Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/1893 |
Resumo: | Subjects with a family history of hypertension (SAH) and Type 2 Diabetes Mellitus (DM2) presented early impairment in heart rate variability (HRV) when compared to those without family history. Despite previous studies reporting the benefits of physical exercise in hypertensive and diabetic subjects, the benefits of a physically active lifestyle in subjects with family history SAH and DM2, especially among young women, have not been fully evaluated. Therefore, the aim of this thesis was to analyze metabolic, hemodynamic and autonomic parameters at rest and in response to sympathetic stimulation in sedentary and physically active women with family history of SAH, DM2 or SAH+DM2. We performed a cross-sectional study with 105 women (age: 18 to 30 years). We evaluated: family history of SAH/DM2; level of physical activity; blood pressure; glycemia; HRV in the time and frequency domain by recording the R-R intervals. For better analysis, the thesis was divided in four studies. In the sStudy 1 we analyzed the quality of life and hemodynamic and autonomic parameters at rest and in response to a mental stress test of sedentary (SW=48) and active (AW=48) young women. The results provided evidence that sedentary lifestyles impaired autonomic cardiac modulation both at rest and in response to physiological stress and worsed quality of life. In the Study 2 we analyzed the HRV in offspring: of normotensive and normoglycemic (NND, n=14), of hypertensive (HD, n=13), of diabetic (DD, n=11), and of diabetic and hypertensive (DFD, n=11). The results showed that the family history of SAH and/or DM2 induced impairment in HRV before clinical cardiovascular or glycemic alterations. In the Study 3 we analyzed the impact of lifestyle on the autonomic cardiac modulation in women with a family history of DM2. We compared offspring of: normoglycemic sedentary (SDN, n = 14), diabetic sedentary (DSD, n=11) and diabetic active (DAD, n = 14). We demonstrated that physically active lifestyles improve cardiac autonomic modulation in diabetic offspring. In the Study 4 we evaluated the influence of the family history of hypertension associated to DM2 on HRV at rest and in response to a mental stress test. We evaluated sedentary offspring of normotensive and normoglycemic (SDNN, n=13), sedentary and active offspring of hypertensive (SHD, n=13 and SAH, n=14), and sedentary and active offspring of hypertensive and diabetic (SHD, n=11 and AHD, n=14). We showed that physically active lifestyles induced improvement on cardiac autonomic modulation of women with a family history of SAH, but that the association with the family history of DM2 is responsible for attenuation of these benefits, especially in response to a mental stress test. In summary, our results demonstrated impairment on HRV in women with family history of SAH and DM2, highlight the importance of a physically active lifestyle in the prevention of early autonomic dysfunctions associated with the development of SAH and DM2 in genetically predisposed women, and also reinforced the HRV analysis as a possible early marker of cardiovascular risk in this population. |
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Angelis, K??tia deAngelis, K??tia deCosta, DirceuDias, Raphael Mendes RittiSanches, Iris Calladohttp://lattes.cnpq.br/8638150719714736Zaffalon J??nior, Jos?? Robertto2018-07-20T20:21:48Z2018-03-09Zaffalon J??nior, Jos?? Robertto. Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes. 2018. 99 f. Tese( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1893Subjects with a family history of hypertension (SAH) and Type 2 Diabetes Mellitus (DM2) presented early impairment in heart rate variability (HRV) when compared to those without family history. Despite previous studies reporting the benefits of physical exercise in hypertensive and diabetic subjects, the benefits of a physically active lifestyle in subjects with family history SAH and DM2, especially among young women, have not been fully evaluated. Therefore, the aim of this thesis was to analyze metabolic, hemodynamic and autonomic parameters at rest and in response to sympathetic stimulation in sedentary and physically active women with family history of SAH, DM2 or SAH+DM2. We performed a cross-sectional study with 105 women (age: 18 to 30 years). We evaluated: family history of SAH/DM2; level of physical activity; blood pressure; glycemia; HRV in the time and frequency domain by recording the R-R intervals. For better analysis, the