Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/2675 |
Resumo: | Heart failure (HF) has as its main etiology myocardial infarction (MI), followed by cardiac remodeling, associated with the effective participation of oxidative stress in its genesis. Our objective was to analyze the effects of Carvedilol therapy and photobiomodulation with low lavel laser therapy (LLLT) on cardiac remodeling and oxidative stress in rats infarcted with HF. The study was approved by the Committee on ethics in the use of animals of the University Nove de Julho under number 0016/2016. The final sample size was 127 rats, arranged in 5 experimental groups: SHAM, IM, IMC (Carvedilol treated myocardial infarction), IML (LLLT treated myocardial infarction), IMCL (Carvedilol treated myocardial infarction associated with LLLT ). The results show increase of body weight over the study period in the SHAM, IMC and IML groups, respectively. The aerobic physical performance of all infarcted groups, regardless of any intervention, presented depression at 29 days of study. LV morphological assessments demonstrate that therapies alone or in combination did not result in benefits, and LV systolic and diastolic function data demonstrate that all infarcted animals exhibited performance depression on systolic function 3 days after coronary occlusion, however, significant improvement was observed in the IMCL group at the end of the study. Oxidative stress decreased in the IML group compared to the IM group. Benefits in the expression of carbonylated proteins were evident only in the IMCL group, compared to the IM group. Data on the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in myocardium remote from infarction, showed that there was no benefit of the isolated or combined therapies in SOD and CAT activity in the IMCL group, was significantly higher than values found in the other experimental groups. Survival curves did not show significant differences between groups over 30 days of follow-up. We conclude in this study that Carvedilol and photobiomodulation therapy with LLLT have similar effects on post-infarction HF, considering changes in physical performance, cardiopulmonary biometry and left ventricular morpho-functionality. However, a local anti-inflammatory effect was more evident in animals treated with LBI. In addition, the combination of therapies resulted in attenuation of myocardial hypertrophy and improvement of LV FEAT. |
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Serra, Andrey Jorgehttp://lattes.cnpq.br/6499058447489317Serra, Andrey Jorgehttp://lattes.cnpq.br/6499058447489317Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Silva Junior, Jose Antoniohttp://lattes.cnpq.br/1990427833073161Cunha, Gisela Arsahttp://lattes.cnpq.br/3487458312770368Lunardi, Adriana Claudiahttp://lattes.cnpq.br/8310494300611620http://lattes.cnpq.br/7832637696275599Grandinétti, Vanessa dos Santos2021-11-04T19:04:13Z2018-03-09Grandinétti, Vanessa dos Santos. Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol. 2018. 65 f. Tese( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2675Heart failure (HF) has as its main etiology myocardial infarction (MI), followed by cardiac remodeling, associated with the effective participation of oxidative stress in its genesis. Our objective was to analyze the effects of Carvedilol therapy and photobiomodulation with low lavel laser therapy (LLLT) on cardiac remodeling and oxidative stress in rats infarcted with HF. The study was approved by the Committee on ethics in the use of animals of the University Nove de Julho under number 0016/2016. The final sample size was 127 rats, arranged in 5 experimental groups: SHAM, IM, IMC (Carvedilol treated myocardial infarction), IML (LLLT treated myocardial infarction), IMCL (Carvedilol treated myocardial infarction associated with LLLT ). The results show increase of body weight over the study period in the SHAM, IMC and IML groups, respectively. The aerobic physical performance of all infarcted groups, regardless of any intervention, presented depression at 29 days of study. LV morphological assessments demonstrate that therapies alone or in combination did not result in benefits, and LV systolic and diastolic function data demonstrate that all infarcted animals exhibited performance depression on systolic function 3 days after coronary occlusion, however, significant improvement was observed in the IMCL group at the end of the study. Oxidative stress decreased in the IML group compared to the IM group. Benefits in the expression of carbonylated proteins were evident only in the IMCL group, compared to the IM group. Data on the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in myocardium remote from infarction, showed that there was no benefit of the isolated or combined therapies in SOD and CAT activity in the IMCL group, was significantly higher than values found in the other experimental groups. Survival curves did not show significant differences between groups over 30 days of follow-up. We conclude in this study that Carvedilol and photobiomodulation therapy with LLLT have similar effects on post-infarction HF, considering changes in physical performance, cardiopulmonary biometry