveira |
dc.subject.por.fl_str_mv |
coabitação tendinite fotobiomodulação laser de baixa intensidade mediadores inflamatórios |
topic |
coabitação tendinite fotobiomodulação laser de baixa intensidade mediadores inflamatórios cohabitation tendonitis photobiomodulation low intensity laser inflammatory mediators CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
cohabitation tendonitis photobiomodulation low intensity laser inflammatory mediators |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Cohabitation is related to the act of living with people with certain diseases and there may be psychological, behavioral and immunological changes. Tendinopathies are changes in the tendon, usually difficult to treat, where photobiomodulation therapy has been shown to have good effects. The works relating changes in the cohabitation model and its reflex in tendon repair in the acute phase of inflammation are rare. In the same sense, a study of the effect of cranial photobiomodulation on the modulation of the peripheral inflammatory process as in tendinopathies is non-existent. The objective of this work was to evaluate the effect of photobiomodulation on the inflammatory process of the tendon in mice cohabited with animals with induced bladder tumor. Material and Methods: Forty female C57BL / 6 mice were divided into 4 groups: (Group 1): Animals with induced tendonitis, untreated and cohabited with healthy mice; (Group 2): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with healthy mice; (Group 3): Animals with induced tendonitis, untreated and cohabited with mice with bladder tumor; (Group 4): Animals with induced tendinitis, treated with LED cranial therapy and cohabited with mice with tumor. Tendonitis was performed after 2 weeks of cohabitation. The 20 healthy animals were induced to tendinitis with collagenase injection (100ml / kg) in the region of the calcaneus tendon. The irradiation parameters were: (LED 810nm; 3J; 160mW; 30s). After 12 h of tendinitis induction, the animals of the 4 groups were euthanized with hyperdose of Xilasina and ketamine. The tendons were removed and stored for molecular and histological analysis. Results: Group 3 animals reduced COX-2 expression; IL1β; IL6 and increased NK-1. Similar results were observed with the animals of group 2. The inflammatory infiltrate was also reduced in groups 2, 3 and 4. Conclusion: Animals with tendinitis in cohabitation with animals with bladder tumor present a lower inflammatory scenario than animals that cohabited with healthy mice. Cranial photobiomodulation therapy using LED was effective in reducing tendinitis inflammation in cohabitated animals with healthy mice. However, further analysis is required to determine the mechanism of action involved. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-02-06 |
dc.date.accessioned.fl_str_mv |
2021-10-26T20:35:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Makabe, Marcia Aparecida. Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido. 2019. 47 f. Dissertação( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2624 |
identifier_str_mv |
Makabe, Marcia Aparecida. Estudo experimental da fotobiomodulação em modelo de coabitação entre camundongos com tendinite e camundongos com tumor de bexiga induzido. 2019. 47 f. Dissertação( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/2624 |
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por |
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Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde |
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UNINOVE |
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Saúde |
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Universidade Nove de Julho |
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