thesis was divided in four studies. In the sStudy 1 we analyzed the quality of life and hemodynamic and autonomic parameters at rest and in response to a mental stress test of sedentary (SW=48) and active (AW=48) young women. The results provided evidence that sedentary lifestyles impaired autonomic cardiac modulation both at rest and in response to physiological stress and worsed quality of life. In the Study 2 we analyzed the HRV in offspring: of normotensive and normoglycemic (NND, n=14), of hypertensive (HD, n=13), of diabetic (DD, n=11), and of diabetic and hypertensive (DFD, n=11). The results showed that the family history of SAH and/or DM2 induced impairment in HRV before clinical cardiovascular or glycemic alterations. In the Study 3 we analyzed the impact of lifestyle on the autonomic cardiac modulation in women with a family history of DM2. We compared offspring of: normoglycemic sedentary (SDN, n = 14), diabetic sedentary (DSD, n=11) and diabetic active (DAD, n = 14). We demonstrated that physically active lifestyles improve cardiac autonomic modulation in diabetic offspring. In the Study 4 we evaluated the influence of the family history of hypertension associated to DM2 on HRV at rest and in response to a mental stress test. We evaluated sedentary offspring of normotensive and normoglycemic (SDNN, n=13), sedentary and active offspring of hypertensive (SHD, n=13 and SAH, n=14), and sedentary and active offspring of hypertensive and diabetic (SHD, n=11 and AHD, n=14). We showed that physically active lifestyles induced improvement on cardiac autonomic modulation of women with a family history of SAH, but that the association with the family history of DM2 is responsible for attenuation of these benefits, especially in response to a mental stress test. In summary, our results demonstrated impairment on HRV in women with family history of SAH and DM2, highlight the importance of a physically active lifestyle in the prevention of early autonomic dysfunctions associated with the development of SAH and DM2 in genetically predisposed women, and also reinforced the HRV analysis as a possible early marker of cardiovascular risk in this population.Indiv??duos com hist??rico familiar de hipertens??o arterial sist??mica (HAS) e Diabetes Mellitus do tipo 2 (DM2) apresentam precocemente preju??zo na variabilidade da frequ??ncia card??aca (VFC) quando comparados aos filhos de normotensos/normoglic??micos. Apesar de diversos estudos avaliarem os benef??cios do exerc??cio f??sico em hipertensos e diab??ticos, poucos analisaram a influ??ncia do estilo de vida fisicamente ativo em filhos de pais com HAS e DM2, principalmente entre mulheres jovens. Destarte, o objetivo desta tese foi analisar par??metros metab??licos, hemodin??micos e auton??micos em repouso e em resposta a estimula????o simp??tica de mulheres sedent??rias e fisicamente ativas com hist??rico familiar positivo de HAS, DM2 e HAS+DM2. Foi conduzido um estudo anal??tico transversal, com 105 mulheres (18 a 30 anos de idade). Foi avaliado: hist??rico familiar de HAS/DM2; n??vel de atividade f??sica; press??o arterial; glicemia; VFC no dom??nio do tempo e da frequ??ncia por meio do registro dos intervalos R-R. Os resultados foram divididos em quatro estudos. No estudo 1 foi analisada a qualidade de vida e os par??metros hemodin??micos e auton??micos em repouso e em resposta ao teste de estresse mental em mulheres jovens sedent??rias (MS=48) e fisicamente ativas (MA=48). Os achados evidenciaram que o sedentarismo em mulheres induziu preju??zo na modula????o auton??mica card??aca em repouso e em resposta ao estresse fisiol??gico e piorou a qualidade de vida, antes mesmo de alterar par??metros cl??nicos cardiovasculares ou metab??licos. No Estudo 2, foi comparada a VFC de mulheres filhas: de normotensos e normoglic??micos (FNN, n=14), de hipertensos (FH, n=13), de diab??ticos (FD, n=11) e de diab??ticos e hipertensos (FHD, n=11). Os resultados demonstraram que o hist??rico familiar de HAS e/ou DM2 induziu preju??zo na VFC antes de altera????es cl??nicas cardiovasculares ou glic??micas. No estudo 3 foi avaliado o impacto do estilo de vida sobre a modula????o auton??mica card??aca de mulheres com hist??rico familiar de DM2. Foram avaliadas filhas: sedent??rias de normoglic??micos (FSN, n=14), sedent??rias de diab??ticos (FSD, n=11) e ativas de diab??ticos (FAD, n=14), concluindo que o estilo de vida fisicamente ativo foi associado a melhor modula????o auton??mica card??aca do grupo FAD. No Estudo 4 foi avaliado a influ??ncia do