and left ventricular morpho-functionality. However, a local anti-inflammatory effect was more evident in animals treated with LBI. In addition, the combination of therapies resulted in attenuation of myocardial hypertrophy and improvement of LV FEAT.A insuficiência cardíaca (IC) tem como principal etiologia o infarto do miocárdio (IM), seguido de remodelamento cardíaco, associada à participação efetiva do estresse oxidativo em sua gênese. Nosso objetivo foi analisar os efeitos da terapia com Carvedilol e fotobiomodulação com laserterapia de baixa intensidade (LBI) no remodelamento cardíaco e estresse oxidativo em ratas infartadas com IC. O estudo foi aprovado pela Comissão de ética no uso de animais da Universidade Nove de Julho sob o número 0016/2016. O tamanho amostral final foi de 127 ratas, dispostas em 5 grupos experimentais: SHAM, IM, IMC (infarto do miocárdio tratado com Carvedilol), IML (infarto do miocárdio tratado com LBI), IMCL (infarto do miocárdio tratado com Carvedilol associado à LBI). Os resultados mostram aumento do peso corporal ao longo do período de estudo nos grupos SHAM, IMC e IML, respectivamente. O desempenho físico aeróbio de todos os grupos infartados, independentemente de qualquer intervenção, apresentou depressão aos 29 dias de estudo. As avaliações morfológicas do VE demonstram que as terapias, isoladas ou combinadas, não resultaram em benefícios, e os dados de função VE sistólica e diastólica demonstram que todos os animais infartados exibiram depressão de desempenho na função sistólica com 3 dias após oclusão coronariana, entretanto, melhora significativa foi observada no grupo IMCL ao final do estudo. O estresse oxidativo diminuiu no grupo IML comparado ao grupo IM. Benefícios na expressão de proteínas carboniladas foram evidentes somente no grupo IMCL, em comparação ao grupo IM. Os dados referentes à atividade das enzimas antioxidantes superóxido dismutase (SOD) e catalase (CAT) no miocárdio remoto ao infarto, mostraram que não houve benefício das terapias isoladas ou combinadas na SOD e a atividade da CAT no grupo IMCL, foi significativamente superior a valores encontrados nos demais grupos experimentais. As curvas de sobrevida não demonstraram diferenças significantes entre os grupos ao longo de 30 dias de seguimento. Concluímos nesse estudo que o Carvedilol e a terapia de fotobiomodulação com LBI possuem efeitos similares na IC pós-infarto, considerando as alterações de desempenho físico, de biometria cardiopulmonar e morfofuncionalidade do VE. Todavia, um efeito anti-inflamatório local foi mais evidente nos animais submetidos ao tratamento com LBI. Além disso, a combinação das terapias resultou em atenuação da hipertrofia miocárdica e melhora da FEAT do VE.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-11-04T19:04:13Z No. of bitstreams: 1 Vanessa dos Santos Grandinetti.pdf: 1506894 bytes, checksum: 1a307f6603c5e353c8729530faacd577 (MD5)Made available in DSpace on 2021-11-04T19:04:13Z (GMT). No. of bitstreams: 1 Vanessa dos Santos Grandinetti.pdf: 1506894 bytes, checksum: 1a307f6603c5e353c8729530faacd577 (MD5) Previous issue date: 2018-03-09application/pdfporUniversidade Nove de JulhoPrograma de Pós-Graduação em Biofotônica Aplicada às Ciências da SaúdeUNINOVEBrasilSaúderemodelamento cardíacoinsuficiência cardíacafotobiomodulaçãolaser de baixa intensidadecarvediloldesempenho físicocardiac remodelingheat failurephotobiomodulationlow level laser therapycarvedilolphysical performanceCIENCIAS DA SAUDEAvaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilolEvaluation of cardiac remodeling and oxidative stress in infarcted rats undergoing photobiomodulation therapy and carvedilolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALVanessa dos Santos Grandinetti.pdfVanessa dos Santos Grandinetti.pdfapplication/pdf1506894http://localhost:8080/tede/bitstream/tede/2675/2/Vanessa+dos+Santos+Grandinetti.pdf1a307f6603c5e353c8729530faacd577MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2675/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/26752021-11-04 17:04:13.168oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2021-11-04T19:04:13Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol |
dc.title.alternative.eng.fl_str_mv |
Evaluation of cardiac remodeling and oxidative stress in infarcted rats undergoing photobiomodulation therapy and carvedilol |
title |
Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol |
spellingShingle |
Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol Grandinétti, Vanessa dos Santos remodelamento cardíaco insuficiência cardíaca fotobiomodulação laser de baixa intensidade carvedilol desempenho físico cardiac remodeling heat failure photobiomodulation low level laser therapy carvedilol physical performance CIENCIAS DA SAUDE |
title_short |
Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol |
title_full |
Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol |
title_fullStr |
Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol |
title_full_unstemmed |
Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol |
title_sort |
Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol |
author |
Grandinétti, Vanessa dos Santos |
author_facet |