hist??rico familiar de HAS associado ou n??o ?? DM2 sobre a VFC em repouso e em resposta a um teste de estresse mental de mulheres sedent??rias e fisicamente ativas. Foram avaliadas filhas: sedent??rias de normotensos e normoglic??micos (FSNN, n=14), sedent??rias de hipertensos (FSH, n=13), ativas de hipertensos (FAH, n=14); e sedent??rias de hipertensos e diab??ticos (FSHD, n=11) e ativas de hipertensos e diab??ticos (FAHD, n=14). Os achados deste estudo mostraram que o estilo de vida fisicamente ativo ?? respons??vel pela melhor modula????o auton??mica card??aca de mulheres com hist??rico familiar de HAS, mas que a associa????o com o hist??rico de DM2 atenua estes benef??cios, n??o s?? na condi????o de repouso, mas principalmente frente ao teste de estresse mental. Em conjunto nossos resultados evidenciam preju??zo na VFC em mulheres com hist??rico familiar de HAS e/ou DM2, ressaltam a import??ncia de uma vida fisicamente ativa na preven????o de disfun????es auton??micas precoces associadas ao desenvolvimento de HAS e DM2 em mulheres geneticamente predispostas, e refor??am a an??lise da VFC como um poss??vel marcador precoce de risco cardiovascular nessa popula????o.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-07-20T20:21:48Z No. of bitstreams: 1 Jos?? Robertto Zaffalon J??nior.pdf: 1226797 bytes, checksum: 98ee59a170b7f0ef47fc560dd2ba5b1f (MD5)Made available in DSpace on 2018-07-20T20:21:48Z (GMT). No. of bitstreams: 1 Jos?? Robertto Zaffalon J??nior.pdf: 1226797 bytes, checksum: 98ee59a170b7f0ef47fc560dd2ba5b1f (MD5) Previous issue date: 2018-03-09application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Ci??ncias da Reabilita????oUNINOVEBrasilSa??dehipertens??odiabetesmulheressistema nervoso aut??nomohereditariedadehypertensiondiabeteswomenautonomic nervous systemheredityCIENCIAS DA SAUDEImpacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetesImpact of physically active lifestyle on heart rate variability in women with family history of hypertension and diabetesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALJos?? Robertto Zaffalon J??nior.pdfJos?? 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dc.title.por.fl_str_mv |
Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes |
dc.title.alternative.eng.fl_str_mv |
Impact of physically active lifestyle on heart rate variability in women with family history of hypertension and diabetes |
title |
Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes |
spellingShingle |
Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes Zaffalon J??nior, Jos?? Robertto hipertens??o diabetes mulheres sistema nervoso aut??nomo hereditariedade hypertension diabetes women autonomic nervous system heredity CIENCIAS DA SAUDE |
title_short |
Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes |
title_full |
Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes |
title_fullStr |
Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes |
title_full_unstemmed |
Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes |
title_sort |
Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes |
author |
Zaffalon J??nior, Jos?? Robertto |
author_facet |
Zaffalon J??nior, Jos?? Robertto |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Angelis, K??tia de |
dc.contributor.referee1.fl_str_mv |
Angelis, K??tia de |
dc.contributor.referee2.fl_str_mv |
Costa, Dirceu |
dc.contributor.referee3.fl_str_mv |
Dias, Raphael Mendes Ritti |
dc.contributor.referee4.fl_str_mv |
Sanches, Iris Callado |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8638150719714736 |
dc.contributor.author.fl_str_mv |
Zaffalon J??nior, Jos?? Robertto |
contributor_str_mv |
Angelis, K??tia de Angelis, K??tia de Costa, Dirceu Dias, Raphael Mendes Ritti Sanches, Iris Callado |
dc.subject.por.fl_str_mv |
hipertens??o diabetes mulheres sistema nervoso aut??nomo hereditariedade |
topic |
hipertens??o diabetes mulheres sistema nervoso aut??nomo hereditariedade hypertension diabetes women autonomic nervous system heredity CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
hypertension diabetes women autonomic nervous system heredity |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Subjects with a family history of hypertension (SAH) and Type 2 Diabetes Mellitus (DM2) presented early impairment in heart rate variability (HRV) when compared to those without family history. Despite previous studies reporting the benefits of physical exercise in hypertensive and diabetic subjects, the benefits of a physically active lifestyle in subjects with family history SAH and DM2, especially among young women, have not been fully evaluated. Therefore, the aim of this thesis was to analyze metabolic, hemodynamic and autonomic parameters at rest and in response to sympathetic stimulation in sedentary and physically active women with family history of SAH, DM2 or SAH+DM2. We performed a cross-sectional study with 105 women (age: 18 to 30 years). We evaluated: family history of SAH/DM2; level of physical activity; blood pressure; glycemia; HRV in the time and frequency domain by recording the R-R intervals. For better analysis, the thesis was divided in four studies. In the sStudy 1 we analyzed the quality of life and hemodynamic and autonomic parameters at rest and in response to a mental stress test of sedentary (SW=48) and active (AW=48) young women. The results provided evidence that sedentary lifestyles impaired autonomic cardiac modulation both at rest and in response to physiological stress and worsed quality of life. In the Study 2 we analyzed the HRV in offspring: of normotensive and normoglycemic (NND, n=14), of hypertensive (HD, n=13), of diabetic (DD, n=11), and of diabetic and hypertensive (DFD, n=11). The results showed that the family history of SAH and/or DM2 induced impairment in HRV before clinical cardiovascular or glycemic alterations. In the Study 3 we analyzed the impact of lifestyle on the autonomic cardiac modulation in women with a family history of DM2. We compared offspring of: normoglycemic sedentary (SDN, n = 14), diabetic sedentary (DSD, n=11) and diabetic active (DAD, n = 14). We demonstrated that physically active lifestyles improve cardiac autonomic modulation in diabetic offspring. In the Study 4 we evaluated the influence of the family history of hypertension associated to DM2 on HRV at rest and in response to a mental stress test. We evaluated sedentary offspring of normotensive and normoglycemic (SDNN, n=13), sedentary and active offspring of hypertensive (SHD, n=13 and SAH, n=14), and sedentary and active offspring of hypertensive and diabetic (SHD, n=11 and AHD, n=14). We showed that physically active lifestyles induced improvement on cardiac autonomic modulation of women with a family history of SAH, but that the association with the family history of DM2 is responsible for attenuation of these benefits, especially in response to a mental stress test. In summary, our results demonstrated impairment on HRV in women with family history of SAH and DM2, highlight the importance of a physically active lifestyle in the prevention of early autonomic dysfunctions associated with the development of SAH and DM2 in genetically predisposed women, and also reinforced the HRV analysis as a possible early marker of cardiovascular risk in this population. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-07-20T20:21:48Z |
dc.date.issued.fl_str_mv |
2018-03-09 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Zaffalon J??nior, Jos?? Robertto. Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes. 2018. 99 f. Tese( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1893 |
identifier_str_mv |
Zaffalon J??nior, Jos?? Robertto. Impacto do estilo de vida fisicamente ativo na variabilidade da frequ??ncia card??aca de mulheres com hist??rico familiar de hipertens??o e diabetes. 2018. 99 f. Tese( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/1893 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
8765449414823306929 |
dc.relation.confidence.fl_str_mv |
600 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.publisher.program.fl_str_mv |
Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o |
dc.publisher.initials.fl_str_mv |
UNINOVE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Sa??de |
publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.source.none.fl_str_mv |
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Universidade Nove de Julho (UNINOVE) |
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UNINOVE |
institution |
UNINOVE |
reponame_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
collection |
Biblioteca Digital de Teses e Dissertações da Uninove |
bitstream.url.fl_str_mv |
http://localhost:8080/tede/bitstream/tede/1893/2/Jos%C3%A9+Robertto+Zaffalon+J%C3%BAnior.pdf http://localhost:8080/tede/bitstream/tede/1893/1/license.txt |
bitstream.checksum.fl_str_mv |
98ee59a170b7f0ef47fc560dd2ba5b1f bd3efa91386c1718a7f26a329fdcb468 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE) |
repository.mail.fl_str_mv |
bibliotecatede@uninove.br||bibliotecatede@uninove.br |
_version_ |
1800312356848271360 |