Grandinétti, Vanessa dos Santos |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Serra, Andrey Jorge |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6499058447489317 |
dc.contributor.referee1.fl_str_mv |
Serra, Andrey Jorge |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/6499058447489317 |
dc.contributor.referee2.fl_str_mv |
Marcos, Rodrigo Labat |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/2964112163504080 |
dc.contributor.referee3.fl_str_mv |
Silva Junior, Jose Antonio |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/1990427833073161 |
dc.contributor.referee4.fl_str_mv |
Cunha, Gisela Arsa |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/3487458312770368 |
dc.contributor.referee5.fl_str_mv |
Lunardi, Adriana Claudia |
dc.contributor.referee5Lattes.fl_str_mv |
http://lattes.cnpq.br/8310494300611620 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7832637696275599 |
dc.contributor.author.fl_str_mv |
Grandinétti, Vanessa dos Santos |
contributor_str_mv |
Serra, Andrey Jorge Serra, Andrey Jorge Marcos, Rodrigo Labat Silva Junior, Jose Antonio Cunha, Gisela Arsa Lunardi, Adriana Claudia |
dc.subject.por.fl_str_mv |
remodelamento cardíaco insuficiência cardíaca fotobiomodulação laser de baixa intensidade carvedilol desempenho físico |
topic |
remodelamento cardíaco insuficiência cardíaca fotobiomodulação laser de baixa intensidade carvedilol desempenho físico cardiac remodeling heat failure photobiomodulation low level laser therapy carvedilol physical performance CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
cardiac remodeling heat failure photobiomodulation low level laser therapy carvedilol physical performance |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Heart failure (HF) has as its main etiology myocardial infarction (MI), followed by cardiac remodeling, associated with the effective participation of oxidative stress in its genesis. Our objective was to analyze the effects of Carvedilol therapy and photobiomodulation with low lavel laser therapy (LLLT) on cardiac remodeling and oxidative stress in rats infarcted with HF. The study was approved by the Committee on ethics in the use of animals of the University Nove de Julho under number 0016/2016. The final sample size was 127 rats, arranged in 5 experimental groups: SHAM, IM, IMC (Carvedilol treated myocardial infarction), IML (LLLT treated myocardial infarction), IMCL (Carvedilol treated myocardial infarction associated with LLLT ). The results show increase of body weight over the study period in the SHAM, IMC and IML groups, respectively. The aerobic physical performance of all infarcted groups, regardless of any intervention, presented depression at 29 days of study. LV morphological assessments demonstrate that therapies alone or in combination did not result in benefits, and LV systolic and diastolic function data demonstrate that all infarcted animals exhibited performance depression on systolic function 3 days after coronary occlusion, however, significant improvement was observed in the IMCL group at the end of the study. Oxidative stress decreased in the IML group compared to the IM group. Benefits in the expression of carbonylated proteins were evident only in the IMCL group, compared to the IM group. Data on the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in myocardium remote from infarction, showed that there was no benefit of the isolated or combined therapies in SOD and CAT activity in the IMCL group, was significantly higher than values found in the other experimental groups. Survival curves did not show significant differences between groups over 30 days of follow-up. We conclude in this study that Carvedilol and photobiomodulation therapy with LLLT have similar effects on post-infarction HF, considering changes in physical performance, cardiopulmonary biometry and left ventricular morpho-functionality. However, a local anti-inflammatory effect was more evident in animals treated with LBI. In addition, the combination of therapies resulted in attenuation of myocardial hypertrophy and improvement of LV FEAT. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-03-09 |
dc.date.accessioned.fl_str_mv |
2021-11-04T19:04:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Grandinétti, Vanessa dos Santos. Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol. 2018. 65 f. Tese( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2675 |
identifier_str_mv |
Grandinétti, Vanessa dos Santos. Avaliação do remodelamento cardíaco e estresse oxidativo em ratas infartadas submetidas a terapia de fotobiomodulação e carvedilol. 2018. 65 f. Tese( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/2675 |
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por |
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por |
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Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde |
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UNINOVE |
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Brasil |
dc.publisher.department.fl_str_mv |
Saúde |
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Universidade Nove de Julho |
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